PRELUDE THERAPEUTICS INC

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PRLD·74065P101·US·Common Stock·Healthcare - Biotechnology-Activist

PRLD (PRELUDE THERAPEUTICS INC) is held by 55 institutional investors as of Q2 2026. Largest holders: BAKER BROS. ADVISORS LP ($54M), RA CAPITAL MANAGEMENT, L.P. ($34.5M), VANGUARD CAPITAL MANAGEMENT LLC ($10.7M). Net institutional sentiment: Bullish.

55

Holders

(4 Elite)

$145.5M

Total Value

72% (57)

Consensus

41 buying - 16 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)26

Insider (Form 4)31

Activist (13D/13G)51

Congressional (STOCK Act)47

Holder Quality

15

★★★★★

Elite

31

★★★★

Strong

23

★★★

Solid

61

★★

Below

64

★

Weak

Held by 55 funds

4 elite

Who's Trading

Source dates: Price Oct 15, 2026 · Insiders Apr 28, 2026 · Activists Jul 8, 2026 · Congress none

ActivistSOSoleus Capital Management, L.P.5.2%Jul 8, 2026

ActivistRA Capital Management, L.P.9.9%Apr 28, 2026

InsiderRLRA CAPITAL MANAGEMENT, L.P.Other 1.4M shApr 27, 2026

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Top Holders

Top Holders (55)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BAKER BROS. ADVISORS LP	Unchanged	10.1M	$54M	0.3%	-88.80%	0
RA CAPITAL MANAGEMENT, L.P.	New	6.5M	$34.5M	0.3%	-39.40%	48
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	2M(+63.3%)	$10.7M	0.0%	-12.15%	40
BlackRock, Inc.	Increased	1.8M(+458.4%)	$9.6M	0.0%	-30.35%	45
TWO SIGMA INVESTMENTS, LP	Increased	993,369(+7.5%)	$5.3M	0.0%	+13.04%	29
MILLENNIUM MANAGEMENT LLC	Increased	844,993(+120.8%)	$4.5M	0.0%	-16.67%	43
GEODE CAPITAL MANAGEMENT, LLC	Increased	841,862(+178.3%)	$4.5M	0.0%	-66.70%	43
AGADAGE CAPITAL PARTNERS GP, L.L.C.	New	766,095	$4.1M	0.0%	-39.40%	37
MORGAN STANLEY	Increased	503,860(+56.4%)	$2.7M	0.0%	-19.51%	37
STATE STREET CORP	Increased	428,787(+210.2%)	$2.3M	0.0%	-46.53%	42
UBS Group AG	Increased	318,797(+394.2%)	$1.7M	0.0%	-32.37%	41
VFVANGUARD FIDUCIARY TRUST CO	Increased	284,886(+81.0%)	$1.5M	0.0%	-15.85%	39
RENAISSANCE TECHNOLOGIES LLC	Increased	281,200(+2.2%)	$1.5M	0.0%	+26.06%	26
NORTHERN TRUST CORP	Increased	240,599(+380.1%)	$1.3M	0.0%	-47.17%	41
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	193,920	$1M	0.0%	-39.40%	38
MWMARSHALL WACE, LLP	Decreased	190,692(-46.9%)	$1M	0.0%	+15.76%	0
Connor, Clark & Lunn Investment Management Ltd.	Increased	125,606(+15.2%)	$669,480	0.0%	+5.48%	28
GOLDMAN SACHS GROUP INC	Decreased	120,834(-48.9%)	$644,045	0.0%	+4.89%	0
Bank of New York Mellon Corp	New	68,187	$363,436	0.0%	-39.40%	33
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	New	67,622	$360,425	0.0%	-39.40%	36

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PRLDPRELUDE THERAPEUTICS INC

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer