Avoro Capital Advisors LLCAvoro Capital Advisors LLC

Institutional investor · Portfolio as of Q2 2021

Top Holdings46 positions

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Activity:

HORIZON THERAPEUTICS PUB L

9M$842.8M14.7%——
9 qtrssince 2019-Q2
Unchanged
0
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

5M$807.7M14.0%——
10 qtrssince 2019-Q1
Increased
67

UNITED THERAPEUTICS CORP DEL

3M$538.2M9.4%$152.56+17.60%
3 qtrssince 2020-Q4
Unchanged
0

ACCELERON PHARMA INC

3M$376.5M6.5%——
6 qtrssince 2020-Q1
Unchanged
0
ARGXARGX
ADR

ARGENX SE

946,500$285M5.0%$139.27+116.17%
10 qtrssince 2019-Q1
Increased
59

ARENA PHARMACEUTICALS INC

4.1M$277.9M4.8%——
5 qtrssince 2020-Q2
Increased
58
ASNDASND
ADR

ASCENDIS PHARMA A/S

1.9M$249.9M4.3%$134.270.00%
1 qtr
New
86

IOVANCE BIOTHERAPEUTICS INC

9.1M$236.8M4.1%$15.07+74.74%
10 qtrssince 2019-Q1
Increased
65

SAREPTA THERAPEUTICS INC

2.4M$186.6M3.2%$108.78-27.54%
10 qtrssince 2019-Q1
Increased
63

ALNYLAM PHARMACEUTICALS INC

1M$169.5M2.9%$165.870.00%
1 qtr
New
80

VERTEX PHARMACEUTICALS INC

790,000$159.3M2.8%$212.99-7.61%
2 qtrssince 2021-Q1
Decreased
0

MADRIGAL PHARMACEUTICALS INC

1.4M$138.8M2.4%$117.61-17.17%
10 qtrssince 2019-Q1
Unchanged
0

BIOMARIN PHARMACEUTICAL INC

1.7M$137.7M2.4%$84.82-1.60%
10 qtrssince 2019-Q1
Unchanged
0
FOLDFOLDDelisted

AMICUS THERAPEUTICS INC

12.5M$120M2.1%$12.00-16.97%
10 qtrssince 2019-Q1
Increased
53
CNSTCNSTDelisted

CONSTELLATION PHARMCETICLS I

3.2M$108.5M1.9%——
7 qtrssince 2019-Q4
Increased
53
MRSNMRSNDelisted

MERSANA THERAPEUTICS INC

6.8M$92.3M1.6%$553.14-39.98%
5 qtrssince 2020-Q2
Unchanged
0

KURA ONCOLOGY INC

4.1M$86.3M1.5%$28.00-23.16%
5 qtrssince 2020-Q2
Increased
50

XENON PHARMACEUTICALS INC

3.7M$68M1.2%$11.96+50.89%
10 qtrssince 2019-Q1
Unchanged
0
APLSAPLSDelisted

APELLIS PHARMACEUTICALS INC

1M$63.5M1.1%$42.16+50.49%
2 qtrssince 2021-Q1
Increased
48

PMV PHARMACEUTICALS INC

1.8M$62.3M1.1%$41.88-18.81%
4 qtrssince 2020-Q3
Decreased
0
$5.7B
AUM
46
Positions
Q2 2021
Filing
HI score · 2.5/5
Quarterly 13F Value Change
-13%Q1'20$3B+71%Q2'20$5.1B+39%Q3'20$7B-18%Q4'20$5.8B-0%Q1'21$5.8B-1%Q2'21$5.7B
Activity profile
$ moved · Q2'21
New39%Increased16%Decreased20%Exited25%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.2 years
<1Q13%1-4Q28%1-2Y26%2Y+33%

Avoro Capital Advisors LLC manages $5.7B across 46 positions as of Q2 2021. Top holdings: HZNP (14.7%), MRTX (14.0%), UTHR (9.4%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 2.5/5.0.

Q2 2021 Summary

Active quarter - 5 new positions, 7 exits, 13 increased. Top move: ASND (NEW, conviction 86). Portfolio: $5.7B across 46 positions.

Top holdings by portfolio weight

Total AUM$6B
HZNP14.66%
MRTX14.05%
UTHR9.36%
XLRN6.55%
ARGX4.96%
ARNA4.83%
ASND4.35%
IOVA4.12%
SRPT3.25%
ALNY2.95%
Other2.77%

Portfolio allocation by GICS sector

Sectors2
Healthcare52.77%
Unknown47.23%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(2.5 / 5.0)
Holdings P&L53
Conviction47
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
4Q
OCULOCULOCULAR THERAPEUTIX INC COM
Q3 2025 → Q2 2026+5.1M shares+$54.5M
3Q
UTHRUTHRUNITED THERAPEUTICS CORP DEL
Q4 2025 → Q2 2026+755,555 shares+$657.3M
2Q
ARWRARWRARROWHEAD PHARMACEUTICALS IN
Q1 2026 → Q2 2026+730,555 shares+$220.2M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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