UPSTREAM BIO INC (UPB) is held by 84 institutional investors that disclose positions via SEC 13F filings. The largest disclosed holder is FMR LLC as of Q1 2026.

Are institutions buying or selling UPB?

In Q1 2026, 56 institutions opened or increased positions in UPSTREAM BIO INC while 38 reduced or exited — a net buying quarter.

What is the Smart Money Verdict on UPB?

The Smart Money Verdict combines four independent sources (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for UPSTREAM BIO INC.

How many hedge funds hold UPB?

84 institutional investors report holding UPSTREAM BIO INC (UPB) as of Q1 2026, based on SEC 13F filings.

Is institutional money flowing into UPB?

As of Q1 2026, tracked institutions in UPSTREAM BIO INC show 56 buyers versus 38 sellers — net inflows.

UPSTREAM BIO INC

UPB·91678A107·US·Common Stock·Healthcare - Biotechnology-13D/G

Holders

Avg rating(18 Elite)

$242.5M

Total Value

60% (99)

Fund Consensus

56 buying - 38 selling

Smart Money Verdict

View all

Held by 84 funds

18 elite

Who's Trading

ActivistDGDecheng Capital Global Life Sciences Fund IV, L.P.5.0%May 15, 2026

InsiderSRSutherland Everett RandSell $19KMar 16, 2026

InsiderDADeykin AaronSell $8KMar 16, 2026

InsiderGMGRAY MICHAELSell $8KMar 16, 2026

InsiderHAHoughton AdamSell $6KMar 16, 2026

InsiderAAAmbrose AllisonSell $4KMar 16, 2026

ActivistHHHBM Healthcare Investments (Cayman) Ltd.4.1%Nov 14, 2025

ActivistTCTCG Crossover GP I, LLC3.9%Nov 14, 2025

Activist

Norges Bank5.3%Oct 24, 2025

Activist

FMR LLC14.8%Aug 6, 2025

View all insider trades View all activist filings

13F: Mar 31, 2026Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	8.1M(+7.8%)	$72.9M	0.0%	-52.47%	32
BlackRock, Inc.	Increased	3.4M(+0.8%)	$30.3M	0.0%	-56.82%	29
VAVANGUARD CAPITAL MANAGEMENT LLC	New	1.9M	$16.9M	0.0%	+2.31%	39
FEDERATED HERMES, INC.	Increased	979,758(+2032x)	$8.8M	0.0%	+2.17%	44
GEODE CAPITAL MANAGEMENT, LLC	Increased	950,617(+11.6%)	$8.6M	0.0%	-47.97%	31
MILLENNIUM MANAGEMENT LLC	Increased	937,323(+81.2%)	$8.4M	0.0%	-58.05%	42
Woodline Partners LP	Increased	831,481(+9.4%)	$7.5M	0.0%	-57.81%	30
DED. E. Shaw & Co., Inc.	Increased	820,480(+2928.6%)	$7.4M	0.0%	-6.10%	44
Pictet Asset Management Holding SA	Decreased	733,431(-5.1%)	$6.6M	0.0%	-72.44%	0
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	727,711	$6.5M	0.0%	+2.31%	38
STATE STREET CORP	Decreased	705,350(-46.5%)	$6.3M	0.0%	-57.12%	0
HSBC HOLDINGS PLC	New	640,326	$5.8M	0.0%	+2.31%	38
Qube Research & Technologies Ltd	New	619,321	$5.6M	0.0%	+2.31%	37
MORGAN STANLEY	Increased	552,609(+352.7%)	$5M	0.0%	-21.12%	43
JPMORGAN CHASE & CO	Increased	463,001(+319.8%)	$4.1M	0.0%	-34.20%	43
WELLINGTON MANAGEMENT GROUP LLP	Decreased	342,353(-61.7%)	$3.1M	0.0%	-56.02%	0
GOLDMAN SACHS GROUP INC	Decreased	316,587(-5.1%)	$2.8M	0.0%	-63.52%	0
AIAlyeska Investment Group, L.P.	Unchanged	298,329	$2.7M	0.0%	-72.44%	0
NORTHERN TRUST CORP	Increased	260,992(+10.2%)	$2.3M	0.0%	-47.04%	29
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	257,729(-9.6%)	$2.3M	0.0%	-53.53%	0