Question 1

How many shares of SYRE does Jefferies Financial Group Inc. own?

Accepted Answer

Jefferies Financial Group Inc. previously held 0 shares of SYRE (Spyre Therapeutics, Inc) before exiting the position in 2025-Q4.

Question 2

What is Jefferies Financial Group Inc.'s SYRE position worth?

Accepted Answer

Jefferies Financial Group Inc.'s SYRE position was last reported at $0 in 2025-Q4 before the exit.

Question 3

Is Jefferies Financial Group Inc. buying or selling SYRE?

Accepted Answer

In 2025-Q4, Jefferies Financial Group Inc. exited their SYRE position entirely (-100.0% change in shares).

Question 4

When did Jefferies Financial Group Inc. first buy SYRE?

Accepted Answer

Based on available 13F filings, Jefferies Financial Group Inc. first reported a position in SYRE in 2024-Q4. They have held the position across 5 quarters.

Quarter	Action	Shares	Change	Value	Weight	Price	Conviction
2025-Q4 Latest	Exited	0	-100.0%	$0	0.0%	$31.88	0
2025-Q3	Unchanged	1.4M	0.0%	$23.3M	0.1%	$16.36	0
2025-Q2	Increased	1.4M	+11.2%	$20.8M	0.2%	$15.22	38
2025-Q1	Increased	1.2M	+2.6%	$20.2M	0.2%	$17.94	35
2024-Q4	New	1.2M	—	$28.3M	0.2%	$22.54	48