UPSTREAM BIO INC

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UPB·91678A107·US·Common Stock·Healthcare - Biotechnology-13D/G

UPB (UPSTREAM BIO INC) is held by 93 institutional investors as of Q2 2026. Largest holders: FMR LLC ($56.5M), BlackRock, Inc. ($26M), VANGUARD CAPITAL MANAGEMENT LLC ($13M). Net institutional sentiment: Bullish.

93

Holders

(6 Elite)

$231.8M

Total Value

75% (96)

Consensus

72 buying - 24 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)67

Insider (Form 4)85

Activist (13D/13G)81

Congressional (STOCK Act)53

Holder Quality

34

★★★★★

Elite

12

★★★★

Strong

42

★★★

Solid

80

★★

Below

45

★

Weak

Held by 93 funds

6 elite

Who's Trading

Source dates: Price Aug 27, 2026 · Insiders Mar 17, 2026 · Activists Aug 12, 2026 · Congress none

ActivistNorges Bank7.7%Aug 12, 2026

ActivistBlackRock, Inc.5.2%Jul 30, 2026

ActivistDGDecheng Capital Global Life Sciences Fund IV, L.P.5.0%May 15, 2026

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Top Holders

Top Holders (93)History

AllNewIncreasedHeldDecreasedExited

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	8.2M(+0.8%)	$56.5M	0.0%	-54.81%	30
BlackRock, Inc.	Increased	3.8M(+11.3%)	$26M	0.0%	-56.44%	32
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	1.9M(+0.2%)	$13M	0.0%	-3.12%	28
MILLENNIUM MANAGEMENT LLC	Increased	1.1M(+22.0%)	$7.9M	0.0%	-55.32%	33
DED. E. Shaw & Co., Inc.	Increased	1M(+26.3%)	$7.2M	0.0%	-8.48%	34
JPMORGAN CHASE & CO	Increased	1M(+118.6%)	$7M	0.0%	-17.99%	44
Qube Research & Technologies Ltd	Increased	978,500(+58.0%)	$6.8M	0.0%	-0.95%	39
GEODE CAPITAL MANAGEMENT, LLC	Decreased	931,261(-2.0%)	$6.4M	0.0%	-50.73%	0
Woodline Partners LP	Unchanged	831,481	$5.8M	0.0%	-60.05%	0
STATE STREET CORP	Increased	766,323(+8.6%)	$5.3M	0.0%	-57.34%	29
VPVANGUARD PORTFOLIO MANAGEMENT LLC	Decreased	712,667(-2.1%)	$4.9M	0.0%	-3.13%	0
AQR CAPITAL MANAGEMENT LLC	Increased	544,869(+655.0%)	$3.8M	0.0%	+1.04%	43
MORGAN STANLEY	Decreased	524,632(-5.1%)	$3.6M	0.0%	-25.31%	0
BNP PARIBAS FINANCIAL MARKETS	Increased	511,546(+306.0%)	$3.5M	0.0%	+0.36%	43
Walleye Capital LLC	New	498,490	$3.4M	0.0%	+3.03%	37
Trexquant Investment LP	Increased	466,430(+164.0%)	$3.2M	0.0%	-15.27%	43
Point72 Asset Management, L.P.	Increased	453,011(+154.3%)	$3.1M	0.0%	+0.52%	43
BANK OF AMERICA CORP /DE/	Increased	391,762(+708.4%)	$2.7M	0.0%	-16.89%	42
DIMENSIONAL FUND ADVISORS LP	Increased	381,613(+377.0%)	$2.6M	0.0%	+1.68%	42
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	Increased	357,756(+93.3%)	$2.5M	0.0%	-0.25%	41

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer