RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q1 2023

SEC EDGAR SourceSEC Filings

Top Holdings59 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
ASNDASND
ADR

ASCENDIS PHARMA A/S

7M$745.9M16.9%$95.96+13.13%
18 qtrssince 2018-Q4
Unchanged
0

VAXCYTE INC

7.3M$273.3M6.2%$34.23+5.95%
12 qtrssince 2020-Q2
Increased
73
DICEDICEDelisted

DICE THERAPEUTICS INC

7.9M$225.1M5.1%
7 qtrssince 2021-Q3
Increased
68
ETNBETNBDelisted

89BIO INC

11.4M$173.9M3.9%
14 qtrssince 2019-Q4
Increased
69
8.3M$166.7M3.8%
8 qtrssince 2021-Q2
Unchanged
0

BIOGEN IDEC INC

532,892$148.2M3.4%$222.99+23.38%
5 qtrssince 2022-Q1
Unchanged
0
VRNAVRNADelisted
ADR

VERONA PHARMA PLC

6.3M$126.9M2.9%
11 qtrssince 2020-Q3
Unchanged
0

CYTEK BIOSCIENCES INC

13.4M$123M2.8%$18.15-50.90%
7 qtrssince 2021-Q3
Unchanged
0

Vor Biopharma Inc.

22.7M$122.4M2.8%
LEGNLEGN
ADR

Legend Biotech Corp. Sponsored ADR

2.4M$117.5M2.7%$40.50+18.51%
3 qtrssince 2022-Q3
Unchanged
0

TYRA BIOSCIENCES INC

7.2M$116.3M2.6%$16.91-7.16%
7 qtrssince 2021-Q3
Unchanged
0

JANUX THERAPEUTICS INC

8.7M$104.9M2.4%$25.37-54.28%
8 qtrssince 2021-Q2
Unchanged
0

PEPGEN INC

8.1M$99.5M2.3%$10.40+14.23%
4 qtrssince 2022-Q2
Unchanged
0
6.4M$98.5M2.2%$20.32-17.32%
7 qtrssince 2021-Q3
Increased
60

RHYTHM PHARMACEUTICALS INC

5.5M$98.4M2.2%$23.47-24.77%
18 qtrssince 2018-Q4
Unchanged
0
DAWNDAWNDelisted

DAY ONE BIOPHARMACEUTICALS I

7M$94.1M2.1%$19.64-35.07%
8 qtrssince 2021-Q2
Unchanged
0
BLUBLUDelisted

BELLUS HEALTH INC NEW

12.6M$91M2.1%
6 qtrssince 2021-Q4
Increased
52
CVACCVACDelisted

CUREVAC N V

12.2M$85.4M1.9%$6.670.00%
1 qtr
New
68
IMGNIMGNDelisted

IMMUNOGEN INC

21.9M$83.9M1.9%
11 qtrssince 2020-Q3
Unchanged
0

WAVE LIFE SCIENCES LTD

17.2M$74.5M1.7%$20.65-80.00%
18 qtrssince 2018-Q4
Unchanged
0
$4.4B
AUM
59
Positions
Q1 2023
Filing
Rating · 2.0
Quarterly Portfolio Change
-21%Q4'21$5.7B-19%Q1'22$4.6B-18%Q2'22$3.8B+25%Q3'22$4.7B+5%Q4'22$4.9B-10%Q1'23$4.4B
Activity profile
$ moved · Q1'23
New30%Increased33%Decreased8%Exited29%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.7 years
<1Q7%1-4Q19%1-2Y34%2Y+41%

RA CAPITAL MANAGEMENT, L.P. manages $4.4B across 59 positions as of Q1 2023. Top holdings: ASND (16.9%), PCVX (6.2%), DICE (5.1%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 2/5.0.

Q1 2023 Summary

Active quarter - 4 new positions, 15 exits, 12 increased. Top move: PCVX (INCREASED, conviction 73). Portfolio: $4.4B across 59 positions.

Top holdings by portfolio weight

Total AUM$4B
ASND16.89%
PCVX6.19%
DICE5.10%
ETNB3.94%
AEROVATE THE3.77%
BIIB3.35%
VRNA2.87%
CTKB2.78%
VOR2.77%
LEGN2.66%
Other2.63%

Portfolio allocation by GICS sector

Sectors2
Healthcare78.39%
Unknown21.61%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Below Average(2.0 / 5.0)
Track RecordNo data
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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