Rhythm Pharmaceuticals, Inc. (RYTM) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling RYTM?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Rhythm Pharmaceuticals, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on RYTM?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Rhythm Pharmaceuticals, Inc..

Is institutional money flowing into RYTM?

147 institutional investors hold Rhythm Pharmaceuticals, Inc. (RYTM). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about RYTM?

Track institutional sentiment and conviction scores for Rhythm Pharmaceuticals, Inc. (RYTM) including Smart Money Verdict and position changes on HoldingsIntel.

Rhythm Pharmaceuticals, Inc.

RYTM·76243J105·US·equity·Healthcare - Biotechnology-13D/G

RYTM (Rhythm Pharmaceuticals, Inc.) is held by 147 institutional investors as of Q4 2025. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($713.6M), BlackRock, Inc. ($674.1M), VANGUARD GROUP INC ($664.8M). Net institutional sentiment: Mixed.

147

Holders

Avg rating(9 Elite)

$6.4B

Total Value

52% (167)

Fund Consensus

84 buying - 78 selling

Smart Money VerdictView all

42Weak MomentumSplit Signals

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See how RYTM's score breaks down across 4 SEC sources

Held by 147 funds

9 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 27, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Increased	6.7M(+17.4%)	$713.6M	7.3%	+130.51%	72
BlackRock, Inc.	Decreased	6.3M(-0.1%)	$674.1M	0.0%	+58.28%	0
VANGUARD GROUP INC	Increased	6.2M(+24.3%)	$664.8M	0.0%	+21.65%	39
BAKER BROS. ADVISORS LP	Unchanged	5.6M	$599.9M	3.5%	+275.65%	0
PRIMECAP MANAGEMENT CO/CA/	Decreased	3.5M(-18.4%)	$372.4M	0.3%	+341.59%	0
STATE STREET CORP	Increased	2.2M(+8.4%)	$235.3M	0.0%	+67.06%	33
GOLDMAN SACHS GROUP INC	Decreased	1.8M(-3.3%)	$196M	0.0%	+48.27%	0
FMR LLC	Decreased	1.7M(-20.5%)	$182.6M	0.0%	+49.37%	0
FEDERATED HERMES, INC.	Decreased	1.6M(-6.0%)	$173.8M	0.3%	+256.02%	0
JPMORGAN CHASE & CO	Increased	1.4M(+19.9%)	$152.4M	0.0%	+11.74%	36
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.4M(+0.9%)	$147.3M	0.0%	+209.92%	30
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	1.3M(-7.1%)	$137.6M	0.9%	+92.94%	0
WESTFIELD CAPITAL MANAGEMENT CO LP	Increased	1.3M(+18.5%)	$135.6M	0.6%	+39.70%	50
Polar Capital Holdings Plc	Decreased	1.2M(-4.8%)	$126.9M	0.5%	+92.44%	0
JANUS HENDERSON GROUP PLC	Decreased	1.1M(-3.0%)	$120.6M	0.1%	+92.74%	0
Capital Research Global Investors	Increased	985,086(+64.7%)	$105.4M	0.0%	-13.09%	44
ALLIANCEBERNSTEIN L.P.	Decreased	930,233(-5.0%)	$99.6M	0.0%	-6.35%	0
JENNISON ASSOCIATES LLC	Increased	918,567(+123.2%)	$98.3M	0.1%	-13.90%	48
FRANKLIN RESOURCES INC	Increased	695,735(+22.5%)	$74.5M	0.0%	+38.96%	36
Woodline Partners LP	Increased	688,779(+18.7%)	$73.7M	0.3%	+22.19%	42
MORGAN STANLEY	Increased	651,402(+40.0%)	$69.7M	0.0%	+43.91%	39
ADAGE CAPITAL PARTNERS GP, L.L.C.	Increased	621,585(+14.3%)	$66.5M	0.1%	+11.11%	40
Pictet Asset Management Holding SA	Decreased	614,663(-10.0%)	$66.2M	0.1%	+25.03%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	549,020(+25.5%)	$58.8M	0.0%	+16.45%	36
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	532,447(+0.9%)	$57M	0.0%	+149.15%	30
Clearbridge Investments, LLC	Increased	506,109(+4.4%)	$54.2M	0.0%	+15.57%	31
LOOMIS SAYLES & CO L P	Decreased	503,901(-4.5%)	$53.9M	0.1%	+74.41%	0
NORTHERN TRUST CORP	Decreased	488,216(-4.4%)	$52.3M	0.0%	+299.96%	0
Point72 Asset Management, L.P.	New	429,420	$46M	0.1%	-16.11%	40
UBS Group AG	Increased	427,236(+1.6%)	$45.7M	0.0%	+23.89%	30
RENAISSANCE TECHNOLOGIES LLC	Decreased	341,193(-37.6%)	$36.5M	0.1%	+13.95%	0
Qube Research & Technologies Ltd	Increased	310,919(+30.2%)	$33.3M	0.0%	+31.84%	36
Bank of New York Mellon Corp	Increased	301,080(+65.1%)	$32.2M	0.0%	+49.01%	42
Invesco Ltd.	Increased	291,150(+102.8%)	$31.2M	0.0%	-0.51%	47
Candriam S.C.A.	Increased	287,907(+29.8%)	$30.8M	0.2%	+50.34%	43
Artisan Partners Limited Partnership	Increased	263,591(+11.3%)	$28.2M	0.0%	+17.58%	32
AMERIPRISE FINANCIAL INC	Increased	261,160(+89.3%)	$28M	0.0%	+15.84%	45
WELLINGTON MANAGEMENT GROUP LLP	Increased	250,156(+922.0%)	$26.8M	0.0%	-10.42%	46
VOYA INVESTMENT MANAGEMENT LLC	Increased	249,874(+12.8%)	$26.7M	0.0%	+43.69%	32
Hood River Capital Management LLC	Increased	237,043(+0.5%)	$25.4M	0.3%	+72.45%	34
BANK OF AMERICA CORP /DE/	Decreased	224,484(-3.7%)	$24M	0.0%	+45.85%	0
MILLENNIUM MANAGEMENT LLC	Increased	186,709(+40.2%)	$20M	0.0%	+28.81%	38
BNP PARIBAS FINANCIAL MARKETS	Decreased	164,563(-26.4%)	$17.6M	0.0%	+11.85%	0
CITADEL ADVISORS LLC	Increased	153,322(+15.6%)	$16.4M	0.0%	-11.73%	32
Connor, Clark & Lunn Investment Management Ltd.	Increased	149,373(+23.2%)	$16M	0.0%	+28.03%	34
M&G Plc	New	137,074	$14.7M	0.1%	-16.11%	39
Russell Investments Group, Ltd.	Decreased	134,180(-14.9%)	$14.4M	0.0%	+41.51%	0
BARCLAYS PLC	Decreased	131,436(-7.7%)	$14.1M	0.0%	+58.41%	0
DEUTSCHE BANK AG\	Increased	129,123(+10.6%)	$13.8M	0.0%	+7.90%	31
M&T BANK CORP	New	85,967	$13.8M	0.0%	-16.11%	39
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	123,537(+21.9%)	$13.2M	0.0%	+32.88%	34
Nuveen, LLC	Decreased	115,934(-1.7%)	$12.4M	0.0%	+63.43%	0
Capital World Investors	New	115,693	$12.4M	0.0%	-16.11%	39
Swiss National Bank	Increased	111,300(+8.8%)	$11.9M	0.0%	+127.49%	30
NEW YORK STATE COMMON RETIREMENT FUND	Increased	93,677(+24.7%)	$10M	0.0%	+24.61%	34
FIRST TRUST ADVISORS LP	Increased	88,505(+9.4%)	$9.5M	0.0%	+58.07%	30
AXIOM INVESTORS LLC /DE	Increased	83,554(+0.6%)	$8.9M	0.1%	+16.50%	28
ExodusPoint Capital Management, LP	New	75,141	$8M	0.1%	-16.11%	38
Neuberger Berman Group LLC	Decreased	73,572(-13.6%)	$7.9M	0.0%	+58.58%	0
WELLS FARGO & COMPANY/MN	Increased	72,617(+54.1%)	$7.8M	0.0%	+30.25%	39
BALYASNY ASSET MANAGEMENT L.P.	Decreased	72,282(-79.3%)	$7.7M	0.0%	-4.37%	0
RHUMBLINE ADVISERS	Decreased	71,212(-13.2%)	$7.6M	0.0%	+291.05%	0
AQR CAPITAL MANAGEMENT LLC	Decreased	70,046(-12.2%)	$7.5M	0.0%	+27.39%	0
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Decreased	60,575(-83.5%)	$6.5M	0.0%	+77.23%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	59,609(-2.1%)	$6.4M	0.0%	+122.88%	0
Rafferty Asset Management, LLC	Decreased	55,526(-0.4%)	$5.9M	0.0%	+121.42%	0
Legal & General Group Plc	Decreased	55,075(-4.0%)	$5.9M	0.0%	+181.54%	0
TD ASSET MANAGEMENT INC	Decreased	55,050(-7.6%)	$5.9M	0.0%	+66.45%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	53,537(+9.4%)	$5.7M	0.0%	+136.66%	30
PRUDENTIAL FINANCIAL INC	Decreased	53,145(-27.2%)	$5.7M	0.0%	-6.99%	0
VICTORY CAPITAL MANAGEMENT INC	Increased	45,381(+5.8%)	$4.9M	0.0%	+8.87%	29
WCM INVESTMENT MANAGEMENT, LLC	Decreased	44,805(-6.1%)	$4.8M	0.0%	-11.01%	0
RAYMOND JAMES FINANCIAL INC	Decreased	41,115(-6.8%)	$4.4M	0.0%	-2.20%	0
SEI INVESTMENTS CO	Increased	37,432(+18.2%)	$4M	0.0%	+50.59%	31
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	36,079(-11.5%)	$3.9M	0.0%	+195.26%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	34,901(+28.7%)	$3.7M	0.0%	+57.00%	33
SILVERCREST ASSET MANAGEMENT GROUP LLC	Increased	34,127(+0.1%)	$3.7M	0.0%	+42.64%	27
Squarepoint Ops LLC	New	32,829	$3.5M	0.0%	-16.11%	37
DIMENSIONAL FUND ADVISORS LP	Increased	32,018(+12.8%)	$3.4M	0.0%	-11.62%	30
D. E. Shaw & Co., Inc.	Increased	31,356(+774.6%)	$3.4M	0.0%	-11.23%	43
Magnetar Financial LLC	New	29,598	$3.2M	0.0%	-16.11%	37
MetLife Investment Management, LLC	Decreased	29,174(-3.9%)	$3.1M	0.0%	+303.68%	0
LAZARD ASSET MANAGEMENT LLC	Decreased	25,571(-15.4%)	$2.7M	0.0%	+58.96%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	Increased	24,334(+45.5%)	$2.7M	0.0%	-7.21%	36
Creative Planning	Increased	25,206(+1.1%)	$2.7M	0.0%	+28.23%	26
INTECH INVESTMENT MANAGEMENT LLC	Decreased	21,350(-12.2%)	$2.3M	0.0%	+65.08%	0
State of New Jersey Common Pension Fund D	Decreased	19,270(-7.9%)	$2.1M	0.0%	+59.01%	0
CAPTRUST FINANCIAL ADVISORS	Increased	18,325(+0.4%)	$2M	0.0%	+57.10%	26
Arizona State Retirement System	Increased	15,762(+0.9%)	$1.7M	0.0%	+266.71%	26
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	14,650	$1.6M	0.0%	+118.12%	0
Police & Firemen's Retirement System of New Jersey	Decreased	14,183(-2.9%)	$1.5M	0.0%	+41.12%	0
STIFEL FINANCIAL CORP	Decreased	13,247(-8.4%)	$1.4M	0.0%	+380.96%	0
NISA INVESTMENT ADVISORS, LLC	Decreased	13,139(-0.9%)	$1.4M	0.0%	-5.83%	0
CITIGROUP INC	Decreased	12,720(-2.8%)	$1.4M	0.0%	+59.80%	0
ProShare Advisors LLC	Increased	12,622(+11.7%)	$1.4M	0.0%	+106.06%	28
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	12,435(+15.9%)	$1.3M	0.0%	+105.88%	29
GUGGENHEIM CAPITAL LLC	Increased	12,401(+442.7%)	$1.3M	0.0%	-15.22%	41
KLP KAPITALFORVALTNING AS	Increased	12,000(+9.1%)	$1.3M	0.0%	+39.99%	28
STRS OHIO	Decreased	12,000(-18.9%)	$1.3M	0.0%	+72.23%	0
Rockefeller Capital Management L.P.	Increased	452,897(+5007.1%)	$1.3M	0.0%	-16.02%	41
DnB Asset Management AS	Increased	11,163(+101.9%)	$1.2M	0.0%	-13.66%	41
XTX Topco Ltd	New	10,433	$1.1M	0.0%	-16.11%	35
Man Group plc	Decreased	9,558(-92.6%)	$1M	0.0%	-11.01%	0
FRED ALGER MANAGEMENT, LLC	Decreased	9,301(-24.6%)	$995,579	0.0%	-11.01%	0
VIRGINIA RETIREMENT SYSTEMS ET Al	Increased	9,200(+37.3%)	$984,768	0.0%	-12.46%	33
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	8,359(-35.5%)	$894,748	0.0%	+168.44%	0
Allianz Asset Management GmbH	Decreased	8,000(-33.9%)	$856,320	0.0%	+54.90%	0
PRINCIPAL FINANCIAL GROUP INC	Decreased	6,198(-50.8%)	$663,434	0.0%	+78.50%	0
EXCHANGE TRADED CONCEPTS, LLC	Decreased	6,080(-4.8%)	$650,803	0.0%	-11.01%	0
LPL Financial LLC	Increased	5,427(+36.0%)	$580,906	0.0%	+39.36%	32
Gotham Asset Management, LLC	Decreased	4,851(-0.1%)	$519,251	0.0%	+194.48%	0
PNC FINANCIAL SERVICES GROUP, INC.	Increased	4,659(+10.5%)	$498,699	0.0%	+47.03%	27
Caption Management, LLC	New	4,614	$493,883	0.0%	-16.11%	33
Verition Fund Management LLC	New	4,504	$482,108	0.0%	-16.11%	33
MACKENZIE FINANCIAL CORP	Unchanged	4,398	$468,607	0.0%	+73.82%	0
XPONANCE LLC	Increased	4,269(+2.6%)	$456,954	0.0%	+55.66%	25
Empowered Funds, LLC	Increased	4,164(+94.1%)	$445,715	0.0%	-13.56%	38
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	4,097(+32.0%)	$438,543	0.0%	+38.96%	31
COMERICA BANK	Decreased	4,014(-98.1%)	$429,564	0.0%	+64.37%	0
Ensign Peak Advisors, Inc	Decreased	3,859(-96.5%)	$413,067	0.0%	+2.38%	0
Quantinno Capital Management LP	Increased	3,831(+49.8%)	$410,070	0.0%	-12.77%	33
Cerity Partners LLC	Increased	3,664(+23.6%)	$392,194	0.0%	-12.03%	29
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	Decreased	3,580(-26.0%)	$383,203	0.0%	+22.03%	0
CIBC WORLD MARKETS CORP	Decreased	3,502(-47.8%)	$374,854	0.0%	+61.52%	0
Tidal Investments LLC	Increased	3,336(+25.2%)	$357,085	0.0%	-12.09%	29
KEYBANK NATIONAL ASSOCIATION/OH	New	3,271	$350,128	0.0%	-16.11%	33
Mirae Asset Global Investments Co., Ltd.	Increased	3,243(+26.3%)	$347,131	0.0%	+48.09%	29
TWO SIGMA ADVISERS, LP	Decreased	2,900(-12.1%)	$310,416	0.0%	+101.38%	0
CIBC Asset Management Inc	New	2,848	$304,850	0.0%	-16.11%	32
Swiss Life Asset Management Ltd	Increased	2,653(+7.8%)	$283,977	0.0%	-11.40%	25
Vanguard Personalized Indexing Management, LLC	Increased	2,379(+15.0%)	$254,648	0.0%	-11.71%	27
JANE STREET GROUP, LLC	Decreased	1,960(-34.0%)	$209,798	0.0%	-11.01%	0
WHITTIER TRUST CO	Unchanged	1,811	$180,050	0.0%	+88.51%	0
ROYAL BANK OF CANADA	Decreased	1,676(-98.7%)	$180,000	0.0%	+42.78%	0
PRICE T ROWE ASSOCIATES INC /MD/	Increased	1.6M(+11.5%)	$167,074	0.0%	+58.77%	25
DANSKE BANK A/S	New	1,100	$117,744	0.0%	-16.11%	30
OSAIC HOLDINGS, INC.	Increased	1,039(+6.0%)	$111,214	0.0%	+73.87%	23
US BANCORP \DE\	Increased	953(+552.7%)	$102,009	0.0%	-5.93%	35
Farther Finance Advisors, LLC	Increased	642(+82.9%)	$68,720	0.0%	-11.66%	33
JONES FINANCIAL COMPANIES LLLP	Decreased	231(-1.3%)	$24,726	0.0%	+114.14%	0
Allworth Financial LP	Decreased	109(-16.8%)	$11,668	0.0%	+13.23%	0
Optiver Holding B.V.	Decreased	92(-74.8%)	$9,848	0.0%	+20.51%	0
TORONTO DOMINION BANK	New	6	$642	0.0%	-16.11%	17
BNP Paribas Asset Management Holding S.A.	Increased	2,415(+385.9%)	$259	0.0%	-9.44%	18
MAI Capital Management	Decreased	2(-99.9%)	$215	0.0%	-11.01%	0
BANK OF MONTREAL /CAN/	Exited	0(-100.0%)	$72,208	0.0%	+6.08%	0
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$101	0.0%	+6.08%	0
SCHRODER INVESTMENT MANAGEMENT GROUP	Exited	0(-100.0%)	$1.8M	0.0%	+91.06%	0
ALPS ADVISORS INC	Exited	0(-100.0%)	$3.3M	0.0%	+89.49%	0
Walleye Capital LLC	Exited	0(-100.0%)	$5.1M	0.0%	+6.08%	0
PANAGORA ASSET MANAGEMENT INC	Exited	0(-100.0%)	$6.5M	0.0%	+94.82%	0
Integrated Wealth Concepts LLC	Exited	0(-100.0%)	$251,567	0.0%	+6.08%	0
Engineers Gate Manager LP	Exited	0(-100.0%)	$1.4M	0.0%	+90.13%	0
Trexquant Investment LP	Exited	0(-100.0%)	$3.8M	0.0%	+16.09%	0
Jain Global LLC	Exited	0(-100.0%)	$3.5M	0.0%	+10.72%	0
Aberdeen Group plc	Exited	0(-100.0%)	$2.7M	0.0%	+139.54%	0
Savant Capital, LLC	Exited	0(-100.0%)	$443,145	0.0%	+70.05%	0
MARSHALL WACE, LLP	Exited	0(-100.0%)	$17.4M	0.0%	+105.74%	0
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Exited	0(-100.0%)	$636,944	0.0%	+6.08%	0
CANADA PENSION PLAN INVESTMENT BOARD	Exited	0(-100.0%)	$3.7M	0.0%	+6.08%	0
ALKEON CAPITAL MANAGEMENT LLC	Exited	0(-100.0%)	$102.8M	0.0%	+129.56%	0
AMERICAN CENTURY COMPANIES INC	Exited	0(-100.0%)	$209,756	0.0%	+6.08%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	+94.82%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$353,162	0.0%	+6.08%	0
Mariner, LLC	Exited	0(-100.0%)	$363,261	0.0%	+89.56%	0
Assenagon Asset Management S.A.	Exited	0(-100.0%)	$22.6M	0.0%	+72.22%	0

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