PRIME MEDICINE INC (PRME) is held by 114 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is Alphabet Inc. as of Q1 2026.

Are institutions buying or selling PRME?

In Q1 2026, 65 institutions opened or increased positions in PRIME MEDICINE INC while 51 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on PRME?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for PRIME MEDICINE INC.

How many hedge funds hold PRME?

114 institutional investors report holding PRIME MEDICINE INC (PRME) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into PRME?

As of Q1 2026, tracked institutions in PRIME MEDICINE INC show 65 buyers versus 51 sellers — net inflows.

PRIME MEDICINE INC

PRME·74168J101·US·Common Stock·Healthcare - Biotechnology-Activist

114

Holders

Avg rating(26 Elite)

$283.9M

Total Value

56% (125)

Fund Consensus

65 buying - 51 selling

Smart Money Verdict

View all

Held by 114 funds

26 elite

Who's Trading

ActivistTRT. Rowe Price Investment Management, Inc.3.3%Feb 17, 2026

ActivistG2GV 2019, L.P.7.5%Nov 12, 2025

Activist

FMR LLC3.8%Nov 5, 2025

ActivistAVARCH Venture Fund X, L.P.10.4%Aug 11, 2025

InsiderGLGV 2021 GP, L.L.C.Buy $5.0MAug 1, 2025

InsiderNRNELSEN ROBERTBuy $10.0MAug 1, 2025

InsiderALARCH Venture Partners X, LLCBuy $10.0MAug 1, 2025

InsiderALARCH Venture Partners XII, LLCBuy $10.0MAug 1, 2025

InsiderLRLiu David R.Buy $53KJun 30, 2025

InsiderLRLiu David R.Buy $45KJun 23, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
ALAlphabet Inc.	Unchanged	16.6M	$57.6M	1.4%	-75.04%	0
BlackRock, Inc.	Increased	8.5M(+2.8%)	$29.6M	0.0%	+12.39%	30
STATE STREET CORP	Increased	6.3M(+24.5%)	$22.1M	0.0%	-12.86%	35
ARK Investment Management LLC	Increased	6.2M(+16.4%)	$21.7M	0.2%	-48.30%	39
VAVANGUARD CAPITAL MANAGEMENT LLC	New	4.5M	$15.6M	0.0%	-10.64%	39
BALYASNY ASSET MANAGEMENT L.P.	Increased	4.1M(+32.0%)	$14.3M	0.0%	+3.47%	36
Woodline Partners LP	Increased	3M(+0.0%)	$10.5M	0.0%	-28.94%	28
Sumitomo Mitsui Trust Group, Inc.	Decreased	2.9M(-9.4%)	$10.2M	0.0%	-58.92%	0
Amova Asset Management Americas, Inc.	Decreased	2.9M(-9.4%)	$10.2M	0.1%	-58.86%	0
UBS Group AG	Increased	2.9M(+18.4%)	$10.1M	0.0%	+4.33%	33
GEODE CAPITAL MANAGEMENT, LLC	Increased	2.7M(+4.4%)	$9.6M	0.0%	-47.14%	29
FMR LLC	Decreased	1.8M(-18.7%)	$6.2M	0.0%	+35.97%	0
TWO SIGMA INVESTMENTS, LP	Decreased	1.6M(-3.5%)	$5.5M	0.0%	-4.90%	0
DED. E. Shaw & Co., Inc.	Decreased	1.4M(-10.2%)	$4.8M	0.0%	-28.95%	0
FARALLON CAPITAL MANAGEMENT, L.L.C.	Unchanged	1.2M	$4.3M	0.0%	-32.32%	0
GOLDMAN SACHS GROUP INC	Decreased	970,425(-44.7%)	$3.4M	0.0%	+5.58%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	917,212(-2.1%)	$3.2M	0.0%	-43.23%	0
NORTHERN TRUST CORP	Increased	886,716(+5.3%)	$3.1M	0.0%	-51.74%	28
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	862,204	$3M	0.0%	-10.64%	36
JPMORGAN CHASE & CO	Increased	844,154(+93.7%)	$2.7M	0.0%	-1.03%	42