PRELUDE THERAPEUTICS INC (PRLD) is held by 41 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is BAKER BROS. ADVISORS LP as of Q1 2026.

Are institutions buying or selling PRLD?

In Q1 2026, 25 institutions opened or increased positions in PRELUDE THERAPEUTICS INC while 10 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on PRLD?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for PRELUDE THERAPEUTICS INC.

How many hedge funds hold PRLD?

41 institutional investors report holding PRELUDE THERAPEUTICS INC (PRLD) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into PRLD?

As of Q1 2026, tracked institutions in PRELUDE THERAPEUTICS INC show 25 buyers versus 10 sellers — net inflows.

PRELUDE THERAPEUTICS INC

PRLD·74065P101·US·Common Stock·Healthcare - Biotechnology-Activist

Holders

Avg rating(6 Elite)

$54.5M

Total Value

71% (44)

Fund Consensus

25 buying - 10 selling

Smart Money Verdict

View all

Held by 41 funds

6 elite

Who's Trading

ActivistSOSoleus Capital Management, L.P.5.2%Jul 8, 2026

Activist

RA Capital Management, L.P.9.9%Apr 28, 2026

InsiderRLRA CAPITAL MANAGEMENT, L.P.Other 1.4M shApr 27, 2026

ActivistOAORBIMED ADVISORS LLC16.0%Apr 23, 2026

Activist

Baker Bros. Advisors LP15.5%Apr 22, 2026

InsiderBPBonita David PBuy $7.5MApr 21, 2026

InsiderOLORBIMED ADVISORS LLCBuy $7.5MApr 21, 2026

InsiderOLORBIMED ADVISORS LLCBuy $5.0MApr 21, 2026

InsiderBPBonita David PBuy $5.0MApr 21, 2026

ActivistVKVaddi Krishna13.2%Feb 13, 2026

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
BAKER BROS. ADVISORS LP	Unchanged	10.1M	$34.6M	0.2%	-83.36%	0
VAVANGUARD CAPITAL MANAGEMENT LLC	New	1.2M	$4.2M	0.0%	+82.51%	37
TWO SIGMA INVESTMENTS, LP	Increased	923,626(+17.1%)	$3.2M	0.0%	+79.73%	31
MILLENNIUM MANAGEMENT LLC	Increased	382,737(+153.5%)	$1.3M	0.0%	+126.36%	41
MWMARSHALL WACE, LLP	Increased	358,906(+31.0%)	$1.2M	0.0%	+72.02%	32
MORGAN STANLEY	Decreased	322,161(-3.8%)	$1.1M	0.0%	+46.79%	0
BlackRock, Inc.	Increased	321,886(+20.9%)	$1.1M	0.0%	+228.34%	20
GEODE CAPITAL MANAGEMENT, LLC	Increased	302,458(+10.8%)	$1M	0.0%	-72.56%	28
RENAISSANCE TECHNOLOGIES LLC	Increased	275,200(+1.4%)	$941,184	0.0%	+91.85%	25
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	267,788(+97.0%)	$915,835	0.0%	+75.40%	40
GOLDMAN SACHS GROUP INC	Increased	236,469(+101.3%)	$808,724	0.0%	+120.04%	40
JANE STREET GROUP, LLC	Increased	192,963(+73.8%)	$659,933	0.0%	+101.60%	37
VFVANGUARD FIDUCIARY TRUST CO	New	157,380	$538,240	0.0%	+82.51%	34
STATE STREET CORP	Increased	138,231(+8.6%)	$472,750	0.0%	+41.42%	18
CITADEL ADVISORS LLC	New	124,378	$425,373	0.0%	+82.51%	33
Connor, Clark & Lunn Investment Management Ltd.	Increased	109,085(+136.7%)	$373,071	0.0%	+76.55%	38
UBS Group AG	Increased	64,505(+3373.6%)	$220,607	0.0%	+85.25%	25
XTX Topco Ltd	Increased	57,190(+14.0%)	$195,590	0.0%	+94.65%	26
BANK OF AMERICA CORP /DE/	Increased	56,525(+476.3%)	$193,316	0.0%	+99.06%	25
NORTHERN TRUST CORP	Unchanged	50,120	$171,410	0.0%	-47.20%	0