RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q1 2021

SEC EDGAR SourceSEC Filings

Top Holdings82 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
ASNDASND
ADR

ASCENDIS PHARMA A/S

6.4M$826.4M12.5%$86.94+47.98%
10 qtrssince 2018-Q4
Increased
68

NOVAVAX INC

3M$544.3M8.2%$107.78+60.81%
4 qtrssince 2020-Q2
Decreased
0

Vor Biopharma Inc.

11.1M$479.3M7.2%

ATEA PHARMACEUTICALS INC

5.4M$331.5M5.0%$41.71+34.81%
2 qtrssince 2020-Q4
Unchanged
0
FMTXFMTXDelisted

FORMA THERAPEUTICS HLDGS INC

9M$252.5M3.8%
4 qtrssince 2020-Q2
Unchanged
0

TG Therapeutics, Inc.

4.6M$223.5M3.4%$8.58+427.48%
10 qtrssince 2018-Q4
Decreased
0

NKARTA INC

5.6M$184.4M2.8%$30.36+3.19%
3 qtrssince 2020-Q3
Unchanged
0
3.6M$182.3M2.7%
6 qtrssince 2019-Q4
Decreased
0

MACROGENICS INC

4.9M$157.1M2.4%$28.60+8.74%
4 qtrssince 2020-Q2
Increased
59
ITOSITOSDelisted

ITEOS THERAPEUTICS INC

4.4M$151M2.3%
3 qtrssince 2020-Q3
Unchanged
0

IMMUNOGEN INC

18.4M$149.2M2.2%
3 qtrssince 2020-Q3
Unchanged
0

TRAVERE THERAPEUTICS INC

5.6M$140.2M2.1%$26.96-9.79%
2 qtrssince 2020-Q4
Increased
63

Instil Bio, Inc.

4.9M$122.2M1.8%

PHATHOM PHARMACEUTICALS INC

3.1M$117M1.8%$32.43+11.97%
6 qtrssince 2019-Q4
Decreased
0
ETNBETNBDelisted

89BIO INC

4.7M$112.2M1.7%
6 qtrssince 2019-Q4
Unchanged
0
KNTEKNTEDelisted

KINNATE BIOPHARMA INC

3.6M$112M1.7%
2 qtrssince 2020-Q4
Unchanged
0

RHYTHM PHARMACEUTICALS INC

4.9M$103.6M1.6%$23.37-13.02%
10 qtrssince 2018-Q4
Increased
55
ZGNXZGNXDelisted

ZOGENIX INC

5.3M$103.1M1.6%
10 qtrssince 2018-Q4
Decreased
0

AXSOME THERAPEUTICS INC

1.7M$93.7M1.4%$50.95+9.73%
9 qtrssince 2019-Q1
Unchanged
0

ROCKET PHARMACEUTICALS INC

2.1M$93.5M1.4%$56.05-22.68%
2 qtrssince 2020-Q4
Decreased
0
$6.6B
AUM
82
Positions
Q1 2021
Filing
Rating · 2.0
Quarterly Portfolio Change
+96%Q4'19$3.3B-4%Q1'20$3.2B+62%Q2'20$5.1B+7%Q3'20$5.5B+31%Q4'20$7.2B-7%Q1'21$6.6B
Activity profile
$ moved · Q1'21
New39%Increased10%Decreased19%Exited32%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.9 quarters
<1Q21%1-4Q50%1-2Y16%2Y+13%

RA CAPITAL MANAGEMENT, L.P. manages $6.6B across 82 positions as of Q1 2021. Top holdings: ASND (12.5%), NVAX (8.2%), VOR (7.2%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 2/5.0.

Q1 2021 Summary

Active quarter - 19 new positions, 19 exits, 9 increased. Top move: ASND (INCREASED, conviction 68). Portfolio: $6.6B across 82 positions.

Top holdings by portfolio weight

Total AUM$7B
ASND12.46%
NVAX8.21%
VOR7.23%
AVIR5.00%
FMTX3.81%
TGTX3.37%
NKTX2.78%
CHEMOCENTRYX2.75%
MGNX2.37%
ITOS2.28%
Other2.25%

Portfolio allocation by GICS sector

Sectors2
Healthcare73.09%
Unknown26.91%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Below Average(2.0 / 5.0)
Track Record47
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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