SPERO THERAPEUTICS INC (SPRO) is held by 34 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is VANGUARD CAPITAL MANAGEMENT LLC as of Q1 2026.

Are institutions buying or selling SPRO?

In Q1 2026, 15 institutions opened or increased positions in SPERO THERAPEUTICS INC while 16 reduced or exited — a net selling quarter.

What is the Smart Money Verdict on SPRO?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for SPERO THERAPEUTICS INC.

How many hedge funds hold SPRO?

34 institutional investors report holding SPERO THERAPEUTICS INC (SPRO) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into SPRO?

As of Q1 2026, tracked institutions in SPERO THERAPEUTICS INC show 15 buyers versus 16 sellers — net outflows.

SPERO THERAPEUTICS INC

SPRO·84833T103·US·Common Stock·Healthcare - Biotechnology-Activist

Holders

Avg rating(6 Elite)

$18.4M

Total Value

48% (41)

Fund Consensus

15 buying - 16 selling

Smart Money Verdict

View all

Held by 34 funds

6 elite

Who's Trading

InsiderRERajavelu EstherSell $63KMay 4, 2026

InsiderRERajavelu EstherSell $95KNov 7, 2025

InsiderKTKeutzer TimothySell $3KAug 28, 2025

InsiderMAMahadevia AnkitSell $13KAug 28, 2025

ActivistANAnson Funds Management LP2.9%Aug 14, 2025

ActivistGPGSK PLC16.4%Mar 28, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VAVANGUARD CAPITAL MANAGEMENT LLC	New	1.8M	$4.2M	0.0%	-4.11%	37
RENAISSANCE TECHNOLOGIES LLC	Decreased	1.2M(-7.1%)	$2.8M	0.0%	+24.47%	0
ALAlphabet Inc.	Unchanged	889,979	$2.1M	0.1%	+21.39%	0
TWO SIGMA INVESTMENTS, LP	Increased	885,631(+137.7%)	$2.1M	0.0%	-4.68%	42
GEODE CAPITAL MANAGEMENT, LLC	Decreased	519,922(-1.8%)	$1.2M	0.0%	-71.14%	0
BlackRock, Inc.	Decreased	433,202(-0.1%)	$1M	0.0%	+105.88%	0
CITADEL ADVISORS LLC	Decreased	376,458(-5.4%)	$880,912	0.0%	-7.49%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	333,115(+13.4%)	$779,489	0.0%	-7.10%	28
VFVANGUARD FIDUCIARY TRUST CO	New	264,115	$618,029	0.0%	-4.11%	34
STATE STREET CORP	Increased	214,751(+2.2%)	$502,517	0.0%	+29.26%	17
SOSquarepoint Ops LLC	Increased	194,301(+62.7%)	$454,664	0.0%	-6.22%	35
MWMARSHALL WACE, LLP	New	157,072	$367,547	0.0%	-4.11%	33
NORTHERN TRUST CORP	Unchanged	120,984	$283,103	0.0%	-67.23%	0
JANE STREET GROUP, LLC	Decreased	106,345(-32.8%)	$248,847	0.0%	-3.21%	0
Point72 Asset Management, L.P.	Increased	59,668(+36.9%)	$139,623	0.0%	-6.60%	29
Invesco Ltd.	Increased	45,374(+83.7%)	$106,175	0.0%	-12.37%	23
Quadrature Capital Ltd	Increased	40,128(+6.2%)	$93,900	0.0%	-7.30%	23
OMERS ADMINISTRATION Corp	Decreased	39,400(-70.0%)	$92,196	0.0%	-7.49%	0
SIMPLEX TRADING, LLC	Decreased	30,304(-15.1%)	$70,911	0.0%	-10.49%	0
DIMENSIONAL FUND ADVISORS LP	Unchanged	29,768	$69,207	0.0%	+9.97%	0