BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q4 2019

Top Holdings99 positions

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Activity:
50.1M$5.7B30.4%——
4 qtrssince 2019-Q1
Unchanged
0

INCYTE CORP

32M$2.8B14.8%$86.01+1.52%
4 qtrssince 2019-Q1
Increased
62
ONCONC
ADR

BEONE MEDICINES LTD

11.8M$2B10.4%$132.00+25.58%
4 qtrssince 2019-Q1
Unchanged
0

ACADIA PHARMACEUTICALS INC

40.9M$1.7B9.3%$27.20+57.28%
4 qtrssince 2019-Q1
Unchanged
0
ALXNALXNDelisted

ALEXION PHARMACEUTICALS INC

8.3M$893.1M4.7%——
4 qtrssince 2019-Q1
Unchanged
0

KODIAK SCIENCES INC

11M$794.9M4.2%$17.79+304.34%
4 qtrssince 2019-Q1
Increased
69
AMRNAMRN
ADR

AMARIN CORP PLC

34.5M$739.6M3.9%$415.20+1.30%
4 qtrssince 2019-Q1
Decreased
0

BIOMARIN PHARMACEUTICAL INC

7.6M$641.7M3.4%$88.83-4.77%
4 qtrssince 2019-Q1
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.4M$471.7M2.5%$117.70+15.52%
4 qtrssince 2019-Q1
Unchanged
0
EXASEXASDelisted

EXACT SCIENCES CORP

2.6M$239.1M1.3%$91.870.00%
1 qtr
New
70
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.3M$168.4M0.9%——
4 qtrssince 2019-Q1
Unchanged
0
ARGXARGX
ADR

ARGENX SE

1M$163.7M0.9%$124.84+28.58%
4 qtrssince 2019-Q1
Unchanged
0
DBVTDBVT
ADR

DBV TECHNOLOGIES S A

14.6M$156.4M0.8%$19.71+13.16%
4 qtrssince 2019-Q1
Increased
69
NVTAQNVTAQDelisted

Invitae Corp

9.1M$146.7M0.8%——
4 qtrssince 2019-Q1
Increased
44

HERON THERAPEUTICS INC

6M$141.4M0.8%$23.47+0.14%
4 qtrssince 2019-Q1
Unchanged
0

NEUROCRINE BIOSCIENCES INC

1.3M$134.8M0.7%$87.28+22.78%
4 qtrssince 2019-Q1
Decreased
0
MYOKMYOKDelisted

MYOKARDIA INC

1.8M$129.3M0.7%——
4 qtrssince 2019-Q1
Increased
49
IGMSIGMSDelisted

IGM BIOSCIENCES INC

3.1M$120M0.6%——
2 qtrssince 2019-Q3
Unchanged
0

MADRIGAL PHARMACEUTICALS INC

1.2M$106.5M0.6%$125.26-27.26%
4 qtrssince 2019-Q1
Unchanged
0
RARXRARXDelisted

RA PHARMACEUTICALS INC

2.1M$98.3M0.5%——
4 qtrssince 2019-Q1
Decreased
0
$18.8B
AUM
99
Positions
Q4 2019
Filing
HI score · 3.0/5
Quarterly 13F Value Change
-6%Q2'19$14.7B-0%Q3'19$14.7B+28%Q4'19$18.8B
Activity profile
$ moved · Q4'19
New12%Increased54%Decreased7%Exited28%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.5 quarters
<1Q8%1-4Q92%1-2Y0%2Y+0%

BAKER BROS. ADVISORS LP manages $18.8B across 99 positions as of Q4 2019. Top holdings: SGEN (30.4%), INCY (14.8%), ONC (10.4%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.

Q4 2019 Summary

Active quarter - 8 new positions, 18 exits, 21 increased. Top move: EXAS (NEW, conviction 70). Portfolio: $18.8B across 99 positions.

Top holdings by portfolio weight

Total AUM$19B
SGEN30.41%
INCY14.84%
ONC10.38%
ACAD9.29%
ALXN4.75%
KOD4.23%
AMRN3.93%
BMRN3.41%
ASND2.51%
EXAS1.27%
Other0.90%

Portfolio allocation by GICS sector

Sectors3
Healthcare58.58%
Unknown41.41%
Financial Services0.01%

Behavioral investing profile

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Concentrated Value- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L45
Conviction36
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
INCYINCYINCYTE CORP
Q4 2024 → Q2 2026+23,310 shares+$1.5B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 → Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 → Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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