Avoro Capital Advisors LLCAvoro Capital Advisors LLC

Institutional investor · Portfolio as of Q3 2023

Top Holdings46 positions

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Activity:

HORIZON THERAPEUTICS PUB L

7M$809.8M12.6%——
18 qtrssince 2019-Q2
Unchanged
0

UNITED THERAPEUTICS CORP DEL

2.9M$644.3M10.0%$154.35+46.34%
12 qtrssince 2020-Q4
Decreased
0
ARGXARGX
ADR

ARGENX SE

1M$491.6M7.7%$187.90+161.65%
19 qtrssince 2019-Q1
Decreased
0

SAREPTA THERAPEUTICS INC

4M$487.9M7.6%$107.90+12.34%
19 qtrssince 2019-Q1
Decreased
0
APLSAPLSDelisted

APELLIS PHARMACEUTICALS INC

11.1M$422.7M6.6%$43.88-13.31%
11 qtrssince 2021-Q1
Unchanged
0
SGENSGENDelisted

SEAGEN INC

1.8M$373.3M5.8%——
7 qtrssince 2022-Q1
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S - ADR

3.7M$343.7M5.4%$121.35-22.84%
10 qtrssince 2021-Q2
Increased
63

BIOMARIN PHARMACEUTICAL INC

3.9M$340.6M5.3%$85.98+2.90%
19 qtrssince 2019-Q1
Decreased
0
FOLDFOLDDelisted

AMICUS THERAPEUTICS INC

27.4M$333.2M5.2%$11.07+9.86%
19 qtrssince 2019-Q1
Unchanged
0

KRYSTAL BIOTECH INC

2.6M$297.6M4.6%$85.59+35.53%
8 qtrssince 2021-Q4
Increased
58
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

6.7M$290.4M4.5%——
19 qtrssince 2019-Q1
Increased
68

MADRIGAL PHARMACEUTICALS INC

1.6M$227.1M3.5%$128.48+13.67%
19 qtrssince 2019-Q1
Increased
59

ALNYLAM PHARMACEUTICALS INC

1M$179.1M2.8%$165.72+6.87%
10 qtrssince 2021-Q2
Decreased
0

XENON PHARMACEUTICALS INC

4.9M$167.4M2.6%$17.33+97.16%
19 qtrssince 2019-Q1
Unchanged
0
CBAYCBAYDelisted

CYMABAY THERAPEUTICS INC

10.3M$153.6M2.4%——
19 qtrssince 2019-Q1
Unchanged
0

MOONLAKE IMMUNOTHERAPEUTICS

2M$114M1.8%$51.89+9.84%
2 qtrssince 2023-Q2
Increased
56

BIOCRYST PHARMACEUTICALS INC

11.6M$81.8M1.3%$11.22-36.88%
7 qtrssince 2022-Q1
Decreased
0

ROIVANT SCIENCES LTD

4.7M$54.3M0.8%$9.90+17.98%
2 qtrssince 2023-Q2
Decreased
0

KYMERA THERAPEUTICS INC

3.9M$53.6M0.8%$29.74-53.27%
9 qtrssince 2021-Q3
Unchanged
0

ULTRAGENYX PHARMACEUTICAL IN

1.5M$53.5M0.8%$49.65-28.20%
7 qtrssince 2022-Q1
Increased
68
$6.4B
AUM
46
Positions
Q3 2023
Filing
HI score · 3.0/5
Quarterly 13F Value Change
-8%Q2'22$5.1B+7%Q3'22$5.4B+24%Q4'22$6.7B+1%Q1'23$6.7B+9%Q2'23$7.4B-13%Q3'23$6.4B
Activity profile
$ moved · Q3'23
New14%Increased29%Decreased14%Exited44%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.3 years
<1Q13%1-4Q15%1-2Y11%2Y+61%

Avoro Capital Advisors LLC manages $6.4B across 46 positions as of Q3 2023. Top holdings: HZNP (12.6%), UTHR (10.0%), ARGX (7.7%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 3/5.0.

Q3 2023 Summary

Active quarter - 7 new positions, 5 exits, 8 increased. Top move: MRTX (INCREASED, conviction 68). Portfolio: $6.4B across 46 positions.

Top holdings by portfolio weight

Total AUM$6B
HZNP12.63%
UTHR10.05%
ARGX7.67%
SRPT7.61%
APLS6.59%
SGEN5.82%
ASND5.36%
BMRN5.31%
FOLD5.20%
KRYS4.64%
Other4.53%

Portfolio allocation by GICS sector

Sectors2
Healthcare73.41%
Unknown26.59%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L51
Conviction47
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
4Q
OCULOCULOCULAR THERAPEUTIX INC
Q3 2025 → Q2 2026+5.1M shares+$54.5M
3Q
UTHRUTHRUNITED THERAPEUTICS CORP DEL
Q4 2025 → Q2 2026+755,555 shares+$657.3M
2Q
ARWRARWRARROWHEAD PHARMACEUTICALS IN
Q1 2026 → Q2 2026+730,555 shares+$220.2M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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