BioCryst Pharmaceuticals, Inc. (BCRX) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling BCRX?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for BioCryst Pharmaceuticals, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on BCRX?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for BioCryst Pharmaceuticals, Inc..

Is institutional money flowing into BCRX?

141 institutional investors hold BioCryst Pharmaceuticals, Inc. (BCRX). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about BCRX?

Track institutional sentiment and conviction scores for BioCryst Pharmaceuticals, Inc. (BCRX) including Smart Money Verdict and position changes on HoldingsIntel.

BioCryst Pharmaceuticals, Inc.

BCRX·09058V103·US·equity·Healthcare - Drug Manufacturers - Specialty & Generic-13D/G

BCRX (BioCryst Pharmaceuticals, Inc.) is held by 141 institutional investors as of Q4 2025. Largest holders: VANGUARD GROUP INC ($173.7M), BlackRock, Inc. ($164.9M), RA CAPITAL MANAGEMENT, L.P. ($123.5M). Net institutional sentiment: Mixed.

141

Holders

Avg rating(10 Elite)

$1.2B

Total Value

44% (169)

Fund Consensus

72 buying - 91 selling

Smart Money VerdictView all

47Weak MomentumSplit Signals

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See how BCRX's score breaks down across 4 SEC sources

Held by 141 funds

10 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 26, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

ActivistDeerfield Mgmt, L.P.6.8%Feb 12, 2026

InsiderBarnes Alane PSell $167KDec 22, 2025

InsiderBarnes Alane PSell $162KDec 15, 2025

CongressGilbert CisnerosBuy $1,001 - $15,000Nov 13, 2025

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VANGUARD GROUP INC	Increased	22.3M(+2.2%)	$173.7M	0.0%	+14.18%	31
BlackRock, Inc.	Decreased	21.1M(-0.5%)	$164.9M	0.0%	+15.26%	0
RA CAPITAL MANAGEMENT, L.P.	New	15.8M	$123.5M	1.3%	+13.45%	69
STATE STREET CORP	Increased	11.1M(+12.9%)	$86.4M	0.0%	+34.47%	34
JANUS HENDERSON GROUP PLC	Increased	7.4M(+7807.2%)	$57.8M	0.0%	+12.84%	47
UBS Group AG	Decreased	5.3M(-11.8%)	$41.1M	0.0%	+0.72%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	5.1M(+0.0%)	$39.4M	0.0%	+20.69%	29
TWO SIGMA INVESTMENTS, LP	Increased	4.5M(+2.2%)	$35.2M	0.0%	-0.96%	30
TWO SIGMA ADVISERS, LP	Decreased	4.1M(-3.6%)	$31.9M	0.1%	-11.45%	0
Nuveen, LLC	Decreased	3.6M(-0.1%)	$28.2M	0.0%	-0.44%	0
GOLDMAN SACHS GROUP INC	Increased	3.2M(+18.5%)	$25.1M	0.0%	+4.72%	34
BAKER BROS. ADVISORS LP	New	2.8M	$22M	0.1%	+13.45%	47
BNP PARIBAS FINANCIAL MARKETS	Increased	2.5M(+21.4%)	$19.8M	0.0%	+1.99%	34
Fisher Asset Management, LLC	Decreased	2.5M(-6.3%)	$19.2M	0.0%	-32.32%	0
Qube Research & Technologies Ltd	Decreased	2.2M(-10.2%)	$16.9M	0.0%	-0.33%	0
RENAISSANCE TECHNOLOGIES LLC	Decreased	2.1M(-0.6%)	$16.6M	0.0%	+0.76%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	2M(+0.5%)	$15.6M	0.0%	+24.15%	28
NORTHERN TRUST CORP	Decreased	1.9M(-1.9%)	$14.5M	0.0%	+5.74%	0
STIFEL FINANCIAL CORP	Increased	1.8M(+0.1%)	$14.2M	0.0%	+333.96%	28
MORGAN STANLEY	Decreased	1.7M(-66.5%)	$13.6M	0.0%	+5.59%	0
Squarepoint Ops LLC	Increased	1.7M(+49.7%)	$12.9M	0.0%	+13.53%	39
BANK OF AMERICA CORP /DE/	Decreased	1.5M(-19.3%)	$12M	0.0%	+2.27%	0
Invesco Ltd.	Increased	1.4M(+40.8%)	$10.6M	0.0%	+10.64%	37
CITADEL ADVISORS LLC	Decreased	1.3M(-4.5%)	$10.1M	0.0%	-2.87%	0
D. E. Shaw & Co., Inc.	Decreased	1.2M(-27.0%)	$9.7M	0.0%	-0.36%	0
DIMENSIONAL FUND ADVISORS LP	New	1.2M	$9.6M	0.0%	+13.45%	38
Point72 Asset Management, L.P.	Increased	1.2M(+409.5%)	$9.5M	0.0%	+13.77%	45
JUPITER ASSET MANAGEMENT LTD	Decreased	1.2M(-41.8%)	$9.3M	0.1%	+12.51%	0
JACOBS LEVY EQUITY MANAGEMENT, INC	Increased	1M(+178.4%)	$8M	0.0%	+14.23%	44
Hudson Bay Capital Management LP	New	1M	$7.9M	0.0%	+13.45%	38
Aberdeen Group plc	New	913,593	$7.1M	0.0%	+13.45%	38
JPMORGAN CHASE & CO	Decreased	843,370(-25.5%)	$6.6M	0.0%	+5.31%	0
Pictet Asset Management Holding SA	Decreased	740,510(-38.1%)	$5.7M	0.0%	+5.54%	0
BARCLAYS PLC	Decreased	726,367(-7.1%)	$5.7M	0.0%	-3.54%	0
AQR CAPITAL MANAGEMENT LLC	Decreased	704,291(-29.6%)	$5.5M	0.0%	+23.20%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	671,693(+173.3%)	$5.2M	0.0%	+19.08%	44
JANE STREET GROUP, LLC	Decreased	649,357(-64.9%)	$5.1M	0.0%	+15.68%	0
VOYA INVESTMENT MANAGEMENT LLC	Increased	625,490(+37.3%)	$4.9M	0.0%	+4.15%	35
Bank of New York Mellon Corp	Decreased	607,992(-1.9%)	$4.7M	0.0%	+0.83%	0
FRANKLIN RESOURCES INC	Increased	570,189(+22.5%)	$4.4M	0.0%	+16.32%	32
FMR LLC	Decreased	560,182(-14.3%)	$4.4M	0.0%	+12.39%	0
DEUTSCHE BANK AG\	Decreased	491,086(-54.1%)	$3.8M	0.0%	+22.73%	0
VOLORIDGE INVESTMENT MANAGEMENT, LLC	Decreased	449,743(-53.0%)	$3.5M	0.0%	+21.67%	0
Man Group plc	Increased	407,850(+15.1%)	$3.2M	0.0%	+3.83%	30
Swiss National Bank	Increased	394,368(+2.3%)	$3.1M	0.0%	+31.11%	27
Rafferty Asset Management, LLC	Increased	382,556(+3.6%)	$3M	0.0%	+6.98%	27
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Decreased	378,853(-4.0%)	$3M	0.0%	+10.05%	0
PRINCIPAL FINANCIAL GROUP INC	Increased	376,568(+54.1%)	$2.9M	0.0%	+3.15%	37
FIRST TRUST ADVISORS LP	Decreased	374,961(-49.0%)	$2.9M	0.0%	+6.08%	0
Assenagon Asset Management S.A.	Decreased	359,580(-88.4%)	$2.8M	0.0%	-7.16%	0
Connor, Clark & Lunn Investment Management Ltd.	Decreased	357,086(-57.9%)	$2.8M	0.0%	+10.12%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	347,190(-7.6%)	$2.7M	0.0%	+22.61%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	Increased	355,055(+14.9%)	$2.6M	0.0%	+20.80%	30
CANADA PENSION PLAN INVESTMENT BOARD	Increased	327,941(+42.4%)	$2.6M	0.0%	-2.20%	35
VICTORY CAPITAL MANAGEMENT INC	Increased	325,051(+446.4%)	$2.5M	0.0%	+6.50%	42
FEDERATED HERMES, INC.	Increased	292,850(+10.3%)	$2.3M	0.0%	+5.72%	29
ALLIANCEBERNSTEIN L.P.	Decreased	278,190(-0.1%)	$2.2M	0.0%	+23.18%	0
RHUMBLINE ADVISERS	Decreased	266,562(-18.4%)	$2.1M	0.0%	+8.13%	0
Walleye Capital LLC	Increased	251,670(+10.8%)	$2M	0.0%	-3.94%	29
Bridgewater Associates, LP	Decreased	235,572(-42.8%)	$1.8M	0.0%	+15.10%	0
WELLS FARGO & COMPANY/MN	Increased	233,639(+75.6%)	$1.8M	0.0%	+11.38%	39
VIRGINIA RETIREMENT SYSTEMS ET Al	Increased	233,354(+106.5%)	$1.8M	0.0%	+10.66%	42
Russell Investments Group, Ltd.	Decreased	229,226(-27.1%)	$1.8M	0.0%	-3.11%	0
Engineers Gate Manager LP	Decreased	224,543(-49.3%)	$1.8M	0.0%	+12.33%	0
Gotham Asset Management, LLC	Decreased	216,946(-36.9%)	$1.7M	0.0%	+3.20%	0
Legal & General Group Plc	Decreased	210,999(-6.7%)	$1.6M	0.0%	+2.77%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	191,847(+5.1%)	$1.5M	0.0%	+28.46%	27
ROYAL BANK OF CANADA	Decreased	161,456(-12.9%)	$1.3M	0.0%	-1.70%	0
MACKENZIE FINANCIAL CORP	Increased	150,728(+16.6%)	$1.2M	0.0%	+14.13%	29
Schonfeld Strategic Advisors LLC	Decreased	141,449(-15.2%)	$1.1M	0.0%	+12.30%	0
MILLENNIUM MANAGEMENT LLC	Decreased	137,626(-70.1%)	$1.1M	0.0%	+10.43%	0
RAYMOND JAMES FINANCIAL INC	Increased	131,103(+24.7%)	$1M	0.0%	+0.66%	31
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	119,567(+2.9%)	$929,499	0.0%	+34.31%	26
MetLife Investment Management, LLC	Decreased	117,853(-0.1%)	$919,253	0.0%	-1.36%	0
TUDOR INVESTMENT CORP ET AL	Increased	114,541(+16.7%)	$893,420	0.0%	+5.90%	29
AMERICAN CENTURY COMPANIES INC	Decreased	105,385(-9.4%)	$822,003	0.0%	+16.83%	0
SEI INVESTMENTS CO	Decreased	103,157(-71.5%)	$804,607	0.0%	+1.79%	0
NEW YORK STATE COMMON RETIREMENT FUND	Increased	100,690(+51.9%)	$785,382	0.0%	-3.98%	34
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	97,634(-8.1%)	$761,545	0.0%	+26.87%	0
PANAGORA ASSET MANAGEMENT INC	Decreased	88,876(-28.3%)	$693,233	0.0%	-25.24%	0
WELLINGTON MANAGEMENT GROUP LLP	Decreased	86,520(-7.5%)	$674,856	0.0%	+14.03%	0
OSAIC HOLDINGS, INC.	Increased	82,766(+34.0%)	$645,566	0.0%	+11.48%	32
COMMONWEALTH EQUITY SERVICES, LLC	Decreased	79,747(-36.7%)	$622,030	0.0%	+9.20%	0
INTECH INVESTMENT MANAGEMENT LLC	Decreased	79,418(-21.6%)	$619,460	0.0%	+13.75%	0
Jain Global LLC	New	74,455	$580,749	0.0%	+13.45%	34
Corient Private Wealth LLC	Decreased	70,378(-0.6%)	$548,774	0.0%	+15.10%	0
LAZARD ASSET MANAGEMENT LLC	Increased	69,598(+30.6%)	$542,864	0.0%	+14.22%	31
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Decreased	66,244(-98.7%)	$516,703	0.0%	-3.09%	0
GROUP ONE TRADING LLC	Increased	60,524(+53.1%)	$472,087	0.0%	+14.52%	34
Sanctuary Advisors, LLC	Increased	58,571(+36.1%)	$456,854	0.0%	+23.00%	31
CITIGROUP INC	Increased	58,269(+105.6%)	$454,498	0.0%	+13.87%	39
Police & Firemen's Retirement System of New Jersey	Unchanged	58,046	$452,759	0.0%	+13.46%	0
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	57,351	$447,338	0.0%	+26.73%	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	56,361	$439,616	0.0%	+7.64%	0
Arizona State Retirement System	Decreased	56,082(-4.6%)	$437,440	0.0%	+103.92%	0
ENVESTNET ASSET MANAGEMENT INC	Increased	54,065(+82.0%)	$421,707	0.0%	+13.41%	37
NewEdge Advisors, LLC	New	50,041	$390,320	0.0%	+13.45%	33
Creative Planning	Decreased	49,780(-43.7%)	$388,284	0.0%	+26.41%	0
ProShare Advisors LLC	Increased	47,604(+9.9%)	$371,311	0.0%	+14.96%	26
KLP KAPITALFORVALTNING AS	Increased	42,900(+7.8%)	$334,620	0.0%	+15.26%	25
Erste Asset Management GmbH	Unchanged	40,000	$308,400	0.0%	-47.14%	0
COMMERCE BANK	Increased	39,065(+31.5%)	$304,707	0.0%	+4.47%	30
Universal- Beteiligungs- und Servicegesellschaft mbH	Decreased	31,791(-22.8%)	$247,969	0.0%	+12.38%	0
Mariner, LLC	Increased	31,495(+60.0%)	$245,612	0.0%	+11.36%	33
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	29,643(-39.3%)	$231,215	0.0%	-16.64%	0
Rockefeller Capital Management L.P.	Increased	26,797(+403.2%)	$206,217	0.0%	+8.65%	37
LPL Financial LLC	Increased	24,480(+43.9%)	$190,944	0.0%	-8.54%	31
HSBC HOLDINGS PLC	Decreased	24,133(-61.0%)	$188,117	0.0%	+41.38%	0
FARALLON CAPITAL MANAGEMENT LLC	Unchanged	24,000	$187,200	0.0%	+15.10%	0
Walleye Trading LLC	New	23,777	$185,461	0.0%	+13.45%	31
Quantinno Capital Management LP	Decreased	23,152(-21.6%)	$180,586	0.0%	+12.36%	0
XPONANCE LLC	Increased	22,258(+0.4%)	$173,612	0.0%	-8.82%	23
BANCO BILBAO VIZCAYA ARGENTARIA, S.A.	New	19,249	$147,840	0.0%	+13.45%	31
HighTower Advisors, LLC	Increased	18,030(+5.4%)	$140,634	0.0%	+25.63%	24
CAPTRUST FINANCIAL ADVISORS	Decreased	17,740(-9.4%)	$138,372	0.0%	+39.38%	0
PNC FINANCIAL SERVICES GROUP, INC.	Increased	17,715(+4.7%)	$138,177	0.0%	+1.81%	23
XTX Topco Ltd	New	17,111	$133,466	0.0%	+13.45%	31
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Decreased	16,018(-26.6%)	$121,416	0.0%	+24.76%	0
Ensign Peak Advisors, Inc	Decreased	14,400(-69.2%)	$112,320	0.0%	-29.96%	0
CIBC WORLD MARKETS CORP	Decreased	13,858(-46.3%)	$108,092	0.0%	+12.55%	0
Kestra Advisory Services, LLC	Decreased	13,060(-0.6%)	$101,868	0.0%	+15.39%	0
PRUDENTIAL FINANCIAL INC	Decreased	12,790(-96.8%)	$99,762	0.0%	+14.65%	0
Cetera Investment Advisers	Increased	12,330(+13.8%)	$96,174	0.0%	+14.90%	25
Farther Finance Advisors, LLC	Increased	11,492(+8.5%)	$89,638	0.0%	+13.92%	23
Envestnet Portfolio Solutions, Inc.	New	10,430	$81,354	0.0%	+13.45%	30
Mirae Asset Global Investments Co., Ltd.	Increased	10,231(+26.1%)	$79,802	0.0%	-3.07%	26
HUNTINGTON NATIONAL BANK	Increased	7,553(+13.8%)	$58,913	0.0%	+0.63%	24
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	6,127(-0.0%)	$47,791	0.0%	+15.32%	0
ASSETMARK, INC	Increased	4,768(+31.6%)	$37,190	0.0%	+4.60%	25
Federation des caisses Desjardins du Quebec	Increased	3,020(+26.1%)	$23,556	0.0%	-3.53%	23
NISA INVESTMENT ADVISORS, LLC	Decreased	2,557(-9.4%)	$19,945	0.0%	+16.70%	0
JONES FINANCIAL COMPANIES LLLP	Increased	2,200(+48.4%)	$17,160	0.0%	+12.48%	17
HRT FINANCIAL LP	Increased	716,826(+1137.9%)	$5,591	0.0%	+12.26%	25
NATIONAL BANK OF CANADA /FI/	New	500	$3,900	0.0%	+13.45%	22
Optiver Holding B.V.	Decreased	483(-62.6%)	$3,767	0.0%	-5.75%	0
Allworth Financial LP	Decreased	432(-20.3%)	$3,370	0.0%	+12.48%	0
BROWN BROTHERS HARRIMAN & CO	Unchanged	219	$1,708	0.0%	-7.16%	0
COMERICA BANK	Increased	184(+24.3%)	$1,435	0.0%	+20.86%	9
PRICE T ROWE ASSOCIATES INC /MD/	Increased	177,392(+9.9%)	$1,384	0.0%	+24.14%	12
MAI Capital Management	New	40	$312	0.0%	+13.45%	17
BNP Paribas Asset Management Holding S.A.	Increased	2,168(+30.3%)	$17	0.0%	-3.07%	10
Hood River Capital Management LLC	Exited	0(-100.0%)	$27.5M	0.0%	-6.26%	0
Magnetar Financial LLC	Exited	0(-100.0%)	$880,592	0.0%	-13.99%	0
MERCER GLOBAL ADVISORS INC /ADV	Exited	0(-100.0%)	$80,553	0.0%	+1.46%	0
ExodusPoint Capital Management, LP	Exited	0(-100.0%)	$2.8M	0.0%	-8.22%	0
STRS OHIO	Exited	0(-100.0%)	$308,913	0.0%	-3.03%	0
Verition Fund Management LLC	Exited	0(-100.0%)	$436,053	0.0%	+5.23%	0
Savant Capital, LLC	Exited	0(-100.0%)	$218,532	0.0%	-8.11%	0
AMERIPRISE FINANCIAL INC	Exited	0(-100.0%)	$813,587	0.0%	+15.51%	0
IEQ CAPITAL, LLC	Exited	0(-100.0%)	$546,101	0.0%	-1.82%	0
Brevan Howard Capital Management LP	Exited	0(-100.0%)	$2.5M	0.0%	-1.63%	0
PUBLIC SECTOR PENSION INVESTMENT BOARD	Exited	0(-100.0%)	$2M	0.0%	+1.46%	0
SIMPLEX TRADING, LLC	Exited	0(-100.0%)	$308	0.0%	+0.29%	0
WHITTIER TRUST CO	Exited	0(-100.0%)	$1,044	0.0%	+1.46%	0
MARSHALL WACE, LLP	Exited	0(-100.0%)	$5.6M	0.0%	-3.10%	0
Avoro Capital Advisors LLC	Exited	0(-100.0%)	$9.5M	0.0%	-27.84%	0
CANTOR FITZGERALD, L. P.	Exited	0(-100.0%)	$806,870	0.0%	-12.60%	0
SCHRODER INVESTMENT MANAGEMENT GROUP	Exited	0(-100.0%)	$4M	0.0%	+1.46%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$139,337	0.0%	+1.46%	0
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	Exited	0(-100.0%)	$999,686	0.0%	-17.11%	0
ALPS ADVISORS INC	Exited	0(-100.0%)	$767,539	0.0%	-20.80%	0
BANK OF MONTREAL /CAN/	Exited	0(-100.0%)	$97,622	0.0%	-9.26%	0
Steward Partners Investment Advisory, LLC	Exited	0(-100.0%)	$4,554	0.0%	-2.54%	0
BALYASNY ASSET MANAGEMENT L.P.	Exited	0(-100.0%)	$660,694	0.0%	+1.30%	0
Cerity Partners LLC	Exited	0(-100.0%)	$193,712	0.0%	+3.70%	0
MATHER GROUP, LLC.	Exited	0(-100.0%)	$2,694	0.0%	+1.46%	0
ALKEON CAPITAL MANAGEMENT LLC	Exited	0(-100.0%)	$41.5M	0.0%	+1.78%	0
Focus Partners Wealth	Exited	0(-100.0%)	$2.1M	0.0%	+1.46%	0
Jefferies Financial Group Inc.	Exited	0(-100.0%)	$2M	0.0%	-11.94%	0

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