BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q2 2019

Top Holdings103 positions

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Activity:
50.1M$3.5B23.5%——
2 qtrssince 2019-Q1
Decreased
0

Incyte Corp

32M$2.7B18.5%$86.01-1.22%
2 qtrssince 2019-Q1
Decreased
0
ONCONC
ADR

BEIGENE LTD

11.8M$1.5B9.9%$132.00-6.10%
2 qtrssince 2019-Q1
Decreased
0
ALXNALXNDelisted

Alexion Pharmaceuticals Inc

8.3M$1.1B7.4%——
2 qtrssince 2019-Q1
Decreased
0

ACADIA PHARMACEUTICALS INC

39.3M$1.1B7.1%$26.85-0.45%
2 qtrssince 2019-Q1
Decreased
0
AMRNAMRN
ADR

AMARIN CORP PLC

41.5M$805.5M5.5%$415.20-6.60%
2 qtrssince 2019-Q1
Decreased
0

BioMarin Pharmaceutical Inc

7.6M$650M4.4%$88.83-3.58%
2 qtrssince 2019-Q1
Unchanged
0
GHDXGHDXDelisted

GENOMIC HEALTH INC

9.3M$538.7M3.7%——
2 qtrssince 2019-Q1
Decreased
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.4M$390.4M2.7%$117.70-2.17%
2 qtrssince 2019-Q1
Unchanged
0
MRTXMRTXDelisted

Mirati Therapeutics Inc

2.5M$258.9M1.8%——
2 qtrssince 2019-Q1
Unchanged
0
ARGXARGX
ADR

ARGENX SE-ADR

1M$144.3M1.0%$124.84+13.41%
2 qtrssince 2019-Q1
Unchanged
0
2.8M$132M0.9%——
2 qtrssince 2019-Q1
Decreased
0

Madrigal Pharmaceuticals Inc

1.2M$122.6M0.8%$125.26-16.33%
2 qtrssince 2019-Q1
Unchanged
0

Neurocrine Biosciences Inc

1.4M$119.5M0.8%$87.28-3.26%
2 qtrssince 2019-Q1
Increased
53

Heron Therapeutics Inc

6M$111.9M0.8%$23.47-20.79%
2 qtrssince 2019-Q1
Increased
50

KODIAK SCIENCES INC

9.1M$107M0.7%$6.53+79.17%
2 qtrssince 2019-Q1
Unchanged
0
NVTAQNVTAQDelisted

INVITAE CORP

3.9M$91.7M0.6%——
2 qtrssince 2019-Q1
Unchanged
0
TCDAQTCDAQDelisted

TRICIDA INC

2M$77.7M0.5%——
2 qtrssince 2019-Q1
Increased
46
ONCEONCEDelisted

SPARK THERAPEUTICS INC

751,927$77M0.5%——
2 qtrssince 2019-Q1
Unchanged
0
BCELBCELDelisted

Atreca Inc

3.5M$66.6M0.5%——
1 qtr
New
49
$14.7B
AUM
103
Positions
Q2 2019
Filing
HI score · 3.0/5
Quarterly 13F Value Change
Not enough history yet
Activity profile
$ moved · Q2'19
New10%Increased9%Decreased74%Exited7%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg <1 quarter
<1Q11%1-4Q89%1-2Y0%2Y+0%

BAKER BROS. ADVISORS LP manages $14.7B across 103 positions as of Q2 2019. Top holdings: SGEN (23.5%), INCY (18.5%), ONC (9.9%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 3/5.0.

Q2 2019 Summary

Active quarter - 11 new positions, 4 exits, 15 increased. Top move: NBIX (INCREASED, conviction 53). Portfolio: $14.7B across 103 positions.

Top holdings by portfolio weight

Total AUM$15B
SGEN23.55%
INCY18.46%
ONC9.92%
ALXN7.35%
ACAD7.14%
AMRN5.47%
BMRN4.42%
GHDX3.66%
ASND2.65%
MRTX1.76%
Other0.98%

Portfolio allocation by GICS sector

Sectors2
Healthcare57.63%
Unknown42.37%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L51
Conviction36
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
INCYINCYINCYTE CORP
Q4 2024 → Q2 2026+23,310 shares+$1.5B
5Q
IDYAIDYAIDEAYA Biosciences Inc.
Q2 2025 → Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC COM
Q4 2025 → Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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