PRELUDE THERAPEUTICS INC (PRLD) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling PRLD?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for PRELUDE THERAPEUTICS INC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on PRLD?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for PRELUDE THERAPEUTICS INC.

Is institutional money flowing into PRLD?

39 institutional investors hold PRELUDE THERAPEUTICS INC (PRLD). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about PRLD?

Track institutional sentiment and conviction scores for PRELUDE THERAPEUTICS INC (PRLD) including Smart Money Verdict and position changes on HoldingsIntel.

PRELUDE THERAPEUTICS INC

PRLD·74065P101·US·equity·Healthcare - Biotechnology-Activist

PRLD (PRELUDE THERAPEUTICS INC) is held by 39 institutional investors as of Q4 2025. Largest holders: BAKER BROS. ADVISORS LP ($29.4M), VANGUARD GROUP INC ($4.1M), TWO SIGMA INVESTMENTS, LP ($2.3M). Net institutional sentiment: Mixed.

Holders

Avg rating(2 Elite)

$44.4M

Total Value

58% (42)

Fund Consensus

21 buying - 12 selling

Smart Money Verdict- Q4 2025View all

55Mixed MomentumConfirmed

Held by 39 funds

2 elite

Who's Trading

ActivistVaddi Krishna13.2%Feb 13, 2026

Activist

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BAKER BROS. ADVISORS LP	Unchanged	10.1M	$29.4M	0.2%	-90.88%	0
VANGUARD GROUP INC	Increased	1.4M(+42.4%)	$4.1M	0.0%	+14.22%	36
TWO SIGMA INVESTMENTS, LP	Increased	788,695(+418.1%)	$2.3M	0.0%	-1.78%	42
MORGAN STANLEY	Increased	334,916(+17.8%)	$971,257	0.0%	-19.57%	29
MARSHALL WACE, LLP	New	273,883	$794,260	0.0%	-7.39%	34
GEODE CAPITAL MANAGEMENT, LLC	Increased	272,886(+25.4%)	$791,502	0.0%	-86.24%	21
RENAISSANCE TECHNOLOGIES LLC	Decreased	271,300(-50.1%)	$786,770	0.0%	+5.20%	0
BlackRock, Inc.	Increased	266,280(+0.5%)	$772,212	0.0%	+115.93%	17
TWO SIGMA ADVISERS, LP	Increased	237,300(+6.6%)	$688,170	0.0%	+29.00%	26
TD ASSET MANAGEMENT INC	Unchanged	160,652	$465,891	0.0%	-69.03%	0
MILLENNIUM MANAGEMENT LLC	Decreased	150,997(-86.8%)	$437,891	0.0%	+96.49%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	New	135,909	$394,136	0.0%	-7.39%	36
STATE STREET CORP	Increased	127,292(+30.4%)	$369,147	0.0%	-23.98%	20
GOLDMAN SACHS GROUP INC	Increased	117,477(+48.1%)	$340,683	0.0%	+52.29%	22
JANE STREET GROUP, LLC	Increased	111,040(+218.9%)	$322,016	0.0%	+19.70%	26
OMERS ADMINISTRATION Corp	New	73,000	$211,700	0.0%	-7.39%	32
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	70,546(+1.9%)	$200,428	0.0%	-53.26%	23
Point72 Asset Management, L.P.	New	59,168	$171,587	0.0%	-7.39%	31
XTX Topco Ltd	Increased	50,159(+222.0%)	$145,461	0.0%	+7.65%	36
NORTHERN TRUST CORP	Increased	50,120(+37.6%)	$145,348	0.0%	-71.07%	20
Focus Partners Wealth	New	50,007	$145,020	0.0%	-7.39%	31
Connor, Clark & Lunn Investment Management Ltd.	New	46,090	$133,661	0.0%	-7.39%	31
Cerity Partners LLC	Decreased	32,953(-4.0%)	$95,564	0.0%	+32.03%	0
Qube Research & Technologies Ltd	New	21,551	$62,498	0.0%	-7.39%	29
PRUDENTIAL FINANCIAL INC	Decreased	15,520(-39.9%)	$45,008	0.0%	+91.97%	0
HSBC HOLDINGS PLC	Decreased	13,652(-0.7%)	$39,454	0.0%	-17.89%	0
BANK OF AMERICA CORP /DE/	Increased	9,808(+10.8%)	$28,443	0.0%	+92.04%	15
BARCLAYS PLC	Decreased	8,602(-1.3%)	$24,946	0.0%	-15.47%	0
FMR LLC	Decreased	6,152(-32.4%)	$17,841	0.0%	+170.52%	0
UBS Group AG	Decreased	1,857(-55.5%)	$5,385	0.0%	+105.60%	0
ROYAL BANK OF CANADA	Decreased	1,742(-77.4%)	$5,000	0.0%	+100.56%	0
NISA INVESTMENT ADVISORS, LLC	Unchanged	1,634	$4,739	0.0%	+194.58%	0
PNC FINANCIAL SERVICES GROUP, INC.	Unchanged	1,171	$3,396	0.0%	+173.50%	0
PRICE T ROWE ASSOCIATES INC /MD/	Decreased	755,956(-13.7%)	$2,193	0.0%	-40.05%	0
GROUP ONE TRADING LLC	Unchanged	500	$1,450	0.0%	+24.06%	0
BNP PARIBAS FINANCIAL MARKETS	Increased	95(+82.7%)	$276	0.0%	+35.02%	12
JPMORGAN CHASE & CO	Decreased	62(-98.4%)	$180	0.0%	+103.94%	0
Optiver Holding B.V.	Unchanged	20	$58	0.0%	+91.97%	0
CITIGROUP INC	Decreased	1(-100.0%)	$3	0.0%	+111.47%	0
HRT FINANCIAL LP	Exited	0(-100.0%)	$24	0.0%	+107.30%	0
SIMPLEX TRADING, LLC	Exited	0(-100.0%)	$0	0.0%	+107.30%	0
AQR CAPITAL MANAGEMENT LLC	Exited	0(-100.0%)	$15,120	0.0%	+210.35%	0

PRELUDE THERAPEUTICS INC

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