IONIS PHARMACEUTICALS INC (IONS) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling IONS?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for IONIS PHARMACEUTICALS INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on IONS?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for IONIS PHARMACEUTICALS INC.

Is institutional money flowing into IONS?

223 institutional investors hold IONIS PHARMACEUTICALS INC (IONS). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about IONS?

Track institutional sentiment and conviction scores for IONIS PHARMACEUTICALS INC (IONS) including Smart Money Verdict and position changes on HoldingsIntel.

IONIS PHARMACEUTICALS INC

IONS·462222100·US·equity·Healthcare - Biotechnology-13D/G

IONS (IONIS PHARMACEUTICALS INC) is held by 223 institutional investors as of Q4 2025. Largest holders: Pictet Asset Management Holding SA ($107.1M), Nuveen, LLC ($48.7M), TEACHER RETIREMENT SYSTEM OF TEXAS ($39.3M). Net institutional sentiment: Mixed.

223

Holders

Avg rating(8 Elite)

$10.6B

Total Value

61% (231)

Fund Consensus

136 buying - 87 selling

Smart Money Verdict

View all

43Weak MomentumSplit Signals

Get 5 free verdicts/month - sign up in 10 seconds

See how IONS's score breaks down across 4 SEC sources

Held by 223 funds

8 elite

Who's Trading

InsiderLJLOSCALZO JOSEPH

13F: Dec 31, 2025Insider & Congress: Updated regularly

InsiderLJLOSCALZO JOSEPHSell $4.5MMay 4, 2026

ActivistVAVanguard Capital Management5.0%Apr 30, 2026

Activist

The Vanguard Group0.0%Mar 27, 2026

Congress

Rohit KhannaBuyMar 14, 2023

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
Pictet Asset Management Holding SA	Increased	1.4M(+1.2%)	$107.1M	0.1%	—	36
NUNuveen, LLC	Decreased	648,496(-1.9%)	$48.7M	0.0%	—	0
TRTEACHER RETIREMENT SYSTEM OF TEXAS	Increased	523,932(+23.9%)	$39.3M	0.2%	—	42
Candriam S.C.A.	Decreased	484,053(-28.6%)	$36.3M	0.2%	—	0
NEW YORK STATE COMMON RETIREMENT FUND	Increased	350,414(+44.9%)	$26.3M	0.0%	—	39
Swiss National Bank	Increased	304,500(+2.0%)	$22.9M	0.0%	—	29
Legal & General Group Plc	Decreased	294,679(-9.4%)	$22.1M	0.0%	—	0
DIMENSIONAL FUND ADVISORS LP	Increased	267,215(+51.8%)	$20.1M	0.0%	—	40
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	Increased	255,485(+19.7%)	$19.2M	0.0%	—	34
DAVENPORT & Co LLC	Increased	238,238(+9.3%)	$17.9M	0.1%	—	31
HSBC HOLDINGS PLC	Increased	185,967(+590.3%)	$14M	0.0%	—	45
$DEUTSCHE BANK AG\$ DEUTSCHE BANK AG\	Increased	159,891(+7.0%)	$12M	0.0%	—	30
Fisher Asset Management, LLC	Decreased	141,544(-0.1%)	$10.6M	0.0%	—	0
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	135,878	$10.2M	0.0%	—	0
Aberdeen Group plc	Increased	113,843(+293.6%)	$8.5M	0.0%	—	44
ENVESTNET ASSET MANAGEMENT INC	Increased	93,382(+3.9%)	$7M	0.0%	—	28
Sumitomo Mitsui Trust Group, Inc.	Decreased	81,876(-12.7%)	$6.1M	0.0%	—	0
Amova Asset Management Americas, Inc.	Decreased	81,696(-12.7%)	$6.1M	0.1%	—	0
Police & Firemen's Retirement System of New Jersey	Increased	67,323(+0.7%)	$5.1M	0.0%	—	27
Russell Investments Group, Ltd.	Increased	62,919(+43.3%)	$4.7M	0.0%	—	36
Jefferies Financial Group Inc.	Increased	59,065(+17.2%)	$4.4M	0.0%	—	31
State of New Jersey Common Pension Fund D	Decreased	52,588(-4.0%)	$3.9M	0.0%	—	0
Arizona State Retirement System	Decreased	42,266(-0.4%)	$3.2M	0.0%	—	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	38,515(+301.1%)	$2.9M	0.0%	—	42
EXCHANGE TRADED CONCEPTS, LLC	Increased	33,941(+60.9%)	$2.5M	0.0%	—	38
KLP KAPITALFORVALTNING AS	Increased	33,900(+1.2%)	$2.5M	0.0%	—	26
BLAIR WILLIAM & CO/IL	Increased	33,857(+0.2%)	$2.5M	0.0%	—	26
Assenagon Asset Management S.A.	Increased	33,673(+14.9%)	$2.5M	0.0%	—	30
Swedbank AB	Increased	32,253(+18.4%)	$2.4M	0.0%	—	31
STRS OHIO	Increased	28,782(+659.8%)	$2.2M	0.0%	—	42
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	Decreased	28,126(-10.6%)	$2.1M	0.0%	—	0
WAWOLVERINE ASSET MANAGEMENT LLC	Decreased	22,815(-25.2%)	$1.7M	0.0%	—	0
Calamos Advisors LLC	Decreased	19,781(-40.4%)	$1.5M	0.0%	—	0
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	13,545(-2.0%)	$1M	0.0%	—	0
TRUIST FINANCIAL CORP	Increased	12,846(+1.5%)	$964,606	0.0%	—	25
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Decreased	11,123(-7.3%)	$835,226	0.0%	—	0
FIFTH THIRD BANCORP	Increased	11,011(+39.6%)	$826,806	0.0%	—	33
ASSETMARK, INC	Increased	9,574(+10.7%)	$718,912	0.0%	—	27
Mirae Asset Global Investments Co., Ltd.	Increased	9,029(+9.2%)	$677,988	0.0%	—	27
Savant Capital, LLC	Increased	8,461(+17.7%)	$635,338	0.0%	—	29
COMMONWEALTH EQUITY SERVICES, LLC	Decreased	7,829(-33.7%)	$587,877	0.0%	—	0
ProShare Advisors LLC	Increased	7,390(+3.3%)	$554,915	0.0%	—	25
PRINCIPAL FINANCIAL GROUP INC	Increased	7,019(+110.2%)	$527,056	0.0%	—	39
Robeco Institutional Asset Management B.V.	New	5,660	$425,009	0.0%	—	33
OneDigital Investment Advisors LLC	Increased	5,390(+7.7%)	$404,735	0.0%	—	26
Vontobel Holding Ltd.	Unchanged	5,240	$393,472	0.0%	—	0
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	Decreased	4,125(-50.0%)	$308,509	0.0%	—	0
Sanctuary Advisors, LLC	Decreased	3,918(-13.0%)	$294,203	0.0%	—	0
HighTower Advisors, LLC	Decreased	3,797(-25.9%)	$285,117	0.0%	—	0
Eurizon Capital SGR S.p.A.	Increased	3,514(+6.0%)	$256,091	0.0%	—	25
MML INVESTORS SERVICES, LLC	Decreased	3,173(-2.8%)	$238,261	0.0%	—	0
QRQRG CAPITAL MANAGEMENT, INC.	New	3,094	$232,328	0.0%	—	32
HB Wealth Management, LLC	Increased	2,926(+0.1%)	$219,713	0.0%	—	23
NEW YORK LIFE INVESTMENT MANAGEMENT LLC	New	2,688	$201,842	0.0%	—	32
LOS ANGELES CAPITAL MANAGEMENT LLC	Unchanged	700	$52,563	0.0%	—	0
MATHER GROUP, LLC.	New	410	$30,787	0.0%	—	27
NISA INVESTMENT ADVISORS, LLC	Unchanged	1	$75	0.0%	—	0
AXXCESS WEALTH MANAGEMENT, LLC	Exited	0(-100.0%)	$227,599	0.0%	—	0
Showing 58 of 223 results.165 more with Pro.PROUpgrade to see all →

IONIS PHARMACEUTICALS INC

Continue exploring