SPYRE THERAPEUTICS INC

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SYRE·00773J202·US·Common Stock·Healthcare - Biotechnology-Activist

SYRE (SPYRE THERAPEUTICS INC) is held by 147 institutional investors as of Q2 2026. Largest holders: FMR LLC ($1.2B), BlackRock, Inc. ($577.7M), RTW INVESTMENTS, LP ($377.5M). Net institutional sentiment: Bullish.

147

Holders

(9 Elite)

$6.3B

Total Value

79% (154)

Consensus

122 buying - 32 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)62

Insider (Form 4)34

Activist (13D/13G)29

Congressional (STOCK Act)85

Holder Quality

64

★★★★★

Elite

46

★★★★

Strong

72

★★★

Solid

30

★★

Below

63

★

Weak

Held by 147 funds

9 elite

Who's Trading

Source dates: Price Oct 16, 2026 · Insiders Oct 2, 2026 · Activists Oct 9, 2026 · Congress none

ActivistFAFairmount Funds Management LLC9.2%Oct 9, 2026

InsiderBLBurrows Scott LSell $135KOct 1, 2026

InsiderTCTurtle CameronSell $466KOct 1, 2026

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Top Holders

Top Holders (147)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	13M(+10.6%)	$1.2B	0.1%	+133.10%	35
BlackRock, Inc.	Increased	6.5M(+17.9%)	$577.7M	0.0%	+114.81%	37
RTW INVESTMENTS, LP	Increased	4.3M(+1.9%)	$377.5M	3.2%	+221.27%	58
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	3.4M(+12.8%)	$306.2M	0.0%	+45.83%	35
STATE STREET CORP	Increased	3.1M(+17.3%)	$271.4M	0.0%	+110.42%	36
PRICE T ROWE ASSOCIATES INC /MD/	Increased	3M(+85.2%)	$262.9M	0.0%	+43.99%	48
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	2.8M(+0.3%)	$248.5M	1.4%	+229.55%	48
GEODE CAPITAL MANAGEMENT, LLC	Increased	2.6M(+48.9%)	$239.3M	0.0%	+65.84%	42
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Increased	2.3M(+298.2%)	$206.9M	0.0%	+0.94%	49
Capital World Investors	Increased	2.3M(+247.4%)	$205.6M	0.0%	+5.97%	49
JTJupiter Topco LLC	First report	2.2M	$195.9M	0.1%	-10.00%	0
BANK OF AMERICA CORP /DE/	Increased	1.8M(+44.8%)	$157.8M	0.0%	+45.45%	41
AGADAGE CAPITAL PARTNERS GP, L.L.C.	New	1.7M	$152.9M	0.2%	-10.00%	50
WELLINGTON MANAGEMENT GROUP LLP	Decreased	1.6M(-13.3%)	$140.4M	0.0%	+180.74%	0
GOLDMAN SACHS GROUP INC	Increased	1.5M(+447.6%)	$131.2M	0.0%	+5.22%	49
FRANKLIN TEMPLETON INC	Increased	1.5M(+66.8%)	$130.8M	0.0%	+57.23%	44
JPMORGAN CHASE & CO	Increased	1.1M(+11.6%)	$98.9M	0.0%	+51.98%	33
Holocene Advisors, LP	New	1M	$90.1M	0.2%	-10.00%	49
MWMARSHALL WACE, LLP	Increased	991,693(+612.1%)	$88M	0.1%	-4.19%	48
Polar Capital Holdings Plc	Increased	988,009(+24.6%)	$87.7M	0.2%	+136.46%	44

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer