Avoro Capital Advisors LLCAvoro Capital Advisors LLC

Institutional investor · Portfolio as of Q3 2021

Top Holdings47 positions

Checking export access…
Activity:

Horizon Pharma Plc

9M$985.9M15.5%——
10 qtrssince 2019-Q2
Unchanged
0
MRTXMRTXDelisted

Mirati Therapeutics Inc

5M$884.6M13.9%——
11 qtrssince 2019-Q1
Unchanged
0

ACCELERON PHARMA INC

4M$688.4M10.8%——
7 qtrssince 2020-Q1
Increased
80

United Therapeutics Corp

3M$553.7M8.7%$152.56+20.99%
4 qtrssince 2020-Q4
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

2M$315.6M5.0%$135.19+16.13%
2 qtrssince 2021-Q2
Increased
60
ARGXARGX
ADR

ARGENX SE-ADR

946,500$285.8M4.5%$139.27+116.84%
11 qtrssince 2019-Q1
Unchanged
0

Sarepta Therapeutics Inc

2.5M$231.2M3.6%$107.98-17.79%
11 qtrssince 2019-Q1
Increased
60

Iovance Biotherapeutics Inc

8.5M$209.6M3.3%$15.07+57.89%
11 qtrssince 2019-Q1
Decreased
0

ARENA PHARMACEUTICALS INC

3.4M$204M3.2%——
6 qtrssince 2020-Q2
Decreased
0
FOLDFOLDDelisted

AMICUS THERAPEUTICS INC

17.7M$168.8M2.7%$11.31-14.55%
11 qtrssince 2019-Q1
Increased
71
APLSAPLSDelisted

Apellis Pharmaceuticals Inc

5M$164.8M2.6%$35.58-4.65%
3 qtrssince 2021-Q1
Increased
85

Alnylam Pharmaceuticals Inc

850,000$160.5M2.5%$165.87+6.98%
2 qtrssince 2021-Q2
Decreased
0

BioMarin Pharmaceutical Inc

1.9M$144.9M2.3%$83.86-8.43%
11 qtrssince 2019-Q1
Increased
60

Vertex Pharmaceuticals Inc

664,000$120.4M1.9%$212.99+139.49%
3 qtrssince 2021-Q1
Decreased
0
ISEEISEEDelisted

IVERIC bio Inc

7.1M$115.3M1.8%——
6 qtrssince 2020-Q2
Increased
53

Madrigal Pharmaceuticals Inc

1.4M$113.7M1.8%$117.61-32.15%
11 qtrssince 2019-Q1
Unchanged
0
TRILTRILDelisted

TRILLIUM THERAPEUTICS INC

5.7M$100.1M1.6%——
7 qtrssince 2020-Q1
Unchanged
0

PMV PHARMACEUTICALS INC

2.9M$87.2M1.4%$37.36-20.05%
5 qtrssince 2020-Q3
Increased
69

Kura Oncology Inc

4M$74.9M1.2%$28.00-33.15%
6 qtrssince 2020-Q2
Decreased
0
MRSNMRSNDelisted

MERSANA THERAPEUTICS INC

6.8M$64.1M1.0%$553.14-57.83%
6 qtrssince 2020-Q2
Unchanged
0
$6.4B
AUM
47
Positions
Q3 2021
Filing
HI score · 2.5/5
Quarterly 13F Value Change
+71%Q2'20$5.1B+39%Q3'20$7B-18%Q4'20$5.8B-0%Q1'21$5.8B-1%Q2'21$5.7B+11%Q3'21$6.4B
Activity profile
$ moved · Q3'21
New14%Increased54%Decreased17%Exited15%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.3 years
<1Q13%1-4Q26%1-2Y28%2Y+34%

Avoro Capital Advisors LLC manages $6.4B across 47 positions as of Q3 2021. Top holdings: HZNP (15.5%), MRTX (13.9%), XLRN (10.8%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 2.5/5.0.

Q3 2021 Summary

Active quarter - 6 new positions, 7 exits, 10 increased. Top move: APLS (INCREASED, conviction 85). Portfolio: $6.4B across 47 positions.

Top holdings by portfolio weight

Total AUM$6B
HZNP15.49%
MRTX13.89%
XLRN10.81%
UTHR8.70%
ASND4.96%
ARGX4.49%
SRPT3.63%
IOVA3.29%
ARNA3.20%
FOLD2.65%
Other2.59%

Portfolio allocation by GICS sector

Sectors2
Healthcare50.44%
Unknown49.56%

Behavioral investing profile

Checking access…
Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(2.5 / 5.0)
Holdings P&L53
Conviction47
Concentration100
Checking access…

Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
4Q
OCULOCULOCULAR THERAPEUTIX INC COM
Q3 2025 → Q2 2026+5.1M shares+$54.5M
3Q
UTHRUTHRUNITED THERAPEUTICS CORP DEL
Q4 2025 → Q2 2026+755,555 shares+$657.3M
2Q
ARWRARWRARROWHEAD PHARMACEUTICALS IN
Q1 2026 → Q2 2026+730,555 shares+$220.2M
Checking access…

Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

Analytics tracking helps us improve the product. Essential functions stay on either way. How analytics data is used