SPERO THERAPEUTICS INC

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SPRO·84833T103·US·Common Stock·Healthcare - Biotechnology-Activist

SPRO (SPERO THERAPEUTICS INC) is held by 40 institutional investors as of Q2 2026. Largest holders: VANGUARD CAPITAL MANAGEMENT LLC ($4.5M), RENAISSANCE TECHNOLOGIES LLC ($2.1M), Alphabet Inc. ($2M). Net institutional sentiment: Mixed.

40

Holders

(1 Elite)

$20M

Total Value

67% (36)

Consensus

24 buying - 12 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)40

Insider (Form 4)57

Activist (13D/13G)59

Congressional (STOCK Act)62

Holder Quality

47

★★★★★

Elite

63

★★★★

Strong

55

★★★

Solid

13

★★

Below

16

★

Weak

Held by 40 funds

1 elite

Who's Trading

Source dates: Price Oct 12, 2026 · Insiders Aug 6, 2026 · Activists Aug 14, 2025 · Congress none

InsiderZDZack DebraVest 162K shAug 3, 2026

InsiderTKTregoning KathleenVest 10K shJun 23, 2026

InsiderPJPottage John C JrVest 10K shJun 23, 2026

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Top Holders

Top Holders (40)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	2M(+13.1%)	$4.5M	0.0%	-45.26%	30
RENAISSANCE TECHNOLOGIES LLC	Decreased	947,904(-20.3%)	$2.1M	0.0%	-28.87%	0
ALAlphabet Inc.	Unchanged	889,979	$2M	0.0%	-30.64%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	759,290(+127.9%)	$1.7M	0.0%	-46.24%	41
BlackRock, Inc.	Increased	594,404(+37.2%)	$1.3M	0.0%	-10.63%	23
GEODE CAPITAL MANAGEMENT, LLC	Increased	566,329(+8.9%)	$1.3M	0.0%	-82.82%	28
RAYMOND JAMES FINANCIAL INC	New	521,705	$1.2M	0.0%	-45.70%	35
TWO SIGMA INVESTMENTS, LP	Decreased	382,814(-56.8%)	$846,019	0.0%	-45.53%	0
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	New	332,970	$735,864	0.0%	-45.70%	34
VFVANGUARD FIDUCIARY TRUST CO	Increased	287,648(+8.9%)	$635,702	0.0%	-45.25%	27
DIMENSIONAL FUND ADVISORS LP	Increased	274,820(+823.2%)	$607,616	0.0%	-44.89%	39
GOLDMAN SACHS GROUP INC	New	256,985	$567,937	0.0%	-45.70%	37
STATE STREET CORP	Unchanged	214,751	$474,600	0.0%	-26.14%	0
JANE STREET GROUP, LLC	Increased	158,097(+48.7%)	$349,394	0.0%	-45.02%	22
UBS Group AG	Increased	139,680(+4542.1%)	$308,693	0.0%	-45.70%	26
NORTHERN TRUST CORP	Decreased	108,274(-10.5%)	$239,286	0.0%	-81.28%	0
Point72 Asset Management, L.P.	Increased	104,377(+74.9%)	$230,673	0.0%	-46.24%	35
Federation des caisses Desjardins du Quebec	New	91,900	$202,180	0.0%	-45.70%	32
Invesco Ltd.	Increased	64,245(+41.6%)	$141,981	0.0%	-48.76%	20
SIMPLEX TRADING, LLC	Increased	61,312(+102.3%)	$135,499	0.0%	-47.30%	36

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SPROSPERO THERAPEUTICS INC

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer