SEPTERNA INC (SEPN) is held by 73 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is RA CAPITAL MANAGEMENT, L.P. as of Q1 2026.

Are institutions buying or selling SEPN?

In Q1 2026, 49 institutions opened or increased positions in SEPTERNA INC while 29 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on SEPN?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for SEPTERNA INC.

How many hedge funds hold SEPN?

73 institutional investors report holding SEPTERNA INC (SEPN) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into SEPN?

As of Q1 2026, tracked institutions in SEPTERNA INC show 49 buyers versus 29 sellers — net inflows.

SEPTERNA INC

SEPN·81734D104·US·Common Stock·Healthcare - Biotechnology-13D/G

Holders

(5 Elite)

$589.2M

Total Value

63% (78)

Consensus

49 buying - 29 selling

13F: Mar 31, 2026Insider & Congress: Updated regularly

Smart Money Verdict

View all

Held by 73 funds

5 elite

Who's Trading

InsiderBEBhatt ElizabethSell $61KApr 15, 2026

InsiderBEBhatt ElizabethSell $28KApr 15, 2026

InsiderBEBhatt ElizabethSell $8KApr 15, 2026

InsiderSSShaikhly SamiraSell $112KMar 2, 2026

InsiderSSShaikhly SamiraSell $1.9MMar 2, 2026

InsiderBEBhatt ElizabethSell $63KFeb 18, 2026

InsiderBEBhatt ElizabethSell $53KFeb 18, 2026

ActivistBVBIOTECHNOLOGY VALUE FUND L P2.0%Feb 17, 2026

InsiderLDLong Daniel D.Sell $63KNov 10, 2025

Activist

DRIEHAUS CAPITAL MANAGEMENT LLC10.5%Jun 10, 2025

View all insider trades View all activist filings

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	7M	$168.1M	1.8%	+54.67%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	4.4M(-8.6%)	$105.6M	0.8%	+110.13%	0
GOLDMAN SACHS GROUP INC	Increased	2.9M(+7.0%)	$69.8M	0.0%	+41.13%	32
BlackRock, Inc.	Increased	1.8M(+1.2%)	$43.8M	0.0%	+56.07%	29
Avoro Capital Advisors LLC	Unchanged	1.3M	$32.1M	0.3%	+78.27%	0
VAVANGUARD CAPITAL MANAGEMENT LLC	New	1.2M	$28.8M	0.0%	+27.73%	40
PRIMECAP MANAGEMENT CO/CA/	Increased	1M(+92.1%)	$25.2M	0.0%	+28.56%	45
Janus Henderson Group Ltd.	New	890,754	$21.3M	0.0%	+27.73%	39
GEODE CAPITAL MANAGEMENT, LLC	Increased	645,146(+12.6%)	$15.5M	0.0%	+69.48%	32
STATE STREET CORP	Increased	631,447(+16.9%)	$15.2M	0.0%	+63.63%	33
BALYASNY ASSET MANAGEMENT L.P.	Increased	236,679(+6527.8%)	$5.7M	0.0%	+27.75%	44
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	223,995(+0.6%)	$5.4M	0.0%	+118.47%	27
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	195,043	$4.7M	0.0%	+27.73%	37
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	181,580(-3.0%)	$4.4M	0.0%	+80.57%	0
NORTHERN TRUST CORP	Increased	164,530(+6.7%)	$4M	0.0%	+61.80%	29
VFVANGUARD FIDUCIARY TRUST CO	New	154,484	$3.7M	0.0%	+27.73%	37
MILLENNIUM MANAGEMENT LLC	Increased	124,101(+15.5%)	$3M	0.0%	+98.76%	30
UBS Group AG	Increased	116,979(+70.0%)	$2.8M	0.0%	+72.00%	39
MORGAN STANLEY	Increased	110,530(+6.3%)	$2.7M	0.0%	+71.06%	28
FEDERATED HERMES, INC.	Increased	89,301(+13.2%)	$2.1M	0.0%	+29.15%	29