Question 1

How many shares of SYRE does DRIEHAUS CAPITAL MANAGEMENT LLC own?

Accepted Answer

As of 2026-Q2, DRIEHAUS CAPITAL MANAGEMENT LLC holds 2.8M shares of SYRE (SPYRE THERAPEUTICS INC).

Question 2

What is DRIEHAUS CAPITAL MANAGEMENT LLC's SYRE position worth?

Accepted Answer

As of 2026-Q2, DRIEHAUS CAPITAL MANAGEMENT LLC's SYRE position is worth $248.5M.

Question 3

Is DRIEHAUS CAPITAL MANAGEMENT LLC buying or selling SYRE?

Accepted Answer

In 2026-Q2, DRIEHAUS CAPITAL MANAGEMENT LLC increased their SYRE position (+0.3% change in shares).

Question 4

When did DRIEHAUS CAPITAL MANAGEMENT LLC first buy SYRE?

Accepted Answer

Based on available 13F filings, DRIEHAUS CAPITAL MANAGEMENT LLC first reported a position in SYRE in 2024-Q3. They have held the position across 12 quarters.

Quarter	Action	Shares	Change	Value	Weight	Price	Conviction
2026-Q2 Latest	Increased	2.8M	+0.3%	$248.5M	1.4%	$88.78	48
2026-Q1	Decreased	2.8M	-3.2%	$140.8M	1.0%	$40.07	0
2025-Q4	Increased	2.9M	+39.9%	$94.4M	0.6%	$31.88	56
2025-Q3	Decreased	2.1M	-1.2%	$34.5M	0.2%	$16.36	0
2025-Q2	Decreased	2.1M	-23.3%	$31.2M	0.2%	$15.22	0
2025-Q1	Decreased	2.7M	-3.1%	$43.8M	0.4%	$17.94	0
2024-Q4	Increased	2.8M	+308.1%	$65.3M	0.5%	$22.54	67
2024-Q3	Unchanged	687,080	0.0%	$20.2M	0.2%	$28.49	0