RTW INVESTMENTS, LP
Institutional investor · Portfolio as of Q4 2021
Top Holdings124 positions
Stock | Shares | Value | Weight | Avg Buy | Est. P&L | Held | Conviction |
|---|---|---|---|---|---|---|---|
STATE STREET SPDR S&P 500 ETF TRUST CL USD INC | 889,739 | $422.6M | 6.2% | $372.76 | +107.28% | 4 qtrssince 2021-Q1 | Increased 62 |
ROCKET PHARMACEUTICALS INC | 15.8M | $345M | 5.0% | $18.70 | +22.62% | 12 qtrssince 2019-Q1 | Unchanged 0 |
ALNYLAM PHARMACEUTICALS INC | 2M | $335.1M | 4.9% | $94.58 | +80.83% | 12 qtrssince 2019-Q1 | Increased 66 |
THERMO FISHER SCIENTIFIC INC | 435,500 | $290.6M | 4.2% | $576.77 | +14.10% | 2 qtrssince 2021-Q3 | Increased 59 |
MASIMO CORP | 849,971 | $248.9M | 3.6% | $195.73 | +51.86% | 12 qtrssince 2019-Q1 | Increased 58 |
MIRATI THERAPEUTICS INC | 1.6M | $229.1M | 3.3% | — | — | 12 qtrssince 2019-Q1 | Increased 59 |
PTC THERAPEUTICS INC | 5.3M | $210.9M | 3.1% | $41.64 | -3.75% | 12 qtrssince 2019-Q1 | Unchanged 0 |
ILLUMINA INC | 490,399 | $186.6M | 2.7% | $335.49 | +11.41% | 6 qtrssince 2020-Q3 | Increased 53 |
PENUMBRA INC | 620,871 | $178.4M | 2.6% | $273.22 | +4.86% | 2 qtrssince 2021-Q3 | Increased 75 |
VERICEL CORP | 4.5M | $177.5M | 2.6% | $17.25 | +132.58% | 12 qtrssince 2019-Q1 | Unchanged 0 |
TANDEM DIABETES CARE INC | 1.2M | $174.7M | 2.6% | $80.01 | +89.83% | 8 qtrssince 2020-Q1 | Unchanged 0 |
NATERA INC | 1.9M | $173.9M | 2.5% | $42.96 | +116.84% | 10 qtrssince 2019-Q3 | Unchanged 0 |
ESTABLISHMENT LABS HLDGS INC | 2.3M | $156.8M | 2.3% | $21.90 | +196.23% | 12 qtrssince 2019-Q1 | Unchanged 0 |
Celldex Therapeutics, Inc. | 3.9M | $151.5M | 2.2% | $14.23 | +173.31% | 7 qtrssince 2020-Q2 | Increased 52 |
PROMETHEUS BIOSCIENCES INC | 3.3M | $129.1M | 1.9% | — | — | 4 qtrssince 2021-Q1 | Unchanged 0 |
GLOBUS MED INC | 1.7M | $120.6M | 1.8% | $64.85 | +11.81% | 5 qtrssince 2020-Q4 | Unchanged 0 |
CYTOKINETICS INC | 2.6M | $116.7M | 1.7% | $26.89 | +69.48% | 6 qtrssince 2020-Q3 | Increased 59 |
Ultragenyx Pharmaceutical, Inc. | 1.4M | $115.5M | 1.7% | $84.25 | 0.00% | 1 qtr | New 69 |
| 4.8M | $114M | 1.7% | $26.39 | -9.31% | 7 qtrssince 2020-Q2 | Unchanged 0 | |
IVERIC BIO INC | 6.7M | $112.4M | 1.6% | — | — | 7 qtrssince 2020-Q2 | Unchanged 0 |
RTW INVESTMENTS, LP manages $6.8B across 124 positions as of Q4 2021. Top holdings: SPY (6.2%), RCKT (5.0%), ALNY (4.9%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.
Active quarter - 17 new positions, 13 exits, 26 increased. Top move: PEN (INCREASED, conviction 75). Portfolio: $6.8B across 124 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
Similar Funds
Funds with similar investing DNA
Explore More
Accumulation Streaks
Positions with 2+ consecutive quarters of increases - persistent directional conviction.
Continue exploring
Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer