Question 1

Does Baker Bros. Advisors own SYRE stock?

Accepted Answer

No. Baker Bros. Advisors exited its SYRE (Spyre Therapeutics) position in Q2 2026. Its Q1 2026 13F listed 1,000,000 shares worth $50.4M.

Question 2

How many shares of SYRE does Baker Bros. Advisors own?

Accepted Answer

None since Q2 2026, when Baker Bros. Advisors exited the position. Its Q1 2026 13F listed 1,000,000 shares worth $50.4M.

Question 3

What is Baker Bros. Advisors' SYRE position worth?

Accepted Answer

Baker Bros. Advisors' SYRE position was worth $50.4M in its Q1 2026 13F, before the exit in Q2 2026.

Question 4

Is Baker Bros. Advisors buying or selling SYRE?

Accepted Answer

In Q2 2026, Baker Bros. Advisors exited its entire SYRE position.

Question 5

When did Baker Bros. Advisors first buy SYRE?

Accepted Answer

Baker Bros. Advisors first reported SYRE in its Q2 2025 13F and listed it in 4 quarterly 13F filings.

Quarter	Action	Shares	Change	Value	Weight	Price	Conviction
2026-Q2 Latest	Exited	0	-100.0%	$0	0.0%	$88.78	0
2026-Q1	Unchanged	1M	0.0%	$50.4M	0.3%	$50.44	0
2025-Q4	Unchanged	1M	0.0%	$32.8M	0.2%	$32.76	0
2025-Q3	Increased	1M	+59.6%	$16.8M	0.1%	$16.76	48
2025-Q2	New	626,703	—	$9.4M	0.1%	$14.97	38