Wave Life Sciences Ltd. (WVE) is held by institutional investors who disclose positions via SEC 13F filings. View the full list of institutional holders on HoldingsIntel.

Are institutions buying or selling WVE?

HoldingsIntel tracks quarter-over-quarter changes in institutional positions for Wave Life Sciences Ltd., showing new buyers, position increases, decreases, and exits with conviction-weighted sentiment.

What is the Smart Money Verdict on WVE?

The Smart Money Verdict combines four independent signals (institutional 13F activity, insider trades, activist filings, and congressional trades) into a single assessment for Wave Life Sciences Ltd..

Is institutional money flowing into WVE?

117 institutional investors hold Wave Life Sciences Ltd. (WVE). View detailed buyer/seller breakdown on HoldingsIntel.

What do hedge funds think about WVE?

Track institutional sentiment and conviction scores for Wave Life Sciences Ltd. (WVE) including Smart Money Verdict and position changes on HoldingsIntel.

Wave Life Sciences Ltd.

WVE·Y95308105·US·equity·Healthcare - Biotechnology-Activist

SHS

WVE (Wave Life Sciences Ltd.) is held by 117 institutional investors as of Q4 2025. Largest holders: RA CAPITAL MANAGEMENT, L.P. ($309.5M), FMR LLC ($257.3M), BlackRock, Inc. ($215M). Net institutional sentiment: Mixed.

117

Holders

Avg rating(6 Elite)

$2B

Total Value

63% (136)

Fund Consensus

83 buying - 48 selling

Smart Money VerdictView all

66Positive MomentumStrong Convergence

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See how WVE's score breaks down across 4 SEC sources

Held by 117 funds

6 elite

Who's Trading

ActivistRA Capital Management, L.P.17.5%Mar 30, 2026

13F: Dec 31, 2025Insider & Congress: Updated regularly

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
RA CAPITAL MANAGEMENT, L.P.	Increased	18.2M(+0.0%)	$309.5M	3.2%	-32.10%	57
FMR LLC	Increased	15.1M(+195.0%)	$257.3M	0.0%	-3.63%	50
BlackRock, Inc.	Increased	12.6M(+21.3%)	$215M	0.0%	+5.01%	37
ADAGE CAPITAL PARTNERS GP, L.L.C.	Decreased	9.8M(-32.8%)	$166.4M	0.3%	+87.94%	0
MAVERICK CAPITAL LTD	Increased	9.3M(+10.6%)	$157.8M	1.7%	+106.81%	53
DRIEHAUS CAPITAL MANAGEMENT LLC	Increased	6.6M(+4.5%)	$111.9M	0.8%	+54.36%	44
FEDERATED HERMES, INC.	Increased	4.7M(+26.5%)	$80.7M	0.1%	+45.62%	44
PRIMECAP MANAGEMENT CO/CA/	Increased	4.1M(+115.7%)	$69.6M	0.1%	-3.76%	48
VANGUARD GROUP INC	Increased	3.6M(+13.8%)	$60.8M	0.0%	+40.53%	33
GEODE CAPITAL MANAGEMENT, LLC	Increased	3.2M(+8.6%)	$53.9M	0.0%	+54.60%	32
STATE STREET CORP	Increased	3M(+5.3%)	$50.9M	0.0%	+113.38%	31
GOLDMAN SACHS GROUP INC	Increased	2.9M(+34.3%)	$48.5M	0.0%	+26.54%	38
LOOMIS SAYLES & CO L P	Decreased	2M(-29.8%)	$34.7M	0.0%	+34.11%	0
RTW INVESTMENTS, LP	Increased	1.4M(+50.0%)	$23M	0.2%	+19.54%	47
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Increased	1.2M(+19.3%)	$20.3M	0.0%	+42.94%	34
NORTHERN TRUST CORP	Increased	1M(+2.1%)	$17.6M	0.0%	+67.91%	29
SCHRODER INVESTMENT MANAGEMENT GROUP	Increased	1M(+81.1%)	$17.3M	0.0%	+10.23%	43
JPMORGAN CHASE & CO	Increased	892,886(+3.8%)	$15.2M	0.0%	+33.01%	29
Squarepoint Ops LLC	Increased	883,586(+223.0%)	$15M	0.0%	-5.43%	45
Pictet Asset Management Holding SA	Increased	805,901(+5024.6%)	$13.8M	0.0%	-20.71%	45
CITADEL ADVISORS LLC	New	789,964	$13.4M	0.0%	-21.63%	39
TWO SIGMA INVESTMENTS, LP	Increased	749,448(+33.1%)	$12.7M	0.0%	+25.94%	36
VOLORIDGE INVESTMENT MANAGEMENT, LLC	New	722,237	$12.3M	0.0%	-21.63%	39
MILLENNIUM MANAGEMENT LLC	Increased	584,633(+49.6%)	$9.9M	0.0%	+32.11%	38
Universal- Beteiligungs- und Servicegesellschaft mbH	Increased	411,494(+11.6%)	$7M	0.0%	+5.26%	30
MORGAN STANLEY	Decreased	409,663(-19.2%)	$7M	0.0%	+75.42%	0
AMERIPRISE FINANCIAL INC	Increased	398,416(+269.4%)	$6.8M	0.0%	-6.91%	44
Trexquant Investment LP	New	391,111	$6.6M	0.1%	-21.63%	38
SUSQUEHANNA INTERNATIONAL GROUP, LLP	Increased	378,987(+93.1%)	$6.4M	0.0%	+6.64%	43
Walleye Capital LLC	Decreased	378,823(-48.1%)	$6.4M	0.0%	+74.50%	0
WELLINGTON MANAGEMENT GROUP LLP	Decreased	365,235(-15.0%)	$6.2M	0.0%	+101.86%	0
Woodline Partners LP	New	350,531	$6M	0.0%	-21.63%	38
BAKER BROS. ADVISORS LP	Unchanged	344,063	$5.8M	0.0%	+62.12%	0
JACOBS LEVY EQUITY MANAGEMENT, INC	New	338,546	$5.8M	0.0%	-21.63%	38
Nuveen, LLC	Increased	332,735(+33.4%)	$5.7M	0.0%	+40.19%	35
Jain Global LLC	New	328,145	$5.6M	0.0%	-21.63%	37
Bank of New York Mellon Corp	Increased	321,445(+7.9%)	$5.5M	0.0%	+96.83%	29
BARCLAYS PLC	Increased	276,781(+1.4%)	$4.7M	0.0%	+78.51%	27
UBS Group AG	Decreased	268,723(-61.9%)	$4.6M	0.0%	+88.71%	0
D. E. Shaw & Co., Inc.	New	266,132	$4.5M	0.0%	-21.63%	37
TD ASSET MANAGEMENT INC	Increased	252,160(+77.1%)	$4.3M	0.0%	+14.91%	41
RENAISSANCE TECHNOLOGIES LLC	New	236,420	$4M	0.0%	-21.63%	37
Swiss National Bank	Increased	219,700(+4.1%)	$3.7M	0.0%	+83.81%	28
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	New	203,744	$3.5M	0.0%	-21.63%	37
AQR CAPITAL MANAGEMENT LLC	Increased	202,721(+1794.9%)	$3.4M	0.0%	-19.14%	43
WELLS FARGO & COMPANY/MN	Increased	200,890(+172.2%)	$3.4M	0.0%	-4.21%	43
MANUFACTURERS LIFE INSURANCE COMPANY, THE	Increased	182,728(+45.8%)	$3.1M	0.0%	+32.69%	36
BANK OF AMERICA CORP /DE/	Decreased	182,855(-72.5%)	$3.1M	0.0%	+25.18%	0
Invesco Ltd.	Increased	179,932(+27.5%)	$3.1M	0.0%	+48.16%	33
PRINCIPAL FINANCIAL GROUP INC	New	170,170	$2.9M	0.0%	-21.63%	36
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	New	164,985	$2.8M	0.0%	-21.63%	36
RHUMBLINE ADVISERS	Decreased	141,895(-10.8%)	$2.4M	0.0%	+141.34%	0
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	Increased	134,558(+0.2%)	$2.3M	0.0%	+98.42%	26
VOYA INVESTMENT MANAGEMENT LLC	Decreased	112,875(-56.3%)	$1.9M	0.0%	+81.18%	0
ALLIANCEBERNSTEIN L.P.	Increased	112,030(+20.7%)	$1.9M	0.0%	+37.21%	31
RAYMOND JAMES FINANCIAL INC	Increased	111,170(+608.7%)	$1.9M	0.0%	-17.71%	42
JANE STREET GROUP, LLC	Decreased	110,924(-82.1%)	$1.9M	0.0%	+88.50%	0
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	Increased	107,680(+9.3%)	$1.8M	0.0%	+79.02%	28
LMR Partners LLP	New	100,000	$1.7M	0.0%	-21.63%	36
DEUTSCHE BANK AG\	Increased	95,706(+1.5%)	$1.6M	0.0%	+75.54%	26
Legal & General Group Plc	Decreased	93,985(-7.8%)	$1.6M	0.0%	+96.55%	0
STATE OF WISCONSIN INVESTMENT BOARD	Increased	87,141(+47.4%)	$1.5M	0.0%	+6.35%	35
BNP PARIBAS FINANCIAL MARKETS	Increased	82,022(+247.2%)	$1.4M	0.0%	-11.09%	41
Connor, Clark & Lunn Investment Management Ltd.	New	69,078	$1.2M	0.0%	-21.63%	35
GROUP ONE TRADING LLC	Increased	67,969(+56.7%)	$1.2M	0.0%	+24.01%	36
MetLife Investment Management, LLC	Increased	64,763(+9.4%)	$1.1M	0.0%	+90.41%	28
Zurcher Kantonalbank (Zurich Cantonalbank)	Increased	62,729(+20.5%)	$1.1M	0.0%	+68.55%	30
SEI INVESTMENTS CO	Decreased	54,457(-24.6%)	$925,769	0.0%	+71.86%	0
JANUS HENDERSON GROUP PLC	Unchanged	51,700	$877,608	0.0%	+169.34%	0
Russell Investments Group, Ltd.	Increased	49,903(+402.6%)	$848,351	0.0%	-11.42%	40
CITIGROUP INC	Increased	46,759(+35.5%)	$794,903	0.0%	+0.65%	32
GLENMEDE TRUST CO NA	Decreased	42,732(-20.6%)	$726,444	0.0%	+77.63%	0
ENVESTNET ASSET MANAGEMENT INC	Decreased	39,820(-0.1%)	$676,940	0.0%	+63.26%	0
Quantinno Capital Management LP	Decreased	38,925(-13.6%)	$661,725	0.0%	+88.50%	0
State of New Jersey Common Pension Fund D	New	38,022	$646,374	0.0%	-21.63%	34
NEW YORK STATE COMMON RETIREMENT FUND	Decreased	35,920(-66.4%)	$610,640	0.0%	+64.49%	0
Walleye Trading LLC	Increased	33,241(+3021.2%)	$565,097	0.0%	-20.14%	39
Mitsubishi UFJ Asset Management Co., Ltd.	Decreased	33,839(-6.4%)	$539,732	0.0%	+125.48%	0
Man Group plc	Decreased	31,418(-76.3%)	$534,106	0.0%	+94.09%	0
Police & Firemen's Retirement System of New Jersey	Unchanged	31,033	$527,561	0.0%	+26.97%	0
INTECH INVESTMENT MANAGEMENT LLC	Decreased	30,667(-33.2%)	$521,339	0.0%	+38.89%	0
Arizona State Retirement System	Decreased	30,645(-4.8%)	$520,965	0.0%	+89.46%	0
ProShare Advisors LLC	Increased	28,536(+14.9%)	$485,112	0.0%	+65.89%	28
Virtu Financial LLC	New	26,889	$457,000	0.0%	-21.63%	33
EXCHANGE TRADED CONCEPTS, LLC	New	25,615	$435,455	0.0%	-21.63%	33
Orion Porfolio Solutions, LLC	Decreased	25,030(-1.5%)	$425,510	0.0%	+66.02%	0
KLP KAPITALFORVALTNING AS	Increased	24,000(+15.4%)	$408,000	0.0%	+3.05%	27
ROYAL BANK OF CANADA	Decreased	23,206(-86.4%)	$396,000	0.0%	+89.42%	0
HighTower Advisors, LLC	Increased	22,830(+87.7%)	$388,110	0.0%	+13.79%	37
Allianz Asset Management GmbH	New	22,000	$374,000	0.0%	-21.63%	33
SIMPLEX TRADING, LLC	Increased	21,126(+1651.7%)	$359,142	0.0%	-18.92%	38
Creative Planning	Increased	18,121(+52.7%)	$308,057	0.0%	+17.50%	33
Cresset Asset Management, LLC	Decreased	17,929(-2.2%)	$304,793	0.0%	+88.50%	0
HSBC HOLDINGS PLC	Increased	16,990(+52.1%)	$290,869	0.0%	+27.22%	33
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	Unchanged	16,950	$288,150	0.0%	+169.34%	0
TEACHER RETIREMENT SYSTEM OF TEXAS	Decreased	16,443(-38.2%)	$279,531	0.0%	+69.78%	0
VICTORY CAPITAL MANAGEMENT INC	Increased	15,721(+7.4%)	$267,257	0.0%	+74.07%	25
Savant Capital, LLC	New	12,951	$220,167	0.0%	-21.63%	32
FIRST TRUST ADVISORS LP	New	11,688	$198,696	0.0%	-21.63%	32
Rafferty Asset Management, LLC	Decreased	11,557(-30.5%)	$196,469	0.0%	+20.60%	0
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	New	10,700	$181,900	0.0%	-21.63%	31
Mirae Asset Global Investments Co., Ltd.	Increased	8,124(+32.0%)	$138,108	0.0%	+48.53%	28
PRICE T ROWE ASSOCIATES INC /MD/	Increased	7.4M(+83.2%)	$125,927	0.0%	+7.54%	34
US BANCORP \DE\	Decreased	6,263(-18.5%)	$106,471	0.0%	+117.01%	0
Farther Finance Advisors, LLC	Increased	1,945(+23.9%)	$33,065	0.0%	+31.78%	24
NISA INVESTMENT ADVISORS, LLC	Decreased	1,308(-17.0%)	$22,236	0.0%	+101.59%	0
OSAIC HOLDINGS, INC.	Increased	1,175(+19.8%)	$19,975	0.0%	+60.72%	15
Rockefeller Capital Management L.P.	New	861	$14,637	0.0%	-21.63%	28
JONES FINANCIAL COMPANIES LLLP	New	500	$8,500	0.0%	-21.63%	25
Steward Partners Investment Advisory, LLC	Unchanged	400	$6,800	0.0%	+57.15%	0
HRT FINANCIAL LP	New	299,718	$5,095	0.0%	-21.63%	21
Optiver Holding B.V.	Decreased	258(-74.2%)	$4,386	0.0%	+88.50%	0
Duquesne Family Office LLC	New	173,000	$2,941	0.1%	-21.63%	18
Allworth Financial LP	Increased	129(+4.0%)	$2,193	0.0%	+89.93%	8
MAI Capital Management	New	11	$187	0.0%	-21.63%	17
PNC FINANCIAL SERVICES GROUP, INC.	Decreased	10(-96.9%)	$170	0.0%	+88.89%	0
Wealthspire Advisors, LLC	Exited	0(-100.0%)	$9,882	0.0%	+140.53%	0
BALYASNY ASSET MANAGEMENT L.P.	Exited	0(-100.0%)	$134,886	0.0%	+140.53%	0
TWO SIGMA ADVISERS, LP	Exited	0(-100.0%)	$1.8M	0.0%	+124.58%	0
OMERS ADMINISTRATION Corp	Exited	0(-100.0%)	$292,800	0.0%	+140.53%	0
Ensign Peak Advisors, Inc	Exited	0(-100.0%)	$2.3M	0.0%	+157.12%	0
NOMURA ASSET MANAGEMENT CO LTD	New	0	$0	0.0%	-21.63%	17
ExodusPoint Capital Management, LP	Exited	0(-100.0%)	$688,666	0.0%	+135.17%	0
Qube Research & Technologies Ltd	Exited	0(-100.0%)	$936,836	0.0%	+117.39%	0
MARSHALL WACE, LLP	Exited	0(-100.0%)	$102,480	0.0%	+157.12%	0
Federation des caisses Desjardins du Quebec	Exited	0(-100.0%)	$17,202	0.0%	+132.53%	0
Engineers Gate Manager LP	Exited	0(-100.0%)	$201,219	0.0%	+99.37%	0
Point72 Asset Management, L.P.	Exited	0(-100.0%)	$4.9M	0.0%	+140.53%	0
MACQUARIE GROUP LTD	Exited	0(-100.0%)	$600,000	0.0%	+72.69%	0
Caption Management, LLC	Exited	0(-100.0%)	$87,840	0.0%	+140.53%	0
PRUDENTIAL FINANCIAL INC	Exited	0(-100.0%)	$90,585	0.0%	+157.04%	0
CIBC WORLD MARKETS CORP	Exited	0(-100.0%)	$89,772	0.0%	+98.96%	0
CAPSTONE INVESTMENT ADVISORS, LLC	Exited	0(-100.0%)	$76,172	0.0%	+140.53%	0
Artisan Partners Limited Partnership	Exited	0(-100.0%)	$9M	0.0%	+105.28%	0
FRANKLIN RESOURCES INC	Exited	0(-100.0%)	$455,737	0.0%	+166.96%	0
Polar Capital Holdings Plc	Exited	0(-100.0%)	$7.8M	0.0%	+41.67%	0

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