DESIGN THERAPEUTICS INC (DSGN) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling DSGN?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for DESIGN THERAPEUTICS INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on DSGN?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for DESIGN THERAPEUTICS INC.

Is institutional money flowing into DSGN?

74 institutional investors hold DESIGN THERAPEUTICS INC (DSGN). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about DSGN?

Track institutional sentiment and conviction scores for DESIGN THERAPEUTICS INC (DSGN) including Smart Money Verdict and position changes on HoldingsIntel.

DESIGN THERAPEUTICS INC

DSGN·25056L103·US·equity·Healthcare - Biotechnology-Activist

DSGN (DESIGN THERAPEUTICS INC) is held by 74 institutional investors as of Q4 2025. Largest holders: Point72 Asset Management, L.P. ($50.4M), BAKER BROS. ADVISORS LP ($20.9M), BlackRock, Inc. ($19.9M). Net institutional sentiment: Bullish.

Holders

Avg rating(3 Elite)

$214.2M

Total Value

74% (76)

Fund Consensus

50 buying - 17 selling

Smart Money Verdict- Q4 2025View all

57Mixed MomentumSplit Signals

Held by 74 funds

3 elite

Who's Trading

ActivistSR One Capital Fund I Aggregator, LP10.6%Mar 11, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
Point72 Asset Management, L.P.	Increased	5.4M(+60.8%)	$50.4M	0.1%	+38.75%	42
BAKER BROS. ADVISORS LP	Increased	2.2M(+30.4%)	$20.9M	0.1%	-2.55%	43
BlackRock, Inc.	Increased	2.1M(+3.6%)	$19.9M	0.0%	+58.87%	29
VANGUARD GROUP INC	Increased	1.6M(+13.0%)	$15.3M	0.0%	+72.00%	32
RA CAPITAL MANAGEMENT, L.P.	Increased	1.5M(+207.2%)	$13.7M	0.1%	+13.21%	54
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	1.2M(+9.6%)	$11.1M	0.1%	+69.47%	31
Woodline Partners LP	Increased	944,039(+54.1%)	$8.9M	0.0%	+63.99%	39
FMR LLC	Increased	771,268(+4.1%)	$7.2M	0.0%	+58.62%	28
MORGAN STANLEY	Increased	702,306(+299.1%)	$6.6M	0.0%	+21.63%	44
GEODE CAPITAL MANAGEMENT, LLC	Decreased	679,590(-2.3%)	$6.4M	0.0%	-36.49%	0
STATE STREET CORP	Increased	647,636(+2.1%)	$6.1M	0.0%	+237.48%	28
CITADEL ADVISORS LLC	Decreased	459,874(-17.0%)	$4.3M	0.0%	-17.55%	0
D. E. Shaw & Co., Inc.	Increased	438,894(+17.6%)	$4.1M	0.0%	+129.42%	31
Invesco Ltd.	Increased	305,757(+1995.8%)	$2.9M	0.0%	+4.25%	42
DIMENSIONAL FUND ADVISORS LP	Increased	297,921(+6.5%)	$2.8M	0.0%	+92.05%	28
RENAISSANCE TECHNOLOGIES LLC	Increased	287,100(+4.7%)	$2.7M	0.0%	+185.52%	27
NORTHERN TRUST CORP	Decreased	286,572(-3.4%)	$2.7M	0.0%	-30.88%	0
GOLDMAN SACHS GROUP INC	Increased	270,654(+3.5%)	$2.5M	0.0%	+57.52%	27
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	236,863(-4.5%)	$2.2M	0.0%	-29.39%	0
JANE STREET GROUP, LLC	Increased	226,512(+92.2%)	$2.1M	0.0%	+27.20%	41
MARSHALL WACE, LLP	New	225,528	$2.1M	0.0%	+2.15%	36
JACOBS LEVY EQUITY MANAGEMENT, INC	New	194,611	$1.8M	0.0%	+2.15%	36
MILLENNIUM MANAGEMENT LLC	Increased	180,866(+162.8%)	$1.7M	0.0%	+15.32%	41
AMERIPRISE FINANCIAL INC	New	158,383	$1.5M	0.0%	+2.15%	35
Nuveen, LLC	Decreased	125,260(-5.8%)	$1.2M	0.0%	+137.53%	0
RAYMOND JAMES FINANCIAL INC	New	109,763	$1M	0.0%	+2.15%	35
Trexquant Investment LP	New	99,967	$937,690	0.0%	+2.15%	35
BNP PARIBAS FINANCIAL MARKETS	Increased	94,828(+1747.4%)	$889,487	0.0%	+4.33%	40
BARCLAYS PLC	Decreased	87,060(-1.3%)	$816,622	0.0%	+143.52%	0
Bank of New York Mellon Corp	Decreased	84,975(-2.9%)	$797,065	0.0%	-45.26%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	61,852(+341.1%)	$580,172	0.0%	+12.25%	39
AMERICAN CENTURY COMPANIES INC	Increased	57,798(+13.7%)	$542,146	0.0%	+92.89%	27
CANADA PENSION PLAN INVESTMENT BOARD	New	54,600	$512,148	0.0%	+2.15%	33
SEI INVESTMENTS CO	New	52,730	$494,607	0.0%	+2.15%	33
STATE OF WISCONSIN INVESTMENT BOARD	Increased	50,657(+87.2%)	$475,163	0.0%	+48.61%	38
ALPS ADVISORS INC	New	46,771	$438,712	0.0%	+2.15%	33
TWO SIGMA INVESTMENTS, LP	Decreased	46,237(-21.9%)	$433,703	0.0%	+208.84%	0
Squarepoint Ops LLC	New	46,142	$432,812	0.0%	+2.15%	33
ALLIANCEBERNSTEIN L.P.	Unchanged	46,120	$432,606	0.0%	+1.93%	0
PRUDENTIAL FINANCIAL INC	Decreased	42,710(-4.7%)	$400,620	0.0%	+129.69%	0
XTX Topco Ltd	Increased	35,284(+197.3%)	$330,964	0.0%	+13.62%	38
RHUMBLINE ADVISERS	Decreased	34,778(-24.9%)	$326,208	0.0%	-31.29%	0
BANK OF AMERICA CORP /DE/	Increased	27,446(+14.8%)	$257,443	0.0%	+55.99%	18
Corient Private Wealth LLC	New	26,965	$252,932	0.0%	+2.15%	32
WELLS FARGO & COMPANY/MN	Increased	26,786(+46.2%)	$251,253	0.0%	+80.16%	21
UBS Group AG	Increased	25,537(+12.5%)	$239,537	0.0%	+63.04%	18
TWO SIGMA ADVISERS, LP	Decreased	25,300(-37.5%)	$237,314	0.0%	+227.68%	0
Russell Investments Group, Ltd.	Increased	25,234(+295.7%)	$236,694	0.0%	+15.78%	37
STRS OHIO	Increased	25,200(+11.5%)	$236,376	0.0%	+210.90%	26
Virtu Financial LLC	New	22,651	$212,000	0.0%	+2.15%	32
DEUTSCHE BANK AG\	New	15,541	$145,775	0.0%	+2.15%	34
MetLife Investment Management, LLC	Increased	15,249(+47.8%)	$143,036	0.0%	+28.20%	31
JPMORGAN CHASE & CO	Decreased	14,451(-37.8%)	$135,550	0.0%	+58.39%	0
Engineers Gate Manager LP	New	14,012	$131,433	0.0%	+2.15%	31
AQR CAPITAL MANAGEMENT LLC	Increased	13,730(+0.5%)	$128,788	0.0%	+104.86%	22
Mariner, LLC	Decreased	12,822(-20.3%)	$119,965	0.0%	+144.00%	0
NISA INVESTMENT ADVISORS, LLC	Unchanged	11,824	$110,909	0.0%	+272.34%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	11,091(+3.4%)	$104,034	0.0%	+162.95%	23
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	New	7,093	$66,532	0.0%	+2.15%	29
Police & Firemen's Retirement System of New Jersey	Unchanged	6,598	$61,889	0.0%	+62.07%	0
CITIGROUP INC	Increased	3,113(+95.8%)	$29,200	0.0%	+25.93%	21
Mirae Asset Global Investments Co., Ltd.	Increased	2,768(+25.7%)	$25,964	0.0%	+50.90%	24
Legal & General Group Plc	Unchanged	2,077	$19,482	0.0%	-49.00%	0
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	2,026	$19,004	0.0%	-45.11%	0
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	1,816(-0.4%)	$17,035	0.0%	+144.23%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	1,471(-25.3%)	$13,798	0.0%	+45.99%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	1,227	$11,509	0.0%	+137.53%	0
Rockefeller Capital Management L.P.	New	738	$6,922	0.0%	+2.15%	25
ROYAL BANK OF CANADA	Increased	638(+43.4%)	$6,000	0.0%	+47.35%	14
Farther Finance Advisors, LLC	Unchanged	385	$3,611	0.0%	+47.60%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	New	380	$3,564	0.0%	+2.15%	21
Optiver Holding B.V.	Unchanged	328	$3,077	0.0%	+45.99%	0
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	15,711(-3.7%)	$148	0.0%	+136.43%	0
OSAIC HOLDINGS, INC.	New	10	$94	0.0%	+2.15%	17
HRT FINANCIAL LP	Exited	0(-100.0%)	$240	0.0%	+42.92%	0
INTECH INVESTMENT MANAGEMENT LLC	Exited	0(-100.0%)	$106,587	0.0%	+66.08%	0

DESIGN THERAPEUTICS INC

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