Sionna Therapeutics, Inc. (SION) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling SION?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Sionna Therapeutics, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on SION?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Sionna Therapeutics, Inc..

Is institutional money flowing into SION?

65 institutional investors hold Sionna Therapeutics, Inc. (SION). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about SION?

Track institutional sentiment and conviction scores for Sionna Therapeutics, Inc. (SION) including Smart Money Verdict and position changes on HoldingsIntel.

Sionna Therapeutics, Inc.

SION·829401108·US·equity·Healthcare - Biotechnology-Activist

SION (Sionna Therapeutics, Inc.) is held by 65 institutional investors as of Q4 2025. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($407.5M), VIKING GLOBAL INVESTORS LP ($131.4M), BlackRock, Inc. ($53.1M). Net institutional sentiment: Bullish.

Holders

Avg rating(2 Elite)

$952.6M

Total Value

75% (70)

Fund Consensus

48 buying - 16 selling

Smart Money VerdictView all

46Weak MomentumSplit Signals

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See how SION's score breaks down across 4 SEC sources

Held by 65 funds

2 elite

Who's Trading

InsiderORBIMED ADVISORS LLCSell $2.1MApr 14, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Decreased	9.9M(-5.2%)	$407.5M	4.2%	+194.90%	0
VIKING GLOBAL INVESTORS LP	Unchanged	3.2M	$131.4M	0.3%	+186.84%	0
BlackRock, Inc.	Increased	1.3M(+52.9%)	$53.1M	0.0%	+30.00%	41
JPMORGAN CHASE & CO	Decreased	1.2M(-37.7%)	$50.7M	0.0%	+192.38%	0
VANGUARD GROUP INC	Increased	1.2M(+3.7%)	$48.7M	0.0%	+64.78%	30
JENNISON ASSOCIATES LLC	Increased	1.1M(+11.8%)	$45.9M	0.0%	+82.77%	33
CITADEL ADVISORS LLC	Increased	1.1M(+2926.8%)	$44.7M	0.0%	-15.63%	47
Aberdeen Group plc	Decreased	839,960(-11.6%)	$34.6M	0.1%	+173.13%	0
STATE STREET CORP	Increased	693,395(+188.7%)	$28.5M	0.0%	-1.85%	46
BAKER BROS. ADVISORS LP	Unchanged	400,000	$16.5M	0.1%	+194.90%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	380,042(+20.1%)	$15.6M	0.0%	+74.26%	33
FRANKLIN RESOURCES INC	Decreased	175,483(-27.5%)	$7.2M	0.0%	+194.90%	0
Alyeska Investment Group, L.P.	Decreased	136,222(-26.9%)	$5.6M	0.0%	+194.90%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	123,686(+10.9%)	$5.1M	0.0%	+87.46%	30
TD ASSET MANAGEMENT INC	Increased	113,352(+30.2%)	$4.7M	0.0%	+39.98%	34
NORTHERN TRUST CORP	Increased	112,116(+14.7%)	$4.6M	0.0%	+81.24%	31
Invesco Ltd.	New	111,162	$4.6M	0.0%	-17.64%	37
AMERIPRISE FINANCIAL INC	Decreased	101,643(-33.6%)	$4.2M	0.0%	+182.72%	0
UBS Group AG	Increased	89,177(+91.1%)	$3.7M	0.0%	+23.81%	42
DRIEHAUS CAPITAL MANAGEMENT LLC	Unchanged	83,850	$3.4M	0.0%	+194.90%	0
MILLENNIUM MANAGEMENT LLC	Decreased	80,546(-62.4%)	$3.3M	0.0%	+20.28%	0
Ensign Peak Advisors, Inc	New	79,862	$3.3M	0.0%	-17.64%	37
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	69,424(+116.4%)	$2.9M	0.0%	+22.45%	42
MORGAN STANLEY	Increased	49,876(+118.4%)	$2.1M	0.0%	+15.50%	42
BARCLAYS PLC	Increased	48,172(+173.0%)	$2M	0.0%	+6.42%	42
BANK OF AMERICA CORP /DE/	Increased	43,567(+566.1%)	$1.8M	0.0%	-8.19%	42
WELLINGTON MANAGEMENT GROUP LLP	Decreased	38,347(-9.2%)	$1.6M	0.0%	+15.48%	0
ALPS ADVISORS INC	New	36,648	$1.5M	0.0%	-17.64%	35
GOLDMAN SACHS GROUP INC	Increased	36,269(+197.8%)	$1.5M	0.0%	+8.66%	41
Bank of New York Mellon Corp	Increased	35,134(+27.9%)	$1.4M	0.0%	+50.07%	32
POLEN CAPITAL MANAGEMENT LLC	Unchanged	31,258	$1.3M	0.0%	+54.32%	0
Rafferty Asset Management, LLC	New	24,690	$1M	0.0%	-17.64%	35
Nuveen, LLC	Increased	23,734(+48.0%)	$976,417	0.0%	+41.32%	34
Russell Investments Group, Ltd.	Increased	21,941(+2046.9%)	$902,688	0.0%	-16.52%	40
RHUMBLINE ADVISERS	Increased	17,694(+2.6%)	$727,924	0.0%	+106.66%	25
WELLS FARGO & COMPANY/MN	Increased	17,551(+131.7%)	$722,048	0.0%	+8.92%	40
Squarepoint Ops LLC	Increased	16,360(+61.0%)	$673,050	0.0%	+0.21%	35
ALLIANCEBERNSTEIN L.P.	New	15,620	$642,607	0.0%	-17.64%	34
DEUTSCHE BANK AG\	Increased	10,029(+4.5%)	$412,593	0.0%	+101.20%	25
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	8,915(+58.0%)	$367,124	0.0%	+35.18%	34
MetLife Investment Management, LLC	Increased	8,565(+6.6%)	$352,364	0.0%	+95.62%	25
INTECH INVESTMENT MANAGEMENT LLC	Increased	7,589(+1.4%)	$312,211	0.0%	+14.85%	24
TWO SIGMA INVESTMENTS, LP	New	6,400	$263,296	0.0%	-17.64%	32
AMERICAN CENTURY COMPANIES INC	New	6,180	$254,245	0.0%	-17.64%	32
D. E. Shaw & Co., Inc.	New	5,742	$236,226	0.0%	-17.64%	32
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	5,300	$218,042	0.0%	+115.21%	0
CITIGROUP INC	Increased	5,185(+654.7%)	$213,311	0.0%	-10.30%	37
XTX Topco Ltd	New	4,926	$202,656	0.0%	-17.64%	32
ProShare Advisors LLC	New	4,903	$201,710	0.0%	-17.64%	32
LOS ANGELES CAPITAL MANAGEMENT LLC	New	5,189	$197,234	0.0%	-17.64%	32
CIBC Private Wealth Group LLC	New	4,500	$185,130	0.0%	-17.64%	31
Police & Firemen's Retirement System of New Jersey	Increased	4,232(+30.9%)	$174,104	0.0%	+42.70%	29
BNP PARIBAS FINANCIAL MARKETS	Decreased	2,264(-4.9%)	$93,141	0.0%	+75.74%	0
Mirae Asset Global Investments Co., Ltd.	New	2,169	$89,233	0.0%	-17.64%	30
Legal & General Group Plc	Decreased	1,682(-77.2%)	$69,197	0.0%	+26.40%	0
BALYASNY ASSET MANAGEMENT L.P.	New	1,406	$57,843	0.0%	-17.64%	29
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	988(+28.1%)	$40,646	0.0%	+58.81%	17
PRICE T ROWE ASSOCIATES INC /MD/	Increased	831,373(+30.4%)	$34,203	0.0%	+84.20%	25
ROYAL BANK OF CANADA	Increased	489(+29.4%)	$21,000	0.0%	+13.59%	16
FMR LLC	Increased	384(+64.1%)	$15,798	0.0%	-0.20%	18
Farther Finance Advisors, LLC	New	190	$7,817	0.0%	-17.64%	23
US BANCORP \DE\	Decreased	65(-41.4%)	$2,674	0.0%	+15.48%	0
Rockefeller Capital Management L.P.	New	48	$1,975	0.0%	-17.64%	17
Allworth Financial LP	Increased	28(+27.3%)	$1,152	0.0%	+6.32%	9
PNC FINANCIAL SERVICES GROUP, INC.	Unchanged	5	$206	0.0%	+15.48%	0
Holocene Advisors, LP	Exited	0(-100.0%)	$1.5M	0.0%	+258.04%	0
Jain Global LLC	Exited	0(-100.0%)	$250,367	0.0%	+40.21%	0
MARSHALL WACE, LLP	Exited	0(-100.0%)	$885,328	0.0%	+40.21%	0
RENAISSANCE TECHNOLOGIES LLC	Exited	0(-100.0%)	$429,386	0.0%	+161.30%	0
FEDERATED HERMES, INC.	Exited	0(-100.0%)	$3,323	0.0%	+40.21%	0

Sionna Therapeutics, Inc.

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