KARYOPHARM THERAPEUTICS INC

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KPTI·48576U205·US·Common Stock·Healthcare - Biotechnology-13D/G

KPTI (KARYOPHARM THERAPEUTICS INC) is held by 44 institutional investors as of Q1 2026. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($10.7M), ADAGE CAPITAL PARTNERS GP, L.L.C. ($10.1M), GOLDMAN SACHS GROUP INC ($5.3M). Net institutional sentiment: Bullish.

44

Holders

(1 Elite)

$47.8M

Total Value

74% (46)

Consensus

34 buying - 12 selling

13F: Mar 31, 2026Insider & Congress: Updated regularly

Smart Money Verdict

View all

Institutional (13F)25

Insider (Form 4)37

Activist (13D/13G)37

Congressional (STOCK Act)69

Holder Quality

15

★★★★★

Elite

79

★★★★

Strong

23

★★★

Solid

61

★★

Below

48

★

Weak

Held by 44 funds

1 elite

Who's Trading

ActivistBlackRock, Inc.5.6%Jul 28, 2026

ActivistTRT. Rowe Price Investment Management, Inc.6.6%Jun 5, 2026

ActivistIKIkarian Capital, LLC0.0%May 15, 2026

InsiderPSPoulton StuartSell $4KMay 14, 2026

InsiderMMMano MichaelSell $3KMay 14, 2026

ActivistAAAffinity Asset Advisors, LLC8.6%May 14, 2026

ActivistADAdage Capital Management, L.P.8.1%May 13, 2026

InsiderRRRangwala ReshmaSell $4KApr 21, 2026

InsiderPAPaulson Richard A.Sell $116KMar 2, 2026

CongressAshley MoodySale $1,001 - $15,000Feb 20, 2025

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Top Holders

Top Holders (44)History

AllNewIncreasedHeldDecreasedExited

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	New	1.9M	$10.7M	0.1%	—	46
AGADAGE CAPITAL PARTNERS GP, L.L.C.	Increased	1.8M(+328.7%)	$10.1M	0.0%	—	45
GOLDMAN SACHS GROUP INC	New	947,579	$5.3M	0.0%	—	37
VAVANGUARD CAPITAL MANAGEMENT LLC	New	739,745	$4.1M	0.0%	—	37
MILLENNIUM MANAGEMENT LLC	New	420,571	$2.3M	0.0%	—	36
Trexquant Investment LP	Increased	257,903(+518.0%)	$1.4M	0.0%	—	41
BlackRock, Inc.	Decreased	244,899(-1.1%)	$1.4M	0.0%	—	0
Brevan Howard Capital Management LP	New	212,367	$1.2M	0.0%	—	35
GEODE CAPITAL MANAGEMENT, LLC	Increased	206,133(+9.8%)	$1.1M	0.0%	—	28
UBS Group AG	Increased	194,017(+119.3%)	$1.1M	0.0%	—	41
GROUP ONE TRADING LLC	Increased	191,527(+87.0%)	$1.1M	0.0%	—	39
XTX Topco Ltd	Increased	164,443(+1281.4%)	$915,948	0.0%	—	40
TWO SIGMA INVESTMENTS, LP	Increased	151,232(+1.6%)	$842,362	0.0%	—	25
MWMARSHALL WACE, LLP	Unchanged	128,451	$715,472	0.0%	—	0
VFVANGUARD FIDUCIARY TRUST CO	New	114,934	$640,182	0.0%	—	34
EGEngineers Gate Manager LP	New	112,432	$626,246	0.0%	—	34
JANE STREET GROUP, LLC	Increased	105,901(+198.0%)	$589,868	0.0%	—	39
RENAISSANCE TECHNOLOGIES LLC	Increased	105,414(+75.9%)	$587,156	0.0%	—	37
STATE STREET CORP	Increased	80,742(+37.0%)	$449,733	0.0%	—	21
Connor, Clark & Lunn Investment Management Ltd.	Increased	79,081(+38.2%)	$440,481	0.0%	—	31

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KPTIKARYOPHARM THERAPEUTICS INC

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer