UPSTREAM BIO INC COM

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UPB·91678A107·US·Common Stock·Healthcare - Biotechnology-13D/G

UPB (UPSTREAM BIO INC COM) is held by 94 institutional investors as of Q2 2026. Largest holders: FMR LLC ($56.5M), BlackRock, Inc. ($26M), VANGUARD CAPITAL MANAGEMENT LLC ($13M). Net institutional sentiment: Bullish.

94

Holders

(7 Elite)

$233.5M

Total Value

74% (97)

Consensus

72 buying - 25 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)67

Insider (Form 4)85

Activist (13D/13G)81

Congressional (STOCK Act)53

Holder Quality

34

★★★★★

Elite

12

★★★★

Strong

42

★★★

Solid

80

★★

Below

45

★

Weak

Held by 94 funds

7 elite

Who's Trading

Source dates: Price Oct 13, 2026 · Insiders Sep 17, 2026 · Activists Aug 12, 2026 · Congress none

InsiderAAAmbrose AllisonSell $3KSep 16, 2026

InsiderSRSutherland Everett RandSell $12KSep 16, 2026

InsiderGMGRAY MICHAELSell $5KSep 16, 2026

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Top Holders

Top Holders (94)History

AllNewIncreasedHeldDecreasedExitedFirst report

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	8.2M(+0.8%)	$56.5M	0.0%	-77.50%	30
BlackRock, Inc.	Increased	3.8M(+11.3%)	$26M	0.0%	-78.31%	32
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	1.9M(+0.2%)	$13M	0.0%	-51.76%	28
MILLENNIUM MANAGEMENT LLC	Increased	1.1M(+22.0%)	$7.9M	0.0%	-77.75%	33
DED. E. Shaw & Co., Inc.	Increased	1M(+26.3%)	$7.2M	0.0%	-54.43%	34
JPMORGAN CHASE & CO	Increased	1M(+118.6%)	$7M	0.0%	-62.87%	44
Qube Research & Technologies Ltd	Increased	978,500(+58.0%)	$6.8M	0.0%	-50.68%	39
GEODE CAPITAL MANAGEMENT, LLC	Decreased	931,261(-2.0%)	$6.4M	0.0%	-75.47%	0
Woodline Partners LP	Unchanged	831,481	$5.8M	0.0%	-80.11%	0
STATE STREET CORP	Increased	766,323(+8.6%)	$5.3M	0.0%	-78.76%	29
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Decreased	712,667(-2.1%)	$4.9M	0.0%	-51.77%	0
AQR CAPITAL MANAGEMENT LLC	Increased	544,869(+655.0%)	$3.8M	0.0%	-49.69%	43
MORGAN STANLEY	Decreased	524,632(-5.1%)	$3.6M	0.0%	-62.81%	0
BNP PARIBAS FINANCIAL MARKETS	Increased	511,546(+306.0%)	$3.5M	0.0%	-50.03%	43
Walleye Capital LLC	New	498,490	$3.4M	0.0%	-48.70%	37
Trexquant Investment LP	Increased	466,430(+164.0%)	$3.2M	0.0%	-57.81%	43
Point72 Asset Management, L.P.	Increased	453,011(+154.3%)	$3.1M	0.0%	-49.95%	43
BANK OF AMERICA CORP /DE/	Increased	391,762(+708.4%)	$2.7M	0.0%	-58.62%	42
DIMENSIONAL FUND ADVISORS LP	Increased	381,613(+377.0%)	$2.6M	0.0%	-49.37%	42
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Increased	357,756(+93.3%)	$2.5M	0.0%	-50.33%	41

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer