BAKER BROS. ADVISORS LP
Institutional investor · Portfolio as of Q3 2025
Top Holdings91 positions
BEONE MEDICINES LTD | 8.8M | $3B | 21.7% | $149.70 | +127.59% | 27 qtrssince 2019-Q1 | Unchanged 0 |
INCYTE CORP | 30.7M | $2.6B | 18.8% | $84.99 | -0.21% | 27 qtrssince 2019-Q1 | Increased 62 |
MADRIGAL PHARMACEUTICALS INC | 2.1M | $982.3M | 7.1% | $167.08 | +174.51% | 27 qtrssince 2019-Q1 | Increased 67 |
INSMED INC | 6.7M | $965.4M | 7.0% | $76.23 | +88.91% | 27 qtrssince 2019-Q1 | Decreased 0 |
ACADIA PHARMACEUTICALS INC | 42.9M | $915.4M | 6.6% | $27.48 | -22.36% | 27 qtrssince 2019-Q1 | Unchanged 0 |
SUMMIT THERAPEUTICS INC | 33.7M | $696.7M | 5.0% | $11.80 | +79.38% | 6 qtrssince 2024-Q2 | Unchanged 0 |
RHYTHM PHARMACEUTICALS INC | 5.6M | $566M | 4.1% | $24.17 | +317.91% | 27 qtrssince 2019-Q1 | Unchanged 0 |
REVOLUTION MEDICINES INC | 9.5M | $441.6M | 3.2% | $30.05 | +53.32% | 19 qtrssince 2021-Q1 | Increased 58 |
CELCUITY INC | 7.9M | $391M | 2.8% | $25.54 | +103.85% | 9 qtrssince 2023-Q3 | Increased 72 |
KYMERA THERAPEUTICS INC | 6.7M | $376.5M | 2.7% | $29.76 | +90.18% | 21 qtrssince 2020-Q3 | Unchanged 0 |
KODIAK SCIENCES INC | 17.3M | $283.4M | 2.0% | $34.00 | -51.85% | 27 qtrssince 2019-Q1 | Unchanged 0 |
ALKERMES PLC | 8.1M | $242.7M | 1.8% | $26.73 | +12.22% | 6 qtrssince 2024-Q2 | Increased 60 |
ABCELLERA BIOLOGICS INC | 27.5M | $138.5M | 1.0% | $18.96 | -74.32% | 20 qtrssince 2020-Q4 | Unchanged 0 |
EDGEWISE THERAPEUTICS INC | 7.3M | $118.5M | 0.9% | $15.71 | +0.26% | 19 qtrssince 2021-Q1 | Unchanged 0 |
KINIKSA PHARMACEUTICALS INTL | 2.8M | $109.7M | 0.8% | $18.69 | +107.76% | 6 qtrssince 2024-Q2 | Unchanged 0 |
STOKE THERAPEUTICS INC | 4.6M | $108.9M | 0.8% | $11.06 | +123.62% | 13 qtrssince 2022-Q3 | Unchanged 0 |
IMMATICS N.V | 12.1M | $103M | 0.7% | $8.87 | -10.80% | 21 qtrssince 2020-Q3 | Increased 50 |
GRAIL INC | 1.6M | $96.4M | 0.7% | $18.64 | +215.29% | 4 qtrssince 2024-Q4 | Unchanged 0 |
IDEAYA BIOSCIENCES INC | 3.3M | $89.1M | 0.6% | $21.71 | +25.24% | 13 qtrssince 2022-Q3 | Increased 59 |
IMMUNOVANT INC | 5.5M | $88M | 0.6% | $21.82 | -26.40% | 9 qtrssince 2023-Q3 | Unchanged 0 |
BAKER BROS. ADVISORS LP manages $13.8B across 91 positions as of Q3 2025. Top holdings: ONC (21.7%), INCY (18.8%), MDGL (7.1%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.
Active quarter - 12 new positions, 10 exits, 14 increased. Top move: CELC (INCREASED, conviction 72). Portfolio: $13.8B across 91 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
Verify source filings on SEC EDGAR