Protagonist Therapeutics, Inc. (PTGX) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling PTGX?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Protagonist Therapeutics, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on PTGX?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Protagonist Therapeutics, Inc..

Is institutional money flowing into PTGX?

159 institutional investors hold Protagonist Therapeutics, Inc. (PTGX). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about PTGX?

Track institutional sentiment and conviction scores for Protagonist Therapeutics, Inc. (PTGX) including Smart Money Verdict and position changes on HoldingsIntel.

Protagonist Therapeutics, Inc.

PTGX·74366E102·US·equity·Healthcare - Biotechnology-13D/G

PTGX (Protagonist Therapeutics, Inc.) is held by 159 institutional investors as of Q4 2025. Largest holders: BlackRock, Inc. ($848.6M), FARALLON CAPITAL MANAGEMENT LLC ($536.6M), VANGUARD GROUP INC ($472.8M). Net institutional sentiment: Mixed.

159

Holders

Avg rating(14 Elite)

$5.2B

Total Value

46% (175)

Fund Consensus

76 buying - 89 selling

Smart Money VerdictView all

41Weak MomentumSplit Signals

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See how PTGX's score breaks down across 4 SEC sources

Held by 159 funds

14 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 27, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BlackRock, Inc.	Increased	9.7M(+3.3%)	$848.6M	0.0%	+127.83%	33
FARALLON CAPITAL MANAGEMENT LLC	Decreased	6.1M(-0.8%)	$536.6M	2.5%	+372.16%	0
VANGUARD GROUP INC	Increased	5.4M(+27.2%)	$472.8M	0.0%	+69.43%	39
RTW INVESTMENTS, LP	Decreased	5.1M(-12.1%)	$441.9M	4.4%	+274.87%	0
STATE STREET CORP	Increased	3.2M(+1.1%)	$279.5M	0.0%	+155.46%	31
WELLINGTON MANAGEMENT GROUP LLP	Increased	3.2M(+66.2%)	$277M	0.0%	+38.92%	45
UBS Group AG	Increased	2.8M(+46.1%)	$241.9M	0.0%	+42.03%	42
JANUS HENDERSON GROUP PLC	Increased	2.6M(+140.7%)	$231.4M	0.1%	+19.79%	59
Invesco Ltd.	Increased	1.6M(+56.2%)	$136.9M	0.0%	+44.97%	43
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.5M(+2.6%)	$126.9M	0.0%	+271.19%	31
Woodline Partners LP	Decreased	1.4M(-2.0%)	$123M	0.5%	+91.08%	0
CITADEL ADVISORS LLC	Increased	1.1M(+373.6%)	$98.4M	0.0%	+11.41%	48
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	1.1M(-3.6%)	$96M	0.7%	+72.59%	0
MARSHALL WACE, LLP	Decreased	1M(-5.6%)	$89.5M	0.1%	+40.16%	0
GOLDMAN SACHS GROUP INC	Increased	961,149(+22.9%)	$83.9M	0.0%	+76.61%	36
MORGAN STANLEY	Increased	879,024(+14.4%)	$76.8M	0.0%	+77.71%	34
BANK OF AMERICA CORP /DE/	Increased	867,580(+4.5%)	$75.8M	0.0%	+77.24%	31
NORTHERN TRUST CORP	Decreased	575,118(-4.7%)	$50.2M	0.0%	+278.80%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	556,762(+0.7%)	$48.6M	0.0%	+250.10%	29
FMR LLC	Increased	539,878(+3.7%)	$47.2M	0.0%	+113.52%	30
AMERICAN CENTURY COMPANIES INC	Decreased	535,423(-10.8%)	$46.8M	0.0%	+107.74%	0
Pictet Asset Management Holding SA	Decreased	529,631(-35.6%)	$46.3M	0.0%	+81.50%	0
Clearbridge Investments, LLC	New	489,842	$42.8M	0.0%	+4.63%	40
DIMENSIONAL FUND ADVISORS LP	Decreased	414,415(-5.5%)	$36.2M	0.0%	+75.38%	0
VOYA INVESTMENT MANAGEMENT LLC	Increased	366,165(+19.9%)	$32M	0.0%	+59.56%	34
Bank of New York Mellon Corp	Decreased	350,388(-3.5%)	$30.6M	0.0%	+173.47%	0
PRINCIPAL FINANCIAL GROUP INC	Increased	347,932(+6.7%)	$30.4M	0.0%	+118.26%	31
JENNISON ASSOCIATES LLC	New	331,164	$28.9M	0.0%	+4.63%	40
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	232,836(-67.6%)	$20.3M	0.0%	+70.50%	0
Holocene Advisors, LP	New	210,019	$18.3M	0.0%	+4.63%	39
Skandinaviska Enskilda Banken AB (publ)	Increased	205,574(+160.9%)	$18M	0.1%	+30.62%	46
PUBLIC SECTOR PENSION INVESTMENT BOARD	Decreased	203,426(-10.8%)	$17.8M	0.1%	+92.98%	0
Alyeska Investment Group, L.P.	New	199,523	$17.4M	0.0%	+4.63%	39
BARCLAYS PLC	Increased	187,642(+9.5%)	$16.4M	0.0%	+86.18%	31
RAYMOND JAMES FINANCIAL INC	Decreased	181,503(-38.3%)	$15.8M	0.0%	+132.70%	0
AMERIPRISE FINANCIAL INC	Increased	169,518(+10.7%)	$14.8M	0.0%	+80.59%	31
TD ASSET MANAGEMENT INC	Increased	158,730(+5.5%)	$13.9M	0.0%	+136.25%	30
JPMORGAN CHASE & CO	Decreased	155,300(-38.5%)	$13.6M	0.0%	+137.08%	0
RHUMBLINE ADVISERS	Decreased	154,950(-5.5%)	$13.5M	0.0%	+184.14%	0
Qube Research & Technologies Ltd	New	153,876	$13.4M	0.0%	+4.63%	39
Legal & General Group Plc	Decreased	149,164(-4.3%)	$13M	0.0%	+130.15%	0
Nuveen, LLC	Decreased	125,861(-2.0%)	$11M	0.0%	+86.78%	0
PANAGORA ASSET MANAGEMENT INC	Decreased	125,384(-15.7%)	$11M	0.0%	+86.78%	0
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	114,036(+26.3%)	$10M	0.0%	+38.05%	34
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	113,340(-16.1%)	$9.9M	0.0%	+135.30%	0
PRUDENTIAL FINANCIAL INC	Decreased	110,360(-12.7%)	$9.6M	0.0%	+68.41%	0
Hudson Bay Capital Management LP	New	109,615	$9.6M	0.0%	+4.63%	38
DEUTSCHE BANK AG\	Decreased	105,460(-10.0%)	$9.2M	0.0%	+130.85%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Decreased	104,528(-5.2%)	$9.1M	0.0%	+214.64%	0
SOROS FUND MANAGEMENT LLC	New	100,000	$8.7M	0.1%	+4.63%	46
Neuberger Berman Group LLC	Decreased	98,473(-20.2%)	$8.6M	0.0%	+57.49%	0
Swiss National Bank	Increased	98,200(+2.2%)	$8.6M	0.0%	+234.51%	28
BNP PARIBAS FINANCIAL MARKETS	Increased	97,764(+644.2%)	$8.5M	0.0%	+11.47%	44
CITIGROUP INC	Decreased	94,909(-37.8%)	$8.3M	0.0%	+77.04%	0
AXIOM INVESTORS LLC /DE	Increased	89,468(+11.7%)	$7.8M	0.1%	+54.75%	31
VICTORY CAPITAL MANAGEMENT INC	Decreased	80,571(-5.8%)	$7M	0.0%	+120.89%	0
FRANKLIN RESOURCES INC	Decreased	76,442(-7.8%)	$6.7M	0.0%	+134.86%	0
GREAT LAKES ADVISORS, LLC	Decreased	73,966(-17.1%)	$6.5M	0.1%	+138.32%	0
ALLIANCEBERNSTEIN L.P.	Decreased	73,222(-71.9%)	$6.4M	0.0%	+67.95%	0
WELLS FARGO & COMPANY/MN	Increased	71,645(+49.9%)	$6.3M	0.0%	+78.94%	38
Fisher Asset Management, LLC	New	65,114	$5.7M	0.0%	+4.63%	37
Rafferty Asset Management, LLC	Decreased	63,661(-14.9%)	$5.6M	0.0%	+124.97%	0
SILVERCREST ASSET MANAGEMENT GROUP LLC	Unchanged	53,217	$4.6M	0.0%	+311.49%	0
Pentwater Capital Management LP	New	50,000	$4.4M	0.0%	+4.63%	38
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	48,894(-17.0%)	$4.3M	0.0%	+163.49%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	48,033(+1.3%)	$4.2M	0.0%	+235.12%	27
FIRST TRUST ADVISORS LP	Decreased	46,454(-25.9%)	$4.1M	0.0%	+132.34%	0
Creative Planning	Increased	41,254(+13.9%)	$3.6M	0.0%	+59.09%	30
LMR Partners LLP	New	40,000	$3.5M	0.0%	+4.63%	37
SEI INVESTMENTS CO	Decreased	37,346(-15.1%)	$3.3M	0.0%	+130.52%	0
EXCHANGE TRADED CONCEPTS, LLC	Increased	35,039(+4.4%)	$3.1M	0.0%	+71.73%	28
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	34,786(-15.0%)	$3M	0.0%	+176.37%	0
JANE STREET GROUP, LLC	Decreased	34,307(-22.6%)	$3M	0.0%	+40.16%	0
MetLife Investment Management, LLC	Decreased	32,440(-4.2%)	$2.8M	0.0%	+259.21%	0
GUGGENHEIM CAPITAL LLC	Increased	31,096(+67.3%)	$2.7M	0.0%	+52.77%	39
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Decreased	30,789(-0.3%)	$2.7M	0.0%	+154.75%	0
Verition Fund Management LLC	New	26,792	$2.3M	0.0%	+4.63%	36
VIRGINIA RETIREMENT SYSTEMS ET Al	Increased	25,400(+62.8%)	$2.2M	0.0%	+42.66%	38
INTECH INVESTMENT MANAGEMENT LLC	Increased	22,485(+3.9%)	$2M	0.0%	+102.84%	27
State of Tennessee, Department of Treasury	Decreased	23,526(-11.2%)	$1.9M	0.0%	+103.12%	0
Gotham Asset Management, LLC	Decreased	21,595(-2.7%)	$1.9M	0.0%	+77.36%	0
POLEN CAPITAL MANAGEMENT LLC	Increased	20,349(+0.1%)	$1.8M	0.0%	+58.13%	26
NEW YORK STATE COMMON RETIREMENT FUND	Decreased	18,382(-6.1%)	$1.6M	0.0%	+303.95%	0
NOMURA HOLDINGS INC	New	17,521	$1.5M	0.0%	+4.63%	35
MILLENNIUM MANAGEMENT LLC	Decreased	17,391(-86.4%)	$1.5M	0.0%	+44.45%	0
ROYCE & ASSOCIATES LP	Unchanged	16,989	$1.5M	0.0%	+70.94%	0
State of New Jersey Common Pension Fund D	Decreased	16,987(-55.3%)	$1.5M	0.0%	+86.78%	0
Pathstone Holdings, LLC	Increased	16,441(+23.0%)	$1.4M	0.0%	+41.39%	31
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	16,303	$1.4M	0.0%	+210.68%	0
M&T BANK CORP	New	11,207	$1.4M	0.0%	+4.63%	35
STRS OHIO	Decreased	15,900(-10.7%)	$1.4M	0.0%	+163.87%	0
Police & Firemen's Retirement System of New Jersey	Decreased	15,834(-1.8%)	$1.4M	0.0%	+108.52%	0
YOUSIF CAPITAL MANAGEMENT, LLC	Decreased	16,281(-11.6%)	$1.4M	0.0%	+102.59%	0
ENVESTNET ASSET MANAGEMENT INC	Decreased	14,673(-39.5%)	$1.3M	0.0%	+106.83%	0
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS	Decreased	14,548(-2.3%)	$1.3M	0.0%	+98.12%	0
ProShare Advisors LLC	Increased	14,084(+6.8%)	$1.2M	0.0%	+159.80%	27
Arizona State Retirement System	Decreased	14,025(-4.4%)	$1.2M	0.0%	+344.36%	0
Erste Asset Management GmbH	Unchanged	13,500	$1.2M	0.0%	+137.08%	0
Connor, Clark & Lunn Investment Management Ltd.	New	13,270	$1.2M	0.0%	+4.63%	35
COMERICA BANK	Decreased	13,005(-20.7%)	$1.1M	0.0%	+103.54%	0
Allianz Asset Management GmbH	Decreased	13,000(-33.9%)	$1.1M	0.0%	+82.91%	0
Jain Global LLC	Decreased	12,850(-13.5%)	$1.1M	0.0%	+40.16%	0
GLENMEDE TRUST CO NA	Decreased	12,755(-38.3%)	$1.1M	0.0%	+123.31%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	11,762(-81.4%)	$1M	0.0%	+109.10%	0
KLP KAPITALFORVALTNING AS	Increased	10,600(+1.9%)	$925,804	0.0%	+116.43%	25
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	10,073	$879,776	0.0%	+234.45%	0
Cerity Partners LLC	Increased	9,049(+5.0%)	$790,339	0.0%	+188.93%	26
BAMCO INC /NY/	New	8,300	$724,922	0.0%	+4.63%	34
RENAISSANCE TECHNOLOGIES LLC	New	8,167	$713,306	0.0%	+4.63%	34
TUDOR INVESTMENT CORP ET AL	New	7,718	$674,090	0.0%	+4.63%	34
Mariner, LLC	Decreased	7,620(-43.8%)	$665,641	0.0%	+261.06%	0
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	7,350(-39.3%)	$641,949	0.0%	+328.59%	0
HighTower Advisors, LLC	Decreased	7,127(-17.3%)	$622,472	0.0%	+78.17%	0
AQR CAPITAL MANAGEMENT LLC	Decreased	6,954(-18.9%)	$607,362	0.0%	+120.50%	0
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	Increased	6,716(+2.5%)	$586,575	0.0%	+100.66%	25
Russell Investments Group, Ltd.	Decreased	5,723(-3.4%)	$499,845	0.0%	+40.93%	0
AVIVA PLC	Decreased	5,609(-28.0%)	$489,890	0.0%	+137.08%	0
Kestra Advisory Services, LLC	Decreased	5,142(-1.6%)	$449,102	0.0%	+101.83%	0
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	New	5,076	$443,338	0.0%	+4.63%	33
Jefferies Financial Group Inc.	Decreased	5,000(-99.4%)	$436,700	0.0%	+114.74%	0
Quantinno Capital Management LP	Increased	4,948(+22.3%)	$432,158	0.0%	+32.00%	29
XPONANCE LLC	Increased	4,588(+1.2%)	$400,716	0.0%	+84.47%	24
Ensign Peak Advisors, Inc	Decreased	4,486(-59.2%)	$391,807	0.0%	+297.17%	0
Orion Porfolio Solutions, LLC	Decreased	4,396(-36.5%)	$383,947	0.0%	+83.89%	0
US BANCORP \DE\	Decreased	4,395(-24.9%)	$383,858	0.0%	+114.89%	0
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	New	4,369	$381,588	0.0%	+4.63%	33
LOS ANGELES CAPITAL MANAGEMENT LLC	New	4,727	$367,999	0.0%	+4.63%	33
OSAIC HOLDINGS, INC.	Increased	4,201(+202.0%)	$366,895	0.0%	+22.92%	38
Vident Advisory, LLC	Decreased	4,191(-17.3%)	$366,042	0.0%	+40.16%	0
Allspring Global Investments Holdings, LLC	New	3,985	$347,412	0.0%	+4.63%	33
CIBC WORLD MARKETS CORP	Decreased	3,851(-46.3%)	$336,346	0.0%	+104.81%	0
BANK OF MONTREAL /CAN/	Decreased	3,808(-1.4%)	$332,286	0.0%	+114.47%	0
NISA INVESTMENT ADVISORS, LLC	Decreased	3,780(-5.1%)	$330,145	0.0%	+129.14%	0
MACKENZIE FINANCIAL CORP	Decreased	3,648(-10.2%)	$317,698	0.0%	+121.61%	0
Vanguard Personalized Indexing Management, LLC	Increased	3,573(+8.3%)	$312,066	0.0%	+36.59%	25
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Increased	3,554(+1.2%)	$292,386	0.0%	+39.59%	24
Rockefeller Capital Management L.P.	Increased	3,292(+10.5%)	$287,524	0.0%	+35.79%	26
LPL Financial LLC	Decreased	3,265(-34.6%)	$285,165	0.0%	+84.62%	0
ROYAL BANK OF CANADA	Decreased	3,183(-95.5%)	$278,000	0.0%	+69.94%	0
Mirae Asset Global Investments Co., Ltd.	Increased	3,038(+26.3%)	$265,339	0.0%	+131.95%	29
PNC FINANCIAL SERVICES GROUP, INC.	Increased	2,959(+8.1%)	$258,439	0.0%	+74.39%	25
CAPTRUST FINANCIAL ADVISORS	Decreased	2,732(-17.5%)	$238,613	0.0%	+40.16%	0
CIBC Asset Management Inc	New	2,667	$232,936	0.0%	+4.63%	32
Sumitomo Mitsui Trust Group, Inc.	New	2,560	$223,590	0.0%	+4.63%	32
Swiss Life Asset Management Ltd	New	2,431	$212,324	0.0%	+4.63%	32
PRICE T ROWE ASSOCIATES INC /MD/	Increased	1.4M(+14.8%)	$122,341	0.0%	+105.34%	25
BNP Paribas Asset Management Holding S.A.	Decreased	330,804(-26.8%)	$28,893	0.0%	+86.77%	0
FIFTH THIRD BANCORP	Increased	327(+6.5%)	$28,560	0.0%	+65.72%	21
Farther Finance Advisors, LLC	Increased	297(+110.6%)	$25,940	0.0%	+28.97%	31
ASSETMARK, INC	Increased	285(+1.8%)	$24,892	0.0%	+105.55%	19
Allworth Financial LP	New	255	$22,272	0.0%	+45.83%	26
Duquesne Family Office LLC	Unchanged	159,700	$13,948	0.3%	+40.16%	0
DANSKE BANK A/S	Unchanged	100	$8,734	0.0%	+86.78%	0
MAI Capital Management	Increased	97(+12.8%)	$8,472	0.0%	+54.04%	13
BROWN BROTHERS HARRIMAN & CO	Unchanged	81	$7,075	0.0%	+63.94%	0
JONES FINANCIAL COMPANIES LLLP	Increased	46(+130.0%)	$4,018	0.0%	+24.16%	16
HUNTINGTON NATIONAL BANK	Decreased	35(-10.3%)	$3,057	0.0%	+63.94%	0
PICTON MAHONEY ASSET MANAGEMENT	Unchanged	25	$2,184	0.0%	+104.89%	0
CIBC Private Wealth Group LLC	New	13	$1,135	0.0%	+4.63%	17
Tidal Investments LLC	Exited	0(-100.0%)	$594,216	0.0%	+126.57%	0
HRT FINANCIAL LP	Exited	0(-100.0%)	$629	0.0%	+33.96%	0
XTX Topco Ltd	Exited	0(-100.0%)	$482,282	0.0%	+86.31%	0
Assenagon Asset Management S.A.	Exited	0(-100.0%)	$4.4M	0.0%	+84.48%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$509,917	0.0%	+54.34%	0
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$3,189	0.0%	+33.96%	0
ALPS ADVISORS INC	Exited	0(-100.0%)	$1.9M	0.0%	+173.07%	0
CAPITAL FUND MANAGEMENT S.A.	Exited	0(-100.0%)	$1.4M	0.0%	+56.69%	0
ExodusPoint Capital Management, LP	Exited	0(-100.0%)	$8.3M	0.0%	+33.96%	0
Schonfeld Strategic Advisors LLC	Exited	0(-100.0%)	$6.3M	0.0%	+67.89%	0
Optiver Holding B.V.	Exited	0(-100.0%)	$11,227	0.0%	+33.96%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	+137.08%	0
Resona Asset Management Co.,Ltd.	Exited	0(-100.0%)	$580,000	0.0%	+33.96%	0
Focus Partners Wealth	Exited	0(-100.0%)	$29.8M	0.0%	+33.96%	0
TORONTO DOMINION BANK	Exited	0(-100.0%)	$29.6M	0.0%	+113.13%	0
Brevan Howard Capital Management LP	Exited	0(-100.0%)	$504,735	0.0%	+69.03%	0

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