BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q1 2022

Top Holdings118 positions

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Activity:
SGENSGENDelisted

SEAGEN INC

46.9M$6.8B38.8%——
7 qtrssince 2020-Q3
Increased
62

INCYTE CORP

36.2M$2.9B16.5%$85.00-6.56%
13 qtrssince 2019-Q1
Increased
67
ONCONC
ADR

BEONE MEDICINES LTD

11.7M$2.2B12.6%$149.70+25.99%
13 qtrssince 2019-Q1
Unchanged
0

ACADIA PHARMACEUTICALS INC

41.9M$1B5.8%$27.58-12.17%
13 qtrssince 2019-Q1
Unchanged
0

BIOMARIN PHARMACEUTICAL INC

7.6M$587.5M3.4%$88.78-12.27%
13 qtrssince 2019-Q1
Unchanged
0
ASNDASND
ADR

<![CDATA[ASCENDIS PHARMA A/S]]>

4.5M$533M3.1%$127.51-9.01%
13 qtrssince 2019-Q1
Unchanged
0
ARGXARGX
ADR

ARGENX SE

1.1M$353M2.0%$138.29+128.01%
13 qtrssince 2019-Q1
Unchanged
0

BIOCRYST PHARMACEUTICALS INC

12.7M$206.7M1.2%$7.50+119.33%
13 qtrssince 2019-Q1
Unchanged
0

MADRIGAL PHARMACEUTICALS INC

1.5M$147.1M0.8%$112.39-12.69%
13 qtrssince 2019-Q1
Unchanged
0

KODIAK SCIENCES INC

15.9M$123M0.7%$36.28-78.72%
13 qtrssince 2019-Q1
Increased
46
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.4M$115.9M0.7%——
13 qtrssince 2019-Q1
Unchanged
0

GLOBAL BLOOD THERAPEUTICS IN

3.3M$114.8M0.7%——
9 qtrssince 2020-Q1
Unchanged
0

ABCELLERA BIOLOGICS INC

10.5M$101.9M0.6%$41.10-76.28%
6 qtrssince 2020-Q4
Unchanged
0

KYMERA THERAPEUTICS INC

2.4M$100.9M0.6%$37.03+14.30%
7 qtrssince 2020-Q3
Unchanged
0

HORIZON THERAPEUTICS PUB L

898,842$94.6M0.5%——
9 qtrssince 2020-Q1
Increased
58

TRAVERE THERAPEUTICS INC

3.3M$85M0.5%$25.43-1.25%
5 qtrssince 2021-Q1
Increased
43
IGMSIGMSDelisted

IGM BIOSCIENCES INC

3.2M$84.4M0.5%——
11 qtrssince 2019-Q3
Unchanged
0
NVTAQNVTAQDelisted

Invitae Corp

9.9M$78.7M0.5%——
13 qtrssince 2019-Q1
Unchanged
0
IMCRIMCR
ADR

IMMUNOCORE HLDGS PLC

2.5M$75.4M0.4%$42.57-29.76%
5 qtrssince 2021-Q1
Unchanged
0

CERUS CORP

13.7M$75.3M0.4%$5.89-6.77%
13 qtrssince 2019-Q1
Unchanged
0
$17.4B
AUM
118
Positions
Q1 2022
Filing
HI score · 3.0/5
Quarterly 13F Value Change
+6%Q4'20$26.5B-13%Q1'21$23.1B-1%Q2'21$22.8B+0%Q3'21$22.8B-10%Q4'21$20.6B-15%Q1'22$17.4B
Activity profile
$ moved · Q1'22
New0%Increased93%Decreased4%Exited3%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.8 years
<1Q2%1-4Q18%1-2Y37%2Y+43%

BAKER BROS. ADVISORS LP manages $17.4B across 118 positions as of Q1 2022. Top holdings: SGEN (38.8%), INCY (16.5%), ONC (12.6%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.

Q1 2022 Summary

Added 2 new positions, exited 5, increased 15, trimmed 4. Top move: INCY (INCREASED, conviction 67). Portfolio: $17.4B across 118 positions.

Top holdings by portfolio weight

Total AUM$17B
SGEN38.83%
INCY16.50%
ONC12.65%
ACAD5.83%
BMRN3.38%
ASND3.06%
ARGX2.03%
BCRX1.19%
MDGL0.85%
KOD0.71%
Other0.67%

Portfolio allocation by GICS sector

Sectors4
Healthcare56.35%
Unknown43.64%
Financial Services0.01%
Consumer Cyclical0.00%

Behavioral investing profile

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Concentrated Value- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L46
Conviction36
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

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Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
INCYINCYINCYTE CORP
Q4 2024 → Q2 2026+23,310 shares+$1.5B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 → Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 → Q2 2026+965,548 shares+$25.9M
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Famous Investors' Portfolios

What the most-followed managers hold, and what they bought and sold each quarter.

Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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