SPYRE THERAPEUTICS INC

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SYRE·00773J202·US·Common Stock·Healthcare - Biotechnology-Activist

SYRE (SPYRE THERAPEUTICS INC) is held by 143 institutional investors as of Q2 2026. Largest holders: FMR LLC ($1.2B), BlackRock, Inc. ($577.7M), RTW INVESTMENTS, LP ($377.5M). Net institutional sentiment: Bullish.

143

Holders

(11 Elite)

$5.8B

Total Value

80% (150)

Consensus

120 buying - 30 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)62

Insider (Form 4)34

Activist (13D/13G)29

Congressional (STOCK Act)85

Holder Quality

64

★★★★★

Elite

46

★★★★

Strong

72

★★★

Solid

30

★★

Below

63

★

Weak

Held by 143 funds

11 elite

Who's Trading

Source dates: Price Aug 31, 2026 · Insiders Aug 10, 2026 · Activists Aug 14, 2026 · Congress none

ActivistPAPerceptive Advisors LLC4.9%Aug 14, 2026

ActivistRTW Investments, LP4.8%Aug 14, 2026

InsiderAWAlbers Jeffrey W.Sell $1.0MAug 7, 2026

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Top Holders

Top Holders (143)History

AllNewIncreasedHeldDecreasedExited

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	13M(+10.6%)	$1.2B	0.1%	+193.22%	35
BlackRock, Inc.	Increased	6.5M(+17.9%)	$577.7M	0.0%	+164.42%	37
RTW INVESTMENTS, LP	Increased	4.3M(+1.9%)	$377.5M	3.2%	+265.94%	58
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	3.4M(+12.8%)	$306.2M	0.0%	+98.17%	35
STATE STREET CORP	Increased	3.1M(+17.3%)	$271.4M	0.0%	+147.01%	36
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	2.8M(+0.3%)	$248.5M	1.4%	+282.93%	48
GEODE CAPITAL MANAGEMENT, LLC	Increased	2.6M(+48.9%)	$239.3M	0.0%	+89.06%	42
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Increased	2.3M(+298.2%)	$206.9M	0.0%	+18.04%	49
Capital World Investors	Increased	2.3M(+247.4%)	$205.6M	0.0%	+23.37%	49
BANK OF AMERICA CORP /DE/	Increased	1.8M(+44.8%)	$157.8M	0.0%	+78.89%	41
AGADAGE CAPITAL PARTNERS GP, L.L.C.	New	1.7M	$152.9M	0.2%	+1.78%	50
WELLINGTON MANAGEMENT GROUP LLP	Decreased	1.6M(-13.3%)	$140.4M	0.0%	+240.81%	0
GOLDMAN SACHS GROUP INC	Increased	1.5M(+447.6%)	$131.2M	0.0%	+19.13%	49
FRANKLIN RESOURCES INC	Increased	1.5M(+66.8%)	$130.8M	0.0%	+78.36%	44
JPMORGAN CHASE & CO	Increased	1.1M(+11.6%)	$98.9M	0.0%	+106.32%	33
Holocene Advisors, LP	New	1M	$90.1M	0.2%	+1.78%	49
MWMARSHALL WACE, LLP	Increased	991,693(+612.1%)	$88M	0.1%	+10.28%	48
Polar Capital Holdings Plc	Increased	988,009(+24.6%)	$87.7M	0.2%	+172.33%	44
Capital International Investors	Decreased	955,196(-45.3%)	$84.8M	0.0%	+304.65%	0
UBS Group AG	Increased	843,071(+25.6%)	$74.8M	0.0%	+133.13%	36

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer