KARYOPHARM THERAPEUTICS INC

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KPTI·48576U205·US·Common Stock·Healthcare - Biotechnology-13D/G

KPTI (KARYOPHARM THERAPEUTICS INC) is held by 60 institutional investors as of Q2 2026. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($18.7M), ADAGE CAPITAL PARTNERS GP, L.L.C. ($14.9M), GOLDMAN SACHS GROUP INC ($13.9M). Net institutional sentiment: Bullish.

60

Holders

(3 Elite)

$121.3M

Total Value

78% (60)

Consensus

47 buying - 13 selling

13F: Jun 30, 2026Insider & Congress: Updated regularly

Smart Money Verdict

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Institutional (13F)25

Insider (Form 4)37

Activist (13D/13G)37

Congressional (STOCK Act)69

Holder Quality

15

★★★★★

Elite

79

★★★★

Strong

23

★★★

Solid

61

★★

Below

48

★

Weak

Held by 60 funds

3 elite

Who's Trading

Source dates: Price Sep 21, 2026 · Insiders Sep 2, 2026 · Activists Sep 4, 2026 · Congress none

ActivistICIntegrated Core Strategies (US) LLC5.7%Sep 4, 2026

InsiderAKAbate KristinSell $38.38Sep 1, 2026

ActivistCOCommodore Capital LP0.0%Aug 14, 2026

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Top Holders

Top Holders (60)History

AllNewIncreasedHeldDecreasedExited

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Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	1.9M	$18.7M	0.2%	-83.13%	0
AGADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	1.5M(-15.8%)	$14.9M	0.0%	-85.34%	0
GOLDMAN SACHS GROUP INC	Increased	1.4M(+50.4%)	$13.9M	0.0%	-83.52%	39
BlackRock, Inc.	Increased	1.4M(+479.3%)	$13.9M	0.0%	-84.38%	45
VAVANGUARD CAPITAL MANAGEMENT LLC	Increased	958,979(+29.6%)	$9.4M	0.0%	-83.40%	35
TWO SIGMA INVESTMENTS, LP	Increased	695,264(+359.7%)	$6.8M	0.0%	-83.34%	44
GEODE CAPITAL MANAGEMENT, LLC	Increased	531,231(+157.7%)	$5.2M	0.0%	-94.16%	44
UBS Group AG	Increased	353,545(+82.2%)	$3.5M	0.0%	-85.83%	41
STATE STREET CORP	Increased	325,991(+303.7%)	$3.2M	0.0%	-84.27%	43
Brevan Howard Capital Management LP	Increased	309,817(+45.9%)	$3M	0.0%	-83.50%	36
MILLENNIUM MANAGEMENT LLC	Decreased	305,676(-27.3%)	$3M	0.0%	-83.13%	0
JPMORGAN CHASE & CO	Increased	207,609(+440x)	$2.1M	0.0%	-84.23%	42
MORGAN STANLEY	Increased	202,506(+990.5%)	$2M	0.0%	-83.98%	42
Trexquant Investment LP	Decreased	188,368(-27.0%)	$1.8M	0.0%	-82.57%	0
BNP PARIBAS FINANCIAL MARKETS	Increased	188,038(+2238x)	$1.8M	0.0%	-84.25%	42
BARCLAYS PLC	Increased	165,904(+2134.7%)	$1.6M	0.0%	-85.91%	41
NORTHERN TRUST CORP	Increased	160,006(+315.0%)	$1.6M	0.0%	-91.56%	41
VFVANGUARD FIDUCIARY TRUST CO	Increased	145,401(+26.5%)	$1.4M	0.0%	-83.38%	31
VPVANGUARD PORTFOLIO MANAGEMENT LLC	New	134,818	$1.3M	0.0%	-84.24%	35
MWMARSHALL WACE, LLP	Unchanged	128,451	$1.3M	0.0%	-95.89%	0

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KPTIKARYOPHARM THERAPEUTICS INC

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High Conviction Moves-Smart Money Convergence-Fund Consensus-Double-Down Detection

Data sourced from four public-disclosure sources: SEC 13F, Form 4, 13D/13G, and House/Senate STOCK Act disclosures. Not financial advice. Full disclaimer