BICYCLE THERAPEUTICS PLC

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BCYC·088786108·US·ADR·Healthcare - Biotechnology-13D/G

BCYC institutional ownership changes in Q2 2026: 30 institutions opened or added positions, 16 trimmed or exited. BCYC (BICYCLE THERAPEUTICS PLC) is held by 56 institutional investors as of Q2 2026. Top institutional shareholders: BAKER BROS. ADVISORS LP ($46.2M), RENAISSANCE TECHNOLOGIES LLC ($6.5M), PRICE T ROWE ASSOCIATES INC /MD/ ($3.8M). Net institutional sentiment: Mixed.

56

Holders

(1 Elite)

$85.7M

Total Value

65% (46)

Consensus

30 buying - 16 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)25

Insider (Form 4)39

Activist (13D/13G)50

Congressional (STOCK Act)33

Holder Quality

62

★★★★★

Elite

16

★★★★

Strong

70

★★★

Solid

28

★★

Below

49

★

Weak

Held by 56 funds

1 elite

Who's Trading

Source dates: Price Oct 21, 2026 · Insiders Oct 6, 2026 · Activists Aug 14, 2026 · Congress none

InsiderSMSkynner MichaelSell $2KOct 5, 2026

InsiderHFHannay Michael Charles FergusonSell $863.94Oct 5, 2026

InsiderPSPerry Jennifer ScottSell $284.8Oct 5, 2026

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Top Holders

Top Holders (56)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BAKER BROS. ADVISORS LP	Unchanged	10.9M	$46.2M	0.2%	-83.40%	0
RENAISSANCE TECHNOLOGIES LLC	Increased	1.5M(+56.6%)	$6.5M	0.0%	-58.01%	39
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	902,150(-12.3%)	$3.8M	0.0%	-86.29%	0
MWMARSHALL WACE, LLP	Increased	797,940(+111.5%)	$3.4M	0.0%	-29.37%	43
Qube Research & Technologies Ltd	Increased	775,567(+151.3%)	$3.3M	0.0%	-27.03%	43
MORGAN STANLEY	Increased	667,269(+7.9%)	$2.8M	0.0%	-76.08%	28
SCHRODER INVESTMENT MANAGEMENT GROUP	Unchanged	615,833	$2.6M	0.0%	-48.62%	0
CITADEL ADVISORS LLC	Increased	554,225(+47.0%)	$2.3M	0.0%	-59.39%	36
MILLENNIUM MANAGEMENT LLC	Increased	553,967(+95.1%)	$2.3M	0.0%	-45.77%	42
TWO SIGMA INVESTMENTS, LP	Increased	434,577(+163.7%)	$1.8M	0.0%	-35.02%	42
JANE STREET GROUP, LLC	Increased	392,163(+79.8%)	$1.7M	0.0%	-34.32%	39
BlackRock, Inc.	Increased	280,386(+0.5%)	$1.2M	0.0%	-82.15%	17
MOORE CAPITAL MANAGEMENT, LP	Unchanged	275,000	$1.2M	0.0%	-53.13%	0
Sculptor Capital LP	New	197,904	$839,113	0.0%	-18.40%	34
Point72 Asset Management, L.P.	Increased	149,936(+15.0%)	$635,729	0.0%	-67.55%	28
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Unchanged	127,863	$542,139	0.0%	-83.55%	0
GOLDMAN SACHS GROUP INC	Increased	121,281(+10.1%)	$514,231	0.0%	-31.40%	18
XTX Topco Ltd	Increased	109,801(+3.2%)	$465,556	0.0%	-43.38%	25
Quadrature Capital Ltd	New	104,092	$441,350	0.0%	-18.40%	33
TD ASSET MANAGEMENT INC	Unchanged	91,992	$390,046	0.0%	-85.35%	0

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer