IONIS PHARMACEUTICALS INC

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IONS·462222100·US·Common Stock·Healthcare - Biotechnology-13D/G

IONS (IONIS PHARMACEUTICALS INC) is held by 221 institutional investors as of Q1 2026. Largest holders: FMR LLC ($1.8B), Capital World Investors ($1.6B), BlackRock, Inc. ($784.1M). Net institutional sentiment: Mixed.

221

Holders

(19 Elite)

$10.9B

Total Value

57% (220)

Consensus

125 buying - 95 selling

13F: Mar 31, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)55

Insider (Form 4)38

Activist (13D/13G)73

Congressional (STOCK Act)35

Holder Quality

78

★★★★★

Elite

16

★★★★

Strong

86

★★★

Solid

44

★★

Below

33

★

Weak

Held by 221 funds

19 elite

Who's Trading

ActivistTRT. Rowe Price Investment Management, Inc.3.7%May 15, 2026

ActivistCapital World Investors12.8%May 14, 2026

InsiderLJLOSCALZO JOSEPHExercise 16K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHExercise 12K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHExercise 16K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHExercise 10K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHExercise 12K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHSell $4.5MMay 4, 2026

InsiderLJLOSCALZO JOSEPHExercise 11K shMay 4, 2026

InsiderLJLOSCALZO JOSEPHSell $1.3MMay 4, 2026

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Top Holders

Top Holders (221)History

AllNewIncreasedHeldDecreasedExited

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	24.6M(+2.0%)	$1.8B	0.1%	+55.43%	33
Capital World Investors	Increased	21.2M(+18.0%)	$1.6B	0.2%	+2.35%	45
BlackRock, Inc.	Decreased	10.4M(-1.9%)	$784.1M	0.0%	+58.22%	0
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	7.8M	$586.4M	0.0%	-28.10%	44
VAVANGUARD CAPITAL MANAGEMENT LLC	New	7.1M	$534.5M	0.0%	-28.10%	43
WELLINGTON MANAGEMENT GROUP LLP	Increased	6.4M(+2.1%)	$480M	0.1%	+20.74%	32
TWO SIGMA INVESTMENTS, LP	Increased	5.9M(+120.3%)	$439.8M	0.4%	-16.89%	60
GEODE CAPITAL MANAGEMENT, LLC	Increased	4M(+26.5%)	$305.2M	0.0%	+1.42%	38
STATE STREET CORP	Increased	4M(+0.5%)	$300M	0.0%	+18.60%	31
ROYAL BANK OF CANADA	Increased	3.8M(+239.8%)	$285.5M	0.1%	-18.02%	50
PRICE T ROWE ASSOCIATES INC /MD/	Increased	3M(+1.3%)	$227.2M	0.0%	+28.61%	31
JPMORGAN CHASE & CO	Increased	2.4M(+2.5%)	$171.4M	0.0%	-19.95%	31
Artisan Partners Limited Partnership	Increased	2.1M(+74.2%)	$154.6M	0.2%	-17.74%	55
BAKER BROS. ADVISORS LP	Increased	2M(+14.3%)	$153.8M	0.9%	-24.41%	49
GOLDMAN SACHS GROUP INC	Increased	1.7M(+98.6%)	$127.6M	0.0%	-3.18%	48
AMERICAN CENTURY COMPANIES INC	Increased	1.7M(+2.9%)	$124.9M	0.1%	-4.48%	31
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	1.6M(+2.7%)	$118.9M	0.0%	+21.91%	31
FRANKLIN RESOURCES INC	Increased	1.6M(+19.2%)	$118.3M	0.0%	-28.20%	36
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	1.5M(+6.3%)	$110.8M	0.0%	+2.73%	32
Pictet Asset Management Holding SA	Increased	1.4M(+1.2%)	$107.1M	0.1%	-0.29%	36

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IONSIONIS PHARMACEUTICALS INC

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Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer