Back to TWO SIGMA INVESTMENTS, LP TWO SIGMA INVESTMENTS, LP

KPTIKPTI
28 quarters

Position history for TWO SIGMA INVESTMENTS, LPTWO SIGMA INVESTMENTS, LP's holdings in KARYOPHARM THERAPEUTICS INC

TWO SIGMA INVESTMENTS, LP holds 151,232 shares of KPTI (KARYOPHARM THERAPEUTICS INC), worth $842,362 as of 2026-Q1. The position was increased (+1.6% shares). KPTI represents 0.0% of TWO SIGMA INVESTMENTS, LP's portfolio.

Current Value

$842,362

Current Shares

151,232

Total Value Change

-$4.9M

Total Shares Change

-459,921

Quarter-by-Quarter History
QuarterActionSharesChangeValueWeightPriceConviction
2026-Q1
Latest
Increased
151,232
+1.6%
$842,3620.0%$9.13
25
2025-Q4
New
148,793
-
$1.1M0.0%$7.31
35
2025-Q1
Exited
0
-100.0%
$00.0%$4.16
0
2024-Q4
Increased
137,786
+60.4%
$93,1850.0%$10.50
31
2024-Q3
Increased
85,930
+519.7%
$71,3220.0%$10.86
34
2024-Q2
Increased
13,866
+1.3%
$12,0300.0%$13.02
12
2024-Q1
Decreased
13,691
-90.4%
$20,6730.0%$22.65
0
2023-Q4
New
142,274
-
$123,0670.0%$12.98
31
2023-Q3
Exited
0
-100.0%
$00.0%$20.10
0
2023-Q2
New
347,555
-
$622,1230.0%$27.45
34
2023-Q1
Exited
0
-100.0%
$00.0%$52.80
0
2022-Q4
Increased
265,308
+16.2%
$902,0470.0%$51.00
29
2022-Q3
Decreased
228,335
-77.7%
$1.2M0.0%$80.55
0
2022-Q2
Decreased
1M
-8.4%
$4.6M0.0%$67.65
0
2022-Q1
Increased
1.1M
+13.0%
$8.2M0.0%$110.25
31
2021-Q4
Decreased
989,031
-9.8%
$6.4M0.0%$100.80
0
2021-Q3
Increased
1.1M
+29.6%
$6.4M0.0%$88.35
34
2021-Q2
Decreased
846,118
-43.3%
$8.7M0.0%$154.05
0
2021-Q1
Increased
1.5M
+3611.9%
$15.7M0.0%$149.32
45
2020-Q4
Decreased
40,212
-96.9%
$622,0000.0%$229.50
0
2020-Q3
Increased
1.3M
+446.2%
$18.8M0.1%$218.85
46
2020-Q2
Decreased
235,734
-46.1%
$4.5M0.0%$270.00
0
2020-Q1
Decreased
437,622
-41.9%
$8.4M0.1%$300.30
0
2019-Q4
Increased
753,334
+3368.7%
$14.4M0.0%$284.10
45
2019-Q3
Decreased
21,718
-64.9%
$209,0000.0%$147.30
0
2019-Q2
Decreased
61,904
-82.2%
$371,0000.0%$89.85
0
2019-Q1
Decreased
346,787
-43.3%
$2M0.0%$87.60
0
2018-Q4
New
611,153
-
$5.7M0.0%$136.95
37

Other major holders of KPTI: Avoro Capital Advisors LLC, ADAGE CAPITAL PARTNERS GP, L.L.C.

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