SPYRE THERAPEUTICS INC (SYRE) is held by 114 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is FMR LLC as of Q1 2026.

Are institutions buying or selling SYRE?

In Q1 2026, 75 institutions opened or increased positions in SPYRE THERAPEUTICS INC while 33 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on SYRE?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for SPYRE THERAPEUTICS INC.

How many hedge funds hold SYRE?

114 institutional investors report holding SPYRE THERAPEUTICS INC (SYRE) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into SYRE?

As of Q1 2026, tracked institutions in SPYRE THERAPEUTICS INC show 75 buyers versus 33 sellers — net inflows.

SPYRE THERAPEUTICS INC

SYRE·00773J202·US·Common Stock·Healthcare - Biotechnology-Activist

114

Holders

(18 Elite)

$2.8B

Total Value

69% (108)

Consensus

75 buying - 33 selling

13F: Mar 31, 2026Insider & Congress: Updated regularly

Smart Money Verdict

View all

Held by 114 funds

18 elite

Who's Trading

InsiderBLBurrows Scott LSell $436KJun 25, 2026

InsiderBLBurrows Scott LSell $871KJun 25, 2026

ActivistFAFairmount Funds Management LLC9.2%Jun 23, 2026

InsiderHTHENDERSON MICHAEL THOMASSell $174KMay 8, 2026

InsiderHTHENDERSON MICHAEL THOMASSell $2.5MMay 8, 2026

InsiderHTHENDERSON MICHAEL THOMASSell $1.9MMay 8, 2026

InsiderHTHENDERSON MICHAEL THOMASSell $1.5MMay 8, 2026

InsiderTCTurtle CameronSell $369KMay 1, 2026

InsiderTCTurtle CameronSell $255KMay 1, 2026

ActivistPAPerceptive Advisors LLC5.0%Apr 22, 2026

View all insider trades View all activist filings

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	11.8M(+1.2%)	$594.2M	0.0%	+295.86%	32
BlackRock, Inc.	Decreased	5.5M(-0.0%)	$278.5M	0.0%	+300.12%	0
RTW INVESTMENTS, LP	Unchanged	4.2M	$210.4M	2.1%	+316.55%	0
VAVANGUARD CAPITAL MANAGEMENT LLC	New	3.1M	$154.2M	0.0%	+143.92%	42
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	2.8M(-3.2%)	$140.8M	1.0%	+317.67%	0
STATE STREET CORP	Increased	2.6M(+15.2%)	$131.5M	0.0%	+254.60%	35
WELLINGTON MANAGEMENT GROUP LLP	Increased	1.8M(+17.8%)	$92M	0.0%	+251.04%	35
Capital International Investors	Decreased	1.7M(-50.0%)	$88.1M	0.0%	+337.70%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.7M(+3.7%)	$86.8M	0.0%	+252.14%	31
Janus Henderson Group Ltd.	Decreased	1.7M(-9.4%)	$83.6M	0.0%	+207.06%	0
RA CAPITAL MANAGEMENT, L.P.	Unchanged	1.6M	$81.8M	0.9%	+206.59%	0
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	1.6M(-0.2%)	$80.6M	0.0%	+267.13%	0
BANK OF AMERICA CORP /DE/	Increased	1.2M(+192.6%)	$61.9M	0.0%	+192.82%	48
BAKER BROS. ADVISORS LP	Unchanged	1M	$50.4M	0.3%	+524.71%	0
FRANKLIN RESOURCES INC	Decreased	882,833(-20.4%)	$44.5M	0.0%	+288.10%	0
JPMORGAN CHASE & CO	Increased	979,299(+1455.7%)	$44.5M	0.0%	+153.23%	47
Polar Capital Holdings Plc	Increased	792,847(+7.1%)	$40M	0.1%	+401.39%	37
UBS Group AG	Decreased	671,235(-1.4%)	$33.9M	0.0%	+276.60%	0
Capital World Investors	Increased	666,564(+233.0%)	$33.6M	0.0%	+180.82%	47
Candriam S.C.A.	Increased	610,282(+43.4%)	$30.8M	0.2%	+234.74%	46