Denali Therapeutics Inc. (DNLI) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling DNLI?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Denali Therapeutics Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on DNLI?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Denali Therapeutics Inc..

Is institutional money flowing into DNLI?

128 institutional investors hold Denali Therapeutics Inc. (DNLI). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about DNLI?

Track institutional sentiment and conviction scores for Denali Therapeutics Inc. (DNLI) including Smart Money Verdict and position changes on HoldingsIntel.

Denali Therapeutics Inc.

DNLI·24823R105·US·equity·Healthcare - Biotechnology-13D/G

DNLI (Denali Therapeutics Inc.) is held by 128 institutional investors as of Q4 2025. Largest holders: VANGUARD GROUP INC ($215.6M), BlackRock, Inc. ($209.9M), BAILLIE GIFFORD & CO ($203.3M). Net institutional sentiment: Mixed.

128

Holders

Avg rating(6 Elite)

$2B

Total Value

50% (143)

Fund Consensus

64 buying - 64 selling

Smart Money VerdictView all

40Weak MomentumSplit Signals

Get 5 free verdicts/month - sign up in 10 seconds

See how DNLI's score breaks down across 4 SEC sources

Held by 128 funds

6 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 26, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VANGUARD GROUP INC	Increased	13.1M(+8.9%)	$215.6M	0.0%	-27.37%	33
BlackRock, Inc.	Increased	12.7M(+3.5%)	$209.9M	0.0%	+0.07%	32
BAILLIE GIFFORD & CO	Increased	12.3M(+6.2%)	$203.3M	0.2%	-45.91%	39
Temasek Holdings (Private) Ltd	Increased	7M(+30.9%)	$115.8M	0.4%	-14.15%	46
STATE STREET CORP	Increased	6.3M(+14.6%)	$103.4M	0.0%	+2.35%	34
FMR LLC	Decreased	6.1M(-3.8%)	$100.7M	0.0%	-0.59%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Decreased	5M(-8.8%)	$82.3M	0.0%	-7.10%	0
GOLDMAN SACHS GROUP INC	Increased	3.8M(+77.3%)	$63.3M	0.0%	+18.17%	45
BAKER BROS. ADVISORS LP	Unchanged	3.7M	$61.6M	0.4%	-15.11%	0
Capital Research Global Investors	Decreased	3.7M(-21.7%)	$61.6M	0.0%	-17.62%	0
ALLIANCEBERNSTEIN L.P.	Increased	3.6M(+1.1%)	$58.7M	0.0%	-17.70%	30
GEODE CAPITAL MANAGEMENT, LLC	Decreased	3.5M(-0.2%)	$57.1M	0.0%	-29.73%	0
Holocene Advisors, LP	Increased	3.2M(+0.5%)	$52.1M	0.1%	+38.29%	35
Fisher Asset Management, LLC	Increased	2.6M(+58.7%)	$42.8M	0.0%	+15.65%	42
UBS Group AG	Increased	2.4M(+19.5%)	$39.7M	0.0%	+18.64%	34
DIMENSIONAL FUND ADVISORS LP	Increased	2.4M(+0.7%)	$39.2M	0.0%	-2.60%	29
Aberdeen Group plc	Increased	2M(+82.6%)	$33.6M	0.1%	+19.76%	45
Point72 Asset Management, L.P.	Decreased	1.7M(-32.5%)	$28.1M	0.0%	+41.48%	0
PRINCIPAL FINANCIAL GROUP INC	Increased	1.5M(+19.9%)	$25.2M	0.0%	-17.74%	34
Pictet Asset Management Holding SA	Increased	1.3M(+166.3%)	$22M	0.0%	+26.33%	46
MORGAN STANLEY	Decreased	1.2M(-27.8%)	$20.1M	0.0%	-9.77%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	1.2M(+4.3%)	$19.8M	0.0%	-28.26%	30
NORTHERN TRUST CORP	Decreased	1.2M(-2.8%)	$19.8M	0.0%	-34.84%	0
Candriam S.C.A.	Increased	1.2M(+39.9%)	$19.3M	0.1%	-24.74%	38
ExodusPoint Capital Management, LP	New	1M	$16.9M	0.1%	+22.00%	47
BANK OF AMERICA CORP /DE/	Decreased	932,144(-3.0%)	$15.4M	0.0%	+24.44%	0
Alyeska Investment Group, L.P.	New	859,108	$14.2M	0.0%	+22.00%	39
CITADEL ADVISORS LLC	Increased	779,148(+13.2%)	$12.9M	0.0%	+9.19%	32
MARSHALL WACE, LLP	Decreased	763,892(-2.9%)	$12.6M	0.0%	-1.14%	0
Bank of New York Mellon Corp	Decreased	762,087(-4.8%)	$12.6M	0.0%	-54.27%	0
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Decreased	591,461(-36.8%)	$9.8M	0.0%	+39.09%	0
Qube Research & Technologies Ltd	Increased	590,314(+158.9%)	$9.7M	0.0%	+27.68%	45
Ensign Peak Advisors, Inc	Decreased	515,721(-3.4%)	$8.5M	0.0%	-2.57%	0
Hudson Bay Capital Management LP	Increased	450,000(+47.5%)	$7.4M	0.0%	+21.80%	38
SCHRODER INVESTMENT MANAGEMENT GROUP	Increased	450,985(+115.2%)	$7.4M	0.0%	+13.38%	44
TWO SIGMA INVESTMENTS, LP	Increased	430,177(+61.5%)	$7.1M	0.0%	+29.02%	39
BARCLAYS PLC	Decreased	407,359(-6.8%)	$6.7M	0.0%	-5.06%	0
AMERICAN CENTURY COMPANIES INC	Increased	379,051(+6.1%)	$6.3M	0.0%	-29.97%	29
MILLENNIUM MANAGEMENT LLC	Decreased	369,767(-71.7%)	$6.1M	0.0%	+27.09%	0
TD ASSET MANAGEMENT INC	Decreased	339,410(-14.0%)	$5.6M	0.0%	-5.76%	0
Invesco Ltd.	Increased	291,936(+17.0%)	$4.8M	0.0%	-16.11%	31
Marex Group plc	Decreased	287,001(-1.4%)	$4.7M	0.0%	+41.57%	0
Nuveen, LLC	Decreased	275,508(-3.3%)	$4.5M	0.0%	+38.37%	0
Swiss National Bank	Increased	273,800(+2.4%)	$4.5M	0.0%	-15.88%	27
Trexquant Investment LP	Decreased	209,609(-51.3%)	$3.5M	0.0%	+26.44%	0
SCS Capital Management LLC	Unchanged	197,998	$3.3M	0.0%	+35.45%	0
WELLS FARGO & COMPANY/MN	Increased	193,681(+85.9%)	$3.2M	0.0%	+7.43%	41
Rafferty Asset Management, LLC	Increased	191,567(+4.8%)	$3.2M	0.0%	-9.77%	28
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	184,238(-10.5%)	$3M	0.0%	-16.61%	0
RHUMBLINE ADVISERS	Decreased	183,000(-9.2%)	$3M	0.0%	-30.92%	0
AMERIPRISE FINANCIAL INC	Increased	180,221(+81.0%)	$3M	0.0%	+32.29%	40
JPMORGAN CHASE & CO	Decreased	171,948(-1.8%)	$2.8M	0.0%	-0.58%	0
TWO SIGMA ADVISERS, LP	Increased	154,800(+72.0%)	$2.6M	0.0%	+26.92%	39
Legal & General Group Plc	Decreased	131,223(-8.8%)	$2.2M	0.0%	-40.65%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	129,409(-0.1%)	$2.1M	0.0%	-35.04%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Decreased	128,800(-0.8%)	$2.1M	0.0%	-0.51%	0
ALPS ADVISORS INC	Increased	120,718(+71.9%)	$2M	0.0%	-12.08%	39
Woodline Partners LP	Increased	114,082(+0.5%)	$1.9M	0.0%	+2.28%	26
B. Metzler seel. Sohn & Co. AG	New	112,300	$1.8M	0.0%	+22.00%	36
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	New	107,493	$1.8M	0.0%	+22.00%	36
D.A. DAVIDSON & CO.	New	106,933	$1.8M	0.0%	+22.00%	36
DEUTSCHE BANK AG\	Decreased	105,086(-49.4%)	$1.7M	0.0%	-21.87%	0
Integrated Wealth Concepts LLC	Increased	94,582(+3.9%)	$1.6M	0.0%	+41.13%	27
MetLife Investment Management, LLC	Decreased	75,164(-5.0%)	$1.2M	0.0%	-34.32%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	73,581(-8.2%)	$1.2M	0.0%	-41.23%	0
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	70,830(+170.1%)	$1.2M	0.0%	+27.01%	41
Creative Planning	Increased	60,766(+10.8%)	$1M	0.0%	-2.13%	28
FRANKLIN RESOURCES INC	Decreased	60,270(-6.8%)	$995,059	0.0%	-5.07%	0
JANUS HENDERSON GROUP PLC	Unchanged	60,028	$991,362	0.0%	-31.26%	0
WELLINGTON MANAGEMENT GROUP LLP	Decreased	54,543(-7.9%)	$900,505	0.0%	-20.03%	0
TUDOR INVESTMENT CORP ET AL	Decreased	53,683(-4.8%)	$886,306	0.0%	+35.49%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	52,632(+12.5%)	$868,954	0.0%	-4.84%	28
Pathstone Holdings, LLC	Increased	51,424(+12.2%)	$849,002	0.0%	+16.95%	28
Man Group plc	New	48,994	$808,891	0.0%	+22.00%	34
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	47,459	$783,548	0.0%	-13.62%	0
State of New Jersey Common Pension Fund D	Decreased	47,410(-66.0%)	$782,739	0.0%	-2.37%	0
MAI Capital Management	Unchanged	46,526	$768,145	0.0%	-1.09%	0
JANE STREET GROUP, LLC	Decreased	42,922(-80.9%)	$708,642	0.0%	+7.46%	0
CAPSTONE INVESTMENT ADVISORS, LLC	New	38,812	$640,786	0.0%	+22.00%	34
ENVESTNET ASSET MANAGEMENT INC	Increased	38,669(+19.3%)	$638,425	0.0%	-25.80%	29
Arizona State Retirement System	Decreased	38,645(-5.3%)	$638,029	0.0%	-18.83%	0
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	38,478	$635,272	0.0%	-55.49%	0
AQR CAPITAL MANAGEMENT LLC	Increased	38,438(+59.2%)	$634,606	0.0%	+33.54%	35
Police & Firemen's Retirement System of New Jersey	Decreased	36,607(-0.1%)	$604,382	0.0%	+7.60%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	34,768(-15.2%)	$574,020	0.0%	+14.11%	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	34,168	$564,114	0.0%	-44.85%	0
CITIGROUP INC	Increased	30,945(+107.2%)	$510,902	0.0%	+11.92%	39
ProShare Advisors LLC	Increased	30,682(+10.2%)	$506,561	0.0%	-35.10%	27
KLP KAPITALFORVALTNING AS	Unchanged	29,900	$493,649	0.0%	+2.60%	0
Erste Asset Management GmbH	Unchanged	26,900	$446,002	0.0%	-3.28%	0
POLEN CAPITAL MANAGEMENT LLC	New	26,900	$444,119	0.0%	+22.00%	33
Quantinno Capital Management LP	Increased	26,313(+6.5%)	$434,428	0.0%	+36.79%	26
RAYMOND JAMES FINANCIAL INC	Increased	25,592(+1.1%)	$422,524	0.0%	-0.14%	24
VOYA INVESTMENT MANAGEMENT LLC	Unchanged	23,805	$393,021	0.0%	-33.35%	0
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	20,540(-39.3%)	$339,115	0.0%	-45.24%	0
BNP PARIBAS FINANCIAL MARKETS	Decreased	15,497(-94.1%)	$255,855	0.0%	+34.04%	0
VICTORY CAPITAL MANAGEMENT INC	Unchanged	15,064	$248,707	0.0%	-33.80%	0
Russell Investments Group, Ltd.	Decreased	13,467(-2.4%)	$222,340	0.0%	+8.92%	0
Walleye Capital LLC	New	12,652	$208,885	0.0%	+22.00%	32
GUGGENHEIM CAPITAL LLC	Decreased	12,468(-74.8%)	$205,847	0.0%	-19.89%	0
HighTower Advisors, LLC	Decreased	11,757(-44.9%)	$194,108	0.0%	-20.58%	0
Vanguard Personalized Indexing Management, LLC	Decreased	11,736(-6.3%)	$193,761	0.0%	+41.99%	0
ROYAL BANK OF CANADA	Decreased	11,335(-97.0%)	$187,000	0.0%	+39.73%	0
Empowered Funds, LLC	Increased	11,325(+2.6%)	$186,976	0.0%	+2.07%	23
RENAISSANCE TECHNOLOGIES LLC	Decreased	10,700(-82.1%)	$176,657	0.0%	+36.18%	0
LPL Financial LLC	Decreased	10,504(-1.4%)	$173,421	0.0%	+37.88%	0
XPONANCE LLC	Increased	10,497(+0.9%)	$173,305	0.0%	+41.75%	23
PNC FINANCIAL SERVICES GROUP, INC.	Increased	8,481(+2.3%)	$140,021	0.0%	-4.11%	23
Mirae Asset Global Investments Co., Ltd.	Increased	7,127(+26.1%)	$117,667	0.0%	-15.75%	27
ASSETMARK, INC	Increased	5,187(+31.8%)	$85,637	0.0%	-5.91%	27
Eurizon Capital SGR S.p.A.	New	5,045	$82,690	0.0%	+22.00%	30
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	3.9M(-14.3%)	$64,654	0.0%	-0.29%	0
NISA INVESTMENT ADVISORS, LLC	Decreased	1,449(-2.3%)	$23,923	0.0%	-12.68%	0
COMERICA BANK	Unchanged	1,284	$21,199	0.0%	-18.19%	0
Rockefeller Capital Management L.P.	Increased	1,265(+16.8%)	$20,886	0.0%	+35.34%	15
OSAIC HOLDINGS, INC.	Decreased	1,074(-22.6%)	$17,731	0.0%	-12.95%	0
Mitsubishi UFJ Asset Management Co., Ltd.	Unchanged	1,001	$16,286	0.0%	-12.37%	0
US BANCORP \DE\	Increased	834(+19.8%)	$13,770	0.0%	-7.02%	14
LOS ANGELES CAPITAL MANAGEMENT LLC	New	627	$10,270	0.0%	+22.00%	26
HUNTINGTON NATIONAL BANK	Increased	491(+59.4%)	$8,106	0.0%	-8.49%	16
Optiver Holding B.V.	Decreased	409(-54.4%)	$6,753	0.0%	+41.74%	0
NewEdge Advisors, LLC	Unchanged	400	$6,604	0.0%	+35.45%	0
BNP Paribas Asset Management Holding S.A.	Increased	298,792(+234x)	$4,933	0.0%	+22.07%	24
Farther Finance Advisors, LLC	Increased	202(+59.1%)	$3,335	0.0%	+30.43%	13
Allworth Financial LP	Decreased	90(-9.1%)	$1,486	0.0%	+33.82%	0
HRT FINANCIAL LP	New	78,352	$1,293	0.0%	+22.00%	15
Jain Global LLC	Exited	0(-100.0%)	$252,851	0.0%	+15.80%	0
Caption Management, LLC	Exited	0(-100.0%)	$106,954	0.0%	+13.02%	0
NATIONAL BANK OF CANADA /FI/	Exited	0(-100.0%)	$726	0.0%	+9.60%	0
HSBC HOLDINGS PLC	Exited	0(-100.0%)	$200,845	0.0%	-6.13%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	-31.97%	0
JENNISON ASSOCIATES LLC	Exited	0(-100.0%)	$659,862	0.0%	+13.02%	0
SIMPLEX TRADING, LLC	Exited	0(-100.0%)	$0	0.0%	+16.38%	0
XTX Topco Ltd	Exited	0(-100.0%)	$948,809	0.0%	+13.02%	0
JACOBS LEVY EQUITY MANAGEMENT, INC	Exited	0(-100.0%)	$667,470	0.0%	+13.02%	0
Squarepoint Ops LLC	Exited	0(-100.0%)	$1.2M	0.0%	+13.02%	0
PRUDENTIAL FINANCIAL INC	Exited	0(-100.0%)	$245,940	0.0%	-40.11%	0
CANTOR FITZGERALD, L. P.	Exited	0(-100.0%)	$653,400	0.0%	+13.02%	0
Verition Fund Management LLC	Exited	0(-100.0%)	$255,973	0.0%	+4.13%	0
CIBC WORLD MARKETS CORP	Exited	0(-100.0%)	$228,289	0.0%	-3.94%	0
Engineers Gate Manager LP	Exited	0(-100.0%)	$1M	0.0%	+9.33%	0
Schonfeld Strategic Advisors LLC	Exited	0(-100.0%)	$3.3M	0.0%	+13.02%	0

Denali Therapeutics Inc.

Continue exploring