PRELUDE THERAPEUTICS INC

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PRLD·74065P101·US·equity·Healthcare - Biotechnology-Activist

PRLD (PRELUDE THERAPEUTICS INC) is held by 38 institutional investors as of Q1 2026. Largest holders: BAKER BROS. ADVISORS LP ($34.6M), TWO SIGMA INVESTMENTS, LP ($3.2M), MILLENNIUM MANAGEMENT LLC ($1.3M). Net institutional sentiment: Mixed.

38

Holders

Avg rating(3 Elite)

$49.8M

Total Value

67% (42)

Fund Consensus

22 buying - 11 selling

Smart Money Verdict

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66Positive MomentumSplit Signals

Institutional (13F)59

Insider (Form 4)90

Activist (13D/13G)46

Congressional (STOCK Act)

No data

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See how PRLD's score breaks down across 4 SEC sources

Holder Quality

3

★★★★★

Elite

13

★★★★

Strong

15

★★★

Solid

7

★★

Below

4

★

Weak

Held by 38 funds

3 elite

Who's Trading

ActivistRA Capital Management, L.P.9.9%Apr 28, 2026

InsiderRLRA CAPITAL MANAGEMENT, L.P.Other 1.4M shApr 27, 2026

ActivistOAORBIMED ADVISORS LLC16.0%Apr 23, 2026

InsiderOLORBIMED ADVISORS LLCBuy $7.5MApr 21, 2026

InsiderBPBonita David PBuy $7.5MApr 21, 2026

InsiderUNUnknownBuy $5.0MApr 21, 2026

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13F: Mar 31, 2026Insider & Congress: Updated regularly

Positions (38)History

AllNewIncreasedHeldDecreasedExited

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BAKER BROS. ADVISORS LP	Unchanged	10.1M	$34.6M	0.2%	-84.47%	0
TWO SIGMA INVESTMENTS, LP	Increased	923,626(+17.1%)	$3.2M	0.0%	+67.75%	31
MILLENNIUM MANAGEMENT LLC	Increased	382,737(+153.5%)	$1.3M	0.0%	+111.27%	41
MWMARSHALL WACE, LLP	Increased	358,906(+31.0%)	$1.2M	0.0%	+60.56%	32
MORGAN STANLEY	Decreased	322,161(-3.8%)	$1.1M	0.0%	+37.01%	0
BlackRock, Inc.	Increased	321,886(+20.9%)	$1.1M	0.0%	+206.45%	20
GEODE CAPITAL MANAGEMENT, LLC	Increased	302,458(+10.8%)	$1M	0.0%	-74.39%	28
RENAISSANCE TECHNOLOGIES LLC	Increased	275,200(+1.4%)	$941,184	0.0%	+79.06%	25
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	267,788(+97.0%)	$915,835	0.0%	+63.71%	40
GOLDMAN SACHS GROUP INC	Increased	236,469(+101.3%)	$808,724	0.0%	+105.37%	40
JANE STREET GROUP, LLC	Increased	192,963(+73.8%)	$659,933	0.0%	+88.16%	37
STATE STREET CORP	Increased	138,231(+8.6%)	$472,750	0.0%	+31.99%	18
CITADEL ADVISORS LLC	New	124,378	$425,373	0.0%	+70.34%	33
Connor, Clark & Lunn Investment Management Ltd.	Increased	109,085(+136.7%)	$373,071	0.0%	+64.78%	38
UBS Group AG	Increased	64,505(+3373.6%)	$220,607	0.0%	+72.90%	25
XTX Topco Ltd	Increased	57,190(+14.0%)	$195,590	0.0%	+81.67%	26
BANK OF AMERICA CORP /DE/	Increased	56,525(+476.3%)	$193,316	0.0%	+85.79%	25
NORTHERN TRUST CORP	Unchanged	50,120	$171,410	0.0%	-50.72%	0
FWFocus Partners Wealth	Unchanged	50,007	$171,024	0.0%	+57.75%	0
DIMENSIONAL FUND ADVISORS LP	New	35,210	$119,690	0.0%	+70.34%	34

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High Conviction Moves-Signal Convergence-Fund Consensus-Double-Down Signals

Data sourced from four SEC data sources: 13F, Form 4, 13D/13G, and STOCK Act. Not financial advice. Full disclaimer