Duquesne Family Office LLC
Institutional investor · Portfolio as of Q4 2025
Top Holdings62 positions
NATERA INC | 2.5M | $575.3M | 12.8% | $98.78 | +131.92% | 14 qtrssince 2022-Q3 | Decreased 0 |
SELECT SECTOR SPDR TR | 5.5M | $301M | 6.7% | $55.18 | -0.82% | 1 qtr | New 95 |
INSMED INC | 1.5M | $257.9M | 5.7% | $88.13 | +97.47% | 7 qtrssince 2024-Q2 | Decreased 0 |
INVESCO S&P 500 EQUAL WEIGHT ETF | 1.2M | $224.9M | 5.0% | $189.30 | 0.00% | 1 qtr | New 95 |
TEVA PHARMACEUTICAL INDS LTD | 5.9M | $183.4M | 4.1% | $18.91 | +65.01% | 6 qtrssince 2024-Q3 | Decreased 0 |
WOODWARD INC | 590,930 | $178.7M | 4.0% | $149.59 | +101.58% | 9 qtrssince 2023-Q4 | Decreased 0 |
Amazon.com, Inc. | 737,940 | $170.3M | 3.8% | $226.39 | +2.71% | 2 qtrssince 2025-Q3 | Increased 83 |
TAIWAN SEMICONDUCTOR MFG LTD | 543,085 | $165M | 3.7% | $178.70 | +68.73% | 6 qtrssince 2024-Q3 | Decreased 0 |
COUPANG INC CL A | 6.8M | $159.8M | 3.6% | $30.64 | -23.01% | 20 qtrssince 2021-Q1 | Increased 76 |
ISHARES INC | 4.2M | $134.3M | 3.0% | — | — | — | New — |
Alphabet Inc. | 385,000 | $120.5M | 2.7% | $293.83 | +6.32% | 2 qtrssince 2025-Q3 | Increased 83 |
SEA LTD SPONSORD ADS | 944,120 | $120.4M | 2.7% | $136.97 | -6.86% | 3 qtrssince 2025-Q2 | Increased 83 |
ISHARES INC | 3.6M | $112.9M | 2.5% | $31.47 | 0.00% | 1 qtr | New 78 |
NEWAMSTERDAM PHARMA COMPANY NV ORDINARY SHARES | 3.1M | $107.7M | 2.4% | $28.37 | +23.64% | 6 qtrssince 2024-Q3 | Increased 74 |
Mercadolibre Inc | 47,149 | $95M | 2.1% | $1,785.15 | +12.83% | 7 qtrssince 2024-Q2 | Decreased 0 |
BBB FOODS INC CL A COM | 2.7M | $89.3M | 2.0% | $30.65 | +8.93% | 3 qtrssince 2025-Q2 | Increased 76 |
RESTAURANT BRANDS INTL INC | 1.2M | $82.5M | 1.8% | $63.09 | +5.28% | 3 qtrssince 2025-Q2 | Increased 50 |
COGENT BIOSCIENCES INC COM | 2.2M | $78.7M | 1.8% | $26.12 | +18.68% | 2 qtrssince 2025-Q3 | Increased 76 |
ALCOA CORP | 1.4M | $73.1M | 1.6% | $52.87 | 0.00% | 1 qtr | New 68 |
Entegris Inc | 844,160 | $71.1M | 1.6% | $84.05 | 0.00% | 1 qtr | New 68 |
Duquesne Family Office LLC manages $4.5B across 62 positions as of Q4 2025. Top holdings: NTRA (12.8%), XLF (6.7%), INSM (5.7%). Fund DNA: Momentum Trader. HoldingsIntel Score: 1.5/5.0.
Active quarter - 26 new positions, 30 exits, 13 increased. Top move: XLF (NEW, conviction 95). Portfolio: $4.5B across 62 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
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Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
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