ZYMEWORKS INC (ZYME) is held by 125 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is BlackRock, Inc. as of Q1 2026.

Are institutions buying or selling ZYME?

In Q1 2026, 70 institutions opened or increased positions in ZYMEWORKS INC while 56 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on ZYME?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for ZYMEWORKS INC.

How many hedge funds hold ZYME?

125 institutional investors report holding ZYMEWORKS INC (ZYME) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into ZYME?

As of Q1 2026, tracked institutions in ZYMEWORKS INC show 70 buyers versus 56 sellers — net inflows.

ZYMEWORKS INC

ZYME·98985Y108·US·Common Stock·Healthcare - Biotechnology-Activist

125

Holders

Avg rating(29 Elite)

$667.8M

Total Value

56% (136)

Fund Consensus

70 buying - 56 selling

Smart Money Verdict

View all

Held by 125 funds

29 elite

Who's Trading

ActivistRURubric Capital Management LP9.5%May 15, 2026

ActivistPAPerceptive Advisors LLC5.4%Apr 15, 2026

Activist

Morgan Stanley3.4%Feb 12, 2026

InsiderHMHollywood MarkSell $139KJan 12, 2026

InsiderGKGalbraith KennethSell $690KJan 12, 2026

InsiderMAMoore Paul AndrewSell $217KJan 12, 2026

InsiderSLSmith Jeffrey T LSell $211KJan 12, 2026

InsiderGKGalbraith KennethSell $1.3MDec 22, 2025

ActivistECEcoR1 Capital, LLC30.7%Nov 19, 2025

ActivistBVBIOTECHNOLOGY VALUE FUND L P2.7%Nov 14, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BlackRock, Inc.	Decreased	4.6M(-0.9%)	$114M	0.0%	+59.63%	0
MORGAN STANLEY	Decreased	2.5M(-4.3%)	$62.1M	0.0%	+179.59%	0
BNP Paribas Asset Management Holding S.A.	Increased	1.9M(+4.7%)	$47.8M	0.1%	-2.14%	31
VAVANGUARD CAPITAL MANAGEMENT LLC	New	1.7M	$42.7M	0.0%	+5.85%	40
CITADEL ADVISORS LLC	Increased	1.2M(+350.4%)	$28.8M	0.0%	+15.54%	46
DIMENSIONAL FUND ADVISORS LP	Decreased	1.1M(-1.7%)	$28.5M	0.0%	+161.91%	0
STATE STREET CORP	Decreased	1M(-2.5%)	$25.3M	0.0%	+148.16%	0
$DEUTSCHE BANK AG\$ DEUTSCHE BANK AG\	Decreased	921,250(-42.3%)	$23.1M	0.0%	+166.08%	0
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Increased	743,898(+6.3%)	$18.6M	0.0%	+15.07%	30
Assenagon Asset Management S.A.	Increased	727,986(+12.4%)	$18.2M	0.0%	+45.75%	32
FMR LLC	Increased	667,153(+19.1%)	$16.7M	0.0%	-1.01%	33
GEODE CAPITAL MANAGEMENT, LLC	Increased	659,940(+1.9%)	$16.5M	0.0%	+187.85%	29
Nuveen, LLC	Increased	651,662(+0.5%)	$16.3M	0.0%	+81.03%	28
GOLDMAN SACHS GROUP INC	Increased	599,486(+42.7%)	$15M	0.0%	+53.97%	38
Qube Research & Technologies Ltd	Increased	511,937(+7.9%)	$12.8M	0.0%	+22.66%	30
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	499,875	$12.5M	0.0%	+5.85%	39
NORTHERN TRUST CORP	Increased	320,210(+4.0%)	$8M	0.0%	+170.96%	29
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Decreased	319,385(-0.3%)	$8M	0.0%	+135.09%	0
ROYCE & ASSOCIATES LP	New	299,202	$7.5M	0.1%	+5.85%	38
PICTON MAHONEY ASSET MANAGEMENT	Increased	256,690(+4.9%)	$6.4M	0.0%	+123.27%	29