Xeris Biopharma Holdings, Inc. (XERS) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling XERS?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Xeris Biopharma Holdings, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on XERS?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Xeris Biopharma Holdings, Inc..

Is institutional money flowing into XERS?

116 institutional investors hold Xeris Biopharma Holdings, Inc. (XERS). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about XERS?

Track institutional sentiment and conviction scores for Xeris Biopharma Holdings, Inc. (XERS) including Smart Money Verdict and position changes on HoldingsIntel.

Xeris Biopharma Holdings, Inc.

XERS·98422E103·US·equity·Healthcare - Biotechnology-13D/G

XERS (Xeris Biopharma Holdings, Inc.) is held by 116 institutional investors as of Q4 2025. Largest holders: BlackRock, Inc. ($99.2M), VANGUARD GROUP INC ($87.8M), D. E. Shaw & Co., Inc. ($59.5M). Net institutional sentiment: Mixed.

116

Holders

Avg rating(8 Elite)

$655.2M

Total Value

49% (135)

Fund Consensus

61 buying - 64 selling

Smart Money VerdictView all

38Weak MomentumStrong Convergence

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See how XERS's score breaks down across 4 SEC sources

Held by 116 funds

8 elite

Who's Trading

InsiderHecht BethSell $100KApr 1, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BlackRock, Inc.	Increased	12.6M(+6.0%)	$99.2M	0.0%	+55.32%	32
VANGUARD GROUP INC	Increased	11.2M(+13.8%)	$87.8M	0.0%	+58.37%	34
D. E. Shaw & Co., Inc.	Increased	7.6M(+29.7%)	$59.5M	0.0%	-1.66%	37
GEODE CAPITAL MANAGEMENT, LLC	Increased	4.3M(+3.3%)	$33.6M	0.0%	+93.06%	30
STATE STREET CORP	Increased	4.1M(+10.1%)	$32.3M	0.0%	+92.79%	32
Qube Research & Technologies Ltd	Increased	3.5M(+6.8%)	$27.5M	0.0%	+14.66%	31
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	3M(+13.8%)	$23.4M	0.2%	+5.76%	39
Nuveen, LLC	Decreased	2.8M(-0.8%)	$22M	0.0%	+4.84%	0
MORGAN STANLEY	Decreased	2.7M(-15.9%)	$21.3M	0.0%	+65.41%	0
WELLINGTON MANAGEMENT GROUP LLP	Increased	2.3M(+293.6%)	$17.9M	0.0%	-8.63%	46
TWO SIGMA INVESTMENTS, LP	Increased	1.7M(+7.3%)	$13.6M	0.0%	-2.78%	30
GOLDMAN SACHS GROUP INC	Decreased	1.6M(-12.6%)	$12.3M	0.0%	+37.32%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	1.4M(-3.0%)	$11M	0.0%	+0.34%	0
Legal & General Group Plc	Increased	1.4M(+2.9%)	$11M	0.0%	+16.48%	29
NORTHERN TRUST CORP	Increased	1.4M(+1.7%)	$10.9M	0.0%	+145.95%	28
Connor, Clark & Lunn Investment Management Ltd.	Decreased	1.1M(-37.7%)	$8.3M	0.0%	+4.30%	0
AQR CAPITAL MANAGEMENT LLC	Decreased	957,579(-2.6%)	$7.5M	0.0%	+110.56%	0
DEUTSCHE BANK AG\	Decreased	940,592(-40.0%)	$7.4M	0.0%	-10.81%	0
JPMORGAN CHASE & CO	Decreased	895,059(-1.1%)	$7M	0.0%	+32.16%	0
MILLENNIUM MANAGEMENT LLC	Increased	859,051(+63.7%)	$6.7M	0.0%	+21.06%	40
FEDERATED HERMES, INC.	Increased	854,888(+21.4%)	$6.7M	0.0%	+0.44%	33
TWO SIGMA ADVISERS, LP	Decreased	849,334(-4.9%)	$6.7M	0.0%	+9.15%	0
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Decreased	811,129(-21.6%)	$6.4M	0.0%	+4.63%	0
BANK OF AMERICA CORP /DE/	Decreased	717,914(-55.0%)	$5.6M	0.0%	+38.02%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	651,445(+255.1%)	$5.1M	0.0%	-18.98%	44
RENAISSANCE TECHNOLOGIES LLC	Decreased	619,660(-61.8%)	$4.9M	0.0%	+121.49%	0
PRUDENTIAL FINANCIAL INC	Decreased	618,949(-56.8%)	$4.9M	0.0%	+12.94%	0
Point72 Asset Management, L.P.	New	608,080	$4.8M	0.0%	-18.74%	37
UBS Group AG	Decreased	601,834(-66.2%)	$4.7M	0.0%	-20.37%	0
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	Increased	537,483(+111.6%)	$4.2M	0.0%	-8.64%	43
Squarepoint Ops LLC	Decreased	482,832(-28.9%)	$3.8M	0.0%	-10.37%	0
VOYA INVESTMENT MANAGEMENT LLC	Increased	458,329(+14.6%)	$3.6M	0.0%	-19.83%	30
FMR LLC	Increased	439,705(+22.1%)	$3.5M	0.0%	+2.13%	32
Bank of New York Mellon Corp	Decreased	434,262(-1.3%)	$3.4M	0.0%	+88.42%	0
CITADEL ADVISORS LLC	Decreased	409,820(-6.3%)	$3.2M	0.0%	-26.49%	0
SEI INVESTMENTS CO	Increased	399,347(+229.6%)	$3.1M	0.0%	-12.29%	43
CANADA PENSION PLAN INVESTMENT BOARD	Increased	390,600(+4.0%)	$3.1M	0.0%	-26.22%	27
Russell Investments Group, Ltd.	Increased	364,786(+45.1%)	$2.9M	0.0%	-13.82%	36
BARCLAYS PLC	Increased	362,751(+4.7%)	$2.8M	0.0%	+72.99%	28
STATE OF WISCONSIN INVESTMENT BOARD	Increased	357,453(+2.0%)	$2.8M	0.0%	+8.27%	27
Swiss National Bank	Increased	318,400(+2.6%)	$2.5M	0.0%	-26.31%	27
BNP PARIBAS FINANCIAL MARKETS	Decreased	258,368(-55.6%)	$2M	0.0%	-25.68%	0
Schonfeld Strategic Advisors LLC	Decreased	234,723(-22.9%)	$1.8M	0.0%	+18.74%	0
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	New	214,786	$1.7M	0.0%	-18.74%	36
Trexquant Investment LP	Decreased	213,581(-6.9%)	$1.7M	0.0%	-26.49%	0
RAYMOND JAMES FINANCIAL INC	Increased	211,419(+3.0%)	$1.7M	0.0%	+10.43%	26
COMMONWEALTH EQUITY SERVICES, LLC	Increased	197,815(+0.0%)	$1.6M	0.0%	+130.33%	25
RHUMBLINE ADVISERS	Decreased	189,567(-11.3%)	$1.5M	0.0%	+172.98%	0
JANE STREET GROUP, LLC	Decreased	177,822(-80.5%)	$1.4M	0.0%	-25.30%	0
WELLS FARGO & COMPANY/MN	Increased	170,796(+75.7%)	$1.3M	0.0%	+13.89%	38
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	151,171(-0.5%)	$1.2M	0.0%	-22.24%	0
PRINCIPAL FINANCIAL GROUP INC	Increased	150,559(+42.7%)	$1.2M	0.0%	+23.67%	34
ALLIANCEBERNSTEIN L.P.	Unchanged	144,830	$1.1M	0.0%	+152.09%	0
AMERIPRISE FINANCIAL INC	Decreased	143,463(-6.9%)	$1.1M	0.0%	+140.70%	0
POLEN CAPITAL MANAGEMENT LLC	Increased	133,416(+0.2%)	$1M	0.0%	+26.13%	25
GROUP ONE TRADING LLC	Increased	123,561(+1951.2%)	$969,954	0.0%	-19.16%	40
FRANKLIN RESOURCES INC	Increased	121,428(+11.3%)	$953,210	0.0%	+10.76%	28
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	117,355(+44.0%)	$921,237	0.0%	+2.81%	34
Creative Planning	Decreased	116,538(-8.2%)	$914,823	0.0%	+60.45%	0
Invesco Ltd.	Decreased	112,130(-80.8%)	$880,221	0.0%	-22.65%	0
Calamos Advisors LLC	Decreased	99,117(-27.7%)	$778,068	0.0%	-26.49%	0
CITIGROUP INC	Increased	98,746(+40.5%)	$775,156	0.0%	+31.59%	33
Brevan Howard Capital Management LP	Decreased	92,416(-30.1%)	$725,466	0.0%	+7.51%	0
Engineers Gate Manager LP	Decreased	89,404(-18.7%)	$701,821	0.0%	-14.05%	0
Jefferies Financial Group Inc.	New	87,800	$689,230	0.0%	-18.74%	34
IEQ CAPITAL, LLC	Decreased	86,520(-19.9%)	$679,182	0.0%	+38.75%	0
LPL Financial LLC	Increased	84,861(+154.8%)	$666,159	0.0%	+8.25%	40
MetLife Investment Management, LLC	Decreased	81,594(-6.6%)	$640,513	0.0%	+147.68%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Decreased	71,311(-0.0%)	$559,791	0.0%	+136.24%	0
JANUS HENDERSON GROUP PLC	Unchanged	69,887	$548,264	0.0%	-26.49%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	65,767(+101.4%)	$516,271	0.0%	-21.50%	39
STRS OHIO	Unchanged	65,500	$514,175	0.0%	+137.08%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	65,090(+17.6%)	$510,957	0.0%	+37.57%	28
OSAIC HOLDINGS, INC.	Increased	52,285(+29.6%)	$410,431	0.0%	+68.56%	30
Man Group plc	New	47,775	$375,033	0.0%	-18.74%	33
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	45,801(-8.7%)	$359,538	0.0%	+238.69%	0
Arizona State Retirement System	Decreased	45,269(-4.4%)	$355,362	0.0%	-26.49%	0
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	43,422	$340,863	0.0%	+73.16%	0
Police & Firemen's Retirement System of New Jersey	Decreased	40,738(-1.5%)	$319,793	0.0%	+32.51%	0
ROYAL BANK OF CANADA	Increased	38,636(+6.5%)	$304,000	0.0%	+7.05%	17
Cetera Investment Advisers	Decreased	38,647(-3.4%)	$303,379	0.0%	+7.08%	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	37,970	$298,065	0.0%	+164.00%	0
Gotham Asset Management, LLC	Decreased	35,412(-17.1%)	$277,984	0.0%	+2.01%	0
ProShare Advisors LLC	Increased	35,390(+10.6%)	$277,813	0.0%	+106.16%	26
Rafferty Asset Management, LLC	Increased	33,689(+93.5%)	$264,459	0.0%	+13.88%	37
KLP KAPITALFORVALTNING AS	Unchanged	33,400	$262,190	0.0%	-26.49%	0
Cerity Partners LLC	Decreased	29,578(-4.7%)	$232,188	0.0%	+28.25%	0
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Decreased	31,105(-0.0%)	$216,491	0.0%	+24.53%	0
Swiss Life Asset Management Ltd	New	26,059	$204,563	0.0%	-18.74%	32
Quantinno Capital Management LP	Increased	24,696(+39.6%)	$193,864	0.0%	-3.28%	30
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	23,936(-39.1%)	$187,897	0.0%	-26.49%	0
Pictet Asset Management Holding SA	Unchanged	23,196	$182,089	0.0%	-26.49%	0
TUDOR INVESTMENT CORP ET AL	Decreased	22,186(-41.6%)	$174,160	0.0%	+145.19%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	Unchanged	17,901	$173,819	0.0%	+26.38%	0
VICTORY CAPITAL MANAGEMENT INC	Increased	17,840(+3.4%)	$140,044	0.0%	+126.17%	23
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	14,192(+7.9%)	$111,408	0.0%	-25.97%	24
XPONANCE LLC	Increased	12,112(+1.1%)	$95,079	0.0%	+5.63%	22
CAPTRUST FINANCIAL ADVISORS	Decreased	11,816(-0.7%)	$92,756	0.0%	+2.23%	0
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	Increased	11,423(+12.4%)	$89,671	0.0%	-25.70%	24
Jain Global LLC	New	11,114	$87,245	0.0%	-18.74%	30
Corient Private Wealth LLC	New	10,734	$84,262	0.0%	-18.74%	30
CIBC WORLD MARKETS CORP	Decreased	10,158(-45.0%)	$79,740	0.0%	+27.68%	0
Mirae Asset Global Investments Co., Ltd.	Increased	8,063(+29.1%)	$63,295	0.0%	+53.35%	26
CIBC Private Wealth Group LLC	Unchanged	6,664	$52,312	0.0%	+167.52%	0
JONES FINANCIAL COMPANIES LLLP	Increased	5,707(+105.2%)	$44,800	0.0%	-12.77%	22
Kestra Advisory Services, LLC	New	3,192	$25,057	0.0%	-18.74%	27
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	2,821(-63.8%)	$22,145	0.0%	-17.33%	0
Farther Finance Advisors, LLC	Increased	2,571(+8.0%)	$20,182	0.0%	-22.03%	20
NISA INVESTMENT ADVISORS, LLC	Unchanged	2,204	$17,301	0.0%	+48.63%	0
Allworth Financial LP	Exited	0(-100.0%)	$14,368	0.0%	+275.38%	0
Rockefeller Capital Management L.P.	New	594	$4,663	0.0%	-18.74%	23
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	399(-35.8%)	$3,132	0.0%	+19.00%	0
HRT FINANCIAL LP	Increased	332,326(+358.1%)	$2,608	0.0%	-20.57%	20
PRICE T ROWE ASSOCIATES INC /MD/	Increased	173,463(+4.0%)	$1,362	0.0%	+125.86%	12
MAI Capital Management	New	27	$212	0.0%	-18.74%	17
BNP Paribas Asset Management Holding S.A.	New	2,353	$18	0.0%	-18.74%	17
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$2,882	0.0%	-9.53%	0
OMERS ADMINISTRATION Corp	Exited	0(-100.0%)	$200,244	0.0%	-9.53%	0
FRED ALGER MANAGEMENT, LLC	Exited	0(-100.0%)	$886,739	0.0%	-9.53%	0
MERCER GLOBAL ADVISORS INC /ADV	Exited	0(-100.0%)	$85,193	0.0%	-9.53%	0
ExodusPoint Capital Management, LP	Exited	0(-100.0%)	$707,529	0.0%	-9.53%	0
Skandinaviska Enskilda Banken AB (publ)	Exited	0(-100.0%)	$203,500	0.0%	-9.53%	0
Tidal Investments LLC	Exited	0(-100.0%)	$158,608	0.0%	-9.53%	0
MACKENZIE FINANCIAL CORP	Exited	0(-100.0%)	$1.2M	0.0%	+87.06%	0
Walleye Capital LLC	Exited	0(-100.0%)	$5.1M	0.0%	+2.88%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$139,438	0.0%	-9.53%	0
Optiver Holding B.V.	Exited	0(-100.0%)	$2,735	0.0%	-9.53%	0
Mariner, LLC	Exited	0(-100.0%)	$84,689	0.0%	+181.92%	0
Verition Fund Management LLC	Exited	0(-100.0%)	$99,544	0.0%	-9.53%	0
Vanguard Personalized Indexing Management, LLC	Exited	0(-100.0%)	$126,667	0.0%	-9.53%	0
SIMPLEX TRADING, LLC	Exited	0(-100.0%)	$373	0.0%	+55.53%	0
Quadrature Capital Ltd	Exited	0(-100.0%)	$140,819	0.0%	+38.29%	0
Savant Capital, LLC	Exited	0(-100.0%)	$218,877	0.0%	+118.83%	0
COMERICA BANK	Exited	0(-100.0%)	$2,507	0.0%	-9.53%	0

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