PROTHENA CORP PLC (PRTA) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling PRTA?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for PROTHENA CORP PLC, showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on PRTA?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for PROTHENA CORP PLC.

Is institutional money flowing into PRTA?

96 institutional investors hold PROTHENA CORP PLC (PRTA). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about PRTA?

Track institutional sentiment and conviction scores for PROTHENA CORP PLC (PRTA) including Smart Money Verdict and position changes on HoldingsIntel.

PROTHENA CORP PLC

PRTA·G72800108·US·equity·Healthcare - Biotechnology-13D/G

SHS

PRTA (PROTHENA CORP PLC) is held by 96 institutional investors as of Q4 2025. Largest holders: FMR LLC ($72.1M), BlackRock, Inc. ($39.2M), STATE STREET CORP ($21.7M). Net institutional sentiment: Mixed.

Holders

Avg rating(8 Elite)

$331.7M

Total Value

58% (102)

Fund Consensus

52 buying - 35 selling

Smart Money Verdict- Q4 2025View all

57Mixed MomentumSplit Signals

Held by 96 funds

8 elite

Who's Trading

ActivistRubric Capital Management LP6.8%Feb 13, 2026

Activist

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Decreased	7.6M(-4.4%)	$72.1M	0.0%	-37.10%	0
BlackRock, Inc.	Increased	4.1M(+14.2%)	$39.2M	0.0%	-34.04%	33
STATE STREET CORP	Increased	2.3M(+151.7%)	$21.7M	0.0%	-48.97%	46
VANGUARD GROUP INC	Increased	2.1M(+4.4%)	$20.4M	0.0%	-31.78%	30
D. E. Shaw & Co., Inc.	Increased	1.7M(+27.8%)	$16.1M	0.0%	+5.41%	35
MORGAN STANLEY	Increased	1.2M(+55.9%)	$11.9M	0.0%	-34.49%	39
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.1M(+4.3%)	$10.2M	0.0%	-65.88%	29
JACOBS LEVY EQUITY MANAGEMENT, INC	Increased	978,011(+11.6%)	$9.3M	0.0%	+29.30%	31
FEDERATED HERMES, INC.	Increased	974,367(+40.6%)	$9.3M	0.0%	-13.66%	37
GOLDMAN SACHS GROUP INC	Increased	935,333(+164.8%)	$8.9M	0.0%	-17.18%	44
CITADEL ADVISORS LLC	Increased	912,382(+18.9%)	$8.7M	0.0%	+22.39%	32
Point72 Asset Management, L.P.	Increased	860,018(+33.0%)	$8.2M	0.0%	-2.99%	35
DIMENSIONAL FUND ADVISORS LP	Decreased	775,207(-3.9%)	$7.4M	0.0%	-78.24%	0
Nuveen, LLC	Increased	759,107(+13.6%)	$7.2M	0.0%	-8.68%	31
TWO SIGMA INVESTMENTS, LP	Increased	670,138(+57.1%)	$6.4M	0.0%	+7.11%	39
Mariner, LLC	Decreased	577,938(-2.2%)	$5.5M	0.0%	-61.88%	0
RENAISSANCE TECHNOLOGIES LLC	Increased	435,515(+17.3%)	$4.2M	0.0%	-25.78%	31
JANE STREET GROUP, LLC	Decreased	428,651(-30.8%)	$4.1M	0.0%	-19.19%	0
TWO SIGMA ADVISERS, LP	Increased	427,400(+60.9%)	$4.1M	0.0%	+11.61%	39
BANK OF AMERICA CORP /DE/	Increased	427,360(+54.2%)	$4.1M	0.0%	-10.43%	38
UBS Group AG	Increased	426,360(+6.4%)	$4.1M	0.0%	-13.89%	28
BNP PARIBAS FINANCIAL MARKETS	Increased	423,955(+85.9%)	$4M	0.0%	-2.79%	42
Qube Research & Technologies Ltd	Increased	407,689(+60.4%)	$3.9M	0.0%	+28.29%	38
NORTHERN TRUST CORP	Increased	363,241(+8.5%)	$3.5M	0.0%	-61.71%	29
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	357,335(+1.9%)	$3.4M	0.0%	-62.29%	27
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Decreased	298,101(-54.4%)	$2.8M	0.0%	-4.10%	0
Man Group plc	Increased	269,513(+104.2%)	$2.6M	0.0%	-7.57%	42
Squarepoint Ops LLC	Increased	218,041(+71.6%)	$2.1M	0.0%	+26.01%	39
AQR CAPITAL MANAGEMENT LLC	Decreased	186,785(-12.9%)	$1.8M	0.0%	-4.10%	0
BARCLAYS PLC	Increased	183,625(+87.2%)	$1.8M	0.0%	-46.66%	40
JPMORGAN CHASE & CO	Decreased	169,955(-76.9%)	$1.6M	0.0%	-12.06%	0
Walleye Capital LLC	Increased	156,035(+2476x)	$1.5M	0.0%	+0.55%	41
Bank of New York Mellon Corp	Decreased	132,700(-13.7%)	$1.3M	0.0%	-79.14%	0
Connor, Clark & Lunn Investment Management Ltd.	New	125,890	$1.2M	0.0%	+0.54%	35
AMERIPRISE FINANCIAL INC	Decreased	105,441(-0.1%)	$1M	0.0%	+53.95%	0
LOS ANGELES CAPITAL MANAGEMENT LLC	Decreased	95,406(-20.1%)	$999,854	0.0%	+1.24%	0
Quantinno Capital Management LP	Increased	103,618(+2.4%)	$989,552	0.0%	+22.64%	26
Russell Investments Group, Ltd.	Decreased	99,350(-22.2%)	$948,796	0.0%	+31.56%	0
ExodusPoint Capital Management, LP	Increased	87,990(+190.8%)	$840,304	0.0%	-5.45%	40
Rafferty Asset Management, LLC	New	82,553	$788,381	0.0%	+0.54%	34
AMERICAN CENTURY COMPANIES INC	Increased	78,804(+9.1%)	$752,578	0.0%	-21.44%	27
Assenagon Asset Management S.A.	Decreased	76,769(-14.4%)	$733,144	0.0%	-4.10%	0
ALLIANCEBERNSTEIN L.P.	Unchanged	69,607	$664,747	0.0%	-32.49%	0
Creative Planning	Decreased	61,969(-3.4%)	$591,804	0.0%	+1.88%	0
Caption Management, LLC	Unchanged	61,009	$582,636	0.0%	+53.95%	0
WELLS FARGO & COMPANY/MN	Increased	60,108(+48.7%)	$574,029	0.0%	-68.81%	33
RHUMBLINE ADVISERS	Decreased	56,527(-8.9%)	$539,817	0.0%	-64.32%	0
XTX Topco Ltd	Increased	54,881(+247.2%)	$524,114	0.0%	-0.84%	39
MARSHALL WACE, LLP	New	54,778	$523,130	0.0%	+0.54%	33
FRANKLIN RESOURCES INC	Decreased	47,251(-22.8%)	$451,247	0.0%	+1.46%	0
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	Decreased	45,970(-3.2%)	$439,013	0.0%	-35.19%	0
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	Unchanged	42,158	$402,609	0.0%	+53.95%	0
DEUTSCHE BANK AG\	Increased	35,482(+5.1%)	$338,853	0.0%	-55.12%	25
Quadrature Capital Ltd	Increased	31,090(+14.2%)	$296,910	0.0%	+35.80%	27
PNC FINANCIAL SERVICES GROUP, INC.	Increased	28,128(+55.1%)	$268,623	0.0%	+22.80%	33
HSBC HOLDINGS PLC	Decreased	27,733(-25.9%)	$260,690	0.0%	-1.45%	0
Invesco Ltd.	Decreased	26,609(-15.0%)	$254,116	0.0%	-79.71%	0
TUDOR INVESTMENT CORP ET AL	Decreased	26,473(-2.2%)	$252,817	0.0%	+53.95%	0
MetLife Investment Management, LLC	Increased	25,501(+31.7%)	$243,535	0.0%	-80.74%	29
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	25,240(+34.0%)	$239,886	0.0%	-46.49%	30
EDGEWOOD MANAGEMENT LLC	Unchanged	24,060	$229,773	0.0%	-24.39%	0
MILLENNIUM MANAGEMENT LLC	Decreased	21,976(-96.5%)	$209,871	0.0%	-6.90%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	20,601(+6.3%)	$196,740	0.0%	-39.70%	24
Trexquant Investment LP	Decreased	19,384(-93.0%)	$185,117	0.0%	+53.95%	0
STRS OHIO	Decreased	17,600(-38.9%)	$168,080	0.0%	+22.12%	0
RAYMOND JAMES FINANCIAL INC	Decreased	16,483(-25.2%)	$157,413	0.0%	-25.08%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	15,975(-89.8%)	$152,561	0.0%	-34.35%	0
JONES FINANCIAL COMPANIES LLLP	Increased	15,900(+13.6%)	$151,845	0.0%	+44.76%	25
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	15,386	$146,936	0.0%	-46.52%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Decreased	13,695(-1.2%)	$130,787	0.0%	-75.14%	0
GREAT LAKES ADVISORS, LLC	Decreased	13,189(-0.7%)	$125,955	0.0%	-4.10%	0
Police & Firemen's Retirement System of New Jersey	Decreased	12,453(-0.1%)	$118,926	0.0%	-32.73%	0
CITIGROUP INC	Increased	12,318(+242.9%)	$117,637	0.0%	-14.40%	35
ProShare Advisors LLC	New	10,425	$99,559	0.0%	+0.54%	30
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	8,979	$85,749	0.0%	-62.71%	0
CANADA PENSION PLAN INVESTMENT BOARD	New	7,100	$67,805	0.0%	+0.54%	32
BROWN BROTHERS HARRIMAN & CO	Unchanged	5,000	$47,750	0.0%	+53.95%	0
Rockefeller Capital Management L.P.	Increased	4,590(+4.2%)	$43,835	0.0%	-3.92%	21
ROYAL BANK OF CANADA	Decreased	4,427(-57.1%)	$42,000	0.0%	+45.37%	0
Legal & General Group Plc	Increased	4,044(+12.4%)	$38,620	0.0%	-75.72%	15
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	2,710(+12.2%)	$25,881	0.0%	-48.54%	15
Mirae Asset Global Investments Co., Ltd.	Increased	2,616(+25.7%)	$24,983	0.0%	-67.06%	24
Farther Finance Advisors, LLC	Unchanged	2,434	$23,245	0.0%	-24.53%	0
SIMPLEX TRADING, LLC	Decreased	1,927(-95.4%)	$18,402	0.0%	+53.95%	0
Federation des caisses Desjardins du Quebec	New	1,000	$9,550	0.0%	+0.54%	26
Allworth Financial LP	Increased	885(+2.3%)	$8,452	0.0%	+3.10%	12
US BANCORP \DE\	Increased	359(+14.3%)	$3,428	0.0%	+6.27%	11
Optiver Holding B.V.	Decreased	296(-15.9%)	$2,827	0.0%	-4.10%	0
OSAIC HOLDINGS, INC.	Decreased	237(-2.5%)	$2,260	0.0%	-76.20%	0
NISA INVESTMENT ADVISORS, LLC	Decreased	112(-81.1%)	$1,070	0.0%	-73.61%	0
PRICE T ROWE ASSOCIATES INC /MD/	Increased	81,515(+3.8%)	$779	0.0%	-81.78%	12
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	71	$678	0.0%	-72.50%	0
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Increased	54(+8.0%)	$516	0.0%	-3.77%	8
CIBC Private Wealth Group LLC	Unchanged	48	$458	0.0%	-62.21%	0
MAI Capital Management	New	10	$96	0.0%	+0.54%	17
Steward Partners Investment Advisory, LLC	Unchanged	6	$57	0.0%	+53.95%	0
GROUP ONE TRADING LLC	Exited	0(-100.0%)	$67,822	0.0%	+53.13%	0
Engineers Gate Manager LP	Exited	0(-100.0%)	$547,341	0.0%	+31.65%	0
HRT FINANCIAL LP	Exited	0(-100.0%)	$303	0.0%	-4.61%	0
BALYASNY ASSET MANAGEMENT L.P.	Exited	0(-100.0%)	$544,257	0.0%	+53.13%	0
Jain Global LLC	Exited	0(-100.0%)	$114,973	0.0%	+53.13%	0
ALPS ADVISORS INC	Exited	0(-100.0%)	$251,096	0.0%	-66.46%	0

PROTHENA CORP PLC

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