ORCHESTRA BIOMED HLDGS INC

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OBIO·68572M106·US·Common Stock·Healthcare - Biotechnology-Activist

OBIO (ORCHESTRA BIOMED HLDGS INC) is held by 49 institutional investors as of Q2 2026. Largest holders: RTW INVESTMENTS, LP ($41.2M), BlackRock, Inc. ($10.8M), VANGUARD CAPITAL MANAGEMENT LLC ($8.7M). Net institutional sentiment: Mixed.

49

Holders

$86M

Total Value

65% (54)

Consensus

35 buying - 19 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)76

Insider (Form 4)35

Activist (13D/13G)72

Congressional (STOCK Act)51

Holder Quality

64

★★★★★

Elite

62

★★★★

Strong

72

★★★

Solid

30

★★

Below

31

★

Weak

Held by 49 funds

Who's Trading

Source dates: Price Oct 12, 2026 · Insiders Oct 2, 2026 · Activists Apr 29, 2026 · Congress none

InsiderSDSherman DarrenSell $95KOct 1, 2026

InsiderHPHochman David PTax 3K shSep 10, 2026

InsiderHPHochman David PTax 3K shSep 10, 2026

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Top Holders

Top Holders (49)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RTW INVESTMENTS, LP	Increased	9.6M(+15.1%)	$41.2M	0.4%	-44.46%	40
BlackRock, Inc.	Increased	2.5M(+294.9%)	$10.8M	0.0%	+37.48%	45
VAVANGUARD CAPITAL MANAGEMENT LLC	Decreased	2M(-8.2%)	$8.7M	0.0%	+35.55%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	1M(+107.6%)	$4.4M	0.0%	+3.48%	43
AIAlyeska Investment Group, L.P.	Unchanged	1M	$4.3M	0.0%	+140.24%	0
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	New	642,154	$2.8M	0.0%	+36.96%	36
STATE STREET CORP	Increased	516,050(+204.6%)	$2.2M	0.0%	—	42
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	349,544(+31.7%)	$1.5M	0.0%	-8.67%	33
NORTHERN TRUST CORP	Increased	343,640(+190.6%)	$1.5M	0.0%	+11.72%	41
UBS Group AG	Increased	325,773(+547.5%)	$1.4M	0.0%	+36.82%	41
VFVANGUARD FIDUCIARY TRUST CO	Increased	292,253(+24.3%)	$1.3M	0.0%	+35.82%	31
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	274,973	$1.2M	0.0%	+36.96%	35
GOLDMAN SACHS GROUP INC	Increased	179,606(+15.7%)	$775,000	0.0%	—	28
RENAISSANCE TECHNOLOGIES LLC	Increased	90,000(+26.9%)	$388,350	0.0%	+99.26%	29
Bank of New York Mellon Corp	New	86,103	$371,534	0.0%	+36.96%	33
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	65,804(-32.5%)	$283,944	0.0%	+66.23%	0
CITADEL ADVISORS LLC	Decreased	56,191(-29.0%)	$242,464	0.0%	+46.45%	0
Nuveen, LLC	New	52,118	$224,889	0.0%	+36.96%	32
NewEdge Advisors, LLC	Unchanged	44,083	$190,218	0.0%	+112.59%	0
DEUTSCHE BANK AG\	New	39,672	$171,383	0.0%	+36.96%	35

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer