Xenon Pharmaceuticals Inc. (XENE) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling XENE?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Xenon Pharmaceuticals Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on XENE?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Xenon Pharmaceuticals Inc..

Is institutional money flowing into XENE?

131 institutional investors hold Xenon Pharmaceuticals Inc. (XENE). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about XENE?

Track institutional sentiment and conviction scores for Xenon Pharmaceuticals Inc. (XENE) including Smart Money Verdict and position changes on HoldingsIntel.

Xenon Pharmaceuticals Inc.

XENE·98420N105·US·equity·Healthcare - Biotechnology-13D/G

XENE (Xenon Pharmaceuticals Inc.) is held by 131 institutional investors as of Q4 2025. Largest holders: FMR LLC ($399.8M), Avoro Capital Advisors LLC ($243.1M), BlackRock, Inc. ($228.6M). Net institutional sentiment: Mixed.

131

Holders

Avg rating(9 Elite)

$3B

Total Value

57% (137)

Fund Consensus

68 buying - 52 selling

Smart Money VerdictView all

46Weak MomentumSplit Signals

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See how XENE's score breaks down across 4 SEC sources

Held by 131 funds

9 elite

Who's Trading

InsiderMORTIMER IANSell $404KMar 13, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	8.9M(+0.0%)	$399.8M	0.0%	+15.98%	31
Avoro Capital Advisors LLC	Increased	5.4M(+0.5%)	$243.1M	2.4%	+103.80%	54
BlackRock, Inc.	Increased	5.1M(+6.9%)	$228.6M	0.0%	+23.94%	33
WELLINGTON MANAGEMENT GROUP LLP	Increased	4.8M(+32.0%)	$213.6M	0.0%	+5.20%	39
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	4.5M(+8.9%)	$203.4M	1.4%	+51.65%	53
JANUS HENDERSON GROUP PLC	Increased	4.1M(+3.5%)	$183.1M	0.1%	+13.67%	32
Capital International Investors	Increased	3.4M(+7.3%)	$153.1M	0.0%	+55.24%	33
Polar Capital Holdings Plc	Decreased	2.5M(-3.2%)	$110.5M	0.4%	+31.00%	0
ALLIANCEBERNSTEIN L.P.	Decreased	1.6M(-3.7%)	$71.4M	0.0%	+17.87%	0
JPMORGAN CHASE & CO	Increased	1.5M(+6.8%)	$67M	0.0%	+12.47%	32
STATE STREET CORP	Increased	1.5M(+1.8%)	$66.9M	0.0%	+23.73%	30
CITADEL ADVISORS LLC	Increased	1.3M(+37.8%)	$59.2M	0.0%	+9.29%	39
JENNISON ASSOCIATES LLC	Increased	1.3M(+13.8%)	$57.9M	0.0%	+6.59%	33
Holocene Advisors, LP	Decreased	1.3M(-35.1%)	$57.5M	0.1%	+32.85%	0
WESTFIELD CAPITAL MANAGEMENT CO LP	Increased	1.2M(+1.7%)	$55M	0.2%	+10.56%	36
GEODE CAPITAL MANAGEMENT, LLC	Decreased	952,679(-2.5%)	$42.7M	0.0%	+36.23%	0
FRANKLIN RESOURCES INC	Increased	758,059(+8.9%)	$34M	0.0%	+11.44%	32
Aberdeen Group plc	Increased	750,291(+29.6%)	$33.6M	0.1%	+13.33%	36
GOLDMAN SACHS GROUP INC	Decreased	696,047(-3.4%)	$31.2M	0.0%	+16.96%	0
Fiera Capital Corp	Increased	686,056(+31.9%)	$30.7M	0.1%	+9.80%	37
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	685,100(-18.0%)	$30.7M	0.0%	+24.58%	0
AMERICAN CENTURY COMPANIES INC	Increased	680,473(+3.2%)	$30.5M	0.0%	+33.65%	30
FEDERATED HERMES, INC.	Increased	672,237(+189.1%)	$30.1M	0.1%	-1.01%	46
VANGUARD GROUP INC	Decreased	664,641(-21.9%)	$29.8M	0.0%	+25.80%	0
Capital World Investors	Unchanged	655,737	$29.4M	0.0%	+67.32%	0
MILLENNIUM MANAGEMENT LLC	Decreased	635,056(-54.1%)	$28.5M	0.0%	+23.20%	0
Pictet Asset Management Holding SA	Decreased	625,985(-50.4%)	$28M	0.0%	+25.55%	0
LOOMIS SAYLES & CO L P	Decreased	612,032(-4.5%)	$27.4M	0.0%	+12.32%	0
BARCLAYS PLC	Increased	600,964(+439.9%)	$26.9M	0.0%	+4.02%	46
DIMENSIONAL FUND ADVISORS LP	Decreased	452,147(-0.4%)	$20.3M	0.0%	+23.40%	0
NORTHERN TRUST CORP	Decreased	438,714(-11.9%)	$19.7M	0.0%	+36.51%	0
TWO SIGMA INVESTMENTS, LP	New	436,743	$19.6M	0.0%	-0.75%	39
Candriam S.C.A.	Increased	417,402(+5.2%)	$18.7M	0.1%	+69.69%	30
Bank of New York Mellon Corp	Decreased	387,158(-7.5%)	$17.4M	0.0%	+38.25%	0
BAKER BROS. ADVISORS LP	Unchanged	370,208	$16.6M	0.1%	+104.80%	0
MORGAN STANLEY	Decreased	294,332(-19.7%)	$13.2M	0.0%	+29.36%	0
DnB Asset Management AS	Increased	272,831(+9.5%)	$12.2M	0.0%	+12.68%	31
TWO SIGMA ADVISERS, LP	Increased	259,320(+1332.7%)	$11.6M	0.0%	-0.36%	45
TUDOR INVESTMENT CORP ET AL	Increased	254,002(+230.6%)	$11.4M	0.0%	+2.82%	45
BANK OF AMERICA CORP /DE/	Increased	221,368(+11.2%)	$9.9M	0.0%	+23.84%	31
Nuveen, LLC	Decreased	216,238(-3.6%)	$9.7M	0.0%	+35.15%	0
STATE OF WISCONSIN INVESTMENT BOARD	Decreased	205,569(-1.4%)	$9.2M	0.0%	+26.00%	0
DEUTSCHE BANK AG\	Increased	190,233(+68.4%)	$8.5M	0.0%	+9.22%	41
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	189,059(+0.2%)	$8.5M	0.0%	+35.07%	27
NEW YORK STATE COMMON RETIREMENT FUND	Increased	186,705(+8.7%)	$8.4M	0.0%	+16.28%	30
Neuberger Berman Group LLC	Increased	178,747(+3.7%)	$8M	0.0%	+24.10%	28
Jain Global LLC	Decreased	173,882(-31.1%)	$7.8M	0.0%	+12.11%	0
MARSHALL WACE, LLP	Decreased	162,551(-73.4%)	$7.3M	0.0%	+34.62%	0
WELLS FARGO & COMPANY/MN	Increased	152,297(+32.2%)	$6.8M	0.0%	+20.49%	35
MOORE CAPITAL MANAGEMENT, LP	Unchanged	140,000	$6.3M	0.1%	+9.08%	0
Assenagon Asset Management S.A.	New	119,186	$5.3M	0.0%	-0.75%	37
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	Increased	116,088(+22.3%)	$5.2M	0.1%	+24.01%	33
Man Group plc	Increased	114,826(+396.7%)	$5.1M	0.0%	+4.86%	44
Swiss National Bank	Decreased	114,000(-9.8%)	$5.1M	0.0%	+72.46%	0
AMERIPRISE FINANCIAL INC	Increased	109,544(+12.3%)	$4.9M	0.0%	+15.16%	30
Verition Fund Management LLC	Increased	93,756(+64.2%)	$4.2M	0.0%	+6.71%	39
BNP PARIBAS FINANCIAL MARKETS	Decreased	93,462(-41.3%)	$4.2M	0.0%	+13.76%	0
RHUMBLINE ADVISERS	Decreased	90,143(-15.6%)	$4M	0.0%	+35.14%	0
ROYAL BANK OF CANADA	Decreased	89,757(-25.5%)	$4M	0.0%	+25.57%	0
Russell Investments Group, Ltd.	Increased	86,220(+23.4%)	$3.9M	0.0%	+14.91%	32
BALYASNY ASSET MANAGEMENT L.P.	Decreased	84,360(-73.8%)	$3.8M	0.0%	+12.44%	0
RAYMOND JAMES FINANCIAL INC	Increased	83,255(+19.1%)	$3.7M	0.0%	+17.99%	31
SCHRODER INVESTMENT MANAGEMENT GROUP	Unchanged	81,156	$3.6M	0.0%	+3.07%	0
LAZARD ASSET MANAGEMENT LLC	New	78,663	$3.5M	0.0%	-0.75%	37
Legal & General Group Plc	Decreased	70,265(-12.0%)	$3.1M	0.0%	+26.47%	0
ALPS ADVISORS INC	Increased	63,302(+69.7%)	$2.8M	0.0%	+12.31%	39
VOYA INVESTMENT MANAGEMENT LLC	Unchanged	60,858	$2.7M	0.0%	+22.26%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Decreased	56,564(-6.1%)	$2.5M	0.0%	+51.77%	0
UBS Group AG	Decreased	52,539(-50.8%)	$2.4M	0.0%	+28.54%	0
Invesco Ltd.	Decreased	50,947(-9.1%)	$2.3M	0.0%	+10.04%	0
Erste Asset Management GmbH	Unchanged	50,000	$2.2M	0.0%	+20.93%	0
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	New	47,957	$2.1M	0.0%	-0.75%	36
SEI INVESTMENTS CO	Increased	43,858(+95.6%)	$2M	0.0%	+13.68%	41
MetLife Investment Management, LLC	Decreased	42,025(-5.0%)	$1.9M	0.0%	+35.15%	0
TD ASSET MANAGEMENT INC	Increased	38,148(+135.1%)	$1.7M	0.0%	+4.34%	41
ENVESTNET ASSET MANAGEMENT INC	Decreased	35,801(-4.4%)	$1.6M	0.0%	+20.02%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	35,310(+0.0%)	$1.6M	0.0%	+35.14%	25
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	32,622(+36.3%)	$1.5M	0.0%	+23.28%	33
D. E. Shaw & Co., Inc.	Decreased	30,851(-36.3%)	$1.4M	0.0%	+16.41%	0
BAMCO INC /NY/	Unchanged	30,000	$1.3M	0.0%	+20.46%	0
INTECH INVESTMENT MANAGEMENT LLC	Increased	25,840(+11.9%)	$1.2M	0.0%	+30.14%	28
Zurcher Kantonalbank (Zurich Cantonalbank)	Unchanged	25,589	$1.1M	0.0%	+16.58%	0
Quantinno Capital Management LP	Increased	24,628(+84.2%)	$1.1M	0.0%	+5.84%	39
Rathbones Group PLC	Unchanged	23,666	$1.1M	0.0%	+28.19%	0
XTX Topco Ltd	New	21,498	$963,540	0.0%	-0.75%	35
ASSETMARK, INC	Decreased	21,269(-5.8%)	$953,277	0.0%	+10.77%	0
Police & Firemen's Retirement System of New Jersey	Decreased	20,128(-4.3%)	$902,137	0.0%	+30.47%	0
State of New Jersey Common Pension Fund D	Decreased	19,738(-64.6%)	$884,657	0.0%	+21.12%	0
Walleye Capital LLC	New	19,587	$877,889	0.0%	-0.75%	34
Creative Planning	Increased	19,200(+45.3%)	$860,544	0.0%	+7.75%	34
STIFEL FINANCIAL CORP	Decreased	17,548(-6.2%)	$786,510	0.0%	+53.46%	0
ProShare Advisors LLC	Increased	17,279(+9.8%)	$774,446	0.0%	+30.94%	27
Arizona State Retirement System	Decreased	16,179(-16.1%)	$725,143	0.0%	+22.56%	0
Orion Porfolio Solutions, LLC	Decreased	14,407(-3.4%)	$645,709	0.0%	+11.13%	0
CIBC WORLD MARKET INC.	Unchanged	13,460	$603,277	0.0%	+28.26%	0
KLP KAPITALFORVALTNING AS	Decreased	12,300(-3.9%)	$551,286	0.0%	+13.65%	0
Marex Group plc	New	10,557	$473,165	0.0%	-0.75%	33
Allianz Asset Management GmbH	Unchanged	9,400	$421,308	0.0%	+21.02%	0
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	8,632(-46.0%)	$386,886	0.0%	+19.70%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Decreased	8,319(-81.9%)	$372,858	0.0%	+35.15%	0
CITIGROUP INC	Decreased	7,361(-50.5%)	$329,920	0.0%	+30.64%	0
PNC FINANCIAL SERVICES GROUP, INC.	Increased	6,574(+11.4%)	$294,646	0.0%	+6.31%	26
FIRST TRUST ADVISORS LP	New	6,361	$285,100	0.0%	-0.75%	32
XPONANCE LLC	Increased	5,975(+0.1%)	$267,800	0.0%	+12.09%	23
Ensign Peak Advisors, Inc	Decreased	5,194(-65.9%)	$232,795	0.0%	+26.63%	0
Magnetar Financial LLC	New	5,153	$230,958	0.0%	-0.75%	32
CIBC WORLD MARKETS CORP	Decreased	5,027(-46.3%)	$225,310	0.0%	+35.15%	0
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	Unchanged	5,000	$224,100	0.0%	+11.07%	0
MACKENZIE FINANCIAL CORP	New	4,772	$210,126	0.0%	-0.75%	32
Amundi	New	4,609	$206,575	0.0%	-0.75%	32
Vanguard Personalized Indexing Management, LLC	New	4,533	$203,169	0.0%	-0.75%	32
PRINCIPAL FINANCIAL GROUP INC	Decreased	4,488(-22.9%)	$201,152	0.0%	+12.11%	0
Mirae Asset Global Investments Co., Ltd.	Increased	3,755(+26.0%)	$168,299	0.0%	+11.50%	28
Corient Private Wealth LLC	New	25,109	$143,380	0.0%	-0.75%	31
STRS OHIO	New	1,300	$58,266	0.0%	-0.75%	29
Rockefeller Capital Management L.P.	Increased	1,100(+450.0%)	$49,302	0.0%	+1.37%	33
BNP Paribas Asset Management Holding S.A.	Increased	1.1M(+58.2%)	$47,519	0.1%	+3.99%	29
Farther Finance Advisors, LLC	Increased	1,058(+25.1%)	$47,420	0.0%	+24.62%	25
NISA INVESTMENT ADVISORS, LLC	Unchanged	924	$41,414	0.0%	+28.44%	0
PRICE T ROWE ASSOCIATES INC /MD/	Increased	862,300(+1968.3%)	$38,650	0.0%	+0.48%	32
DANSKE BANK A/S	Unchanged	800	$35,856	0.0%	+35.15%	0
Kestra Advisory Services, LLC	New	740	$33,167	0.0%	-0.75%	27
OSAIC HOLDINGS, INC.	Decreased	319(-76.8%)	$14,297	0.0%	+30.28%	0
Mitsubishi UFJ Asset Management Co., Ltd.	Unchanged	276	$12,279	0.0%	+1.72%	0
MAI Capital Management	New	261	$11,699	0.0%	-0.75%	24
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	New	236	$10,578	0.0%	-0.75%	26
NATIONAL BANK OF CANADA /FI/	Decreased	190(-5.0%)	$8,516	0.0%	+12.31%	0
US BANCORP \DE\	Unchanged	175	$7,844	0.0%	+0.48%	0
JONES FINANCIAL COMPANIES LLLP	New	150	$6,723	0.0%	-0.75%	24
Allworth Financial LP	Decreased	116(-7.9%)	$5,200	0.0%	+15.30%	0
RENAISSANCE TECHNOLOGIES LLC	Exited	0(-100.0%)	$208,780	0.0%	+26.99%	0
PRUDENTIAL FINANCIAL INC	Exited	0(-100.0%)	$355,328	0.0%	+16.05%	0
GROUP ONE TRADING LLC	Exited	0(-100.0%)	$142,773	0.0%	+36.17%	0
NOMURA ASSET MANAGEMENT CO LTD	Unchanged	0	$0	0.0%	+45.39%	0
Freestone Grove Partners LP	Exited	0(-100.0%)	$270,932	0.0%	+12.95%	0
Schonfeld Strategic Advisors LLC	Exited	0(-100.0%)	$507,977	0.0%	+31.40%	0
JANE STREET GROUP, LLC	Exited	0(-100.0%)	$3.6M	0.0%	+23.16%	0

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