Septerna, Inc. (SEPN) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling SEPN?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Septerna, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on SEPN?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Septerna, Inc..

Is institutional money flowing into SEPN?

69 institutional investors hold Septerna, Inc. (SEPN). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about SEPN?

Track institutional sentiment and conviction scores for Septerna, Inc. (SEPN) including Smart Money Verdict and position changes on HoldingsIntel.

Septerna, Inc.

SEPN·81734D104·US·equity·Healthcare - Biotechnology-13D/G

Common

SEPN (Septerna, Inc.) is held by 69 institutional investors as of Q4 2025. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($195M), DRIEHAUS CAPITAL MANAGEMENT LLC ($134.1M), GOLDMAN SACHS GROUP INC ($75.7M). Net institutional sentiment: Bullish.

Holders

Avg rating(3 Elite)

$656.6M

Total Value

72% (72)

Fund Consensus

46 buying - 18 selling

Smart Money VerdictView all

56Mixed MomentumSplit Signals

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See how SEPN's score breaks down across 4 SEC sources

Held by 69 funds

3 elite

Who's Trading

InsiderShaikhly SamiraSell $112KMar 2, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	7M	$195M	2.0%	+21.09%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	4.8M(-2.2%)	$134.1M	0.9%	+64.51%	0
GOLDMAN SACHS GROUP INC	Increased	2.7M(+86.6%)	$75.7M	0.0%	+11.32%	46
BlackRock, Inc.	Increased	1.8M(+23.4%)	$50.2M	0.0%	+22.50%	36
VANGUARD GROUP INC	Decreased	1.5M(-0.7%)	$42M	0.0%	+46.08%	0
Avoro Capital Advisors LLC	Unchanged	1.3M	$37.3M	0.4%	+39.57%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	572,734(+5.0%)	$16M	0.0%	+38.41%	30
PRIMECAP MANAGEMENT CO/CA/	New	546,100	$15.2M	0.0%	+1.26%	39
STATE STREET CORP	Increased	540,028(+28.9%)	$15.1M	0.0%	+34.51%	35
Woodline Partners LP	Increased	385,310(+36.4%)	$10.7M	0.0%	+53.30%	36
MARSHALL WACE, LLP	New	226,901	$6.3M	0.0%	+1.26%	38
Universal- Beteiligungs- und Servicegesellschaft mbH	Unchanged	222,702	$6.2M	0.0%	+71.75%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	187,241(+0.2%)	$5.2M	0.0%	+41.37%	27
Invesco Ltd.	Decreased	162,014(-8.5%)	$4.5M	0.0%	+52.18%	0
NORTHERN TRUST CORP	Decreased	154,196(-7.9%)	$4.3M	0.0%	+28.98%	0
MILLENNIUM MANAGEMENT LLC	Decreased	107,463(-72.0%)	$3M	0.0%	+70.27%	0
MORGAN STANLEY	Increased	103,985(+91.0%)	$2.9M	0.0%	+36.85%	42
TWO SIGMA INVESTMENTS, LP	Increased	92,809(+0.5%)	$2.6M	0.0%	+240.90%	26
FEDERATED HERMES, INC.	New	78,905	$2.2M	0.0%	+1.26%	36
CITADEL ADVISORS LLC	New	75,945	$2.1M	0.0%	+1.26%	36
UBS Group AG	Increased	68,817(+16.6%)	$1.9M	0.0%	+77.79%	30
JPMORGAN CHASE & CO	Increased	68,338(+682.3%)	$1.9M	0.0%	+4.24%	42
JACOBS LEVY EQUITY MANAGEMENT, INC	Increased	61,370(+71.5%)	$1.7M	0.0%	+26.91%	38
Bank of New York Mellon Corp	Increased	55,332(+7.2%)	$1.5M	0.0%	+35.02%	27
AMERICAN CENTURY COMPANIES INC	Increased	50,689(+100.5%)	$1.4M	0.0%	+22.43%	41
JANE STREET GROUP, LLC	New	44,070	$1.2M	0.0%	+1.26%	35
Trexquant Investment LP	New	44,005	$1.2M	0.0%	+1.26%	35
BARCLAYS PLC	Increased	38,147(+26.7%)	$1.1M	0.0%	+36.93%	31
ExodusPoint Capital Management, LP	New	37,867	$1.1M	0.0%	+1.26%	35
BANK OF AMERICA CORP /DE/	Decreased	37,594(-27.0%)	$1M	0.0%	+134.57%	0
Alyeska Investment Group, L.P.	Unchanged	35,000	$975,800	0.0%	+21.09%	0
WELLS FARGO & COMPANY/MN	Increased	26,529(+31.7%)	$739,628	0.0%	+32.07%	31
RHUMBLINE ADVISERS	Decreased	26,419(-4.3%)	$736,552	0.0%	+48.85%	0
Nuveen, LLC	Increased	25,798(+7.7%)	$719,248	0.0%	+179.99%	27
TWO SIGMA ADVISERS, LP	Increased	25,700(+24.1%)	$716,516	0.0%	+40.48%	30
XTX Topco Ltd	New	23,315	$650,022	0.0%	+1.26%	34
ALLIANCEBERNSTEIN L.P.	Decreased	19,600(-11.3%)	$546,448	0.0%	+167.65%	0
TUDOR INVESTMENT CORP ET AL	New	18,053	$503,318	0.0%	+1.26%	33
FRANKLIN RESOURCES INC	New	16,852	$469,834	0.0%	+1.26%	33
Russell Investments Group, Ltd.	Increased	15,310(+707.5%)	$426,840	0.0%	+5.80%	39
DEUTSCHE BANK AG\	Increased	14,879(+5.3%)	$414,827	0.0%	+56.97%	25
Squarepoint Ops LLC	New	14,847	$413,934	0.0%	+1.26%	33
STRS OHIO	New	14,600	$407,048	0.0%	+1.26%	33
LOS ANGELES CAPITAL MANAGEMENT LLC	New	18,550	$398,639	0.0%	+1.26%	33
AMERIPRISE FINANCIAL INC	New	14,090	$392,829	0.0%	+1.26%	33
MetLife Investment Management, LLC	Unchanged	13,685	$381,538	0.0%	+167.65%	0
INTECH INVESTMENT MANAGEMENT LLC	New	13,283	$370,330	0.0%	+1.26%	33
OSAIC HOLDINGS, INC.	Decreased	12,693(-1.3%)	$353,880	0.0%	+56.08%	0
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	New	10,594	$295,361	0.0%	+1.26%	32
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	9,934(+1.5%)	$276,960	0.0%	+28.69%	24
CITIGROUP INC	Increased	9,561(+3739.8%)	$266,561	0.0%	+2.71%	37
BANK OF NOVA SCOTIA	New	8,300	$231,404	0.0%	+1.26%	32
AQR CAPITAL MANAGEMENT LLC	New	7,826	$218,189	0.0%	+1.26%	32
NEW YORK STATE COMMON RETIREMENT FUND	Increased	5,600(+93.1%)	$156,128	0.0%	+35.01%	36
BNP PARIBAS FINANCIAL MARKETS	Increased	5,449(+31.1%)	$151,918	0.0%	+40.51%	28
Police & Firemen's Retirement System of New Jersey	Unchanged	5,175	$144,279	0.0%	+184.94%	0
BALYASNY ASSET MANAGEMENT L.P.	New	3,571	$99,559	0.0%	+1.26%	30
FMR LLC	Decreased	3,307(-3.8%)	$92,199	0.0%	+28.91%	0
Mirae Asset Global Investments Co., Ltd.	New	2,176	$60,667	0.0%	+1.26%	29
Legal & General Group Plc	Unchanged	1,945	$54,168	0.0%	+24.78%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	1,316(-4.0%)	$36,690	0.0%	+323.81%	0
GROUP ONE TRADING LLC	Decreased	944(-44.1%)	$26,319	0.0%	+92.92%	0
ROYAL BANK OF CANADA	Decreased	628(-42.0%)	$18,000	0.0%	+75.22%	0
NISA INVESTMENT ADVISORS, LLC	Increased	341(+138.5%)	$9,507	0.0%	+49.59%	19
Empowered Funds, LLC	New	340	$9,479	0.0%	+1.26%	23
PNC FINANCIAL SERVICES GROUP, INC.	Unchanged	198	$5,520	0.0%	+54.99%	0
US BANCORP \DE\	Decreased	190(-28.3%)	$5,297	0.0%	+167.65%	0
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	25,443(-7.2%)	$710	0.0%	+28.68%	0
Farther Finance Advisors, LLC	New	1	$28	0.0%	+1.26%	17
Verition Fund Management LLC	Exited	0(-100.0%)	$378,664	0.0%	+53.06%	0
Walleye Capital LLC	Exited	0(-100.0%)	$1.5M	0.0%	+53.06%	0
NATIONAL BANK OF CANADA /FI/	Exited	0(-100.0%)	$150	0.0%	+355.41%	0

Septerna, Inc.

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