SEPTERNA INC (SEPN) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling SEPN?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for SEPTERNA INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on SEPN?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for SEPTERNA INC.

Is institutional money flowing into SEPN?

68 institutional investors hold SEPTERNA INC (SEPN). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about SEPN?

Track institutional sentiment and conviction scores for SEPTERNA INC (SEPN) including Smart Money Verdict and position changes on HoldingsIntel.

SEPTERNA INC

SEPN·81734D104·US·equity·Healthcare - Biotechnology-13D/G

Holders

Avg rating(5 Elite)

$550.8M

Total Value

59% (81)

Fund Consensus

44 buying - 30 selling

Smart Money Verdict

View all

39Weak MomentumStrong Convergence

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See how SEPN's score breaks down across 4 SEC sources

Held by 68 funds

5 elite

Who's Trading

InsiderBEBhatt ElizabethSell $61KApr 15, 2026

InsiderUNUnknownSell $28KApr 15, 2026

InsiderUNUnknownSell $8KApr 15, 2026

InsiderSSShaikhly SamiraSell $112KMar 2, 2026

ActivistBVBIOTECHNOLOGY VALUE FUND L P2.0%Feb 17, 2026

Activist

DRIEHAUS CAPITAL MANAGEMENT LLC10.5%Jun 10, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	7M	$168.1M	1.8%	+16.01%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	4.4M(-8.6%)	$105.6M	0.8%	+57.61%	0
GOLDMAN SACHS GROUP INC	Increased	2.9M(+7.0%)	$69.8M	0.0%	+5.86%	32
BlackRock, Inc.	Increased	1.8M(+1.2%)	$43.8M	0.0%	+17.06%	29
Avoro Capital Advisors LLC	Unchanged	1.3M	$32.1M	0.3%	+33.72%	0
PRIMECAP MANAGEMENT CO/CA/	Increased	1M(+92.1%)	$25.2M	0.0%	-3.57%	45
JANUS HENDERSON GROUP PLC	New	890,754	$21.3M	0.0%	-4.19%	39
GEODE CAPITAL MANAGEMENT, LLC	Increased	645,146(+12.6%)	$15.5M	0.0%	+27.12%	32
STATE STREET CORP	Increased	631,447(+16.9%)	$15.2M	0.0%	+22.73%	33
BALYASNY ASSET MANAGEMENT L.P.	Increased	236,679(+6527.8%)	$5.7M	0.0%	-4.18%	44
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	223,995(+0.6%)	$5.4M	0.0%	+63.86%	27
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	181,580(-3.0%)	$4.4M	0.0%	+35.44%	0
NORTHERN TRUST CORP	Increased	164,530(+6.7%)	$4M	0.0%	+21.36%	29
MILLENNIUM MANAGEMENT LLC	Increased	124,101(+15.5%)	$3M	0.0%	+49.08%	30
UBS Group AG	Increased	116,979(+70.0%)	$2.8M	0.0%	+29.01%	39
MORGAN STANLEY	Increased	110,530(+6.3%)	$2.7M	0.0%	+28.31%	28
FEDERATED HERMES, INC.	Increased	89,301(+13.2%)	$2.1M	0.0%	-3.13%	29
Invesco Ltd.	Decreased	82,868(-48.9%)	$2M	0.0%	+45.79%	0
JPMORGAN CHASE & CO	Increased	84,674(+23.9%)	$2M	0.0%	-0.95%	31
TWO SIGMA INVESTMENTS, LP	Decreased	75,367(-18.8%)	$1.8M	0.0%	+226.60%	0

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High Conviction Moves-Signal Convergence-Fund Consensus-Double-Down Signals

Data sourced from four SEC data sources: 13F, Form 4, 13D/13G, and STOCK Act. Not financial advice. Full disclaimer