APELLIS PHARMACEUTICALS INC (APLS) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling APLS?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for APELLIS PHARMACEUTICALS INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on APLS?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for APELLIS PHARMACEUTICALS INC.

Is institutional money flowing into APLS?

147 institutional investors hold APELLIS PHARMACEUTICALS INC (APLS). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about APLS?

Track institutional sentiment and conviction scores for APELLIS PHARMACEUTICALS INC (APLS) including Smart Money Verdict and position changes on HoldingsIntel.

APELLIS PHARMACEUTICALS INC

APLS·03753U106·US·equity·Healthcare - Biotechnology-Activist

APLS (APELLIS PHARMACEUTICALS INC) is held by 147 institutional investors as of Q4 2025. Largest holders: WELLINGTON MANAGEMENT GROUP LLP ($319.6M), Avoro Capital Advisors LLC ($307M), VANGUARD GROUP INC ($268.2M). Net institutional sentiment: Mixed.

147

Holders

Avg rating(11 Elite)

$2.6B

Total Value

50% (164)

Fund Consensus

75 buying - 72 selling

Smart Money Verdict- Q4 2025View all

42Weak MomentumSplit Signals

Held by 147 funds

11 elite

Who's Trading

ActivistWellington Management Group LLP0.2%Apr 7, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
WELLINGTON MANAGEMENT GROUP LLP	Increased	12.7M(+36.9%)	$319.6M	0.1%	-47.40%	40
Avoro Capital Advisors LLC	Unchanged	12.2M	$307M	3.0%	-52.89%	0
VANGUARD GROUP INC	Increased	10.7M(+6.9%)	$268.2M	0.0%	-30.92%	33
MORGAN STANLEY	Decreased	9.2M(-4.9%)	$230.4M	0.0%	-38.54%	0
RTW INVESTMENTS, LP	New	7.7M	$192.6M	1.9%	-20.13%	70
BlackRock, Inc.	Decreased	6.3M(-0.1%)	$157.3M	0.0%	-36.46%	0
STATE STREET CORP	Increased	4.6M(+14.3%)	$115.9M	0.0%	-55.17%	34
UBS Group AG	Increased	4.2M(+22.1%)	$105.2M	0.0%	-24.83%	36
Polar Capital Holdings Plc	Increased	3.7M(+39.9%)	$93.1M	0.4%	-35.54%	47
AQR CAPITAL MANAGEMENT LLC	Decreased	2.3M(-49.3%)	$57.2M	0.0%	-18.36%	0
GEODE CAPITAL MANAGEMENT, LLC	Decreased	2M(-2.3%)	$50.9M	0.0%	-44.45%	0
JENNISON ASSOCIATES LLC	Decreased	1.5M(-65.4%)	$37.8M	0.0%	-32.30%	0
DEUTSCHE BANK AG\	Decreased	1.4M(-7.9%)	$34.8M	0.0%	-63.53%	0
Hudson Bay Capital Management LP	Increased	1.2M(+181.9%)	$29.6M	0.1%	-24.13%	46
BANK OF NOVA SCOTIA	Decreased	1.1M(-26.5%)	$26.9M	0.0%	-1.74%	0
MARSHALL WACE, LLP	Increased	990,848(+149.8%)	$24.9M	0.0%	-9.03%	46
BANK OF AMERICA CORP /DE/	Decreased	956,773(-35.2%)	$24M	0.0%	-28.92%	0
MILLENNIUM MANAGEMENT LLC	Decreased	946,459(-29.6%)	$23.8M	0.0%	-18.03%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	Increased	951,716(+53.3%)	$19.7M	0.1%	-14.40%	40
NORTHERN TRUST CORP	Increased	696,521(+26.8%)	$17.5M	0.0%	-29.71%	35
Nuveen, LLC	Increased	681,819(+2.5%)	$17.1M	0.0%	-15.40%	29
CITADEL ADVISORS LLC	Increased	648,229(+10.5%)	$16.3M	0.0%	-24.26%	31
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	644,445(-0.4%)	$16.2M	0.0%	-50.36%	0
RENAISSANCE TECHNOLOGIES LLC	Decreased	633,058(-12.4%)	$15.9M	0.0%	-10.68%	0
CITIGROUP INC	Increased	622,158(+39.8%)	$15.6M	0.0%	-17.82%	37
M&T BANK CORP	Increased	55,066(+322.8%)	$15.2M	0.0%	-18.14%	45
Point72 Asset Management, L.P.	Increased	597,672(+175.3%)	$15M	0.0%	-17.03%	45
AMERIPRISE FINANCIAL INC	Decreased	589,597(-17.9%)	$14.8M	0.0%	-43.82%	0
TWO SIGMA INVESTMENTS, LP	Increased	562,361(+123.1%)	$14.1M	0.0%	-15.01%	45
BNP PARIBAS FINANCIAL MARKETS	Decreased	557,591(-42.7%)	$14M	0.0%	-30.35%	0
Woodline Partners LP	Unchanged	542,981	$13.6M	0.1%	-38.13%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	533,909(+70.1%)	$13.4M	0.0%	-10.44%	42
FIRST TRUST ADVISORS LP	New	495,947	$12.5M	0.0%	-20.13%	39
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Decreased	461,186(-53.5%)	$11.6M	0.0%	-19.96%	0
D. E. Shaw & Co., Inc.	Decreased	449,676(-1.6%)	$11.3M	0.0%	+1.92%	0
Pictet Asset Management Holding SA	Increased	390,884(+7.5%)	$9.8M	0.0%	-48.29%	30
SCHRODER INVESTMENT MANAGEMENT GROUP	Increased	329,134(+90.2%)	$8.3M	0.0%	-24.74%	43
Bank of New York Mellon Corp	Increased	271,925(+9.6%)	$6.8M	0.0%	-61.32%	30
NATIXIS	Increased	257,268(+392.5%)	$6.5M	0.0%	-24.19%	44
Caption Management, LLC	Decreased	254,563(-16.5%)	$6.4M	0.0%	+6.29%	0
JANUS HENDERSON GROUP PLC	Increased	230,320(+569.3%)	$5.8M	0.0%	-31.68%	44
Invesco Ltd.	Increased	225,976(+23.5%)	$5.7M	0.0%	-56.41%	33
CANADA PENSION PLAN INVESTMENT BOARD	Increased	222,200(+2.4%)	$5.6M	0.0%	-17.86%	28
TUDOR INVESTMENT CORP ET AL	New	215,000	$5.4M	0.0%	-20.13%	37
Trexquant Investment LP	Decreased	194,592(-66.8%)	$4.9M	0.0%	-21.86%	0
Squarepoint Ops LLC	Increased	192,156(+263.7%)	$4.8M	0.0%	-22.36%	43
SILVERCREST ASSET MANAGEMENT GROUP LLC	Increased	190,759(+0.1%)	$4.8M	0.0%	-11.01%	27
GOLDMAN SACHS GROUP INC	Increased	189,205(+52.1%)	$4.8M	0.0%	-29.42%	38
BARCLAYS PLC	Decreased	187,712(-30.4%)	$4.7M	0.0%	-35.07%	0
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	Increased	186,328(+27.5%)	$4.7M	0.0%	-60.65%	33
DIMENSIONAL FUND ADVISORS LP	Increased	180,925(+868.0%)	$4.5M	0.0%	-19.27%	43
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	178,888(+6.8%)	$4.5M	0.0%	-43.91%	29
BANK OF MONTREAL /CAN/	Increased	176,571(+10.2%)	$4.4M	0.0%	-27.51%	30
Rafferty Asset Management, LLC	Increased	171,456(+1.8%)	$4.3M	0.0%	-44.95%	27
ExodusPoint Capital Management, LP	Decreased	171,156(-12.1%)	$4.3M	0.0%	-10.99%	0
Gotham Asset Management, LLC	Increased	168,455(+32.5%)	$4.2M	0.0%	-8.71%	34
JPMORGAN CHASE & CO	Increased	157,754(+194.8%)	$4M	0.0%	-26.49%	43
Swiss National Bank	Increased	149,500(+2.3%)	$3.8M	0.0%	-37.54%	27
Man Group plc	Increased	144,271(+114.7%)	$3.6M	0.0%	-16.12%	43
Bridgewater Associates, LP	New	143,805	$3.6M	0.0%	-20.13%	37
ING GROEP NV	Decreased	139,000(-88.2%)	$3.5M	0.0%	-9.81%	0
RHUMBLINE ADVISERS	Decreased	116,917(-0.4%)	$2.9M	0.0%	-45.06%	0
TWO SIGMA ADVISERS, LP	New	110,900	$2.8M	0.0%	-20.13%	36
NEW YORK STATE COMMON RETIREMENT FUND	Increased	104,018(+113.0%)	$2.6M	0.0%	-43.21%	42
WELLS FARGO & COMPANY/MN	Increased	103,815(+4115.0%)	$2.6M	0.0%	-19.54%	42
ALPS ADVISORS INC	Increased	103,696(+65.1%)	$2.6M	0.0%	-1.70%	38
MACKENZIE FINANCIAL CORP	Increased	96,211(+25.4%)	$2.4M	0.0%	-22.68%	32
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Increased	96,125(+0.6%)	$2.4M	0.0%	-54.24%	26
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	95,755(+107.7%)	$2.4M	0.0%	-15.18%	42
ROYAL BANK OF CANADA	Decreased	88,687(-39.3%)	$2.2M	0.0%	-36.71%	0
Legal & General Group Plc	Decreased	85,489(-7.5%)	$2.1M	0.0%	-42.41%	0
Steward Partners Investment Advisory, LLC	Decreased	81,698(-28.4%)	$2.1M	0.0%	-45.39%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	73,203(-0.1%)	$1.8M	0.0%	-19.14%	0
RAYMOND JAMES FINANCIAL INC	Decreased	66,997(-13.8%)	$1.7M	0.0%	-25.44%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	66,916(-22.0%)	$1.7M	0.0%	-33.71%	0
BALYASNY ASSET MANAGEMENT L.P.	New	65,133	$1.6M	0.0%	-20.13%	35
SEI INVESTMENTS CO	Decreased	60,291(-61.1%)	$1.5M	0.0%	-7.94%	0
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	53,526(-1.0%)	$1.3M	0.0%	-70.68%	0
JANE STREET GROUP, LLC	Decreased	50,114(-82.9%)	$1.3M	0.0%	-28.88%	0
Police & Firemen's Retirement System of New Jersey	Decreased	46,009(-4.9%)	$1.2M	0.0%	-31.91%	0
VOYA INVESTMENT MANAGEMENT LLC	Decreased	43,661(-74.8%)	$1.1M	0.0%	-52.18%	0
PANAGORA ASSET MANAGEMENT INC	New	42,134	$1.1M	0.0%	-20.13%	35
STIFEL FINANCIAL CORP	New	36,661	$920,925	0.0%	-20.13%	35
GUGGENHEIM CAPITAL LLC	Increased	36,647(+8.3%)	$920,572	0.0%	-43.26%	27
ALLIANCEBERNSTEIN L.P.	Decreased	34,530(-57.2%)	$867,394	0.0%	-23.66%	0
Vontobel Holding Ltd.	New	34,039	$855,060	0.0%	-20.13%	34
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	Decreased	32,448(-3.7%)	$815,094	0.0%	-76.31%	0
FMR LLC	Increased	32,163(+73.8%)	$807,941	0.0%	-30.65%	25
Quantinno Capital Management LP	Decreased	31,763(-34.4%)	$797,887	0.0%	-10.99%	0
Amundi	Decreased	30,721(-97.9%)	$771,712	0.0%	-1.17%	0
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Decreased	30,175(-61.1%)	$722,390	0.0%	-17.40%	0
SIMPLEX TRADING, LLC	Decreased	27,187(-49.6%)	$682,937	0.0%	+15.66%	0
State of New Jersey Common Pension Fund D	New	25,863	$649,679	0.0%	-20.13%	34
IEQ CAPITAL, LLC	Decreased	25,500(-91.4%)	$640,558	0.0%	-22.20%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	25,364(+19.0%)	$637,144	0.0%	-51.64%	29
Erste Asset Management GmbH	Unchanged	25,300	$636,801	0.0%	-66.83%	0
VIRGINIA RETIREMENT SYSTEMS ET Al	Decreased	24,365(-4.3%)	$612,049	0.0%	-39.88%	0
Quadrature Capital Ltd	New	24,075	$604,764	0.0%	-20.13%	34
Cerity Partners LLC	Decreased	23,971(-81.3%)	$602,152	0.0%	-16.96%	0
Marex Group plc	New	23,000	$577,760	0.0%	-20.13%	34
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	22,852(+0.6%)	$574,042	0.0%	-64.93%	24
IMC-Chicago, LLC	New	21,324	$535,659	0.0%	-20.13%	34
Arizona State Retirement System	Decreased	21,010(-5.8%)	$527,771	0.0%	-42.70%	0
Qube Research & Technologies Ltd	Decreased	18,843(-84.3%)	$473,336	0.0%	-10.99%	0
XPONANCE LLC	Increased	18,164(+3.9%)	$456,280	0.0%	-64.02%	25
MERCER GLOBAL ADVISORS INC /ADV	Decreased	17,668(-54.8%)	$443,818	0.0%	-22.15%	0
Allianz Asset Management GmbH	Unchanged	17,000	$427,040	0.0%	-10.99%	0
Jain Global LLC	New	16,877	$423,950	0.0%	-20.13%	33
Creative Planning	Decreased	16,439(-53.9%)	$412,948	0.0%	+3.64%	0
KLP KAPITALFORVALTNING AS	Increased	16,200(+3.9%)	$406,944	0.0%	-31.27%	25
Brevan Howard Capital Management LP	Decreased	16,117(-82.3%)	$404,859	0.0%	-10.99%	0
Vident Advisory, LLC	Decreased	15,553(-56.0%)	$390,691	0.0%	-10.99%	0
VICTORY CAPITAL MANAGEMENT INC	Decreased	15,197(-0.5%)	$381,749	0.0%	-40.37%	0
NewEdge Advisors, LLC	New	14,570	$365,998	0.0%	-20.13%	33
NOMURA HOLDINGS INC	Decreased	14,200(-61.2%)	$356,704	0.0%	-10.99%	0
Empowered Funds, LLC	Increased	13,381(+0.3%)	$336,131	0.0%	+15.51%	24
Walleye Trading LLC	Increased	12,699(+21.6%)	$318,999	0.0%	-11.57%	28
Freestone Grove Partners LP	New	12,537	$314,929	0.0%	-20.13%	33
FRANKLIN RESOURCES INC	New	11,304	$283,956	0.0%	-20.13%	32
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	11,225(-39.4%)	$281,972	0.0%	-58.40%	0
Swiss Life Asset Management Ltd	New	10,832	$272,100	0.0%	-20.13%	32
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	10,044(+16.7%)	$253,511	0.0%	-20.61%	27
Russell Investments Group, Ltd.	Increased	9,998(+1.0%)	$251,166	0.0%	-26.24%	23
Dynasty Wealth Management, LLC	New	9,227	$231,783	0.0%	-20.13%	32
Jefferies Financial Group Inc.	Decreased	8,718(-96.5%)	$218,997	0.0%	-29.55%	0
MetLife Investment Management, LLC	Increased	6,962(+0.9%)	$174,885	0.0%	-43.23%	23
Mirae Asset Global Investments Co., Ltd.	Increased	6,148(+25.9%)	$154,438	0.0%	-53.65%	28
Ensign Peak Advisors, Inc	Decreased	4,747(-71.3%)	$119,245	0.0%	-56.09%	0
Walleye Capital LLC	Decreased	3,955(-97.2%)	$99,350	0.0%	-30.86%	0
US BANCORP \DE\	Increased	3,042(+14.1%)	$76,415	0.0%	-41.13%	24
OSAIC HOLDINGS, INC.	Decreased	2,730(-13.4%)	$68,576	0.0%	-36.28%	0
STRS OHIO	Increased	2,582(+0.2%)	$64,860	0.0%	+15.57%	21
JONES FINANCIAL COMPANIES LLLP	Unchanged	2,037	$51,169	0.0%	-12.68%	0
Allworth Financial LP	Decreased	1,010(-54.0%)	$25,372	0.0%	-5.32%	0
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	600(-0.2%)	$15,072	0.0%	-66.09%	0
Rockefeller Capital Management L.P.	Decreased	503(-51.2%)	$12,635	0.0%	-10.99%	0
Farther Finance Advisors, LLC	Increased	367(+10.5%)	$9,219	0.0%	-15.63%	19
CIBC Private Wealth Group LLC	Decreased	343(-9.0%)	$8,616	0.0%	-70.07%	0
COMERICA BANK	Decreased	315(-13.9%)	$7,913	0.0%	-55.21%	0
HRT FINANCIAL LP	Decreased	192,488(-45.6%)	$4,835	0.0%	-4.31%	0
Mitsubishi UFJ Asset Management Co., Ltd.	Unchanged	97	$2,508	0.0%	-47.00%	0
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	95,035(-3.0%)	$2,388	0.0%	-67.93%	0
BROWN BROTHERS HARRIMAN & CO	Unchanged	95	$2,386	0.0%	+15.66%	0
NISA INVESTMENT ADVISORS, LLC	Unchanged	50	$1,256	0.0%	-50.78%	0
ASSETMARK, INC	New	10	$251	0.0%	-20.13%	17
BNP Paribas Asset Management Holding S.A.	Increased	840(+41.4%)	$21	0.0%	+2.25%	10
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$91	0.0%	+11.43%	0
WORLDQUANT MILLENNIUM ADVISORS LLC	Exited	0(-100.0%)	$2.5M	0.0%	+11.43%	0
HSBC HOLDINGS PLC	Exited	0(-100.0%)	$344,674	0.0%	-3.53%	0
Schonfeld Strategic Advisors LLC	Exited	0(-100.0%)	$1.1M	0.0%	+4.00%	0
Compagnie Lombard Odier SCmA	Exited	0(-100.0%)	$248,930	0.0%	-36.49%	0
Mariner, LLC	Exited	0(-100.0%)	$978,499	0.0%	+24.21%	0
GROUP ONE TRADING LLC	Exited	0(-100.0%)	$337,753	0.0%	+4.00%	0
Merit Financial Group, LLC	Exited	0(-100.0%)	$442,281	0.0%	-3.18%	0
Focus Partners Wealth	Exited	0(-100.0%)	$492,247	0.0%	+0.76%	0
MACQUARIE GROUP LTD	Exited	0(-100.0%)	$1.5M	0.0%	+11.43%	0
XTX Topco Ltd	Exited	0(-100.0%)	$326,030	0.0%	+11.43%	0
Integrated Wealth Concepts LLC	Exited	0(-100.0%)	$230,600	0.0%	+44.81%	0
CAPTRUST FINANCIAL ADVISORS	Exited	0(-100.0%)	$477,742	0.0%	-8.13%	0
Engineers Gate Manager LP	Exited	0(-100.0%)	$1.5M	0.0%	+12.79%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$483,626	0.0%	+27.52%	0
Savant Capital, LLC	Exited	0(-100.0%)	$1.1M	0.0%	+7.03%	0
KEYBANK NATIONAL ASSOCIATION/OH	Exited	0(-100.0%)	$205,571	0.0%	+11.43%	0

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