ORCHESTRA BIOMED HLDGS INC (OBIO) is held by 39 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is RTW INVESTMENTS, LP as of Q1 2026.

Are institutions buying or selling OBIO?

In Q1 2026, 25 institutions opened or increased positions in ORCHESTRA BIOMED HLDGS INC while 22 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on OBIO?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for ORCHESTRA BIOMED HLDGS INC.

How many hedge funds hold OBIO?

39 institutional investors report holding ORCHESTRA BIOMED HLDGS INC (OBIO) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into OBIO?

As of Q1 2026, tracked institutions in ORCHESTRA BIOMED HLDGS INC show 25 buyers versus 22 sellers — net inflows.

ORCHESTRA BIOMED HLDGS INC

OBIO·68572M106·US·Common Stock·Healthcare - Biotechnology-Activist

Holders

Avg rating(6 Elite)

$65.9M

Total Value

53% (51)

Fund Consensus

25 buying - 22 selling

Smart Money Verdict

View all

Held by 39 funds

6 elite

Who's Trading

InsiderAJAryeh JasonBuy $2KMay 18, 2026

InsiderHPHochman David PBuy $19KMay 15, 2026

InsiderAJAryeh JasonBuy $35KMay 15, 2026

InsiderFSFain Eric SBuy $83KMay 14, 2026

Activist

RTW Investments, LP19.2%Apr 29, 2026

InsiderRLRTW INVESTMENTS, LPSell $132.16Apr 27, 2026

InsiderHPHochman David PBuy $43KMar 13, 2026

ActivistMPMedtronic plc17.8%Feb 27, 2026

ActivistTATasso Partners, LLC5.0%Nov 19, 2025

InsiderHPHochman David PBuy $20KNov 14, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RTW INVESTMENTS, LP	Unchanged	8.3M	$35.3M	0.4%	-65.58%	0
VAVANGUARD CAPITAL MANAGEMENT LLC	New	2.2M	$9.4M	0.0%	-8.49%	38
AIAlyeska Investment Group, L.P.	Unchanged	1M	$4.3M	0.0%	+62.20%	0
MILLENNIUM MANAGEMENT LLC	Increased	702,543(+188.6%)	$3M	0.0%	+4.66%	43
BlackRock, Inc.	Increased	635,714(+0.8%)	$2.7M	0.0%	-6.14%	18
GEODE CAPITAL MANAGEMENT, LLC	Increased	485,492(+2.6%)	$2.1M	0.0%	-44.69%	27
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	265,499(+0.7%)	$1.1M	0.0%	-44.22%	25
VFVANGUARD FIDUCIARY TRUST CO	New	235,214	$999,660	0.0%	-8.49%	35
MWMARSHALL WACE, LLP	Increased	188,484(+9.8%)	$801,059	0.0%	-4.08%	27
STATE STREET CORP	Increased	169,410(+6.5%)	$719,993	0.0%	-38.18%	18
GOLDMAN SACHS GROUP INC	Increased	155,242(+15.8%)	$659,779	0.0%	-2.10%	28
NORTHERN TRUST CORP	Increased	118,274(+6.7%)	$502,665	0.0%	-44.18%	26
Qube Research & Technologies Ltd	Increased	108,953(+2.1%)	$463,050	0.0%	+6.55%	24
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	97,521(-37.1%)	$414,464	0.0%	+12.23%	0
Point72 Asset Management, L.P.	Decreased	87,888(-45.7%)	$373,524	0.0%	-3.62%	0
CITADEL ADVISORS LLC	Increased	79,185(+162.4%)	$336,536	0.0%	-1.13%	38
Hudson Bay Capital Management LP	Increased	71,134(+43.9%)	$302,320	0.0%	-5.16%	32
RENAISSANCE TECHNOLOGIES LLC	Decreased	70,900(-53.1%)	$301,325	0.0%	+53.31%	0
TWO SIGMA INVESTMENTS, LP	Decreased	60,107(-30.6%)	$255,455	0.0%	-3.62%	0
BARCLAYS PLC	Decreased	59,342(-37.2%)	$252,204	0.0%	-3.62%	0