Praxis Precision Medicines, Inc (PRAX) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

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What is the Smart Money Verdict on PRAX?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Praxis Precision Medicines, Inc.

Is institutional money flowing into PRAX?

141 institutional investors hold Praxis Precision Medicines, Inc (PRAX). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about PRAX?

Track institutional sentiment and conviction scores for Praxis Precision Medicines, Inc (PRAX) including Smart Money Verdict and position changes on HoldingsIntel.

Praxis Precision Medicines, Inc

PRAX·74006W207·US·equity·Healthcare - Biotechnology-13D/G

PRAX (Praxis Precision Medicines, Inc) is held by 141 institutional investors as of Q4 2025. Largest holders: JANUS HENDERSON GROUP PLC ($954.8M), BlackRock, Inc. ($612.6M), VANGUARD GROUP INC ($430.6M). Net institutional sentiment: Bullish.

141

Holders

Avg rating(5 Elite)

$6.4B

Total Value

80% (147)

Fund Consensus

117 buying - 29 selling

Smart Money VerdictView all

55Mixed MomentumSplit Signals

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See how PRAX's score breaks down across 4 SEC sources

Held by 141 funds

5 elite

Who's Trading

ActivistThe Vanguard Group0.0%Mar 27, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
JANUS HENDERSON GROUP PLC	Increased	3.2M(+17.2%)	$954.8M	0.4%	+266.89%	44
BlackRock, Inc.	Increased	2.1M(+15.4%)	$612.6M	0.0%	+216.54%	36
VANGUARD GROUP INC	Increased	1.5M(+15.3%)	$430.6M	0.0%	+261.45%	36
FMR LLC	Increased	1.4M(+3044.3%)	$400.5M	0.0%	+9.79%	50
Orbis Allan Gray Ltd	New	1.3M	$369.9M	1.6%	+7.14%	71
BAKER BROS. ADVISORS LP	Increased	1.1M(+63.4%)	$332M	1.9%	+121.93%	71
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	965,313(-59.3%)	$284.5M	0.4%	+576.65%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	933,061(+86.4%)	$275M	1.9%	+95.99%	76
MORGAN STANLEY	Increased	889,889(+38.3%)	$262.3M	0.0%	+136.83%	41
STATE STREET CORP	Decreased	882,215(-2.7%)	$260M	0.0%	+629.80%	0
GOLDMAN SACHS GROUP INC	Increased	716,184(+20.8%)	$211.1M	0.0%	+219.10%	37
GEODE CAPITAL MANAGEMENT, LLC	Increased	562,379(+23.1%)	$165.8M	0.0%	+198.66%	37
BARCLAYS PLC	Increased	530,751(+592.5%)	$156.4M	0.0%	+22.07%	49
BANK OF AMERICA CORP /DE/	Increased	522,763(+8.3%)	$154.1M	0.0%	+434.44%	33
Point72 Asset Management, L.P.	Decreased	492,346(-67.1%)	$145.1M	0.2%	+626.73%	0
Assenagon Asset Management S.A.	Decreased	408,787(-0.2%)	$120.5M	0.2%	+350.13%	0
RA CAPITAL MANAGEMENT, L.P.	New	373,787	$110.2M	1.1%	+7.14%	69
FRANKLIN RESOURCES INC	Increased	356,074(+13.3%)	$104.9M	0.0%	+279.66%	34
Hood River Capital Management LLC	New	289,467	$85.3M	0.9%	+7.14%	58
Pictet Asset Management Holding SA	New	240,588	$71.1M	0.1%	+7.14%	41
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	198,301(+22.7%)	$58.4M	0.0%	+223.99%	36
NORTHERN TRUST CORP	Increased	192,284(+14.2%)	$56.7M	0.0%	+243.35%	34
WELLINGTON MANAGEMENT GROUP LLP	Increased	176,562(+188.3%)	$52M	0.0%	+49.14%	47
Qube Research & Technologies Ltd	Increased	168,897(+194.7%)	$49.8M	0.1%	+48.69%	47
Aberdeen Group plc	New	134,992	$39.8M	0.1%	+7.14%	40
Candriam S.C.A.	Increased	110,590(+75.9%)	$32.6M	0.2%	+97.59%	52
Woodline Partners LP	Decreased	105,412(-74.8%)	$31.1M	0.1%	+522.68%	0
UBS Group AG	Decreased	89,200(-7.9%)	$26.3M	0.0%	+463.20%	0
FIRST TRUST ADVISORS LP	Increased	88,704(+206.2%)	$26.1M	0.0%	+46.55%	46
Bank of New York Mellon Corp	Increased	77,897(+38.4%)	$23M	0.0%	+181.76%	38
Invesco Ltd.	Increased	77,088(+269.4%)	$22.7M	0.0%	+37.67%	46
AMERICAN CENTURY COMPANIES INC	Increased	75,366(+393.6%)	$22.2M	0.0%	+28.59%	46
Alyeska Investment Group, L.P.	Decreased	74,376(-47.4%)	$21.9M	0.1%	+333.11%	0
CANADA PENSION PLAN INVESTMENT BOARD	New	69,712	$20.5M	0.0%	+7.14%	39
MARSHALL WACE, LLP	Increased	69,242(+1.6%)	$20.4M	0.0%	+465.52%	29
RENAISSANCE TECHNOLOGIES LLC	New	66,230	$19.5M	0.0%	+7.14%	39
Ensign Peak Advisors, Inc	New	64,283	$18.9M	0.0%	+7.14%	39
JPMORGAN CHASE & CO	Increased	55,300(+111.0%)	$16.3M	0.0%	+72.57%	45
DEUTSCHE BANK AG\	Increased	50,811(+266.7%)	$15M	0.0%	+37.46%	45
Nuveen, LLC	Increased	49,970(+29.6%)	$14.7M	0.0%	+218.93%	35
TD ASSET MANAGEMENT INC	Increased	46,146(+12.9%)	$13.6M	0.0%	+298.25%	32
Swiss National Bank	Increased	40,500(+14.1%)	$11.9M	0.0%	+323.47%	32
D. E. Shaw & Co., Inc.	Increased	37,481(+89.3%)	$11M	0.0%	+92.02%	44
Universal- Beteiligungs- und Servicegesellschaft mbH	New	37,377	$11M	0.0%	+7.14%	38
Empowered Funds, LLC	New	36,852	$10.9M	0.1%	+7.14%	38
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	Increased	35,288(+48.5%)	$10.4M	0.0%	+155.80%	38
CITADEL ADVISORS LLC	Increased	34,917(+347.8%)	$10.3M	0.0%	+13.83%	45
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	33,291(-7.1%)	$9.9M	0.0%	+540.89%	0
Caption Management, LLC	Increased	33,300(+423.8%)	$9.8M	0.1%	+28.24%	45
CONGRESS ASSET MANAGEMENT CO	Increased	31,246(+2.6%)	$9.2M	0.1%	+442.13%	28
AQR CAPITAL MANAGEMENT LLC	Increased	28,828(+31.6%)	$8.5M	0.0%	+199.09%	35
RHUMBLINE ADVISERS	Increased	28,324(+5.7%)	$8.3M	0.0%	+459.02%	29
Neuberger Berman Group LLC	New	25,678	$7.6M	0.0%	+7.14%	38
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	25,559(+11.9%)	$7.5M	0.0%	+322.22%	31
WELLS FARGO & COMPANY/MN	Increased	25,235(+85.5%)	$7.4M	0.0%	+93.40%	43
ALLIANCEBERNSTEIN L.P.	Increased	25,070(+38.8%)	$7.4M	0.0%	+140.70%	36
DIMENSIONAL FUND ADVISORS LP	Decreased	23,543(-37.1%)	$6.9M	0.0%	+507.52%	0
TWO SIGMA INVESTMENTS, LP	Increased	23,098(+319.4%)	$6.8M	0.0%	+33.21%	44
AMERIPRISE FINANCIAL INC	New	22,715	$6.7M	0.0%	+7.14%	38
Rafferty Asset Management, LLC	Decreased	22,240(-40.8%)	$6.6M	0.0%	+605.51%	0
Man Group plc	New	21,170	$6.2M	0.0%	+7.14%	38
Russell Investments Group, Ltd.	Increased	20,612(+368.0%)	$6.1M	0.0%	+30.08%	44
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	19,671(+5.8%)	$5.8M	0.0%	+460.79%	29
Legal & General Group Plc	Increased	17,981(+6.9%)	$5.3M	0.0%	+438.25%	29
TUDOR INVESTMENT CORP ET AL	New	16,009	$4.7M	0.0%	+7.14%	37
SEI INVESTMENTS CO	New	15,796	$4.7M	0.0%	+7.14%	37
STATE OF WISCONSIN INVESTMENT BOARD	Increased	15,231(+68.6%)	$4.5M	0.0%	+118.90%	40
PRUDENTIAL FINANCIAL INC	New	14,862	$4.4M	0.0%	+7.14%	37
VOYA INVESTMENT MANAGEMENT LLC	New	13,655	$4M	0.0%	+7.14%	37
VICTORY CAPITAL MANAGEMENT INC	New	13,298	$3.9M	0.0%	+7.14%	37
MetLife Investment Management, LLC	Increased	12,424(+18.1%)	$3.7M	0.0%	+255.54%	31
Erste Asset Management GmbH	New	10,500	$3.2M	0.0%	+7.14%	37
Creative Planning	Increased	10,843(+62.8%)	$3.2M	0.0%	+125.47%	38
JACOBS LEVY EQUITY MANAGEMENT, INC	Decreased	10,140(-27.0%)	$3M	0.0%	+1224.08%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	8,734(+12.6%)	$2.6M	0.0%	+275.77%	29
Trexquant Investment LP	Decreased	8,331(-6.5%)	$2.5M	0.0%	+507.52%	0
NISA INVESTMENT ADVISORS, LLC	Increased	7,770(+9.0%)	$2.3M	0.0%	+343.07%	28
NEW YORK STATE COMMON RETIREMENT FUND	Increased	7,300(+10.6%)	$2.2M	0.0%	+359.32%	29
State of New Jersey Common Pension Fund D	New	7,018	$2.1M	0.0%	+7.14%	36
Connor, Clark & Lunn Investment Management Ltd.	New	6,870	$2M	0.0%	+7.14%	36
GLENMEDE TRUST CO NA	New	6,288	$1.9M	0.0%	+7.14%	36
Police & Firemen's Retirement System of New Jersey	Increased	6,057(+23.2%)	$1.8M	0.0%	+180.51%	31
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Decreased	5,806(-9.6%)	$1.7M	0.0%	+667.57%	0
Arizona State Retirement System	Increased	5,723(+5.7%)	$1.7M	0.0%	+386.13%	27
CITIGROUP INC	Increased	5,586(+99.0%)	$1.6M	0.0%	+71.01%	41
ENVESTNET ASSET MANAGEMENT INC	New	5,550	$1.6M	0.0%	+7.14%	35
GROUP ONE TRADING LLC	Decreased	5,539(-66.7%)	$1.6M	0.0%	+507.52%	0
RAYMOND JAMES FINANCIAL INC	New	5,235	$1.5M	0.0%	+7.14%	35
ProShare Advisors LLC	Increased	5,214(+36.3%)	$1.5M	0.0%	+170.81%	33
M&T BANK CORP	New	12,586	$1.4M	0.0%	+7.14%	35
BNP PARIBAS FINANCIAL MARKETS	Increased	4,626(+5.5%)	$1.4M	0.0%	+416.77%	27
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	New	4,587	$1.4M	0.0%	+7.14%	35
KLP KAPITALFORVALTNING AS	Increased	4,400(+10.0%)	$1.3M	0.0%	+254.30%	28
Cerity Partners LLC	Decreased	3,927(-27.9%)	$1.2M	0.0%	+640.05%	0
Walleye Capital LLC	New	3,587	$1.1M	0.0%	+7.14%	35
VIRGINIA RETIREMENT SYSTEMS ET Al	Decreased	3,500(-10.3%)	$1M	0.0%	+507.52%	0
ROYAL BANK OF CANADA	Decreased	3,378(-14.6%)	$995,000	0.0%	+637.32%	0
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	New	3,316	$977,358	0.0%	+7.14%	35
PUBLIC SECTOR PENSION INVESTMENT BOARD	New	3,297	$971,758	0.0%	+7.14%	35
STRS OHIO	New	3,200	$943,168	0.0%	+7.14%	35
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	3,053(-31.7%)	$899,842	0.0%	+507.52%	0
Quantinno Capital Management LP	New	2,723	$802,577	0.0%	+7.14%	34
Allianz Asset Management GmbH	New	2,400	$707,376	0.0%	+7.14%	34
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	2,343(-92.0%)	$690,576	0.0%	+388.65%	0
Orion Porfolio Solutions, LLC	New	1,985	$585,059	0.0%	+7.14%	34
Squarepoint Ops LLC	New	1,890	$557,059	0.0%	+7.14%	34
US BANCORP \DE\	Increased	1,825(+1529.5%)	$537,901	0.0%	+13.01%	39
XPONANCE LLC	New	1,764	$519,921	0.0%	+7.14%	33
Allspring Global Investments Holdings, LLC	New	1,732	$496,045	0.0%	+7.14%	33
CIBC WORLD MARKETS CORP	New	1,490	$439,163	0.0%	+7.14%	33
MACKENZIE FINANCIAL CORP	New	1,399	$414,713	0.0%	+7.14%	33
Mirae Asset Global Investments Co., Ltd.	Increased	1,215(+49.3%)	$358,109	0.0%	+121.21%	33
MERCER GLOBAL ADVISORS INC /ADV	New	1,212	$357,224	0.0%	+7.14%	33
Kestra Advisory Services, LLC	New	1,180	$347,793	0.0%	+7.14%	33
PRINCIPAL FINANCIAL GROUP INC	New	995	$293,266	0.0%	+7.14%	32
Swiss Life Asset Management Ltd	New	946	$278,824	0.0%	+7.14%	32
CIBC Asset Management Inc	Decreased	900(-99.8%)	$265,266	0.0%	+599.67%	0
MML INVESTORS SERVICES, LLC	New	864	$254,655	0.0%	+7.14%	32
HSBC HOLDINGS PLC	Decreased	825(-92.6%)	$244,382	0.0%	+507.52%	0
IEQ CAPITAL, LLC	New	815	$240,213	0.0%	+7.14%	32
Amundi	New	790	$232,845	0.0%	+7.14%	32
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	785,987(-21.7%)	$231,662	0.0%	+511.89%	0
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	New	768	$226,360	0.0%	+7.14%	32
COMMONWEALTH EQUITY SERVICES, LLC	New	745	$219,580	0.0%	+7.14%	32
PNC FINANCIAL SERVICES GROUP, INC.	Increased	714(+2875.0%)	$210,445	0.0%	+10.28%	37
Sanctuary Advisors, LLC	New	681	$200,718	0.0%	+7.14%	32
LOS ANGELES CAPITAL MANAGEMENT LLC	New	552	$110,952	0.0%	+7.14%	30
Farther Finance Advisors, LLC	Increased	368(+60.0%)	$108,464	0.0%	+134.16%	31
DANSKE BANK A/S	New	200	$58,948	0.0%	+7.14%	29
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	98	$28,885	0.0%	+723.12%	0
OSAIC HOLDINGS, INC.	Increased	83(+3.8%)	$24,462	0.0%	+411.52%	14
Rockefeller Capital Management L.P.	Increased	64(+3100.0%)	$18,863	0.0%	+9.97%	20
Optiver Holding B.V.	Decreased	60(-57.1%)	$17,684	0.0%	+507.52%	0
FEDERATED HERMES, INC.	New	44	$12,969	0.0%	+7.14%	27
Allworth Financial LP	Increased	28(+133.3%)	$8,253	0.0%	+69.27%	18
COMERICA BANK	New	17	$5,190	0.0%	+7.14%	23
CIBC Private Wealth Group LLC	New	17	$5,011	0.0%	+7.14%	23
MAI Capital Management	New	4	$1,179	0.0%	+7.14%	17
BNP Paribas Asset Management Holding S.A.	Increased	279(+71.2%)	$82	0.0%	+112.68%	17
ALPS ADVISORS INC	Exited	0(-100.0%)	$552,472	0.0%	+556.44%	0
NOMURA ASSET MANAGEMENT CO LTD	New	0	$0	0.0%	+7.14%	17
Jefferies Financial Group Inc.	Exited	0(-100.0%)	$106,000	0.0%	+590.74%	0
JANE STREET GROUP, LLC	Exited	0(-100.0%)	$1.7M	0.0%	+475.66%	0
Phoenix Financial Ltd.	Exited	0(-100.0%)	$361,520	0.0%	+467.05%	0
Freestone Grove Partners LP	Exited	0(-100.0%)	$438,257	0.0%	+467.05%	0
SIMPLEX TRADING, LLC	Exited	0(-100.0%)	$1,194	0.0%	+554.12%	0

Praxis Precision Medicines, Inc

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