Spyre Therapeutics, Inc. (SYRE) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling SYRE?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Spyre Therapeutics, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on SYRE?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Spyre Therapeutics, Inc..

Is institutional money flowing into SYRE?

95 institutional investors hold Spyre Therapeutics, Inc. (SYRE). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about SYRE?

Track institutional sentiment and conviction scores for Spyre Therapeutics, Inc. (SYRE) including Smart Money Verdict and position changes on HoldingsIntel.

Spyre Therapeutics, Inc.

SYRE·00773J202·US·equity·Healthcare - Biotechnology-Activist

SYRE (Spyre Therapeutics, Inc.) is held by 95 institutional investors as of Q4 2025. Largest holders: FMR LLC ($381.3M), BlackRock, Inc. ($180.9M), RTW INVESTMENTS, LP ($136.7M). Net institutional sentiment: Bullish.

Holders

Avg rating(4 Elite)

$1.7B

Total Value

71% (103)

Fund Consensus

67 buying - 27 selling

Smart Money VerdictView all

46Weak MomentumSplit Signals

Get 5 free verdicts/month - sign up in 10 seconds

See how SYRE's score breaks down across 4 SEC sources

Held by 95 funds

4 elite

Who's Trading

InsiderTurtle CameronSell $607KApr 1, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	11.6M(+28.5%)	$381.3M	0.0%	+63.53%	39
BlackRock, Inc.	Increased	5.5M(+38.6%)	$180.9M	0.0%	+64.03%	40
RTW INVESTMENTS, LP	Increased	4.2M(+15.2%)	$136.7M	1.4%	+70.77%	55
VANGUARD GROUP INC	Increased	4M(+32.3%)	$132.2M	0.0%	+42.36%	39
Capital International Investors	Increased	3.5M(+46.0%)	$114.4M	0.0%	+79.44%	41
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	2.9M(+39.9%)	$94.4M	0.6%	+71.23%	56
STATE STREET CORP	Increased	2.3M(+26.8%)	$74.1M	0.0%	+56.15%	37
JANUS HENDERSON GROUP PLC	Increased	1.8M(+140x)	$59.9M	0.0%	+25.88%	48
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.7M(+35.4%)	$54.4M	0.0%	+46.79%	38
RA CAPITAL MANAGEMENT, L.P.	New	1.6M	$53.1M	0.5%	+25.69%	57
WELLINGTON MANAGEMENT GROUP LLP	Decreased	1.5M(-5.5%)	$50.8M	0.0%	+56.11%	0
FRANKLIN RESOURCES INC	Increased	1.1M(+39.5%)	$36.3M	0.0%	+59.11%	38
BAKER BROS. ADVISORS LP	Unchanged	1M	$32.8M	0.2%	+156.11%	0
Pictet Asset Management Holding SA	Decreased	913,960(-11.8%)	$29.9M	0.0%	+59.15%	0
Polar Capital Holdings Plc	Decreased	740,326(-6.1%)	$24.3M	0.1%	+122.19%	0
UBS Group AG	Increased	680,566(+76.5%)	$22.3M	0.0%	+54.39%	43
Point72 Asset Management, L.P.	New	662,351	$21.7M	0.0%	+25.69%	39
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	574,622(+35.1%)	$18.8M	0.0%	+46.30%	37
NORTHERN TRUST CORP	Increased	561,023(+26.9%)	$18.4M	0.0%	+44.42%	35
Blackstone Inc.	Unchanged	500,998	$16.4M	0.1%	+77.97%	0
Candriam S.C.A.	Increased	425,534(+5.2%)	$13.9M	0.1%	+63.69%	30
BANK OF AMERICA CORP /DE/	Increased	419,727(+21.7%)	$13.8M	0.0%	+95.54%	34
GOLDMAN SACHS GROUP INC	Decreased	275,065(-16.5%)	$9M	0.0%	+122.91%	0
Woodline Partners LP	Increased	265,892(+101.6%)	$8.7M	0.0%	+40.49%	44
Capital World Investors	Unchanged	200,172	$6.6M	0.0%	+77.77%	0
Bank of New York Mellon Corp	Increased	192,830(+41.8%)	$6.3M	0.0%	+59.25%	36
MORGAN STANLEY	Decreased	182,734(-45.4%)	$6M	0.0%	+114.49%	0
BARCLAYS PLC	Increased	182,524(+8.4%)	$6M	0.0%	+79.15%	29
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	171,211(+55.0%)	$5.6M	0.0%	+55.24%	38
Nuveen, LLC	Increased	150,980(+57.0%)	$4.9M	0.0%	+74.21%	38
Invesco Ltd.	Increased	150,934(+197.7%)	$4.9M	0.0%	+41.19%	43
TD ASSET MANAGEMENT INC	Increased	149,822(+107.0%)	$4.9M	0.0%	+57.33%	43
VICTORY CAPITAL MANAGEMENT INC	Decreased	146,079(-55.2%)	$4.8M	0.0%	+96.17%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	129,013(+79.3%)	$4.1M	0.0%	+41.69%	41
DEUTSCHE BANK AG\	Increased	121,941(+216.4%)	$4M	0.0%	+39.38%	43
MERCER GLOBAL ADVISORS INC /ADV	Decreased	106,316(-0.3%)	$3.5M	0.0%	+163.18%	0
CITIGROUP INC	Increased	100,058(+204.2%)	$3.3M	0.0%	+40.95%	43
Swiss National Bank	Increased	96,500(+37.5%)	$3.2M	0.0%	+26.91%	35
RHUMBLINE ADVISERS	Increased	82,956(+17.0%)	$2.7M	0.0%	+73.17%	31
WELLS FARGO & COMPANY/MN	Increased	82,416(+109.6%)	$2.7M	0.0%	+48.39%	42
DIMENSIONAL FUND ADVISORS LP	Decreased	77,290(-8.2%)	$2.5M	0.0%	+144.93%	0
MILLENNIUM MANAGEMENT LLC	Decreased	76,194(-81.3%)	$2.5M	0.0%	+144.93%	0
BALYASNY ASSET MANAGEMENT L.P.	New	73,465	$2.4M	0.0%	+25.69%	36
ALLIANCEBERNSTEIN L.P.	Increased	67,500(+86.3%)	$2.2M	0.0%	+46.31%	41
CITADEL ADVISORS LLC	New	63,904	$2.1M	0.0%	+25.69%	36
ALPS ADVISORS INC	New	63,708	$2.1M	0.0%	+25.69%	36
JPMORGAN CHASE & CO	Decreased	62,951(-77.2%)	$2.1M	0.0%	+133.48%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	62,216(+57.5%)	$2M	0.0%	+65.49%	37
SCHRODER INVESTMENT MANAGEMENT GROUP	Decreased	61,574(-42.9%)	$2M	0.0%	+87.68%	0
Legal & General Group Plc	Increased	56,448(+20.5%)	$1.8M	0.0%	+44.02%	31
Rafferty Asset Management, LLC	Decreased	53,410(-10.5%)	$1.7M	0.0%	+77.36%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	48,038(+44.7%)	$1.6M	0.0%	+26.20%	35
AMERIPRISE FINANCIAL INC	New	38,256	$1.3M	0.0%	+25.69%	35
MetLife Investment Management, LLC	Increased	38,011(+27.1%)	$1.2M	0.0%	+59.94%	31
ExodusPoint Capital Management, LP	Decreased	37,871(-44.8%)	$1.2M	0.0%	+133.27%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	35,144(+32.9%)	$1.1M	0.0%	+49.52%	32
VOYA INVESTMENT MANAGEMENT LLC	New	27,277	$893,594	0.0%	+25.69%	34
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	27,252(-18.8%)	$892,776	0.0%	+38.54%	0
Waverly Advisors, LLC	Increased	25,954	$850,253	0.0%	+128.42%	25
VIRGINIA RETIREMENT SYSTEMS ET Al	Increased	24,950(+34.9%)	$817,362	0.0%	+96.69%	32
Assenagon Asset Management S.A.	Unchanged	22,136	$725,175	0.0%	+40.82%	0
NEW YORK STATE COMMON RETIREMENT FUND	Increased	19,165(+15.7%)	$627,845	0.0%	+36.18%	28
Police & Firemen's Retirement System of New Jersey	Increased	18,360(+33.0%)	$601,474	0.0%	+77.00%	31
INTECH INVESTMENT MANAGEMENT LLC	Decreased	18,274(-10.3%)	$598,656	0.0%	+81.86%	0
AQR CAPITAL MANAGEMENT LLC	Increased	17,820(+4.5%)	$583,783	0.0%	+151.34%	25
State of New Jersey Common Pension Fund D	New	16,698	$547,026	0.0%	+25.69%	34
ProShare Advisors LLC	Increased	15,989(+49.7%)	$523,801	0.0%	+58.94%	33
Arizona State Retirement System	Increased	13,797(+29.0%)	$451,990	0.0%	+46.14%	30
BNP PARIBAS FINANCIAL MARKETS	Decreased	11,844(-96.3%)	$388,009	0.0%	+145.70%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	11,164(+2.7%)	$365,733	0.0%	+155.99%	24
KLP KAPITALFORVALTNING AS	Increased	10,400(+33.3%)	$340,704	0.0%	+61.09%	30
TUDOR INVESTMENT CORP ET AL	New	10,127	$331,761	0.0%	+25.69%	33
Carlyle Group Inc.	New	9,620	$315,055	0.0%	+25.69%	36
LOS ANGELES CAPITAL MANAGEMENT LLC	Decreased	12,882(-29.1%)	$312,519	0.0%	+144.93%	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	New	9,030	$295,823	0.0%	+25.69%	32
TEACHER RETIREMENT SYSTEM OF TEXAS	New	7,173	$234,987	0.0%	+25.69%	32
Brevan Howard Capital Management LP	New	6,198	$203,046	0.0%	+25.69%	32
SEI INVESTMENTS CO	New	6,117	$200,393	0.0%	+25.69%	32
SUSQUEHANNA INTERNATIONAL GROUP, LLP	New	6,111	$200,196	0.0%	+25.69%	35
Russell Investments Group, Ltd.	Increased	5,554(+31.2%)	$181,948	0.0%	+100.16%	29
Mirae Asset Global Investments Co., Ltd.	Increased	3,770(+61.5%)	$123,505	0.0%	+57.74%	32
ROYAL BANK OF CANADA	Decreased	1,988(-74.8%)	$65,000	0.0%	+134.38%	0
PRICE T ROWE ASSOCIATES INC /MD/	Increased	1.6M(+158.1%)	$52,479	0.0%	+50.51%	33
NISA INVESTMENT ADVISORS, LLC	Unchanged	705	$23,096	0.0%	+123.77%	0
Rockefeller Capital Management L.P.	Increased	549(+36.9%)	$17,985	0.0%	+95.05%	16
GROUP ONE TRADING LLC	New	400	$13,104	0.0%	+25.69%	27
OSAIC HOLDINGS, INC.	Increased	367(+16.9%)	$12,022	0.0%	+117.51%	14
Optiver Holding B.V.	Decreased	240(-52.0%)	$7,862	0.0%	+144.93%	0
PNC FINANCIAL SERVICES GROUP, INC.	Unchanged	86	$2,818	0.0%	+144.93%	0
Allworth Financial LP	Increased	58(+81.3%)	$1,901	0.0%	+61.77%	12
Farther Finance Advisors, LLC	Increased	37(+270.0%)	$1,212	0.0%	+44.73%	12
US BANCORP \DE\	Unchanged	10	$328	0.0%	+126.79%	0
COMERICA BANK	Unchanged	5	$164	0.0%	+144.93%	0
BNP Paribas Asset Management Holding S.A.	Increased	656(+95.8%)	$21	0.0%	+71.44%	12
Quadrature Capital Ltd	Exited	0(-100.0%)	$324,768	0.0%	+94.87%	0
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Exited	0(-100.0%)	$4.4M	0.0%	+32.20%	0
Schonfeld Strategic Advisors LLC	Exited	0(-100.0%)	$1.4M	0.0%	+94.87%	0
Verition Fund Management LLC	Exited	0(-100.0%)	$812,793	0.0%	+109.46%	0
HUNTINGTON NATIONAL BANK	Exited	0(-100.0%)	$24,637	0.0%	+41.44%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	+70.44%	0
Jefferies Financial Group Inc.	Exited	0(-100.0%)	$23.3M	0.0%	+46.94%	0
JANE STREET GROUP, LLC	Exited	0(-100.0%)	$1.6M	0.0%	+94.87%	0
Squarepoint Ops LLC	Exited	0(-100.0%)	$339,088	0.0%	+62.54%	0

Spyre Therapeutics, Inc.

Continue exploring