AMYLYX PHARMACEUTICALS INC (AMLX) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling AMLX?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for AMYLYX PHARMACEUTICALS INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on AMLX?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for AMYLYX PHARMACEUTICALS INC.

Is institutional money flowing into AMLX?

100 institutional investors hold AMYLYX PHARMACEUTICALS INC (AMLX). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about AMLX?

Track institutional sentiment and conviction scores for AMYLYX PHARMACEUTICALS INC (AMLX) including Smart Money Verdict and position changes on HoldingsIntel.

AMYLYX PHARMACEUTICALS INC

AMLX·03237H101·US·equity·Healthcare - Drug Manufacturers - Specialty & Generic-13D/G

AMLX (AMYLYX PHARMACEUTICALS INC) is held by 100 institutional investors as of Q4 2025. Largest holders: FMR LLC ($199.5M), BlackRock, Inc. ($109.4M), VANGUARD GROUP INC ($70.1M). Net institutional sentiment: Bullish.

100

Holders

Avg rating(5 Elite)

$815M

Total Value

70% (107)

Fund Consensus

68 buying - 28 selling

Smart Money Verdict- Q4 2025View all

40Weak MomentumSplit Signals

Held by 100 funds

5 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 26, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	16.5M(+45.2%)	$199.5M	0.0%	+15.30%	41
BlackRock, Inc.	Increased	9.1M(+26.8%)	$109.4M	0.0%	+67.72%	37
VANGUARD GROUP INC	Increased	5.8M(+10.1%)	$70.1M	0.0%	+141.96%	33
JANUS HENDERSON GROUP PLC	Increased	4.5M(+76.1%)	$54M	0.0%	+3.39%	44
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	3.1M(+28.4%)	$37.6M	0.3%	+31.00%	43
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	2.8M(-59.3%)	$33.5M	0.1%	+206.65%	0
GOLDMAN SACHS GROUP INC	Increased	2.6M(+30.0%)	$31.6M	0.0%	+61.60%	36
MORGAN STANLEY	Increased	2.4M(+21.0%)	$28.5M	0.0%	+20.13%	34
GEODE CAPITAL MANAGEMENT, LLC	Increased	2.2M(+19.5%)	$26.2M	0.0%	+22.64%	34
STATE STREET CORP	Increased	2.1M(+27.7%)	$25M	0.0%	+36.69%	36
BANK OF AMERICA CORP /DE/	Increased	1.3M(+211.1%)	$16.1M	0.0%	+50.48%	45
DEUTSCHE BANK AG\	Decreased	1.3M(-2.4%)	$16.1M	0.0%	-3.53%	0
FRANKLIN RESOURCES INC	New	1.2M	$14.5M	0.0%	+17.58%	39
Connor, Clark & Lunn Investment Management Ltd.	Decreased	1M(-9.3%)	$12.1M	0.0%	+139.65%	0
NORTHERN TRUST CORP	Increased	937,764(+14.1%)	$11.3M	0.0%	+54.99%	32
BALYASNY ASSET MANAGEMENT L.P.	Decreased	858,684(-41.8%)	$10.4M	0.0%	-5.30%	0
Woodline Partners LP	Increased	845,408(+0.0%)	$10.2M	0.0%	+285.39%	28
DIMENSIONAL FUND ADVISORS LP	Increased	771,248(+51.3%)	$9.3M	0.0%	+50.93%	38
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	712,990(+10.5%)	$8.6M	0.0%	+7.53%	30
UBS Group AG	Decreased	543,323(-61.3%)	$6.6M	0.0%	+189.47%	0
AMERIPRISE FINANCIAL INC	Increased	502,366(+276.3%)	$6.1M	0.0%	+27.31%	44
FEDERATED HERMES, INC.	Increased	457,412(+115.4%)	$5.5M	0.0%	-1.37%	44
Qube Research & Technologies Ltd	Increased	412,873(+147.1%)	$5M	0.0%	+53.71%	43
CITADEL ADVISORS LLC	Increased	344,968(+47.0%)	$4.2M	0.0%	+28.59%	37
TWO SIGMA INVESTMENTS, LP	Increased	344,401(+249.9%)	$4.2M	0.0%	+47.39%	43
Point72 Asset Management, L.P.	Decreased	335,000(-88.0%)	$4M	0.0%	+143.68%	0
TWO SIGMA ADVISERS, LP	Increased	328,401(+129.7%)	$4M	0.0%	+72.31%	43
BARCLAYS PLC	Decreased	295,177(-28.7%)	$3.6M	0.0%	+13.00%	0
Nuveen, LLC	Increased	283,948(+77.0%)	$3.4M	0.0%	+57.76%	40
JANE STREET GROUP, LLC	New	263,235	$3.2M	0.0%	+17.58%	37
WELLINGTON MANAGEMENT GROUP LLP	Decreased	225,782(-4.4%)	$2.7M	0.0%	+272.31%	0
Bank of New York Mellon Corp	Increased	217,347(+18.8%)	$2.6M	0.0%	+66.13%	31
RENAISSANCE TECHNOLOGIES LLC	Increased	192,500(+867.3%)	$2.3M	0.0%	+26.35%	42
XTX Topco Ltd	New	189,673	$2.3M	0.1%	+17.58%	36
Invesco Ltd.	Decreased	175,914(-78.3%)	$2.1M	0.0%	+65.13%	0
Swiss National Bank	New	161,700	$2M	0.0%	+17.58%	36
VOLORIDGE INVESTMENT MANAGEMENT, LLC	New	153,363	$1.9M	0.0%	+17.58%	36
WELLS FARGO & COMPANY/MN	Increased	146,309(+56.2%)	$1.8M	0.0%	+21.12%	36
BANK OF MONTREAL /CAN/	Decreased	138,525(-3.6%)	$1.7M	0.0%	+265.69%	0
RHUMBLINE ADVISERS	Increased	99,274(+0.6%)	$1.2M	0.0%	+121.67%	25
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	New	98,838	$1.2M	0.0%	+17.58%	35
ALPS ADVISORS INC	New	90,172	$1.1M	0.0%	+17.58%	35
STATE OF WISCONSIN INVESTMENT BOARD	Increased	84,144(+506.4%)	$1M	0.0%	+13.08%	40
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	79,090(+1726.1%)	$955,407	0.0%	+20.70%	40
Squarepoint Ops LLC	New	76,562	$924,869	0.0%	+17.58%	35
D. E. Shaw & Co., Inc.	Increased	73,224(+6.3%)	$884,546	0.0%	-7.53%	26
Legal & General Group Plc	Increased	72,612(+8.0%)	$877,153	0.0%	+2.17%	27
ALLIANCEBERNSTEIN L.P.	Unchanged	71,500	$863,720	0.0%	+25.62%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	New	68,892	$832,215	0.0%	+17.58%	34
JPMORGAN CHASE & CO	Increased	66,547(+85.7%)	$803,888	0.0%	+73.73%	39
Russell Investments Group, Ltd.	Increased	65,438(+18.1%)	$790,491	0.0%	+6.25%	29
SEI INVESTMENTS CO	New	52,856	$638,500	0.0%	+17.58%	34
MetLife Investment Management, LLC	Increased	49,654(+15.7%)	$599,820	0.0%	+98.79%	28
Trexquant Investment LP	Decreased	48,112(-78.4%)	$581,193	0.0%	-5.30%	0
MILLENNIUM MANAGEMENT LLC	Decreased	46,455(-88.9%)	$561,176	0.0%	+128.81%	0
Mariner, LLC	Decreased	46,342(-3.5%)	$559,858	0.0%	-52.50%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	41,166(+28.6%)	$497,285	0.0%	+85.84%	30
CITIGROUP INC	Decreased	38,032(-0.1%)	$459,427	0.0%	+140.43%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	35,877(+1782.3%)	$433,394	0.0%	+22.09%	39
INTECH INVESTMENT MANAGEMENT LLC	Increased	32,006(+64.2%)	$386,632	0.0%	+65.09%	35
Verition Fund Management LLC	Decreased	29,487(-53.9%)	$356,203	0.0%	-5.30%	0
AQR CAPITAL MANAGEMENT LLC	Decreased	27,847(-62.2%)	$336,391	0.0%	-5.30%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	26,988(+13.4%)	$326,015	0.0%	+101.52%	27
GUGGENHEIM CAPITAL LLC	Increased	25,243(+1.4%)	$304,935	0.0%	+78.44%	24
BNP PARIBAS FINANCIAL MARKETS	Increased	25,201(+72.5%)	$304,428	0.0%	+27.42%	35
Police & Firemen's Retirement System of New Jersey	Increased	23,752(+23.3%)	$286,924	0.0%	+64.42%	28
Arizona State Retirement System	New	22,914	$276,801	0.0%	+17.58%	32
TUDOR INVESTMENT CORP ET AL	New	22,402	$270,616	0.0%	+17.58%	32
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	21,900	$264,552	0.0%	+122.91%	0
ProShare Advisors LLC	Increased	21,068(+40.1%)	$254,501	0.0%	+77.42%	31
Schonfeld Strategic Advisors LLC	Decreased	21,052(-51.8%)	$254,307	0.0%	+145.96%	0
Vanguard Personalized Indexing Management, LLC	Decreased	20,840(-1.2%)	$251,747	0.0%	+444.75%	0
BROWN ADVISORY INC	Unchanged	19,930	$240,754	0.0%	-33.71%	0
Engineers Gate Manager LP	New	18,358	$221,765	0.0%	+17.58%	32
Rafferty Asset Management, LLC	New	17,673	$213,490	0.0%	+17.58%	32
KLP KAPITALFORVALTNING AS	New	17,400	$210,192	0.0%	+17.58%	32
JUPITER ASSET MANAGEMENT LTD	New	15,574	$188,134	0.0%	+17.58%	31
ROYAL BANK OF CANADA	Decreased	15,643(-83.2%)	$188,000	0.0%	+4.79%	0
Quadrature Capital Ltd	Decreased	15,465(-45.3%)	$186,817	0.0%	+172.72%	0
VOYA INVESTMENT MANAGEMENT LLC	Increased	15,247(+17.4%)	$184,184	0.0%	+96.81%	26
TEACHER RETIREMENT SYSTEM OF TEXAS	New	12,174	$147,061	0.0%	+17.58%	31
VICTORY CAPITAL MANAGEMENT INC	New	10,552	$127,468	0.0%	+17.58%	31
Walleye Capital LLC	New	5,740	$69,339	0.0%	+17.58%	29
Mirae Asset Global Investments Co., Ltd.	Increased	5,337(+54.8%)	$64,471	0.0%	-16.29%	30
SIMPLEX TRADING, LLC	New	3,727	$45,022	0.0%	+17.58%	31
STRS OHIO	Unchanged	3,400	$41,072	0.0%	+122.91%	0
Walleye Trading LLC	New	2,825	$34,126	0.0%	+17.58%	30
LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA	Unchanged	1,803	$27,892	0.0%	-32.75%	0
US BANCORP \DE\	Decreased	2,000(-50.0%)	$24,160	0.0%	+267.45%	0
Steward Partners Investment Advisory, LLC	Unchanged	1,500	$18,120	0.0%	-18.67%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	New	852	$11,971	0.0%	+17.58%	27
NISA INVESTMENT ADVISORS, LLC	Increased	922(+223.5%)	$11,138	0.0%	+53.59%	19
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	438(-9.7%)	$5,291	0.0%	-4.48%	0
Rockefeller Capital Management L.P.	Increased	261(+5120.0%)	$3,152	0.0%	+17.04%	15
OSAIC HOLDINGS, INC.	Increased	249(+10.7%)	$3,007	0.0%	+105.19%	10
PRICE T ROWE ASSOCIATES INC /MD/	Increased	107,548(+7.1%)	$1,300	0.0%	+22.99%	12
JONES FINANCIAL COMPANIES LLLP	Unchanged	30	$362	0.0%	-5.30%	0
Farther Finance Advisors, LLC	Unchanged	20	$242	0.0%	-5.30%	0
Allworth Financial LP	Unchanged	12	$145	0.0%	-5.30%	0
BNP Paribas Asset Management Holding S.A.	New	1,315	$16	0.0%	+17.58%	17
Brevan Howard Capital Management LP	Exited	0(-100.0%)	$770,105	0.0%	-19.46%	0
HSBC HOLDINGS PLC	Exited	0(-100.0%)	$278,139	0.0%	-19.46%	0
JENNISON ASSOCIATES LLC	Exited	0(-100.0%)	$7.9M	0.0%	-19.46%	0
PRUDENTIAL FINANCIAL INC	Exited	0(-100.0%)	$138,006	0.0%	+278.86%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$144,516	0.0%	-19.46%	0
FRED ALGER MANAGEMENT, LLC	Exited	0(-100.0%)	$2.2M	0.0%	-19.46%	0
TD ASSET MANAGEMENT INC	Exited	0(-100.0%)	$556,728	0.0%	-19.46%	0

AMYLYX PHARMACEUTICALS INC

Continue exploring