Axsome Therapeutics, Inc. (AXSM) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling AXSM?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Axsome Therapeutics, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on AXSM?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Axsome Therapeutics, Inc..

Is institutional money flowing into AXSM?

180 institutional investors hold Axsome Therapeutics, Inc. (AXSM). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about AXSM?

Track institutional sentiment and conviction scores for Axsome Therapeutics, Inc. (AXSM) including Smart Money Verdict and position changes on HoldingsIntel.

Axsome Therapeutics, Inc.

AXSM·05464T104·US·equity·Healthcare - Biotechnology-13D/G

AXSM (Axsome Therapeutics, Inc.) is held by 180 institutional investors as of Q4 2025. Largest holders: VANGUARD GROUP INC ($760.7M), BlackRock, Inc. ($714.8M), Invesco Ltd. ($232.6M). Net institutional sentiment: Mixed.

180

Holders

Avg rating(12 Elite)

$5.4B

Total Value

58% (188)

Fund Consensus

102 buying - 74 selling

Smart Money VerdictView all

42Weak MomentumSplit Signals

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See how AXSM's score breaks down across 4 SEC sources

Held by 180 funds

12 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 26, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VANGUARD GROUP INC	Decreased	4.2M(-0.4%)	$760.7M	0.0%	+79.41%	0
BlackRock, Inc.	Increased	3.9M(+3.2%)	$714.8M	0.0%	+85.91%	33
Invesco Ltd.	Increased	1.3M(+28.6%)	$232.6M	0.0%	+47.58%	38
WELLINGTON MANAGEMENT GROUP LLP	Decreased	1.2M(-8.5%)	$223.1M	0.0%	+68.68%	0
FMR LLC	Increased	1.2M(+27.4%)	$215.8M	0.0%	+58.09%	38
GEODE CAPITAL MANAGEMENT, LLC	Increased	1M(+1.3%)	$184.5M	0.0%	+193.04%	31
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	New	989,447	$180.7M	0.3%	+10.26%	50
STATE STREET CORP	Increased	958,150(+1.6%)	$175M	0.0%	+99.75%	31
RTW INVESTMENTS, LP	Decreased	888,001(-20.6%)	$162.2M	1.6%	+164.54%	0
BANK OF AMERICA CORP /DE/	Increased	618,033(+71.1%)	$112.9M	0.0%	+33.20%	45
D. E. Shaw & Co., Inc.	Increased	549,113(+85.3%)	$100.3M	0.1%	+24.44%	47
MORGAN STANLEY	Increased	491,201(+19.9%)	$89.7M	0.0%	+74.44%	35
Assenagon Asset Management S.A.	Increased	467,982(+58.8%)	$85.5M	0.1%	+26.76%	51
Pictet Asset Management Holding SA	Increased	436,063(+20.4%)	$79.6M	0.1%	+35.78%	35
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	402,700(+5.4%)	$73.5M	0.0%	+164.98%	31
NORTHERN TRUST CORP	Decreased	390,431(-4.7%)	$71.3M	0.0%	+250.49%	0
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	367,578(-17.4%)	$67.1M	0.1%	+63.28%	0
Hood River Capital Management LLC	Increased	366,176(+1.7%)	$66.9M	0.7%	+57.54%	42
PRINCIPAL FINANCIAL GROUP INC	Decreased	363,114(-1.4%)	$66.3M	0.0%	+69.29%	0
UBS Group AG	Increased	355,318(+67.3%)	$64.9M	0.0%	+36.24%	44
Nuveen, LLC	Increased	349,209(+17.1%)	$63.8M	0.0%	+33.48%	34
FRANKLIN RESOURCES INC	Increased	342,573(+19.9%)	$62.6M	0.0%	+60.25%	35
Qube Research & Technologies Ltd	Decreased	325,440(-0.1%)	$59.4M	0.1%	+62.04%	0
MARSHALL WACE, LLP	Decreased	320,568(-15.2%)	$58.5M	0.1%	+45.57%	0
LOOMIS SAYLES & CO L P	Decreased	315,391(-4.5%)	$57.6M	0.1%	+89.33%	0
BNP PARIBAS FINANCIAL MARKETS	Increased	304,388(+60.1%)	$55.6M	0.0%	+50.13%	42
GOLDMAN SACHS GROUP INC	Increased	300,906(+34.3%)	$55M	0.0%	+51.73%	38
Bank of New York Mellon Corp	Increased	255,097(+0.7%)	$46.6M	0.0%	+80.89%	29
JPMORGAN CHASE & CO	Decreased	233,191(-6.9%)	$42.6M	0.0%	+67.95%	0
Man Group plc	Decreased	228,641(-20.6%)	$41.8M	0.1%	+52.34%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	220,518(-1.3%)	$40.3M	0.3%	+39.13%	0
CITIGROUP INC	Increased	204,104(+43.7%)	$37.3M	0.0%	+39.50%	39
TWO SIGMA ADVISERS, LP	New	188,500	$34.4M	0.1%	+10.26%	40
Connor, Clark & Lunn Investment Management Ltd.	Decreased	188,258(-9.9%)	$34.4M	0.1%	+57.44%	0
VOYA INVESTMENT MANAGEMENT LLC	Increased	173,301(+52.0%)	$31.7M	0.0%	+51.95%	40
RENAISSANCE TECHNOLOGIES LLC	Increased	170,000(+13.3%)	$31M	0.0%	+34.86%	33
MetLife Investment Management, LLC	Decreased	164,871(-16.4%)	$30.1M	0.1%	+49.51%	0
FRONTIER CAPITAL MANAGEMENT CO LLC	Increased	157,691(+24.8%)	$28.8M	0.3%	+40.84%	42
Squarepoint Ops LLC	Unchanged	155,000	$28.3M	0.0%	+67.36%	0
Woodline Partners LP	Decreased	150,864(-54.5%)	$27.6M	0.1%	+115.36%	0
TWO SIGMA INVESTMENTS, LP	Increased	145,597(+1674.1%)	$26.6M	0.0%	+11.57%	46
CITADEL ADVISORS LLC	Decreased	138,213(-12.8%)	$25.2M	0.0%	+43.95%	0
JANE STREET GROUP, LLC	Increased	137,283(+4.9%)	$25.1M	0.0%	+37.76%	30
RAYMOND JAMES FINANCIAL INC	Decreased	150,098(-5.4%)	$24.8M	0.0%	+91.85%	0
US BANCORP \DE\	Decreased	130,985(-0.4%)	$23.9M	0.0%	+310.32%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	133,884(+0.9%)	$23.7M	0.0%	+69.99%	29
AQR CAPITAL MANAGEMENT LLC	Decreased	103,418(-12.8%)	$18.9M	0.0%	+65.17%	0
CANADA PENSION PLAN INVESTMENT BOARD	Increased	103,200(+60.3%)	$18.8M	0.0%	+31.16%	41
DnB Asset Management AS	Decreased	101,102(-0.9%)	$18.5M	0.1%	+71.86%	0
AMERIPRISE FINANCIAL INC	Decreased	99,916(-7.7%)	$18.2M	0.0%	+54.79%	0
DEUTSCHE BANK AG\	Increased	98,257(+1.6%)	$17.9M	0.0%	+116.29%	29
Aberdeen Group plc	Increased	97,413(+2.9%)	$17.8M	0.0%	+74.74%	29
ROYCE & ASSOCIATES LP	Increased	94,017(+67.8%)	$17.2M	0.2%	+35.49%	50
WCM INVESTMENT MANAGEMENT, LLC	Decreased	112,058(-6.4%)	$16.7M	0.0%	+165.19%	0
M&G Plc	New	90,328	$16.5M	0.1%	+10.26%	39
WELLS FARGO & COMPANY/MN	Increased	89,661(+62.2%)	$16.4M	0.0%	+48.63%	41
FEDERATED HERMES, INC.	Increased	87,280(+52.4%)	$15.9M	0.0%	+32.70%	39
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	87,249(+0.6%)	$15.9M	0.0%	+75.56%	28
BARCLAYS PLC	Increased	76,853(+6.6%)	$14M	0.0%	+68.16%	30
Neuberger Berman Group LLC	Decreased	69,483(-23.8%)	$12.7M	0.0%	+53.93%	0
Swiss National Bank	Increased	68,900(+3.1%)	$12.6M	0.0%	+200.05%	29
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	68,858(+1.4%)	$12.6M	0.0%	+38.64%	28
AXIOM INVESTORS LLC /DE	Increased	63,390(+28.7%)	$11.6M	0.1%	+31.48%	42
Walleye Capital LLC	Increased	60,100(+119x)	$11M	0.0%	+10.64%	45
HighTower Advisors, LLC	Decreased	55,972(-2.0%)	$10.2M	0.0%	+47.31%	0
ALLIANCEBERNSTEIN L.P.	Decreased	53,140(-15.7%)	$9.7M	0.0%	+75.82%	0
RHUMBLINE ADVISERS	Decreased	52,233(-14.1%)	$9.5M	0.0%	+170.74%	0
Trexquant Investment LP	Increased	49,136(+416.1%)	$9M	0.1%	+14.92%	44
SEI INVESTMENTS CO	Decreased	47,600(-1.1%)	$8.7M	0.0%	+104.76%	0
Bridgewater Associates, LP	New	47,444	$8.7M	0.0%	+10.26%	38
BLAIR WILLIAM & CO/IL	Decreased	46,840(-6.5%)	$8.6M	0.0%	+111.97%	0
Clearbridge Investments, LLC	Decreased	46,326(-19.7%)	$8.5M	0.0%	+101.49%	0
M&T BANK CORP	Increased	49,466(+2553.8%)	$8.3M	0.0%	+11.13%	44
FIRST TRUST ADVISORS LP	Increased	43,413(+16.9%)	$7.9M	0.0%	+60.67%	32
NEW YORK STATE COMMON RETIREMENT FUND	Increased	42,509(+27.8%)	$7.8M	0.0%	+57.96%	34
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	Decreased	42,040(-0.6%)	$7.7M	0.1%	+148.22%	0
TD ASSET MANAGEMENT INC	Decreased	41,972(-5.0%)	$7.7M	0.0%	+44.11%	0
Legal & General Group Plc	Decreased	36,702(-2.9%)	$6.7M	0.0%	+173.25%	0
Russell Investments Group, Ltd.	Increased	35,575(+39.0%)	$6.5M	0.0%	+39.23%	36
HB Wealth Management, LLC	Decreased	34,102(-15.2%)	$6.2M	0.0%	+38.81%	0
MILLENNIUM MANAGEMENT LLC	Increased	33,937(+491.1%)	$6.2M	0.0%	+14.30%	44
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	33,667(-1.9%)	$6.1M	0.0%	+256.59%	0
XTX Topco Ltd	Increased	31,854(+1632.1%)	$5.8M	0.2%	+11.61%	52
ENVESTNET ASSET MANAGEMENT INC	Decreased	30,491(-2.7%)	$5.6M	0.0%	+105.40%	0
LPL Financial LLC	Increased	30,408(+14.9%)	$5.6M	0.0%	+90.75%	31
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	29,841(-40.6%)	$5.5M	0.0%	+56.56%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	26,603(-12.3%)	$4.9M	0.0%	+141.27%	0
Engineers Gate Manager LP	Increased	26,055(+114.0%)	$4.8M	0.1%	+25.43%	43
SIMPLEX TRADING, LLC	Increased	25,222(+100.6%)	$4.6M	0.0%	+30.06%	43
Creative Planning	Increased	24,647(+15.8%)	$4.5M	0.0%	+68.49%	31
Blackstone Inc.	Decreased	24,500(-82.5%)	$4.5M	0.0%	+58.72%	0
Pinnacle Financial Partners, Inc.	New	22,739	$4.2M	0.0%	+10.26%	37
GROUP ONE TRADING LLC	Decreased	22,211(-29.9%)	$4.1M	0.0%	+74.94%	0
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Increased	21,758(+1.2%)	$3.7M	0.0%	+95.20%	27
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	19,032(+1.2%)	$3.5M	0.0%	+94.59%	27
Ensign Peak Advisors, Inc	Decreased	18,845(-22.6%)	$3.4M	0.0%	+107.22%	0
Point72 Asset Management, L.P.	Decreased	17,999(-3.8%)	$3.3M	0.0%	+79.78%	0
OSAIC HOLDINGS, INC.	Increased	17,642(+175.5%)	$3.2M	0.0%	+24.41%	43
CIBC Private Wealth Group LLC	Increased	15,684(+9.1%)	$2.9M	0.0%	+110.23%	29
Virtu Financial LLC	New	15,573	$2.8M	0.1%	+10.26%	44
Mariner, LLC	Decreased	15,288(-8.0%)	$2.8M	0.0%	+82.90%	0
JANUS HENDERSON GROUP PLC	Unchanged	15,104	$2.8M	0.0%	+176.06%	0
INTECH INVESTMENT MANAGEMENT LLC	Decreased	14,428(-10.1%)	$2.6M	0.0%	+71.73%	0
1832 Asset Management L.P.	New	13,700	$2.5M	0.0%	+10.26%	36
LAZARD ASSET MANAGEMENT LLC	Decreased	13,410(-38.6%)	$2.4M	0.0%	+91.68%	0
GUGGENHEIM CAPITAL LLC	Increased	13,030(+4.1%)	$2.4M	0.0%	+79.72%	27
COMERICA BANK	Decreased	12,683(-0.6%)	$2.3M	0.0%	+51.55%	0
DIMENSIONAL FUND ADVISORS LP	Decreased	12,431(-35.2%)	$2.3M	0.0%	+39.06%	0
ROYAL BANK OF CANADA	Increased	12,074(+9.2%)	$2.2M	0.0%	+62.81%	28
State of New Jersey Common Pension Fund D	Decreased	11,923(-34.3%)	$2.2M	0.0%	+131.61%	0
CAPTRUST FINANCIAL ADVISORS	Increased	11,244(+41.3%)	$2.1M	0.0%	+43.33%	35
Police & Firemen's Retirement System of New Jersey	Decreased	10,982(-2.0%)	$2M	0.0%	+75.76%	0
STRS OHIO	Decreased	10,800(-9.2%)	$2M	0.0%	+62.57%	0
Arizona State Retirement System	Decreased	9,787(-4.0%)	$1.8M	0.0%	+144.90%	0
ProShare Advisors LLC	Increased	9,730(+11.9%)	$1.8M	0.0%	+80.72%	29
Cetera Investment Advisers	Increased	9,706(+0.4%)	$1.8M	0.0%	+81.12%	26
IEQ CAPITAL, LLC	Decreased	9,395(-13.2%)	$1.7M	0.0%	+43.87%	0
B. Metzler seel. Sohn & Co. AG	Unchanged	9,241	$1.7M	0.0%	+168.92%	0
Erste Asset Management GmbH	Unchanged	11,000	$1.7M	0.0%	+112.69%	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	9,064	$1.7M	0.0%	+90.95%	0
KLP KAPITALFORVALTNING AS	Unchanged	9,000	$1.6M	0.0%	+82.77%	0
OneDigital Investment Advisors LLC	Decreased	8,635(-11.9%)	$1.6M	0.0%	+131.96%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	7,464(+6.8%)	$1.4M	0.0%	+115.69%	27
Rockefeller Capital Management L.P.	Increased	418,141(+7188.5%)	$1.4M	0.0%	+10.57%	41
GLENMEDE TRUST CO NA	Decreased	6,924(-9.0%)	$1.3M	0.0%	+122.82%	0
GREAT LAKES ADVISORS, LLC	Increased	6,765(+1.3%)	$1.2M	0.0%	+92.01%	26
Quantinno Capital Management LP	Increased	6,478(+127.9%)	$1.2M	0.0%	+25.87%	41
D.A. DAVIDSON & CO.	Unchanged	6,180	$1.1M	0.0%	+171.31%	0
STIFEL FINANCIAL CORP	Increased	5,868(+6.6%)	$1.1M	0.0%	+50.46%	27
PRUDENTIAL FINANCIAL INC	Increased	5,415(+7.1%)	$988,996	0.0%	+39.95%	27
Cerity Partners LLC	Decreased	5,389(-0.3%)	$984,246	0.0%	+77.36%	0
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	5,164(-38.9%)	$943,152	0.0%	+121.50%	0
VICTORY CAPITAL MANAGEMENT INC	Increased	4,776(+0.8%)	$872,289	0.0%	+128.72%	25
Tidal Investments LLC	Increased	4,519(+12.4%)	$825,351	0.0%	+51.38%	28
LOS ANGELES CAPITAL MANAGEMENT LLC	Unchanged	5,555	$739,647	0.0%	+47.78%	0
FARALLON CAPITAL MANAGEMENT LLC	Unchanged	4,000	$730,560	0.0%	+124.36%	0
Verition Fund Management LLC	Increased	3,409(+71.4%)	$622,620	0.0%	+25.61%	36
Pathstone Holdings, LLC	Decreased	3,277(-13.7%)	$598,511	0.0%	+92.53%	0
XPONANCE LLC	Increased	3,265(+2.4%)	$596,320	0.0%	+74.41%	25
MERCER GLOBAL ADVISORS INC /ADV	Increased	3,222(+64.2%)	$588,465	0.0%	+26.38%	35
TRUIST FINANCIAL CORP	Increased	3,055(+56.3%)	$557,965	0.0%	+27.33%	34
MACKENZIE FINANCIAL CORP	Unchanged	3,382	$502,218	0.0%	+38.75%	0
CIBC WORLD MARKETS CORP	Decreased	2,715(-45.6%)	$495,868	0.0%	+57.29%	0
FIFTH THIRD BANCORP	Increased	2,477(+1068.4%)	$452,399	0.0%	+16.41%	39
Mirae Asset Global Investments Co., Ltd.	Increased	2,450(+27.0%)	$447,468	0.0%	+95.49%	30
MML INVESTORS SERVICES, LLC	New	2,388	$436,144	0.0%	+10.26%	33
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	Increased	2,370(+1.7%)	$432,857	0.0%	+38.85%	24
Vanguard Personalized Indexing Management, LLC	Increased	2,190(+4.2%)	$399,982	0.0%	+54.65%	25
PNC FINANCIAL SERVICES GROUP, INC.	Increased	1,921(+3.5%)	$350,852	0.0%	+85.52%	24
Sumitomo Mitsui Trust Group, Inc.	New	1,900	$347,016	0.0%	+10.26%	33
DAVENPORT & Co LLC	Decreased	1,800(-3.6%)	$328,752	0.0%	+39.47%	0
CIBC Asset Management Inc	New	1,699	$310,305	0.0%	+10.26%	32
Orion Porfolio Solutions, LLC	Decreased	1,683(-23.1%)	$307,383	0.0%	+38.43%	0
Vident Advisory, LLC	Decreased	1,677(-14.3%)	$306,287	0.0%	+39.47%	0
&PARTNERS	New	1,602	$292,589	0.0%	+10.26%	32
Swiss Life Asset Management Ltd	New	1,576	$287,841	0.0%	+10.26%	32
Rafferty Asset Management, LLC	Decreased	1,567(-10.1%)	$286,197	0.0%	+114.52%	0
COMMONWEALTH EQUITY SERVICES, LLC	New	1,522	$277,980	0.0%	+10.26%	32
PRICE T ROWE ASSOCIATES INC /MD/	Increased	1.5M(+45.5%)	$275,763	0.0%	+35.46%	32
Allworth Financial LP	Increased	1,459(+1.2%)	$266,472	0.0%	+64.02%	23
Empowered Funds, LLC	New	1,302	$237,797	0.0%	+10.26%	32
Allianz Asset Management GmbH	New	1,300	$237,432	0.0%	+10.26%	32
Brevan Howard Capital Management LP	Decreased	1,238(-83.1%)	$226,108	0.0%	+58.72%	0
Walleye Trading LLC	Increased	1,219(+259.6%)	$222,638	0.0%	+16.87%	37
ASSETMARK, INC	Decreased	1,103(-12.0%)	$201,452	0.0%	+63.53%	0
NISA INVESTMENT ADVISORS, LLC	Decreased	1,036(-4.3%)	$189,215	0.0%	+211.77%	0
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	370(-21.6%)	$67,577	0.0%	+87.74%	0
JONES FINANCIAL COMPANIES LLLP	Increased	295(+17.1%)	$53,879	0.0%	+74.11%	16
MAI Capital Management	Increased	292(+0.3%)	$53,331	0.0%	+93.00%	21
Farther Finance Advisors, LLC	Increased	274(+602.6%)	$50,043	0.0%	+16.84%	33
HUNTINGTON NATIONAL BANK	Increased	265(+16.2%)	$48,400	0.0%	+104.28%	24
Optiver Holding B.V.	Decreased	112(-61.1%)	$20,456	0.0%	+45.23%	0
DANSKE BANK A/S	Unchanged	100	$18,264	0.0%	+58.72%	0
BROWN BROTHERS HARRIMAN & CO	New	54	$9,863	0.0%	+10.26%	24
NewEdge Advisors, LLC	New	50	$9,132	0.0%	+10.26%	26
Steward Partners Investment Advisory, LLC	Increased	35(+250.0%)	$6,392	0.0%	+22.71%	17
HRT FINANCIAL LP	Increased	18,862(+726.9%)	$3,444	0.0%	+13.12%	22
BNP Paribas Asset Management Holding S.A.	Increased	468(+43.6%)	$85	0.0%	+40.04%	15
Freestone Grove Partners LP	Exited	0(-100.0%)	$302,896	0.0%	+26.50%	0
NATIXIS	Exited	0(-100.0%)	$58,903	0.0%	+43.95%	0
ALPS ADVISORS INC	Exited	0(-100.0%)	$3M	0.0%	+75.50%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	+38.40%	0
MACQUARIE GROUP LTD	Exited	0(-100.0%)	$131.7M	0.0%	+78.02%	0
CAPITAL FUND MANAGEMENT S.A.	Exited	0(-100.0%)	$3.5M	0.0%	+39.56%	0
HSBC HOLDINGS PLC	Exited	0(-100.0%)	$12.3M	0.0%	+61.79%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$795,740	0.0%	+26.50%	0
Jain Global LLC	Exited	0(-100.0%)	$1.1M	0.0%	+26.50%	0

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