BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q2 2020

SEC EDGAR SourceSEC Filings

Top Holdings114 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
47.3M$8B35.4%
6 qtrssince 2019-Q1
Decreased
0

INCYTE CORP

32M$3.3B14.7%$86.02+19.14%
6 qtrssince 2019-Q1
Increased
62
ONCONC
ADR

BEIGENE LTD-ADR

11.8M$2.2B9.8%$132.00+43.33%
6 qtrssince 2019-Q1
Unchanged
0

ACADIA Pharmaceuticals Inc.

41.9M$2B9.0%$27.58+74.60%
6 qtrssince 2019-Q1
Unchanged
0
ALXNALXNDelisted

ALEXION PHARMACEUTICALS INC

8.8M$983.3M4.3%
6 qtrssince 2019-Q1
Unchanged
0

BIOMARIN PHARMACEUTICAL INC

7.6M$936.1M4.1%$88.83+37.54%
6 qtrssince 2019-Q1
Unchanged
0

Kodiak Sciences, Inc.

11.6M$626.4M2.8%$19.52+175.05%
6 qtrssince 2019-Q1
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.4M$501.4M2.2%$117.70+23.37%
6 qtrssince 2019-Q1
Unchanged
0
NVTAQNVTAQDelisted

INVITAE CORP

11.9M$359M1.6%
6 qtrssince 2019-Q1
Increased
62
MYOKMYOKDelisted

MYOKARDIA INC

3.2M$305.7M1.3%
6 qtrssince 2019-Q1
Increased
74
AMRNAMRN
ADR

Amarin Corporation plc

34.5M$238.7M1.1%
ARGXARGX
ADR

ARGENX SE - ADR

1M$229.6M1.0%$124.84+78.86%
6 qtrssince 2019-Q1
Unchanged
0
IGMSIGMSDelisted

IGM BIOSCIENCES INC

3.1M$229.5M1.0%
4 qtrssince 2019-Q3
Increased
48

MADRIGAL PHARMACEUTICALS INC

1.5M$169.8M0.7%$113.12-9.18%
6 qtrssince 2019-Q1
Unchanged
0
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.4M$161M0.7%
6 qtrssince 2019-Q1
Unchanged
0
EXASEXASDelisted

EXACT SCIENCES CORP

1.8M$160.5M0.7%$91.87-6.37%
3 qtrssince 2019-Q4
Unchanged
0

NEUROCRINE BIOSCIENCES INC

906,986$110.7M0.5%$87.28+43.79%
6 qtrssince 2019-Q1
Decreased
0
PRPRNBDelisted

Principia Biopharma Inc

1.6M$94.5M0.4%
6 qtrssince 2019-Q1
Decreased
0
FMTXFMTXDelisted

FORMA THERAPEUTICS HLDGS INC

2M$93M0.4%
1 qtr
New
49

CERUS CORP

13.7M$90.5M0.4%$5.89+10.64%
6 qtrssince 2019-Q1
Unchanged
0
$22.7B
AUM
114
Positions
Q2 2020
Filing
Rating · 3.5
Quarterly Portfolio Change
-6%Q2'19$14.7B-0%Q3'19$14.7B+28%Q4'19$18.8B-14%Q1'20$16.2B+40%Q2'20$22.7B
Activity profile
$ moved · Q2'20
New6%Increased39%Decreased52%Exited3%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.0 years
<1Q11%1-4Q23%1-2Y54%2Y+12%

BAKER BROS. ADVISORS LP manages $22.7B across 114 positions as of Q2 2020. Top holdings: SGEN (35.4%), INCY (14.7%), ONC (9.8%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3.5/5.0.

Q2 2020 Summary

Active quarter - 15 new positions, 11 exits, 20 increased. Top move: MYOK (INCREASED, conviction 74). Portfolio: $22.7B across 114 positions.

Top holdings by portfolio weight

Total AUM$23B
SGEN35.43%
INCY14.67%
ONC9.79%
ACAD8.96%
ALXN4.34%
BMRN4.13%
KOD2.76%
ASND2.21%
NVTAQ1.58%
MYOK1.35%
Other1.05%

Portfolio allocation by GICS sector

Sectors3
Healthcare52.56%
Unknown47.43%
Financial Services0.01%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Strong(3.5 / 5.0)
Track Record66
Conviction39
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
8Q
INCYINCYINCYTE CORP
Q3 2024 Q2 2026+23,806 shares+$1.6B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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