IONIS PHARMACEUTICALS INC

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IONS·462222100·US·Common Stock·Healthcare - Biotechnology-13D/G

IONS (IONIS PHARMACEUTICALS INC) is held by 221 institutional investors as of Q2 2026. Largest holders: FMR LLC ($2B), Capital World Investors ($1.7B), BlackRock, Inc. ($848.8M). Net institutional sentiment: Mixed.

221

Holders

(18 Elite)

$12B

Total Value

57% (218)

Consensus

124 buying - 94 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)55

Insider (Form 4)38

Activist (13D/13G)73

Congressional (STOCK Act)35

Holder Quality

78

★★★★★

Elite

16

★★★★

Strong

86

★★★

Solid

44

★★

Below

33

★

Weak

Held by 221 funds

18 elite

Who's Trading

Source dates: Price Sep 18, 2026 · Insiders Sep 2, 2026 · Activists May 15, 2026 · Congress none

InsiderBFBENNETT C FRANKOther 110 shAug 31, 2026

InsiderBBBirchler BrianOther 58 shAug 31, 2026

InsiderMPMonia Brett POther 98 shAug 31, 2026

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Top Holders

Top Holders (221)History

AllNewIncreasedHeldDecreasedExited

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	24.6M(+0.3%)	$2B	0.1%	+29.38%	32
Capital World Investors	Increased	21.7M(+2.3%)	$1.7B	0.2%	-15.31%	39
BlackRock, Inc.	Increased	10.7M(+2.5%)	$848.8M	0.0%	+28.35%	33
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Increased	7.9M(+0.7%)	$623.2M	0.0%	-39.93%	32
WELLINGTON MANAGEMENT GROUP LLP	Increased	7.7M(+19.7%)	$606.7M	0.1%	-9.46%	45
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	7.2M(+1.3%)	$571.8M	0.0%	-39.94%	32
TWO SIGMA INVESTMENTS, LP	Increased	6.3M(+6.7%)	$495.7M	0.4%	-31.29%	40
ROYAL BANK OF CANADA	Increased	6.2M(+62.6%)	$490.2M	0.1%	-33.94%	45
STATE STREET CORP	Increased	4.3M(+8.5%)	$343.7M	0.0%	-5.80%	34
GEODE CAPITAL MANAGEMENT, LLC	Decreased	3.6M(-10.1%)	$294.8M	0.0%	-16.69%	0
JPMORGAN CHASE & CO	Increased	2.7M(+13.0%)	$216.2M	0.0%	-31.15%	35
Artisan Partners Limited Partnership	Increased	2.6M(+28.3%)	$209.3M	0.3%	-33.52%	46
GOLDMAN SACHS GROUP INC	Increased	2.1M(+24.1%)	$167.3M	0.0%	-24.37%	37
BAKER BROS. ADVISORS LP	Unchanged	2M	$162.4M	0.8%	-36.86%	0
AMERICAN CENTURY COMPANIES INC	Increased	1.9M(+17.0%)	$154.4M	0.1%	-23.95%	35
FRANKLIN RESOURCES INC	Increased	1.6M(+3.1%)	$128.7M	0.0%	-40.03%	31
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	1.6M(+1.4%)	$127.3M	0.0%	+0.87%	31
BARCLAYS PLC	Increased	1.6M(+453.1%)	$127.1M	0.0%	-36.16%	49
Pictet Asset Management Holding SA	Increased	1.6M(+11.3%)	$127M	0.1%	-19.93%	40
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Decreased	1.5M(-1.4%)	$115.3M	0.0%	-14.18%	0

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer