Question 1

How many shares of SYRE does RTW INVESTMENTS, LP own?

Accepted Answer

As of 2026-Q2, RTW INVESTMENTS, LP holds 4.3M shares of SYRE (Spyre Therapeutics, Inc).

Question 2

What is RTW INVESTMENTS, LP's SYRE position worth?

Accepted Answer

As of 2026-Q2, RTW INVESTMENTS, LP's SYRE position is worth $377.5M.

Question 3

Is RTW INVESTMENTS, LP buying or selling SYRE?

Accepted Answer

In 2026-Q2, RTW INVESTMENTS, LP increased their SYRE position (+1.9% change in shares).

Question 4

When did RTW INVESTMENTS, LP first buy SYRE?

Accepted Answer

Based on available 13F filings, RTW INVESTMENTS, LP first reported a position in SYRE in 2024-Q3. They have held the position across 11 quarters.

Quarter	Action	Shares	Change	Value	Weight	Price	Conviction
2026-Q2 Latest	Increased	4.3M	+1.9%	$377.5M	3.2%	$88.78	58
2026-Q1	Unchanged	4.2M	0.0%	$210.4M	2.1%	$40.07	0
2025-Q4	Increased	4.2M	+15.2%	$136.7M	1.4%	$31.88	55
2025-Q3	Unchanged	3.6M	0.0%	$60.7M	0.7%	$16.36	0
2025-Q2	Unchanged	3.6M	0.0%	$54.2M	0.8%	$15.22	0
2025-Q1	Unchanged	3.6M	0.0%	$58.4M	0.9%	$17.94	0
2024-Q4	Increased	3.6M	+11.2%	$84.3M	1.3%	$22.54	52
2024-Q3	Unchanged	3.3M	0.0%	$95.8M	1.4%	$28.49	0