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Showing 8 of 31 quarters

Position history for TWO SIGMA INVESTMENTS, LPTWO SIGMA INVESTMENTS, LP's holdings in IONIS PHARMACEUTICALS INC

Yes. Two Sigma holds 6,252,342 shares of IONS (Ionis Pharmaceuticals), worth $495.7M, as of its Q2 2026 13F filing. It increased the position by 394,713 shares (+6.7%) from Q1 2026. Two Sigma has held IONS in every 13F on record since Q4 2018, 31 quarterly filings. IONS is 0.4% of Two Sigma's reported 13F portfolio.

Current Value

$495.7M

Current Shares

6.3M

Total Value Change

+$458.9M

Total Shares Change

+5.3M

Quarter-by-Quarter History
QuarterActionSharesChangeValueWeightPriceConviction
2026-Q2
Latest
Increased
6.3M
+6.7%
$495.7M0.4%$79.29
40
2026-Q1
Increased
5.9M
+120.3%
$439.8M0.4%$75.09
60
2025-Q4
Increased
2.7M
+68.7%
$210.3M0.3%$79.11
54
2025-Q3
Decreased
1.6M
-11.9%
$103.1M0.2%$65.42
0
2025-Q2
Increased
1.8M
+6.1%
$70.7M0.1%$39.51
38
2025-Q1
Increased
1.7M
+83.0%
$50.9M0.1%$30.17
54
2024-Q4
Increased
921,439
+0.3%
$32.2M0.1%$34.96
29
2024-Q3
Decreased
919,077
-10.6%
$36.8M0.1%$40.06
0

Other major holders of IONS: FMR LLC, Capital World Investors

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