Avoro Capital Advisors LLC
Institutional investor · Portfolio as of Q4 2025
Top Holdings34 positions
United Therapeutics Corp | 2.6M | $1.3B | 12.5% | $229.04 | +112.74% | 21 qtrssince 2020-Q4 | Increased 79 |
ASCENDIS PHARMA A/S | 5.1M | $1.1B | 10.7% | $129.53 | +61.61% | 19 qtrssince 2021-Q2 | Increased 63 |
Madrigal Pharmaceuticals Inc | 1.8M | $1.1B | 10.3% | $157.14 | +270.60% | 28 qtrssince 2019-Q1 | Decreased 0 |
ARGENX SE-ADR | 990,000 | $832.5M | 8.2% | $225.01 | +273.74% | 28 qtrssince 2019-Q1 | Unchanged 0 |
Krystal Biotech Inc | 2.9M | $712.2M | 7.0% | $104.94 | +136.20% | 17 qtrssince 2021-Q4 | Increased 65 |
Arrowhead Pharmaceuticals Inc | 10.6M | $705.4M | 6.9% | $27.07 | +145.27% | 11 qtrssince 2023-Q2 | Decreased 0 |
Kymera Therapeutics Inc | 7.5M | $581.6M | 5.7% | $39.18 | +98.62% | 18 qtrssince 2021-Q3 | Increased 72 |
STRUCTURE THERAPEUTICS INC | 6.6M | $455.9M | 4.5% | $36.87 | +88.62% | 2 qtrssince 2025-Q3 | Increased 72 |
AVIDITY BIOSCIENCES INC | 5.5M | $393.5M | 3.9% | $28.19 | — | 23 qtrssince 2020-Q2 | Decreased 0 |
CENTESSA PHARMACEUTICALS PLC | 14.6M | $364M | 3.6% | $21.02 | +17.68% | 4 qtrssince 2025-Q1 | Increased 75 |
CELCUITY INC | 3.1M | $310.3M | 3.0% | $99.92 | 0.00% | 1 qtr | New 87 |
Apellis Pharmaceuticals Inc | 12.2M | $307M | 3.0% | $42.79 | -41.02% | 20 qtrssince 2021-Q1 | Unchanged 0 |
VERA THERAPEUTICS INC | 5.9M | $298.2M | 2.9% | $40.81 | +24.08% | 8 qtrssince 2024-Q1 | Decreased 0 |
SPDR S&P Biotech ETF | 2.1M | $256.1M | 2.5% | $121.67 | +26.38% | 1 qtr | New 81 |
XENON PHARMACEUTICALS INC | 5.4M | $243.1M | 2.4% | $21.49 | +105.34% | 28 qtrssince 2019-Q1 | Increased 54 |
TERNS PHARMACEUTICALS INC | 4.4M | $175.7M | 1.7% | $40.59 | 0.00% | 1 qtr | New 71 |
REVOLUTION MEDICINES INC | 2.2M | $172.8M | 1.7% | $79.67 | 0.00% | 1 qtr | New 71 |
UNIQURE NV | 6.2M | $147.2M | 1.4% | $23.95 | -0.07% | 5 qtrssince 2024-Q4 | Increased 64 |
SOLENO THERAPEUTICS INC | 2.9M | $134.3M | 1.3% | $47.38 | -2.30% | 9 qtrssince 2023-Q4 | Increased 55 |
OCULAR THERAPEUTIX INC | 10.8M | $130.8M | 1.3% | $9.98 | +22.20% | 8 qtrssince 2024-Q1 | Increased 51 |
Avoro Capital Advisors LLC manages $10.2B across 34 positions as of Q4 2025. Top holdings: UTHR (12.5%), ASND (10.7%), MDGL (10.3%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 2.5/5.0.
Active quarter - 11 new positions, 8 exits, 10 increased. Top move: CELC (NEW, conviction 87). Portfolio: $10.2B across 34 positions.
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Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
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