Avoro Capital Advisors LLCAvoro Capital Advisors LLC

Institutional investor · Portfolio as of Q4 2021

Top Holdings41 positions

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Activity:

Horizon Pharma Plc

9.3M$1B17.0%——
11 qtrssince 2019-Q2
Increased
65
MRTXMRTXDelisted

Mirati Therapeutics Inc

5.1M$744.5M12.7%——
12 qtrssince 2019-Q1
Increased
63

United Therapeutics Corp

3M$655.8M11.2%$153.30+40.96%
5 qtrssince 2020-Q4
Increased
63
APLSAPLSDelisted

Apellis Pharmaceuticals Inc

8.6M$404.5M6.9%$40.72+17.74%
4 qtrssince 2021-Q1
Increased
91
ARGXARGX
ADR

ARGENX SE-ADR

965,000$337.9M5.8%$143.32+144.35%
12 qtrssince 2019-Q1
Increased
62

Sarepta Therapeutics Inc

3.1M$281.4M4.8%$104.50-13.31%
12 qtrssince 2019-Q1
Increased
70
ASNDASND
ADR

ASCENDIS PHARMA A/S

2M$269.1M4.6%$135.20+0.89%
3 qtrssince 2021-Q2
Increased
58

BioMarin Pharmaceutical Inc

2.8M$247.4M4.2%$85.58+4.09%
12 qtrssince 2019-Q1
Increased
79
FOLDFOLDDelisted

AMICUS THERAPEUTICS INC

18.5M$213.7M3.6%$11.32+3.08%
12 qtrssince 2019-Q1
Increased
60

Alnylam Pharmaceuticals Inc

1.1M$182.3M3.1%$166.95+2.44%
3 qtrssince 2021-Q2
Increased
70

Iovance Biotherapeutics Inc

8.7M$165.6M2.8%$15.16+28.14%
12 qtrssince 2019-Q1
Increased
54

XENON PHARMACEUTICALS INC

5M$155.7M2.7%$17.33+84.63%
12 qtrssince 2019-Q1
Increased
69
ISEEISEEDelisted

IVERIC bio Inc

7.3M$121.2M2.1%——
7 qtrssince 2020-Q2
Increased
54

Madrigal Pharmaceuticals Inc

1.4M$120.8M2.1%$117.61-27.95%
12 qtrssince 2019-Q1
Unchanged
0
XBIXBI
ETF

SPDR S&P Biotech ETF

1.1M$117.6M2.0%$112.640.00%
1 qtr
New
79

ARENA PHARMACEUTICALS INC

1.2M$114.8M2.0%——
7 qtrssince 2020-Q2
Decreased
0

MONTE ROSA THERAPEUTICS INC

3.3M$67.6M1.2%$19.98+4.60%
3 qtrssince 2021-Q2
Unchanged
0

Kura Oncology Inc

4M$56M1.0%$28.00-49.01%
7 qtrssince 2020-Q2
Unchanged
0

ACADIA PHARMACEUTICALS INC

2.2M$51.3M0.9%$47.53-50.48%
5 qtrssince 2020-Q4
Unchanged
0

SYNDAX PHARMACEUTICALS INC

2.2M$47.6M0.8%$20.98+3.82%
5 qtrssince 2020-Q4
Increased
56
$5.9B
AUM
41
Positions
Q4 2021
Filing
HI score · 2.5/5
Quarterly 13F Value Change
+39%Q3'20$7B-18%Q4'20$5.8B-0%Q1'21$5.8B-1%Q2'21$5.7B+11%Q3'21$6.4B-8%Q4'21$5.9B
Activity profile
$ moved · Q4'21
New7%Increased43%Decreased8%Exited42%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.6 years
<1Q7%1-4Q20%1-2Y34%2Y+39%

Avoro Capital Advisors LLC manages $5.9B across 41 positions as of Q4 2021. Top holdings: HZNP (17.0%), MRTX (12.7%), UTHR (11.2%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 2.5/5.0.

Q4 2021 Summary

Active quarter - 3 new positions, 6 exits, 18 increased. Top move: APLS (INCREASED, conviction 91). Portfolio: $5.9B across 41 positions.

Top holdings by portfolio weight

Total AUM$6B
HZNP17.05%
MRTX12.67%
UTHR11.16%
APLS6.88%
ARGX5.75%
SRPT4.79%
ASND4.58%
BMRN4.21%
FOLD3.64%
ALNY3.10%
Other2.82%

Portfolio allocation by GICS sector

Sectors2
Healthcare62.32%
Unknown37.68%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(2.5 / 5.0)
Holdings P&L53
Conviction47
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
4Q
OCULOCULOCULAR THERAPEUTIX INC COM
Q3 2025 → Q2 2026+5.1M shares+$54.5M
3Q
UTHRUTHRUNITED THERAPEUTICS CORP DEL
Q4 2025 → Q2 2026+755,555 shares+$657.3M
2Q
ARWRARWRARROWHEAD PHARMACEUTICALS IN
Q1 2026 → Q2 2026+730,555 shares+$220.2M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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