Tyra Biosciences, Inc. (TYRA) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling TYRA?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Tyra Biosciences, Inc., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on TYRA?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Tyra Biosciences, Inc..

Is institutional money flowing into TYRA?

77 institutional investors hold Tyra Biosciences, Inc. (TYRA). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about TYRA?

Track institutional sentiment and conviction scores for Tyra Biosciences, Inc. (TYRA) including Smart Money Verdict and position changes on HoldingsIntel.

Tyra Biosciences, Inc.

TYRA·90240B106·US·equity·Healthcare - Biotechnology-Activist

TYRA (Tyra Biosciences, Inc.) is held by 77 institutional investors as of Q4 2025. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($320.7M), JANUS HENDERSON GROUP PLC ($77.1M), BlackRock, Inc. ($54.9M). Net institutional sentiment: Mixed.

Holders

Avg rating(4 Elite)

$724.5M

Total Value

60% (84)

Fund Consensus

45 buying - 30 selling

Smart Money VerdictView all

47Weak MomentumSplit Signals

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See how TYRA's score breaks down across 4 SEC sources

Held by 77 funds

4 elite

Who's Trading

ActivistFMR LLC14.4%Apr 7, 2026

Insider

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Unchanged	12.2M	$320.7M	3.3%	+109.95%	0
JANUS HENDERSON GROUP PLC	Increased	2.9M(+2.1%)	$77.1M	0.0%	+106.73%	30
BlackRock, Inc.	Increased	2.1M(+11.6%)	$54.9M	0.0%	+125.30%	33
FARALLON CAPITAL MANAGEMENT LLC	Increased	2.1M(+80.7%)	$54.3M	0.3%	+75.88%	54
VANGUARD GROUP INC	Increased	1.6M(+3.5%)	$41.3M	0.0%	+57.92%	30
Point72 Asset Management, L.P.	Increased	874,192(+210.0%)	$23M	0.0%	+60.69%	46
BALYASNY ASSET MANAGEMENT L.P.	Decreased	818,326(-3.3%)	$21.5M	0.0%	+211.47%	0
STATE STREET CORP	Increased	749,463(+74.9%)	$19.7M	0.0%	+71.42%	43
MARSHALL WACE, LLP	Increased	711,891(+18.3%)	$18.7M	0.0%	+143.08%	33
GEODE CAPITAL MANAGEMENT, LLC	Increased	657,756(+10.1%)	$17.3M	0.0%	+120.98%	31
NORTHERN TRUST CORP	Decreased	200,956(-3.6%)	$5.3M	0.0%	+98.26%	0
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	199,426(-1.1%)	$5.2M	0.0%	+137.01%	0
GOLDMAN SACHS GROUP INC	Increased	182,387(+82.1%)	$4.8M	0.0%	+82.21%	41
RAYMOND JAMES FINANCIAL INC	Increased	170,032(+34.5%)	$4.5M	0.0%	+101.40%	35
JACOBS LEVY EQUITY MANAGEMENT, INC	Decreased	129,753(-48.4%)	$3.4M	0.0%	+171.39%	0
Invesco Ltd.	Increased	129,435(+734.5%)	$3.4M	0.0%	+37.63%	43
BNP PARIBAS FINANCIAL MARKETS	Decreased	120,278(-6.7%)	$3.2M	0.0%	+211.07%	0
MORGAN STANLEY	Decreased	118,898(-63.1%)	$3.1M	0.0%	+208.65%	0
MILLENNIUM MANAGEMENT LLC	Decreased	114,388(-20.6%)	$3M	0.0%	+150.03%	0
TWO SIGMA INVESTMENTS, LP	Decreased	107,023(-46.3%)	$2.8M	0.0%	+156.40%	0
WELLINGTON MANAGEMENT GROUP LLP	Increased	104,305(+25.9%)	$2.7M	0.0%	+144.81%	32
DIMENSIONAL FUND ADVISORS LP	Increased	95,640(+141.0%)	$2.5M	0.0%	+55.93%	42
BARCLAYS PLC	Increased	76,309(+33.6%)	$2M	0.0%	+77.84%	33
JPMORGAN CHASE & CO	Decreased	71,175(-4.1%)	$1.9M	0.0%	+152.23%	0
Bank of New York Mellon Corp	Increased	60,901(+6.5%)	$1.6M	0.0%	+159.55%	27
TWO SIGMA ADVISERS, LP	Decreased	58,900(-48.0%)	$1.5M	0.0%	+205.16%	0
UBS Group AG	Decreased	58,856(-0.5%)	$1.5M	0.0%	+128.77%	0
SUSQUEHANNA INTERNATIONAL GROUP, LLP	New	55,135	$1.4M	0.0%	+29.76%	35
AMERIPRISE FINANCIAL INC	Decreased	54,625(-37.3%)	$1.4M	0.0%	+250.66%	0
Squarepoint Ops LLC	Increased	54,424(+345.6%)	$1.4M	0.0%	+51.61%	41
Nuveen, LLC	Decreased	47,349(-41.1%)	$1.2M	0.0%	+246.87%	0
AMERICAN CENTURY COMPANIES INC	Increased	46,227(+20.4%)	$1.2M	0.0%	+106.31%	30
ALPS ADVISORS INC	Increased	43,827(+77.4%)	$1.2M	0.0%	+103.38%	38
ExodusPoint Capital Management, LP	New	42,791	$1.1M	0.0%	+29.76%	35
STATE OF WISCONSIN INVESTMENT BOARD	Increased	39,023(+31.6%)	$1M	0.0%	+100.14%	32
RHUMBLINE ADVISERS	Decreased	38,790(-4.5%)	$1M	0.0%	+210.63%	0
BANK OF AMERICA CORP /DE/	Decreased	38,310(-71.5%)	$1M	0.0%	+230.68%	0
ALLIANCEBERNSTEIN L.P.	Decreased	31,990(-3.8%)	$841,017	0.0%	+164.15%	0
XTX Topco Ltd	Decreased	30,414(-9.8%)	$799,584	0.0%	+262.75%	0
VOYA INVESTMENT MANAGEMENT LLC	New	29,887	$785,729	0.0%	+29.76%	34
WELLS FARGO & COMPANY/MN	Increased	29,049(+57.3%)	$763,698	0.0%	+92.02%	35
CANADA PENSION PLAN INVESTMENT BOARD	New	28,900	$759,781	0.0%	+29.76%	34
Fisher Asset Management, LLC	New	28,800	$757,152	0.0%	+29.76%	34
AQR CAPITAL MANAGEMENT LLC	Increased	28,631(+2.0%)	$752,707	0.0%	+250.40%	25
Creative Planning	New	19,603	$515,363	0.0%	+29.76%	33
VICTORY CAPITAL MANAGEMENT INC	Unchanged	18,790	$493,989	0.0%	+127.44%	0
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	Decreased	18,542(-25.7%)	$487,469	0.0%	+224.10%	0
DEUTSCHE BANK AG\	Increased	16,377(+5.8%)	$430,551	0.0%	+104.06%	25
Rafferty Asset Management, LLC	New	15,455	$406,312	0.0%	+29.76%	33
MetLife Investment Management, LLC	Increased	15,356(+5.0%)	$403,709	0.0%	+117.13%	25
Russell Investments Group, Ltd.	Increased	12,996(+2.0%)	$341,664	0.0%	+135.78%	24
FRANKLIN RESOURCES INC	New	12,970	$340,981	0.0%	+29.76%	33
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	12,908(+14.1%)	$338,585	0.0%	+78.03%	27
FMR LLC	Increased	12,563(+0.3%)	$330,280	0.0%	+137.22%	16
BANK OF NOVA SCOTIA	New	11,100	$291,819	0.0%	+29.76%	32
BAKER BROS. ADVISORS LP	Unchanged	10,607	$278,858	0.0%	+138.34%	0
INTECH INVESTMENT MANAGEMENT LLC	Decreased	9,801(-14.0%)	$257,668	0.0%	+245.39%	0
MANUFACTURERS LIFE INSURANCE COMPANY, THE	New	8,357	$219,706	0.0%	+29.76%	32
NEW YORK STATE COMMON RETIREMENT FUND	Unchanged	7,423	$195,151	0.0%	+111.05%	0
Police & Firemen's Retirement System of New Jersey	Unchanged	6,440	$169,308	0.0%	+139.72%	0
CITIGROUP INC	Increased	3,817(+123.6%)	$100,349	0.0%	+62.78%	24
Mirae Asset Global Investments Co., Ltd.	Increased	2,594(+25.9%)	$68,196	0.0%	+111.67%	26
Legal & General Group Plc	Increased	2,367(+8.0%)	$62,228	0.0%	+53.98%	15
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	1,595(+8.3%)	$41,933	0.0%	+47.21%	15
FEDERATED HERMES, INC.	Decreased	1,297(-39.8%)	$34,098	0.0%	+137.71%	0
OSAIC HOLDINGS, INC.	Decreased	1,188(-0.3%)	$31,232	0.0%	+216.12%	0
ROYAL BANK OF CANADA	Decreased	742(-35.8%)	$19,000	0.0%	+254.93%	0
STRS OHIO	Unchanged	700	$18,403	0.0%	+101.28%	0
PNC FINANCIAL SERVICES GROUP, INC.	Unchanged	208	$5,469	0.0%	+178.37%	0
BNP Paribas Asset Management Holding S.A.	New	129,779	$3,412	0.0%	+29.76%	19
Optiver Holding B.V.	Decreased	128(-65.2%)	$3,365	0.0%	+148.20%	0
Allworth Financial LP	Unchanged	100	$2,629	0.0%	+237.87%	0
NISA INVESTMENT ADVISORS, LLC	Unchanged	86	$2,261	0.0%	+222.34%	0
Rockefeller Capital Management L.P.	New	84	$2,208	0.0%	+29.76%	18
Steward Partners Investment Advisory, LLC	New	77	$2,024	0.0%	+29.76%	17
Farther Finance Advisors, LLC	Increased	60(+445.4%)	$1,577	0.0%	+42.20%	12
PRICE T ROWE ASSOCIATES INC /MD/	Increased	14,432(+12.7%)	$380	0.0%	+195.44%	9
Trexquant Investment LP	Exited	0(-100.0%)	$220,454	0.0%	+179.56%	0
TUDOR INVESTMENT CORP ET AL	Exited	0(-100.0%)	$150,546	0.0%	+62.49%	0
Walleye Capital LLC	Exited	0(-100.0%)	$4.2M	0.0%	+123.87%	0
CITADEL ADVISORS LLC	Exited	0(-100.0%)	$1.6M	0.0%	+121.09%	0
JANE STREET GROUP, LLC	Exited	0(-100.0%)	$625,073	0.0%	+167.76%	0
Brevan Howard Capital Management LP	Exited	0(-100.0%)	$435,103	0.0%	+160.39%	0
RENAISSANCE TECHNOLOGIES LLC	Exited	0(-100.0%)	$2.4M	0.0%	+133.97%	0

Tyra Biosciences, Inc.

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