LEXICON PHARMACEUTICALS INC (LXRX) is held by 72 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is FMR LLC as of Q1 2026.

Are institutions buying or selling LXRX?

In Q1 2026, 43 institutions opened or increased positions in LEXICON PHARMACEUTICALS INC while 25 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on LXRX?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for LEXICON PHARMACEUTICALS INC.

How many hedge funds hold LXRX?

72 institutional investors report holding LEXICON PHARMACEUTICALS INC (LXRX) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into LXRX?

As of Q1 2026, tracked institutions in LEXICON PHARMACEUTICALS INC show 43 buyers versus 25 sellers — net inflows.

LEXICON PHARMACEUTICALS INC

LXRX·528872302·US·Common Stock·Healthcare - Biotechnology-Activist

Holders

Avg rating(17 Elite)

$156.5M

Total Value

63% (78)

Fund Consensus

43 buying - 25 selling

Smart Money Verdict

View all

Held by 72 funds

17 elite

Who's Trading

ActivistINInvus, L.P.9.6%May 8, 2026

InsiderARArtal Participations S.a r.l.Exercise 20.4M shApr 30, 2026

InsiderDRDEBBANE RAYMONDBuy $3KFeb 25, 2026

InsiderDRDEBBANE RAYMONDBuy $147KFeb 23, 2026

InsiderDRDEBBANE RAYMONDBuy $148KFeb 20, 2026

InsiderDRDEBBANE RAYMONDBuy $72KFeb 19, 2026

InsiderDRDEBBANE RAYMONDBuy $176KFeb 18, 2026

InsiderDRDEBBANE RAYMONDBuy $101KFeb 17, 2026

InsiderDRDEBBANE RAYMONDBuy $76KFeb 13, 2026

ActivistINInvus, L.P.10.0%Feb 2, 2026

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	45.1M(+19.1%)	$70.3M	0.0%	+152.76%	35
VAVANGUARD CAPITAL MANAGEMENT LLC	New	9.5M	$14.8M	0.0%	+37.89%	39
Point72 Asset Management, L.P.	Increased	7.8M(+2651.4%)	$12.2M	0.0%	+39.33%	45
MILLENNIUM MANAGEMENT LLC	Increased	4.9M(+2.5%)	$7.7M	0.0%	+91.73%	28
BlackRock, Inc.	Increased	3.3M(+4.1%)	$5.2M	0.0%	+191.19%	28
GEODE CAPITAL MANAGEMENT, LLC	Increased	3.2M(+26.8%)	$4.9M	0.0%	-12.92%	33
JANE STREET GROUP, LLC	Increased	2.7M(+54.6%)	$4.2M	0.0%	+76.75%	38
UBS Group AG	Decreased	2.5M(-17.4%)	$3.9M	0.0%	+102.15%	0
MWMARSHALL WACE, LLP	Increased	2.4M(+88.2%)	$3.7M	0.0%	+62.57%	42
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	2.1M(+75.7%)	$3.3M	0.0%	+80.58%	40
CIBC Bancorp USA Inc.	Decreased	1.8M(-25.0%)	$2.8M	0.0%	+59.71%	0
RENAISSANCE TECHNOLOGIES LLC	Increased	1.6M(+508.0%)	$2.5M	0.0%	+41.06%	42
VFVANGUARD FIDUCIARY TRUST CO	New	1.3M	$2.1M	0.0%	+37.89%	36
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	1.3M(+24.3%)	$2M	0.0%	-4.60%	32
TWO SIGMA INVESTMENTS, LP	Increased	1.2M(+88.2%)	$1.9M	0.0%	+72.70%	40
CITADEL ADVISORS LLC	Decreased	1.1M(-36.0%)	$1.7M	0.0%	+59.71%	0
GOLDMAN SACHS GROUP INC	Increased	1.1M(+16.2%)	$1.7M	0.0%	+86.51%	30
STATE STREET CORP	Increased	964,038(+9.0%)	$1.5M	0.0%	+47.22%	28
MACKENZIE FINANCIAL CORP	New	772,677	$1.2M	0.0%	+37.89%	35
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	546,600	$852,696	0.0%	+37.89%	38