BAKER BROS. ADVISORS LP
Institutional investor · Portfolio as of Q1 2025
Top Holdings89 positions
BEONE MEDICINES LTD | 8.8M | $2.4B | 26.5% | $149.70 | +81.81% | 25 qtrssince 2019-Q1 | Decreased 0 |
INCYTE CORP | 30.7M | $1.9B | 20.6% | $84.99 | -28.75% | 25 qtrssince 2019-Q1 | Increased 62 |
ACADIA PHARMACEUTICALS INC | 42.9M | $712.2M | 7.9% | $27.49 | -39.57% | 25 qtrssince 2019-Q1 | Unchanged 0 |
MADRIGAL PHARMACEUTICALS INC | 2M | $654M | 7.2% | $142.52 | +132.41% | 25 qtrssince 2019-Q1 | Unchanged 0 |
SUMMIT THERAPEUTICS INC | 24.4M | $471.2M | 5.2% | $8.44 | +140.63% | 4 qtrssince 2024-Q2 | Unchanged 0 |
INSMED INC | 5.4M | $410.5M | 4.5% | $65.65 | +16.20% | 25 qtrssince 2019-Q1 | Increased 62 |
RHYTHM PHARMACEUTICALS INC | 5.6M | $296.9M | 3.3% | $24.17 | +119.20% | 25 qtrssince 2019-Q1 | Decreased 0 |
REVOLUTION MEDICINES INC | 7.9M | $280.7M | 3.1% | $28.63 | +30.45% | 17 qtrssince 2021-Q1 | Unchanged 0 |
KYMERA THERAPEUTICS INC | 6M | $164.1M | 1.8% | $28.24 | -3.10% | 19 qtrssince 2020-Q3 | Unchanged 0 |
ALKERMES PLC | 4.5M | $148M | 1.6% | $24.70 | +33.68% | 4 qtrssince 2024-Q2 | Increased 51 |
EDGEWISE THERAPEUTICS INC | 6.2M | $135.4M | 1.5% | $16.18 | +43.79% | 17 qtrssince 2021-Q1 | Unchanged 0 |
REPLIMUNE GROUP INC | 11M | $107.7M | 1.2% | $13.45 | -27.49% | 20 qtrssince 2020-Q2 | Unchanged 0 |
| 42.9M | $101.6M | 1.1% | — | — | 4 qtrssince 2024-Q2 | Unchanged 0 | |
IMMUNOVANT INC | 5.5M | $93.3M | 1.0% | $21.82 | -15.81% | 7 qtrssince 2023-Q3 | Increased 76 |
BICYCLE THERAPEUTICS PLC | 10.9M | $92.4M | 1.0% | $20.84 | -56.96% | 11 qtrssince 2022-Q3 | Unchanged 0 |
IMMUNOCORE HLDGS PLC | 2.3M | $68.9M | 0.8% | $38.09 | -22.10% | 17 qtrssince 2021-Q1 | Increased 58 |
KINIKSA PHARMACEUTICALS INTL | 2.8M | $62.6M | 0.7% | $18.67 | +18.96% | 4 qtrssince 2024-Q2 | Unchanged 0 |
ABCELLERA BIOLOGICS INC | 27.5M | $61.4M | 0.7% | $18.96 | -87.82% | 18 qtrssince 2020-Q4 | Unchanged 0 |
ULTRAGENYX PHARMACEUTICAL IN | 1.6M | $57.1M | 0.6% | $70.98 | -46.72% | 18 qtrssince 2020-Q4 | Unchanged 0 |
DENALI THERAPEUTICS INC | 3.7M | $50.7M | 0.6% | $23.61 | -42.41% | 21 qtrssince 2020-Q1 | Unchanged 0 |
BAKER BROS. ADVISORS LP manages $9B across 89 positions as of Q1 2025. Top holdings: ONC (26.5%), INCY (20.6%), ACAD (7.9%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.
Active quarter - 4 new positions, 10 exits, 11 increased. Top move: IMVT (INCREASED, conviction 76). Portfolio: $9.0B across 89 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
Similar Funds
Funds with similar investing DNA
Explore More
Accumulation Streaks
Positions with 2+ consecutive quarters of increases - persistent directional conviction.
Continue exploring
Famous Investors' Portfolios
What the most-followed managers hold, and what they bought and sold each quarter.
- Warren Buffett (Chairman Emeritus)Berkshire Hathaway
- Leopold AschenbrennerSituational Awareness
- Michael BurryScion Asset Management
- Cathie WoodARK Invest
- Bill AckmanPershing Square
- Stanley DruckenmillerDuquesne Family Office
- David TepperAppaloosa
- Ray Dalio (Founder)Bridgewater Associates
- Li LuHimalaya Capital
- Carl IcahnCarl C. Icahn
- Brad GerstnerAltimeter Capital
- Seth KlarmanThe Baupost Group
- Howard Marks (Co‑founder)Oaktree Capital Management
- Ken GriffinCitadel
- Paul Tudor JonesTudor Investment Corp
- George Soros (Founder)Soros Fund Management
- Steve CohenPoint72
- Terry SmithFundsmith
- Ken Fisher (Founder)Fisher Investments
Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
Verify source filings on SEC EDGAR