UPSTREAM BIO INC

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UPB·91678A107·US·equity·Healthcare - Biotechnology-13D/G

UPB (UPSTREAM BIO INC) is held by 79 institutional investors as of Q1 2026. Largest holders: FMR LLC ($72.9M), BlackRock, Inc. ($30.3M), FEDERATED HERMES, INC. ($8.8M). Net institutional sentiment: Mixed.

79

Holders

Avg rating(7 Elite)

$216.6M

Total Value

57% (95)

Fund Consensus

51 buying - 39 selling

Smart Money Verdict

View all

47Weak MomentumStrong Convergence

Institutional (13F)48

Insider (Form 4)45

Activist (13D/13G)50

Congressional (STOCK Act)

No data

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See how UPB's score breaks down across 4 SEC sources

Holder Quality

7

★★★★★

Elite

33

★★★★

Strong

28

★★★

Solid

21

★★

Below

5

★

Weak

Held by 79 funds

7 elite

Who's Trading

ActivistDGDecheng Capital Global Life Sciences Fund IV, L.P.5.0%May 15, 2026

InsiderSRSutherland Everett RandSell $19KMar 16, 2026

InsiderDADeykin AaronSell $8KMar 16, 2026

InsiderGMGRAY MICHAELSell $8KMar 16, 2026

InsiderHAHoughton AdamSell $6KMar 16, 2026

ActivistHHHBM Healthcare Investments (Cayman) Ltd.4.1%Nov 14, 2025

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13F: Mar 31, 2026Insider & Congress: Updated regularly

Positions (79)History

AllNewIncreasedHeldDecreasedExited

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	8.1M(+7.8%)	$72.9M	0.0%	-42.63%	32
BlackRock, Inc.	Increased	3.4M(+0.8%)	$30.3M	0.0%	-47.88%	29
FEDERATED HERMES, INC.	Increased	979,758(+2032x)	$8.8M	0.0%	+23.34%	44
GEODE CAPITAL MANAGEMENT, LLC	Increased	950,617(+11.6%)	$8.6M	0.0%	-37.19%	31
MILLENNIUM MANAGEMENT LLC	Increased	937,323(+81.2%)	$8.4M	0.0%	-49.35%	42
Woodline Partners LP	Increased	831,481(+9.4%)	$7.5M	0.0%	-49.07%	30
DED. E. Shaw & Co., Inc.	Increased	820,480(+2928.6%)	$7.4M	0.0%	+13.36%	44
Pictet Asset Management Holding SA	Decreased	733,431(-5.1%)	$6.6M	0.0%	-66.73%	0
STATE STREET CORP	Decreased	705,350(-46.5%)	$6.3M	0.0%	-48.23%	0
HSBC HOLDINGS PLC	New	640,326	$5.8M	0.0%	+23.51%	38
Qube Research & Technologies Ltd	New	619,321	$5.6M	0.0%	+23.51%	37
MORGAN STANLEY	Increased	552,609(+352.7%)	$5M	0.0%	-4.77%	43
JPMORGAN CHASE & CO	Increased	463,001(+319.8%)	$4.1M	0.0%	-20.57%	43
WELLINGTON MANAGEMENT GROUP LLP	Decreased	342,353(-61.7%)	$3.1M	0.0%	-46.90%	0
GOLDMAN SACHS GROUP INC	Decreased	316,587(-5.1%)	$2.8M	0.0%	-55.96%	0
AIAlyeska Investment Group, L.P.	Unchanged	298,329	$2.7M	0.0%	-66.73%	0
NORTHERN TRUST CORP	Increased	260,992(+10.2%)	$2.3M	0.0%	-36.06%	29
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	257,729(-9.6%)	$2.3M	0.0%	-43.91%	0
UBS Group AG	Decreased	231,254(-87.2%)	$2.1M	0.0%	-64.27%	0
XTX Topco Ltd	Increased	209,277(+1286.8%)	$1.9M	0.0%	+3.30%	42

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High Conviction Moves-Signal Convergence-Fund Consensus-Double-Down Signals

Data sourced from four SEC data sources: 13F, Form 4, 13D/13G, and STOCK Act. Not financial advice. Full disclaimer