TWO SIGMA INVESTMENTS, LP

View all activity View 13F on SEC

Data as of Q4 2025

Institutional investor tracked via SEC 13F filings. Portfolio snapshot as of 2025-12-31.SEC EDGAR Source

Assets Under Management

$67.1B

Total Positions

3,467

New This Quarter

590

Filing Period

2025-12-31

Portfolio Allocation

Top holdings by portfolio weight

XLY0.57%

XLK0.57%

VUG0.56%

IWF0.54%

QQQ0.45%

SPY0.45%

VNQ0.45%

MU0.42%

AMD0.41%

PLTR0.39%

Other5.49%

Position Outcomes

Best and worst performing positions by estimated return

Top Winners

HOOD13Q held

Robinhood Markets Inc

Avg $15.86 · $13.3M est. P&L

Est. P&L

+627.78%

VISN14Q held

COMMSCOPE HLDG CO INC

Avg $3.68 · $39.9M est. P&L

Est. P&L

+396.70%

OMER20Q held

OMEROS CORP

Avg $3.60 · $7M est. P&L

Est. P&L

+371.40%

Top Losers

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View plans

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Top Holdings(Showing 25 of 3372 — sorted by value)

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Activity:

Stock	Shares	Value	Weight	Price Trend	Avg Buy	Est. P&L	Held	Conviction
XLY SELECT SECTOR SPDR TR S	3.4M	$404M	0.6%	—	$120.34	+0.02%	2 qtrs	Increased 71
XLK SELECT SECTOR SPDR TR	2.8M	$403.3M	0.6%	—	$144.96	+0.31%	15 qtrs	Increased 71
VUG VANGUARD INDEX FDS	816,840	$398.5M	0.6%	—	$360.07	+36.55%	11 qtrs	Decreased 0
IWF ISHARES TR	813,789	$385.2M	0.5%	—	$379.33	+25.73%	11 qtrs	Increased 58
QQQ INVESCO QQQ TR	523,077	$321.3M	0.5%	—	$443.66	+39.62%	28 qtrs	Decreased 0
SPY SPDR S&P 500 ETF TR	464,197	$316.5M	0.4%	—	$509.77	+34.77%	29 qtrs	Decreased 0
VNQ VANGUARD INDEX FDS R	3.6M	$316.2M	0.4%	—	$89.22	0.00%	1 qtr	New 51
MU Micron Technology Inc	1M	$296.8M	0.4%	—	$151.01	+93.79%	12 qtrs	Decreased 0
AMD Advanced Micro Devices Inc	1.3M	$287.5M	0.4%	—	$159.62	+34.91%	4 qtrs	Decreased 0
PLTR Palantir Technologies Inc	1.6M	$278.1M	0.4%	—	$85.22	+112.20%	15 qtrs	Decreased 0
IVV ISHARES TR	392,760	$269M	0.4%	—	$518.59	+33.04%	11 qtrs	Decreased 0
GM General Motors Co	3.3M	$268.5M	0.4%	—	$57.64	+42.84%	13 qtrs	Decreased 0
AMZN Amazon.com Inc	1.1M	$265M	0.4%	—	$221.61	+4.93%	18 qtrs	Decreased 0
TSM TAIWAN SEMICONDUCTOR MFG LTD	868,449	$263.9M	0.4%	—	$267.80	+11.87%	6 qtrs	Increased 37
ISRG Intuitive Surgical Inc	459,879	$260.5M	0.4%	—	$481.47	+18.93%	22 qtrs	Decreased 0
MSFT Microsoft Corp	538,234	$260.3M	0.4%	—	$357.77	+36.26%	11 qtrs	Increased 38
RIVN RIVIAN AUTOMOTIVE INC C	13.2M	$260.2M	0.4%	—	$13.65	+43.48%	4 qtrs	Decreased 0
ABNB Airbnb Inc	1.9M	$259.7M	0.4%	—	$130.92	+4.57%	5 qtrs	Increased 37
ADBE Adobe Inc	741,976	$259.7M	0.4%	—	$439.37	-19.77%	16 qtrs	Increased 39
TJX TJX Cos Inc/The	1.7M	$258.2M	0.4%	—	$142.25	+8.90%	8 qtrs	Increased 37
SCHW Charles Schwab Corp/The	2.6M	$257.7M	0.4%	—	$78.27	+28.02%	16 qtrs	Increased 37
TSLA Tesla Inc	568,358	$255.6M	0.4%	—	$381.98	+18.97%	5 qtrs	Increased 37
MA Mastercard Inc	441,496	$252M	0.4%	—	$430.54	+33.91%	15 qtrs	Increased 41
BMY Bristol-Myers Squibb Co	4.7M	$251.5M	0.4%	—	$43.84	+22.22%	29 qtrs	Decreased 0
IBB ISHARES TR	1.5M	$248.9M	0.4%	—	$167.70	+0.71%	2 qtrs	Increased 59
Showing 25 of 3,372 results.PROUpgrade to see all →

Accumulation Streaks

Positions with 2+ consecutive quarters of increases — persistent directional conviction.

Security

ADBEAdobe Inc

Q2 2024 → Q4 2025+738,870 shares+$258.1M

BCRXBIOCRYST PHARMACEUTICALS INC

Q2 2024 → Q4 2025+2.9M shares+$27.2M

GOSSGOSSAMER BIO INC

Q3 2024 → Q4 2025+3.1M shares+$10.3M

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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer