Agios Pharmaceuticals, Inc. (AGIO) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling AGIO?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Agios Pharmaceuticals, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on AGIO?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Agios Pharmaceuticals, Inc..

Is institutional money flowing into AGIO?

127 institutional investors hold Agios Pharmaceuticals, Inc. (AGIO). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about AGIO?

Track institutional sentiment and conviction scores for Agios Pharmaceuticals, Inc. (AGIO) including Smart Money Verdict and position changes on HoldingsIntel.

Agios Pharmaceuticals, Inc.

AGIO·00847X104·US·equity·Healthcare - Biotechnology-13D/G

AGIO (Agios Pharmaceuticals, Inc.) is held by 127 institutional investors as of Q4 2025. Largest holders: VANGUARD GROUP INC ($152.3M), BlackRock, Inc. ($142.5M), FARALLON CAPITAL MANAGEMENT LLC ($140.4M). Net institutional sentiment: Mixed.

127

Holders

Avg rating(9 Elite)

$1.3B

Total Value

61% (144)

Fund Consensus

83 buying - 53 selling

Smart Money VerdictView all

41Weak MomentumSplit Signals

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See how AGIO's score breaks down across 4 SEC sources

Held by 127 funds

9 elite

Who's Trading

InsiderJones CeciliaSell $109KApr 2, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

InsiderMilanova TsvetaSell $113KApr 2, 2026

ActivistThe Vanguard Group0.0%Mar 26, 2026

CongressGilbert CisnerosBuy $1,001 - $15,000Mar 3, 2026

ActivistArmistice Capital, LLC5.2%Feb 17, 2026

CongressGilbert CisnerosBuy $1,001 - $15,000Dec 11, 2025

CongressGilbert CisnerosBuy $1,001 - $15,000Apr 17, 2025

CongressGilbert CisnerosBuy $1,001 - $15,000Jan 29, 2025

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VANGUARD GROUP INC	Decreased	5.6M(-0.2%)	$152.3M	0.0%	-37.07%	0
BlackRock, Inc.	Increased	5.2M(+15.2%)	$142.5M	0.0%	-11.65%	35
FARALLON CAPITAL MANAGEMENT LLC	Decreased	5.2M(-10.8%)	$140.4M	0.7%	-6.23%	0
STATE STREET CORP	Increased	3.1M(+37.4%)	$84.6M	0.0%	+2.72%	39
Erste Asset Management GmbH	Increased	2.8M(+1.4%)	$76.3M	0.6%	-27.44%	42
D. E. Shaw & Co., Inc.	Increased	1.8M(+399.6%)	$50M	0.0%	-0.67%	47
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	New	1.7M	$46.3M	0.1%	+4.21%	40
GEODE CAPITAL MANAGEMENT, LLC	Decreased	1.4M(-0.2%)	$38.5M	0.0%	-30.63%	0
CITADEL ADVISORS LLC	Increased	1.3M(+174.2%)	$36.7M	0.0%	-3.19%	47
SUSQUEHANNA INTERNATIONAL GROUP, LLP	New	1.1M	$31.1M	0.0%	+4.21%	40
JANE STREET GROUP, LLC	Increased	1.1M(+183.7%)	$30.5M	0.0%	-9.06%	46
GOLDMAN SACHS GROUP INC	Increased	1M(+28.5%)	$28.1M	0.0%	-12.30%	36
DIMENSIONAL FUND ADVISORS LP	Decreased	1M(-1.6%)	$27.3M	0.0%	+23.69%	0
MORGAN STANLEY	Increased	894,037(+114.4%)	$24.3M	0.0%	-15.99%	46
Capital International Investors	New	703,865	$19.2M	0.0%	+4.21%	39
BALYASNY ASSET MANAGEMENT L.P.	Increased	635,069(+28.2%)	$17.3M	0.0%	-22.28%	35
SCS Capital Management LLC	Unchanged	598,765	$16.3M	0.2%	-5.94%	0
WELLINGTON MANAGEMENT GROUP LLP	Decreased	597,826(-75.8%)	$16.3M	0.0%	-25.49%	0
Connor, Clark & Lunn Investment Management Ltd.	Increased	562,642(+6.1%)	$15.3M	0.0%	-11.53%	30
BANK OF AMERICA CORP /DE/	Decreased	539,341(-52.3%)	$14.7M	0.0%	-9.09%	0
NORTHERN TRUST CORP	Decreased	511,901(-7.8%)	$13.9M	0.0%	-40.95%	0
Artisan Partners Limited Partnership	Increased	504,485(+25.2%)	$13.7M	0.0%	-25.91%	34
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	482,622(+0.1%)	$13.1M	0.0%	-36.37%	28
MILLENNIUM MANAGEMENT LLC	Increased	398,267(+7788.0%)	$10.8M	0.0%	+3.92%	45
Qube Research & Technologies Ltd	New	378,373	$10.3M	0.0%	+4.21%	38
MARSHALL WACE, LLP	Increased	353,639(+55.9%)	$9.6M	0.0%	-17.71%	39
Legal & General Group Plc	Increased	328,211(+1.6%)	$8.9M	0.0%	-28.18%	28
BARCLAYS PLC	Increased	320,352(+48.3%)	$8.7M	0.0%	-15.52%	38
TWO SIGMA INVESTMENTS, LP	Increased	300,156(+403.4%)	$8.2M	0.0%	-4.11%	44
Nuveen, LLC	Increased	297,908(+149.1%)	$8.1M	0.0%	-1.46%	44
JPMORGAN CHASE & CO	Increased	251,777(+37.5%)	$6.9M	0.0%	-9.33%	36
BNP PARIBAS FINANCIAL MARKETS	Increased	242,670(+1551.0%)	$6.6M	0.0%	+2.99%	44
Trexquant Investment LP	New	226,600	$6.2M	0.1%	+4.21%	38
Pictet Asset Management Holding SA	Decreased	205,019(-24.7%)	$5.6M	0.0%	+14.86%	0
Point72 Asset Management, L.P.	Increased	200,000(+2973.6%)	$5.4M	0.0%	+2.75%	44
Bank of New York Mellon Corp	Decreased	196,893(-27.1%)	$5.4M	0.0%	-27.02%	0
GROUP ONE TRADING LLC	New	166,614	$4.5M	0.0%	+4.21%	37
AMERICAN CENTURY COMPANIES INC	Increased	151,486(+4.4%)	$4.1M	0.0%	-12.30%	28
MOORE CAPITAL MANAGEMENT, LP	Increased	150,000(+172.7%)	$4.1M	0.1%	-12.39%	43
Allianz Asset Management GmbH	Increased	147,950(+0.9%)	$4M	0.0%	-13.54%	27
Invesco Ltd.	Increased	142,580(+12.3%)	$3.9M	0.0%	-13.49%	30
UBS Group AG	Decreased	126,665(-47.8%)	$3.4M	0.0%	-22.70%	0
DEUTSCHE BANK AG\	Decreased	122,875(-86.7%)	$3.3M	0.0%	-29.32%	0
Squarepoint Ops LLC	New	121,763	$3.3M	0.0%	+4.21%	37
JACOBS LEVY EQUITY MANAGEMENT, INC	New	111,150	$3M	0.0%	+4.21%	37
Assenagon Asset Management S.A.	Increased	110,440(+64.5%)	$3M	0.0%	-17.66%	38
Swiss National Bank	Increased	108,860(+2.1%)	$3M	0.0%	-33.04%	27
Rafferty Asset Management, LLC	Increased	107,490(+57.6%)	$2.9M	0.0%	-10.65%	38
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	106,996(+0.1%)	$2.9M	0.0%	-17.84%	26
Hudson Bay Capital Management LP	Decreased	100,000(-18.4%)	$2.7M	0.0%	-4.35%	0
Caption Management, LLC	Increased	93,486(+434.4%)	$2.5M	0.0%	-3.26%	42
CITIGROUP INC	Increased	88,238(+102.3%)	$2.4M	0.0%	-5.53%	42
TWO SIGMA ADVISERS, LP	Increased	85,200(+526.5%)	$2.3M	0.0%	-2.59%	42
PRUDENTIAL FINANCIAL INC	Decreased	81,055(-17.5%)	$2.2M	0.0%	-6.98%	0
PANAGORA ASSET MANAGEMENT INC	New	79,840	$2.2M	0.0%	+4.21%	36
FIRST TRUST ADVISORS LP	Increased	78,656(+5.7%)	$2.1M	0.0%	-29.52%	27
Woodline Partners LP	Increased	74,423(+0.6%)	$2M	0.0%	-14.11%	26
RHUMBLINE ADVISERS	Decreased	74,153(-15.4%)	$2M	0.0%	-29.27%	0
ExodusPoint Capital Management, LP	New	71,146	$1.9M	0.0%	+4.21%	36
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	70,256(-26.8%)	$1.9M	0.0%	-24.83%	0
WELLS FARGO & COMPANY/MN	Increased	64,772(+44.7%)	$1.8M	0.0%	-0.78%	35
ALLIANCEBERNSTEIN L.P.	Decreased	61,494(-0.0%)	$1.7M	0.0%	-37.67%	0
TUDOR INVESTMENT CORP ET AL	New	61,345	$1.7M	0.0%	+4.21%	36
Universal- Beteiligungs- und Servicegesellschaft mbH	Decreased	60,560(-15.0%)	$1.6M	0.0%	-11.88%	0
TD ASSET MANAGEMENT INC	Decreased	57,292(-55.3%)	$1.6M	0.0%	-20.01%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	53,239(-13.1%)	$1.4M	0.0%	-33.39%	0
NEW YORK STATE COMMON RETIREMENT FUND	Increased	51,707(+3.9%)	$1.4M	0.0%	-32.27%	26
Engineers Gate Manager LP	New	49,128	$1.3M	0.0%	+4.21%	35
ALPS ADVISORS INC	Increased	47,881(+73.8%)	$1.3M	0.0%	-16.64%	38
State of New Jersey Common Pension Fund D	New	47,414	$1.3M	0.0%	+4.21%	35
SCHRODER INVESTMENT MANAGEMENT GROUP	New	46,242	$1.3M	0.0%	+4.21%	35
XTX Topco Ltd	New	46,039	$1.3M	0.0%	+4.21%	35
VIRGINIA RETIREMENT SYSTEMS ET Al	Increased	41,361(+0.7%)	$1.1M	0.0%	-18.94%	25
Freestone Grove Partners LP	Increased	40,841(+164.8%)	$1.1M	0.0%	-10.55%	41
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	39,455(+7.8%)	$1.1M	0.0%	-31.08%	27
Quadrature Capital Ltd	New	35,857	$976,028	0.0%	+4.21%	35
CAPITAL FUND MANAGEMENT S.A.	New	35,788	$974,149	0.0%	+4.21%	35
EDGEWOOD MANAGEMENT LLC	Unchanged	35,000	$952,700	0.0%	-1.16%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	34,637(-2.6%)	$942,819	0.0%	-32.45%	0
MetLife Investment Management, LLC	Decreased	32,217(-5.3%)	$876,947	0.0%	-34.48%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	27,827(+18.0%)	$757,451	0.0%	-24.55%	29
AQR CAPITAL MANAGEMENT LLC	Decreased	27,926(-69.5%)	$754,002	0.0%	-21.13%	0
VICTORY CAPITAL MANAGEMENT INC	Decreased	27,697(-8.4%)	$753,912	0.0%	-12.28%	0
Quantinno Capital Management LP	New	26,855	$730,993	0.0%	+4.21%	34
FEDERATED HERMES, INC.	Increased	25,055(+472x)	$681,997	0.0%	+4.22%	40
Russell Investments Group, Ltd.	Increased	24,679(+260.0%)	$671,759	0.0%	-2.56%	40
FMR LLC	Increased	24,334(+17.5%)	$662,380	0.0%	-13.01%	19
JANUS HENDERSON GROUP PLC	Unchanged	23,797	$648,230	0.0%	+17.22%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	23,620(+15.3%)	$642,936	0.0%	-26.43%	28
Rockefeller Capital Management L.P.	Increased	211,428(+1218.3%)	$573,553	0.0%	+0.87%	39
Brevan Howard Capital Management LP	Increased	19,336(+60.2%)	$526,326	0.0%	-8.61%	35
CANADA PENSION PLAN INVESTMENT BOARD	New	18,200	$495,404	0.0%	+4.21%	33
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	15,847	$431,355	0.0%	-32.38%	0
Police & Firemen's Retirement System of New Jersey	Increased	15,640(+0.0%)	$425,721	0.0%	-16.56%	24
Arizona State Retirement System	Decreased	15,330(-5.7%)	$417,283	0.0%	-16.50%	0
SEI INVESTMENTS CO	Decreased	14,352(-55.6%)	$390,680	0.0%	-29.60%	0
Tidal Investments LLC	Decreased	14,247(-4.5%)	$387,803	0.0%	-2.60%	0
ROYAL BANK OF CANADA	Decreased	13,055(-25.5%)	$354,000	0.0%	-13.78%	0
ProShare Advisors LLC	Increased	12,897(+10.0%)	$351,057	0.0%	-28.22%	26
ENVESTNET ASSET MANAGEMENT INC	Increased	12,735(+35.1%)	$346,647	0.0%	+1.78%	31
COMMERCE BANK	Increased	12,656(+38.2%)	$344,496	0.0%	-4.44%	31
NOMURA HOLDINGS INC	New	12,355	$336,303	0.0%	+4.21%	33
KLP KAPITALFORVALTNING AS	Unchanged	11,800	$321,196	0.0%	-13.95%	0
Creative Planning	Decreased	10,370(-20.9%)	$282,271	0.0%	-19.78%	0
CAPSTONE INVESTMENT ADVISORS, LLC	New	10,355	$281,863	0.0%	+4.21%	32
VOYA INVESTMENT MANAGEMENT LLC	Unchanged	10,134	$275,847	0.0%	-18.21%	0
STRS OHIO	New	10,000	$272,200	0.0%	+4.21%	32
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	8,167(-39.4%)	$222,306	0.0%	-8.83%	0
Ensign Peak Advisors, Inc	Decreased	6,570(-47.9%)	$178,835	0.0%	-5.31%	0
SIMPLEX TRADING, LLC	New	6,209	$169,008	0.0%	+4.21%	31
PNC FINANCIAL SERVICES GROUP, INC.	Increased	4,710(+3.4%)	$128,206	0.0%	-6.03%	23
Mirae Asset Global Investments Co., Ltd.	Increased	2,834(+26.2%)	$77,141	0.0%	+1.50%	26
Eurizon Capital SGR S.p.A.	New	2,647	$72,256	0.0%	+4.21%	29
OSAIC HOLDINGS, INC.	Increased	1,747(+419.9%)	$47,553	0.0%	+0.10%	33
BNP Paribas Asset Management Holding S.A.	Increased	1.4M(+37.8%)	$37,039	0.0%	-19.37%	26
ASSETMARK, INC	Increased	1,317(+37.9%)	$35,849	0.0%	-3.11%	26
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	637,886(-61.5%)	$17,364	0.0%	-11.67%	0
US BANCORP \DE\	Decreased	509(-10.5%)	$13,855	0.0%	-10.09%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	New	300	$12,954	0.0%	+4.21%	27
NISA INVESTMENT ADVISORS, LLC	Decreased	295(-62.2%)	$8,030	0.0%	-4.24%	0
COMERICA BANK	Decreased	209(-44.1%)	$5,703	0.0%	-8.21%	0
Farther Finance Advisors, LLC	Decreased	151(-6.2%)	$4,110	0.0%	-15.44%	0
HRT FINANCIAL LP	New	146,469	$3,986	0.0%	+4.21%	20
BROWN BROTHERS HARRIMAN & CO	New	144	$3,920	0.0%	+4.21%	22
Allworth Financial LP	Decreased	11(-35.3%)	$300	0.0%	-11.21%	0
Steward Partners Investment Advisory, LLC	Unchanged	9	$245	0.0%	-23.76%	0
JONES FINANCIAL COMPANIES LLLP	Unchanged	1	$27	0.0%	-14.91%	0
NewEdge Advisors, LLC	Exited	0(-100.0%)	$51,098	0.0%	-9.74%	0
Optiver Holding B.V.	Exited	0(-100.0%)	$12,443	0.0%	-12.83%	0
BAKER BROS. ADVISORS LP	Exited	0(-100.0%)	$7.6M	0.0%	-18.34%	0
MATHER GROUP, LLC.	Exited	0(-100.0%)	$3,813	0.0%	-30.40%	0
MAI Capital Management	Exited	0(-100.0%)	$1,004	0.0%	-13.86%	0
Savant Capital, LLC	Exited	0(-100.0%)	$277,087	0.0%	-18.39%	0
Cerity Partners LLC	Exited	0(-100.0%)	$258,461	0.0%	-18.34%	0
Fisher Asset Management, LLC	Exited	0(-100.0%)	$34.9M	0.0%	-13.63%	0
ADAGE CAPITAL PARTNERS GP, L.L.C.	Exited	0(-100.0%)	$32.1M	0.0%	-13.55%	0
MACQUARIE GROUP LTD	Exited	0(-100.0%)	$78.6M	0.0%	-17.43%	0
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$241	0.0%	-30.40%	0
CIBC WORLD MARKETS CORP	Exited	0(-100.0%)	$231,456	0.0%	-9.74%	0
AMERIPRISE FINANCIAL INC	Exited	0(-100.0%)	$1.5M	0.0%	-5.31%	0
FIFTH THIRD BANCORP	Exited	0(-100.0%)	$1,204	0.0%	-30.40%	0
GUGGENHEIM CAPITAL LLC	Exited	0(-100.0%)	$638,306	0.0%	-15.36%	0
OMERS ADMINISTRATION Corp	Exited	0(-100.0%)	$449,568	0.0%	-30.40%	0
Alyeska Investment Group, L.P.	Exited	0(-100.0%)	$5.9M	0.0%	-30.40%	0

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