RTW INVESTMENTS, LP
Institutional investor · Portfolio as of Q4 2021
Top Holdings124 positions
STATE STR SPDR S&P 500 ETF T | 889,739 | $422.6M | 6.2% | $372.76 | +104.76%as of Oct 16 | 4 qtrssince 2021-Q1 | Increased 62 |
ROCKET PHARMACEUTICALS INC | 15.8M | $345M | 5.0% | $18.68 | +16.89% | 12 qtrssince 2019-Q1 | Unchanged 0 |
ALNYLAM PHARMACEUTICALS INC | 2M | $335.1M | 4.9% | $94.58 | +80.83% | 12 qtrssince 2019-Q1 | Increased 66 |
THERMO FISHER SCIENTIFIC INC | 435,500 | $290.6M | 4.2% | $576.77 | +14.10% | 2 qtrssince 2021-Q3 | Increased 59 |
MASIMO CORP | 849,971 | $248.9M | 3.6% | $195.73 | +51.86% | 12 qtrssince 2019-Q1 | Increased 58 |
MIRATI THERAPEUTICS INC | 1.6M | $229.1M | 3.3% | — | — | 12 qtrssince 2019-Q1 | Increased 59 |
PTC THERAPEUTICS INC | 5.3M | $210.9M | 3.1% | $41.64 | -3.75% | 12 qtrssince 2019-Q1 | Unchanged 0 |
ILLUMINA INC | 490,399 | $186.6M | 2.7% | $342.46 | +8.07% | 6 qtrssince 2020-Q3 | Increased 53 |
PENUMBRA INC | 620,871 | $178.4M | 2.6% | $273.22 | +4.86% | 2 qtrssince 2021-Q3 | Increased 75 |
VERICEL CORP | 4.5M | $177.5M | 2.6% | $17.15 | +129.22% | 12 qtrssince 2019-Q1 | Unchanged 0 |
Tandem Diabetes Care Inc New | 1.2M | $174.7M | 2.6% | $81.43 | +84.85% | 8 qtrssince 2020-Q1 | Unchanged 0 |
NATERA INC | 1.9M | $173.9M | 2.5% | $44.14 | +111.60% | 10 qtrssince 2019-Q3 | Unchanged 0 |
ESTABLISHMENT LABS HOLDINGS INC | 2.3M | $156.8M | 2.3% | $22.02 | +206.97% | 12 qtrssince 2019-Q1 | Unchanged 0 |
CELLDEX THERAPEUTICS INC NEW | 3.9M | $151.5M | 2.2% | $14.61 | +164.45% | 7 qtrssince 2020-Q2 | Increased 52 |
PROMETHEUS BIOSCIENCES INC | 3.3M | $129.1M | 1.9% | — | — | 4 qtrssince 2021-Q1 | Unchanged 0 |
GLOBUS MED INC | 1.7M | $120.6M | 1.8% | $64.85 | +11.81% | 5 qtrssince 2020-Q4 | Unchanged 0 |
CYTOKINETICS INC | 2.6M | $116.7M | 1.7% | $26.89 | +69.48% | 6 qtrssince 2020-Q3 | Increased 59 |
ULTRAGENYX PHARMACEUTICAL IN | 1.4M | $115.5M | 1.7% | $84.09 | 0.00% | 1 qtr | New 69 |
AVIDITY BIOSCIENCES INC | 4.8M | $114M | 1.7% | $26.39 | -9.31% | 7 qtrssince 2020-Q2 | Unchanged 0 |
IVERIC BIO INC | 6.7M | $112.4M | 1.6% | — | — | 7 qtrssince 2020-Q2 | Unchanged 0 |
RTW INVESTMENTS, LP manages $6.8B across 124 positions as of Q4 2021. Top holdings: SPY (6.2%), RCKT (5.0%), ALNY (4.9%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 2/5.0.
Active quarter - 17 new positions, 13 exits, 26 increased. Top move: PEN (INCREASED, conviction 75). Portfolio: $6.8B across 124 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
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Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
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