Septerna, Inc.

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SEPN·81734D104·US·Common Stock·Healthcare - Biotechnology-Activist

SEPN (Septerna, Inc.) is held by 95 institutional investors as of Q2 2026. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($234.3M), DRIEHAUS CAPITAL MANAGEMENT LLC ($148.5M), GOLDMAN SACHS GROUP INC ($102.6M). Net institutional sentiment: Bullish.

95

Holders

(8 Elite)

$862.9M

Total Value

76% (93)

Consensus

71 buying - 22 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)64

Insider (Form 4)35

Activist (13D/13G)52

Congressional (STOCK Act)38

Holder Quality

25

★★★★★

Elite

69

★★★★

Strong

33

★★★

Solid

71

★★

Below

22

★

Weak

Held by 95 funds

8 elite

Who's Trading

Source dates: Price Aug 28, 2026 · Insiders Aug 14, 2026 · Activists Aug 14, 2026 · Congress none

ActivistRA Capital Management, L.P.11.8%Aug 14, 2026

ActivistDRIEHAUS CAPITAL MANAGEMENT LLC9.8%Aug 14, 2026

InsiderRLRA CAPITAL MANAGEMENT, L.P.Sell $31.7MAug 12, 2026

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Top Holders

Top Holders (95)History

AllNewIncreasedHeldDecreasedExited

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	7M	$234.3M	2.0%	+73.27%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	4.4M(+0.8%)	$148.5M	0.9%	+133.50%	43
GOLDMAN SACHS GROUP INC	Increased	3.1M(+5.4%)	$102.6M	0.0%	+55.59%	32
BlackRock, Inc.	Increased	1.9M(+6.0%)	$64.7M	0.0%	+70.43%	31
Avoro Capital Advisors LLC	Unchanged	1.3M	$44.8M	0.4%	+99.71%	0
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	1.2M(+2.1%)	$40.9M	0.0%	+42.54%	30
PRIMECAP MANAGEMENT CO/CA/	Increased	1.2M(+11.3%)	$39.1M	0.0%	+41.18%	32
GEODE CAPITAL MANAGEMENT, LLC	Increased	679,163(+5.3%)	$22.8M	0.0%	+84.50%	30
STATE STREET CORP	Increased	652,630(+3.4%)	$21.9M	0.0%	+80.23%	29
LOOMIS SAYLES & CO L P	New	624,752	$20.9M	0.0%	+20.19%	39
BALYASNY ASSET MANAGEMENT L.P.	Increased	350,442(+48.1%)	$11.7M	0.0%	+34.77%	38
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Increased	230,184(+18.0%)	$7.7M	0.0%	+39.04%	32
Universal- Beteiligungs- und Servicegesellschaft mbH	Decreased	222,702(-0.6%)	$7.5M	0.0%	+144.73%	0
TWO SIGMA INVESTMENTS, LP	Increased	220,885(+193.1%)	$7.4M	0.0%	+61.79%	44
NORTHERN TRUST CORP	Increased	201,131(+22.3%)	$6.7M	0.0%	+65.91%	33
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	187,041(+3.0%)	$6.3M	0.0%	+98.32%	28
Woodline Partners LP	New	185,535	$6.2M	0.0%	+20.19%	38
VFVANGUARD FIDUCIARY TRUST CO	Increased	165,656(+7.2%)	$5.5M	0.0%	+41.27%	29
MORGAN STANLEY	Increased	134,377(+21.6%)	$4.5M	0.0%	+73.34%	32
UBS Group AG	Decreased	89,874(-23.2%)	$3M	0.0%	+92.68%	0

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SEPNSepterna, Inc.

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer